Advances in Small Bioactive Molecules: From Molecular Pathways to Health Benefits

Dear Colleagues,

Small bioactive molecules play a central role in shaping physiological functions, influencing pathways that regulate metabolism, inflammation, oxidative stress, and cellular communication. Their structural diversity and biological activity make them key candidates for advancing therapeutic strategies, improving disease prevention, and supporting precision nutrition. Recent advances in molecular biology, nutrigenomics, and analytical chemistry have expanded our understanding of how these compounds interact with biological systems, providing new opportunities to translate basic science into clinical and nutritional applications. This Special Issue aims to gather original research and critical reviews exploring the identification, characterization, and functional mechanisms of small bioactive molecules. We invite contributions on molecular targets, signaling pathways, and mechanistic insights, as well as translational studies addressing their role in health promotion and disease management. In particular, we welcome studies highlighting innovative methodologies for analysis, novel sources of bioactive compounds, and their impact on sustainable nutrition and preventive medicine. By integrating evidence across disciplines, this collection seeks to provide a comprehensive overview of recent progress, from fundamental molecular pathways to practical health benefits, advancing the knowledge base of small bioactive molecules as modulators of human health.

Dr. Raffaella Comitato
Dr. Srinivasa Reddy Telukutla
Guest Editors

Dr. Maria Cristina Sorrentino
Guest Editor Assistant

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.