Next Article in Journal
Determination of the Absolute Configurations of Chiral Drugs Using Chiroptical Spectroscopy
Next Article in Special Issue
Effect of Mono- and Poly-CH/P Exchange(s) on the Aromaticity of the Tropylium Ion
Previous Article in Journal
Insecticidal Properties of a Highly Potent Wax Isolated from Dolichandra cynanchoides Cham
Previous Article in Special Issue
Synthesis, Spectral Characterization of Several Novel Pyrene-Derived Aminophosphonates and Their Ecotoxicological Evaluation Using Heterocypris incongruens and Vibrio fisheri Tests
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessReview
Molecules 2016, 21(8), 1046;

Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary
Gedeon Richter Plc., 1475 Budapest, Hungary
Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 15 July 2016 / Revised: 2 August 2016 / Accepted: 3 August 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Recent Advances in Organophosphorus Chemistry)
Full-Text   |   PDF [3436 KB, uploaded 11 August 2016]   |  


The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions. View Full-Text
Keywords: hydroxymethylenebisphosphonic acid (dronic acid) derivatives; solvent; P-reagents; synthesis hydroxymethylenebisphosphonic acid (dronic acid) derivatives; solvent; P-reagents; synthesis

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Nagy, D.I.; Grün, A.; Garadnay, S.; Greiner, I.; Keglevich, G. Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents. Molecules 2016, 21, 1046.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top