Special Issue "Organophosphorus Chemistry 2018"
Deadline for manuscript submissions: 31 August 2019
Prof. György Keglevich
Department of Organic Chemistry and Technology; Budapest University of Technology and Economics
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Interests: organophoshorus chemistry, P-heterocycles, green chemistry, microwave chemistry, ionic liquids,phase transfer catalysis, selective reactions, P-refunctionalizations, esterification of P-acids, P-C couplings, Pudovik reaction, Kabachnik-Fields reaction, mechanisms, theoretical studies, phosphine-transition metal complexes, phosphine-boranes
Organophosphorus chemistry is an important discipline within organic chemistry. Phosphorus compounds, such as phosphines, trialkyl phosphites, phosphine oxides (chalcogenides), phosphonates, phosphinates and >P(O)H species, etc., may be important starting materials or intermediates in syntheses. Let us mention the Wittig reaction and the related transformations, the Arbuzov- and the Pudovik reactions, the Kabachnik–Fields condensation, the Hirao reaction, the Mitsunobu reaction, etc. Other reactions, e.g., homogeneous catalytic transformations or C-C coupling reactions involve P-ligands in transition metal (Pt, Pd, etc.) complex catalysts. The synthesis of chiral organophosphorus compounds means a continuous challenge. Methods have been elaborated for the resolution of tertiary phosphine oxides and for stereoselective organophosphorus transformations. P-heterocyclic compounds, including aromatic and bridged derivatives, P-functionalized macrocycles, dendrimers and low coordinated P-fragments, are also of interest. An important segment of organophosphorus chemistry is the pool of biologically-active compounds that are searched and used as drugs, or as plant-protecting agents. The natural analogue of P-compounds may also be mentioned. Many new phosphine oxides, phosphinates, phosphonates and phosphoric esters have been described, which may find application on a broad scale. Phase transfer catalysis, ionic liquids and detergents also have connections to phosphorus chemistry. Green chemical aspects of organophosphorus chemistry (e.g., microwave-assisted syntheses, solvent-free accomplishments, optimizations, and atom-efficient syntheses) represent a dynamically developing field. Last, but not least, theoretical approaches and computational chemistry are also a strong sub-discipline within organophosphorus chemistry. All potential authors working in the field of phosphorus chemistry are invited to contribute, and to enrich the Special Issue “Organophosphorus Chemistry 2018”.
Prof. Dr. György Keglevich
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- organophosphorus chemistry
- phosphine chalcogenides
- phosphinic acids
- phosphonic acids
- phosphine boranes
- phosphine complexes
- homogeneous catalysis
- phase transfer catalysis
- ionic liquids
- biologically active substrates
- theoretical calculations
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Continuous flow alcoholysis of dialkyl-H-phosphonates with aliphatic alcohols
Article type: Article
Authors: E. Bálint, Á. Tajti, N. Tóth and G. Keglevich
Affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungar
Title： 1-(N-Acylamino)alkylphosphonic Acids -Alkaline Deacylation
Article type: Article
Author: Marek Cypryk1, Jozef Drabowicz*1,2, Bartlomiej Gostynski1, Marcin H. Kudzin3, Zbigniew H. Kudzin*4 and Pawel Urbaniak4
Title: Towards the Greener Synthesis of α–Hydroxyphosphonic Derivatives Including Dronic
Article type: Article
Authors: G. Keglevich, A. Grün, Z. Rádai, D. I. Nagy and I. Greiner
Affiliation: Department of Organic Chemistry and Technology, Budapest University of Technology and Economics,
H-1521 Budapest, Hungary; [email protected]
Abstract: α-Hydroxyphosphonates that may be biologically active substrates due to their enzyme inhibitory properties may be best synthesized by the Pudovik reaction. We could elaborate the, for the time being, greenest protocol . The use of α-ketophosphonates as the starting materials led to α-hydroxymethylenebisphosphonates (HMBPs). Special HMBP derivatives are the dronic acid derivatives  prepared by the reaction of the corresponding substituted acetic acids with phosphorus trichloride and phosphorous acid in sulfolane. We found that this reaction may be promoted by ionic liquid additives .
References:  G. Keglevich, Z. Rádai, N.Z. Kiss, Green Process. Synth., 6, 197 (2017).
 D.I. Nagy, A. Grün, S. Garadnay, I. Greiner, G. Keglevich, Molecules, 21(8), e1046 (2016).
 D.I. Nagy, A. Grün, K. Lévay, S. Garadnay, I. Greiner, G. Keglevich, Synth. Commun., in press (2018).