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Medicinal Chemistry in Europe IV

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1185

Special Issue Editor


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Guest Editor
Institute of NeuroPhysiopathology, UMR 7051, Faculté de Médecine Secteur Nord, 51, Boulevard Pierre Dramard - CS80011, 13344 - Marseille Cedex 15, France
Interests: antimicrobial peptides; antibacterial; antibiotics; structure-activity relationships; bacteriocins; drug design; peptide engineering
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Special Issue Information

Dear Colleagues,

This Special Issue, “Medicinal Chemistry in Europe IV”, of the journal Molecules deals with the structure–activity relationship of all of the natural molecules of interest in a wide range of areas (microbiology, neurobiology, pharmacology, immunology, cancerology, toxicology, etc.), from basic research to more applied clinical developments. Studies on molecules of a varied nature (i.e., peptides/proteins and organic compounds), size, and function—as well as molecular complexes—will be considered for publication in the Special Issue.

Scientists working on the various fields of medicinal chemistry from all over Europe are cordially invited to submit to this Special Issue.

Dr. Jean-Marc Sabatier
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural molecules
  • organic compounds
  • drug design
  • pharmacophores
  • peptides
  • proteins
  • carbohydrates
  • lipids
  • glycopeptides/glycoproteins
  • lipopeptides/lipoproteins
  • structure–function

Published Papers (1 paper)

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Research

13 pages, 2257 KiB  
Article
Direct Immersion–Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
by Magdalena Świądro-Piętoń, Dominika Dudek and Renata Wietecha-Posłuszny
Molecules 2024, 29(3), 676; https://doi.org/10.3390/molecules29030676 - 31 Jan 2024
Viewed by 623
Abstract
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood [...] Read more.
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick screening analysis while minimizing the volume of the tested sample and solvent, in line with the principles of green analytical chemistry. The method was used to analyze 38 blood samples taken from patients with mood disorders, and drug concentrations were determined and compared with therapeutic and toxic dose ranges. This allowed for better control of the course of treatment. Full article
(This article belongs to the Special Issue Medicinal Chemistry in Europe IV)
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