Chiral Stationary Phases for Enantioseparations: Fundamentals, Preparation, Methods, Applications and Chiral Recognition Mechanisms

Dear Colleagues,

Chiral stationary phases (CSPs) are special tools for the enantioseparation of chiral compounds, and the evolution of the techniques, as well as the development of chiral columns of high efficiency, have made chromatography a strategic tool for the chemical sciences. Chromatography techniques on CSPs based on small selectors, chiral crown ethers, synthetic polymers, polysaccharide derivatives, cyclodextrins, cyclofructans, macrocyclic glycopeptides, and proteins, are largely used by academic, industrial, and pharmaceutical chemists for resolving racemic mixtures. Homochiral metal–organic framework (MOFs)- and single-walled carbon nanotube (SWCNT)-based CSPs represent the last frontier in this field. CSPs have been fruitfully exploited coupled with gas chromatography (GC), high-performance liquid chromatography (HPLC), supercritical fluid chromatography (SFC), capillary electrochromatography (CEC), and nano-liquid chromatography (nano-LC). On the other hand, the understanding of the chiral recognition mechanisms of a given CSP is a fundamental tool to design a successful enantioseparation.

This Special Issue welcomes the submission of contributions in the form of original research and review articles with the aim of profiling recent and future trends in the preparation, applications, and chiral recognition mechanisms of CSPs used to produce pure enantiomers. Fundamentals and method development studies in this field will be covered by this Special Issue along with CSP applications for separation of non-enantiomeric compounds that are difficult to separate with conventional achiral materials.

Dr. Paola Peluso
Dr. Victor Mamane
Guest Editors

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