Diels-Alder Reaction in Organic Synthesis

Dear Colleagues,

The Diels–Alder reaction is one of the most effective and reliable strategies for the construction of six-membered carbocyclic and heterocyclic rings. Since the seminal work of Otto Diels and Kurt Alder in 1928, the advances and developments of the Diels–Alder reaction, as well as extensive mechanistic and computational studies, have emerged at an impressive rate. The high regio- and stereoselectivity of the Diels–Alder reaction and its versatility, mainly due to the available panoply of dienes and dienophiles, including heterodienes and heterodienophiles, make it a powerful tool for organic chemists. Furthermore, the asymmetric Diels–Alder reaction has become an important synthetic approach to optically active six-membered rings. Despite the enormous advances in this area, from asymmetric Diels–Alder reaction to total synthesis of drugs and natural products, new contributions continue to be reported.

This Special Issue on “Diels–Alder Reaction in Organic Synthesis” aims to bring together the latest developments on this topic. Full papers, communications, and reviews are all welcome for submission.

Prof. Dr. Teresa Pinho e Melo
Dr. Maria Isabel L. Soares
Guest Editors

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