Advances in the Structure and Functions of High-Density Lipoprotein (HDL)

Dear Colleagues,

The structure and functions of high-density lipoproteins (HDLs) are critical for determining HDL quality.

The quality of HDLs is dependent on the morphologies of HDL, such as particle size, shape, and number. The HDL quality also depends on the composition of HDL, such as apolipoproteins (apoA-I, apoA-II, apoC-III, serum amyloid A, and a-synuclein), cholesterol, and triglyceride. HDL quality is also associated with the extent of HDL modification, such as glycation and oxidation, resulting in the multimerization of apoA-I and the aggregation of amyloidogenesis. HDL quality frequently determines HDL functionality, which depends on the enzyme activity of the corresponding antioxidant, such as the paraoxonase and cholesterol efflux activity. Conventional HDL functionality involves the regression and removal of cholesterol from the atherosclerotic lesions, and the removal of oxidized species from low-density lipoprotein (LDL). Recently, HDL functionality was reported to expand the removal of b-amyloid plaques and inhibit a-synuclein aggregation in the brain to attenuate Alzheimer’s disease and Parkinson’s disease, respectively. HDL functionality is associated with the susceptibility to and recovery from COVID-19 infection by inhibiting the activity of SARS-CoV-2. The appearance of dysfunctional HDL is frequently associated with many acute infectious diseases and chronic aging-related diseases. This Special Issue aims to highlight the recent advances in HDL quantity, quality, and functionality depending on the state of health and disease.

Prof. Dr. Kyung-Hyun Cho
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.