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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Translational Oncology and Oncometabolism

edited by Graham Pidgeon and

Zivile Useckaite

submission deadline 31 Oct 2025 | Viewed by 153 | Submission Open

Keywords: oncometabolism; obesity; clinical research; clinical trials; oncogenes; translational oncology

(This special issue belongs to the Section Cell Metabolism)

Salivary Biomarkers and Metabolites in Pigs

edited by

Fernando Tecles

submission deadline 31 Oct 2025 | Viewed by 107 | Submission Open

Keywords: saliva; biomarkers; welfare and health; animals

(This special issue belongs to the Section Animal Metabolism)

The Interaction Between Metabolic Dysfunction and Hypothalamic Inflammation

edited by

Joana M. Gaspar

submission deadline 31 Oct 2025 | Viewed by 82 | Submission Open

Keywords: metabolic disorders; neuroinflammation; hypothalamus; energy homeostasis; feeding behavior; high-fat diets; obesity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Biomarkers and Nutrition in Degenerative Conditions and Gastrointestinal Cancer Surgery: 2nd Edition

edited by

Irene Lidoriki

Dimitrios Schizas

and Maximos Frountzas

submission deadline 31 Oct 2025 | Viewed by 81 | Submission Open

Keywords: biomarkers; nutrition; metabolism; metabolomics; degenerative disease; Parkinson’ s disease; Alzheimer’ s disease; cardiovascular disease; gastrointestinal cancer surgery

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics of Human Nutrition: The Dot of Human Nutrition and the Circle of Soil, Plants, Animals and Microbes in Relation to It, 2nd Edition

edited by

Shoma Berkemeyer

submission deadline 31 Oct 2025 | Viewed by 77 | Submission Open

Keywords: human nutrition; metabolomics; physiology; biochemistry; dietetics; pathophysiology; soil science; crop science; animal husbandry; microbes

(This special issue belongs to the Section Nutrition and Metabolism)

Dysbiosis and Metabolic Disorders of the Microbiota

edited by

Guozhu Ye

submission deadline 1 Nov 2025 | 4 articles | Viewed by 3446 | Submission Open

Keywords: metabolomics; metagenomics; metaproteomics; metatranscriptomics; Liquid Chromatograph-Mass Spectrometer; Gas Chromatography-Mass Spectrometer; gut microbiota; environmental microbiota; metabolism; metabolic disorders

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Nutrition and Metabolism in Poultry

edited by

Catarina Stefanello

submission deadline 10 Nov 2025 | 1 articles | Viewed by 809 | Submission Open

Keywords: ingredient; feed additive; feed quality; nutrient utilization; intestinal health

(This special issue belongs to the Section Animal Metabolism)

Mechanistic Insights into Metabolic Interactions with the Tumor Microenvironment

edited by

Jyoti Kaushal

submission deadline 15 Nov 2025 | 1 articles | Viewed by 1408 | Submission Open

Keywords: metabolism; tumor microenvironment; therapy; immune cells; clinical oncology; metabolic pathways

(This special issue belongs to the Section Cell Metabolism)

The Relationship Between Adipose Tissue Insulin Resistance and Metabolic Syndrome

edited by

Atefeh Rabiee

submission deadline 15 Nov 2025 | Viewed by 89 | Submission Open

Keywords: adipose insulin resistance; metabolic syndrome; visceral adiposity; adipocytokines; insulin signaling; lipolysis dysregulation; cardiometabolic risk; lipotoxicity; adipose inflammation; insulin sensitivity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Targeted and Non-Targeted LC- and GC-HRMS Workflows for the Analysis of Emerging Contaminants and the Environmental Exposome

edited by Lapo Renai and

Massimo Del Bubba

submission deadline 16 Nov 2025 | Viewed by 187 | Submission Open

Keywords: chromatography; high-resolution mass spectrometry; non-targeted analysis; exposome; data analysis; environmental analysis; pharmaceuticals; poly- and perfluorinated substances; personal care products; transformation products feature detection and identification

(This special issue belongs to the Section Environmental Metabolomics)

Diet, Gut Microbiota and Metabolic Health

edited by

Hui Han

and

Jing Wang

submission deadline 17 Nov 2025 | 1 articles | Viewed by 714 | Submission Open

Keywords: diet; nutrition; gut microbiota; metabolites; metabolism

(This special issue belongs to the Section Animal Metabolism)

Neurometabolics in a Nutshell

edited by

Justyna Paprocka

submission deadline 20 Nov 2025 | Viewed by 146 | Submission Open

Keywords: neurometabolic disorders; rare diseases; diagnosis; differential diagnosis; treatment options

(This special issue belongs to the Section Cell Metabolism)

Effects of Various Exercise Methods on Metabolic Health

edited by

Hun-Young Park

and Won-Sang Jung

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1700 | Submission Open

Keywords: exercise physiology; metabolism; insulin sensitivity; energy expenditure; cardiovascular health; resistance training; high-intensity interval training; hypoxia; mitochondrial function; metabolic syndrome

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Sex Differences in Physical Exercise and Dietary Habits Effects on Metabolic Health

edited by Hannah Cabre and

Adam M. Gonzalez

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1642 | Submission Open

Keywords: sex differences; metabolomics; metabolites; menstrual cycle; aging; exercise performance; nutrition intervention; cardiometabolic

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring and Expanding Horizons in Secondary Metabolites: Biosynthesis, Identification, Regulation and Biological Activity

edited by

Alberto Jorge Oliveira Lopes

Antônio José Cantanhede Filho

and Claúdia Quintino Da Rocha

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4625 | Submission Open

Keywords: secondary metabolites; biosynthesis; regulation; identification; plants; microorganisms; marine organisms; animals; bioactivity; drug discovery; natural products

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Environmental Metabolites Insights into Health and Disease

edited by

Yu Sun

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4253 | Submission Open

Keywords: environmental metabolites; probiotics; health; disease; toxic metabolites; protective metabolites; metabolomics; environmental exposure; molecular mechanisms; metabolic pathways

(This special issue belongs to the Section Environmental Metabolomics)

Inflammation and Oxidative Stress in Age-Related Metabolic Changes and Disorders

edited by

Sylwia Dzięgielewska-Gęsiak

Teresa Grzelak

and Grzegorz Dziubanek

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4128 | Submission Open

Keywords: nutritional attitudes and behaviors; bioconcentration factor; health risk assessment; dietary exposure; farm-fresh foods; medicinal plants; gut microbiota; dietary supplements; trace elements— Zn; Cu; heavy metals

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Biomarkers in Type 2 Diabetes: From Discovery to Application

edited by Eiji Kutoh and

Shengshuai Shan

submission deadline 30 Nov 2025 | 1 articles | Viewed by 3067 | Submission Open

Keywords: metabolic biomarkers; type 2 diabetes (T2DM); glucose metabolism; insulin resistance; lipid profiles; diagnosis and prognosis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

One-Carbon Metabolism in Pregnant Women, Fetuses, and Infants

edited by

Yoshinori Kubo

and

Hikaru Hori

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1659 | Submission Open

Keywords: folate cycle (5-methyltetrahydrofolate; folic acid; vitamin B12; serine; glycine); methionine cycle (homocysteine; methionine; S-adenosylmethionine; S-adenosylhomocysteine); choline metabolic pathway (betaine; choline); trans-sulfuration pathway (cysteine; taurine; vitamin B6); epigenetics; developmental origins of health and disease (DOHaD)

(This special issue belongs to the Section Nutrition and Metabolism)

Mass Spectrometry-Based Metabolomics in Health and Disease: Targeted Analysis and Its Trends

edited by

Mohammad Mehdi Banoei

and

Mehdi Mirsaeidi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1383 | Submission Open

Keywords: mass spectrometry-based metabolomics; targeted metabolomics; health and disease; precision medi-cine; biomarker discovery; metabolic pathways

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 30 Nov 2025 | 1 articles | Viewed by 613 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

Environmental Exposure and Its Effects on Cardio-Respiratory and Metabolic Health

edited by

Kristine McGrath

and Tatt Jhong Haw

submission deadline 30 Nov 2025 | 1 articles | Viewed by 583 | Submission Open

Keywords: environmental factors; pollution; cardiovascular; cardiometabolic risk factor; biomarkers; mechanisms; cardio-oncology; cardio-respiratory

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Role of Isotope Tracers in Investigating Metabolic Disorders

edited by Nadezda Khodorova

submission deadline 30 Nov 2025 | Viewed by 294 | Submission Open

Keywords: kinetics effect; isotope ratio mass spectrometry; biomarker; fluxomics; metabolomics; stable isotope; tracing experiments; mass spectrometry; breath tests

(This special issue belongs to the Section Metabolomic Profiling Technology)

Phenological Regulation of Secondary Metabolism

edited by

Iván De-la-Cruz-Chacón

, Alma Rosa González-Esquinca and

Xin Fang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 169 | Submission Open

Keywords: phenological fluctuations; metabolites’ phenological fluctuations; secondary metabolites; natural products; specialized metabolites

(This special issue belongs to the Section Plant Metabolism)

Investigating the Impact of Teas on Metabolic Disorders: Insights into Underlying Mechanisms and Therapeutic Potential

edited by

Ran Wei

and

Michał Tomczyk

submission deadline 30 Nov 2025 | Viewed by 134 | Submission Open

Keywords: teas; metabolic disorders; mechanism of action; therapeutic potential; diabetes; obesity; cardiovascular diseases; biochemical properties; clinical studies; therapeutic strategies

(This special issue belongs to the Section Nutrition and Metabolism)

The Future Perspective on Screening and Diagnosis of Inborn Errors of Metabolism

edited by Luiz Carlos Santana-Da-Silva, Olga Yaneth Echeverri-Peña and

Angela J. Espejo-Mojica

submission deadline 30 Nov 2025 | Viewed by 129 | Submission Open

Keywords: inborn errors of metabolism (IEM); genetic disorders; diagnostics; biomarkers; omics sciences; imaging techniques (MRS; PET); molecular techniques (NGS; gene editing); personalized medi-cine; early detection

Imaging and Spectroscopic Based Methods to Understand Cancer Metabolism and Biology 2025

edited by

Madhu Basetti

submission deadline 30 Nov 2025 | Viewed by 114 | Submission Open

Keywords: PET; CT; MRI; NMR; molecular imaging; optical imaging; opto-acoustic imaging; Raman imag-ing and spectroscopy; mass spectroscopy imaging; metabolic pathways; theranostic imaging; machine learning; deep learning; artificial intelligence; image analysis; tumors; cancer; cancer metabolism; cancer biology; tumor microenvironment; tumor heterogeneity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Proteomics and Metabolomics in Human Health and Disease

edited by

Michele Costanzo

and

Margherita Ruoppolo

submission deadline 30 Nov 2025 | Viewed by 101 | Submission Open

Keywords: proteomics; metabolomics; lipidomics; multi-omics; disease mechanisms; machine learning; omics integrations; artificial intelligence

(This special issue belongs to the Section Advances in Metabolomics)

Exposome and Metabolic Effects: Neurological Implications of Environmental Pollutants

edited by

Roberta Zupo

submission deadline 30 Nov 2025 | Viewed by 99 | Submission Open

Keywords: exposome; environmental pollutants; metabolic effects; neurological implications; neurodegenerative diseases; cognitive dysfunction; brain metabolism; toxins; environmental health; developmental disorders; neurobiology; genetic predisposition; preventive strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Autophagy and Antioxidant Pathways in Neurodegenerative Diseases

edited by

Federica Armeli

and

Rita Businaro

submission deadline 30 Nov 2025 | Viewed by 97 | Submission Open

Keywords: neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; autophagy; neuroinflammation; oxidative stress; antioxidant pathways; neuroprotection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Personalized Medicine

edited by

Angom Ramcharan Singh

submission deadline 30 Nov 2025 | Viewed by 94 | Submission Open

Keywords: metabolomics; personalized medicine; biomarkers; precision health; disease stratification; metabolic profiling; NMR spectroscopy; mass spectrometry; therapeutic response; systems biology

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Breath Biomarker Discovery

edited by Waqar Ahmed

submission deadline 30 Nov 2025 | Viewed by 78 | Submission Open

Keywords: exhaled breath volatiles; metabolomics; biomarkers; volatile organic compounds

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Disease Mechanisms and Drug Targets, 2nd Edition

edited by

Kefeng Li

submission deadline 30 Nov 2025 | Viewed by 73 | Submission Open

Keywords: metabolomics; disease mechanism; drug target; biomarker; disease prediction

(This special issue belongs to the Section Metabolomic Profiling Technology)

Advances in Gut Microbiome Metabolomics

edited by

Ulrike E. Rolle-Kampczyk

Beatrice Engelmann

and

Sven-Bastiaan Haange

submission deadline 1 Dec 2025 | 2 articles | Viewed by 2018 | Submission Open

Keywords: gut microbiome– host interaction; cross talk; metabolomics; omics- technologies; microbiome signatures; new diagnostic tools; novel therapeutic strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Respiratory, Cardiovascular and Metabolic Disorders

edited by Joaquim Gea

submission deadline 1 Dec 2025 | Viewed by 113 | Submission Open

Keywords: metabolomics; small molecules; mass spectrometry; NMR; personalized medicine; biomarkers; car-diovascular disorders; respiratory diseases; endocrine metabolic abnormalities

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics and Plant Defence, 2nd Edition

edited by

Shitou Xia

and

Junxing Lu

submission deadline 5 Dec 2025 | Viewed by 227 | Submission Open

Keywords: metabolomics; plant defence; biotic and abiotic stress; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Metabolite Profiles in Inflammatory Diseases

edited by Rodica Pădureanu and

Ionut Donoiu

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1006 | Submission Open

Keywords: gut; inflammation; markers; metabolomics; multiple sclerosis; rheumatoid arthritis; lung disease; osteoarthritis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Expanding Boundaries in Spatial Metabolomics and Lipidomics: Advances in Mass Spectrometry Imaging

edited by

Vanna Denti

and

Simone Serrao

submission deadline 15 Dec 2025 | Viewed by 106 | Submission Open

Keywords: spatial omics; mass spectrometry imaging; multimodal; imaging data analysis; spatial functional analysis; small-molecule biochemistry

(This special issue belongs to the Section Advances in Metabolomics)

Metabolomics in Plant Natural Products Research, 2nd Edition

edited by

Junsong Wang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 484 | Submission Open

Keywords: natural products; metabolomics; plant– environment interactions; chemical markers; active principles; LC/MS; GC/MS; NMR

(This special issue belongs to the Section Plant Metabolism)

Exploring Uric Acid and Beyond

edited by

Pietro Cirillo

and

Claudio Borghi

submission deadline 31 Dec 2025 | 7 articles | Viewed by 15560 | Submission Open

Keywords: uric acid; cardiovascular risk; kidney disease; obesity; diabetes; lipid metabolism; immune programming

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Meeting the Challenge of Metabolomics Analysis by Using Multidimensional Gas Chromatography with Mass Spectrometry

edited by

Yong Foo Wong

and

Philip J. Marriott

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15352 | Submission Open

Keywords: GC× GC; MDGC; metabolites; high-resolution mass spectrometry; metabolite profiling; metabolite fingerprinting; biomarker; plant secondary compounds; disease diagnosis

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolic Insights into Natural Health Products and Dietary Supplements for Human Health

edited by

Julia Solnier

and Mary Hardy

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3307 | Submission Open

Keywords: bioactive natural compounds; traditional medicine; metabolic pathways; absorption; distribution; metabolism; and excretion (ADME); clinical efficacy; pharmacokinetics; nutritional supplements; health benefits; safety and toxicology; delivery systems

(This special issue belongs to the Section Nutrition and Metabolism)

Lipid Signaling, Therapeutics and Controlled-Release

edited by Wen-Lung Ma and Hung-Yu Sun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2509 | Submission Open

Keywords: lipid signaling; therapeutics; controlled release

(This special issue belongs to the Section Lipid Metabolism)

Insights into Tumor Cell Metabolism and Epigenetics

edited by

Sara Granja

, Vera Miranda-Gonçalves and Filipa Vieira

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2207 | Submission Open

Keywords: Warburg effect; epigenetic alterations; metabolic reprogramming; epigenome; transcriptional regula-tion; fatty acid metabolism

(This special issue belongs to the Section Cell Metabolism)

Harnessing the Power of NMR Metabolomics in Unraveling Metabolic Diseases

edited by

Chi-Jen Lo

and

Mei-Ling Cheng

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1991 | Submission Open

Keywords: metabolomics; NMR; precision medicine; translational medicine; metabolic disease

(This special issue belongs to the Section Integrative Metabolomics)

Mitochondrial Metabolism in Health and Disease: A Clinical Perspective

edited by

Joao Pessoa

Ana Duarte

and

Susana P. Pereira

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1490 | Submission Open

Keywords: mitochondrion; bioenergetics; oxidative stress; calcium homeostasis; apoptosis; cancer; metabolic diseases; cardiovascular diseases; neurodegenerative diseases

(This special issue belongs to the Section Cell Metabolism)

Metabolomics in Neurodegenerative Diseases, 2nd Edition

edited by

Stewart Francis Graham

and Nazia M. Saiyed

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1179 | Submission Open

Keywords: neurodegenerative disease; Alzheimer’ s; Parkinson’ s; Huntington’ s; ALS; neurodegeneration; bi-omarkers; metabolism; etiology; pathophysiology; biochemistry

(This special issue belongs to the Section Cell Metabolism)

Metabolic and Endocrine Adaptations in Aquatic Animals

edited by

Anapaula Sommer Vinagre

, Luiz C. Kucharski and Mariana Leivas Müller Hoff

submission deadline 31 Dec 2025 | 1 articles | Viewed by 939 | Submission Open

Keywords: aquatic animal metabolism; animal endocrinology; fish metabolism; fish endocrinology; crustacean metabolism; crustacean endocrinology

(This special issue belongs to the Section Animal Metabolism)

Advancing Metabolite Biomarkers in Neurodegenerative Disease: Discovery, Integration, and Therapeutic Potential

edited by Robert Logan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 790 | Submission Open

Keywords: biomarkers; neurodegeneration; metabolites; metabolic pathways; metabolomic; Alzheimer’ s disease; Parkinson’ s disease

(This special issue belongs to the Section Cell Metabolism)

Energy Metabolism in Brown Adipose Tissue

edited by

Chuanhai Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 769 | Submission Open

Keywords: energy metabolism; thermogenic fat tissue; metabolites; mitochondrial function; ER stress

(This special issue belongs to the Section Cell Metabolism)

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