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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Application of Metabolomics in Chemistry and Biochemistry

edited by Nerilson Marques Lima,

Teresinha Andrade

and

Felipe de Almeida La Porta

submission deadline 25 Dec 2026 | Viewed by 159 | Submission Open

Keywords: metabolomics; analytical chemistry; biochemistry; mass spectrometry; nuclear magnetic resonance; chemometrics; metabolite annotation; pathway analysis; multi-omics

(This special issue belongs to the Section Advances in Metabolomics)

Nutritional Regulation of Gut Microbiome in Humans and Livestock

edited by Junquan Tian and

Qian Jiang

submission deadline 25 Dec 2026 | Viewed by 156 | Submission Open

Keywords: microbial metabolites; precision nutrition and synbiotics; multi-omics integration; livestock resilience optimization; dysbiosis-amended interventions

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Adaptations to Exercise: Mechanisms, Modulators, and Health Impacts

edited by

Kiwon Lim

and

Jisu Kim

submission deadline 31 Dec 2026 | 8 articles | Viewed by 9704 | Submission Open

Keywords: exercise metabolism; metabolic adaptations; mitochondrial function; metabolic flexibility; energy substrate utilization; exercise-induced remodeling; skeletal muscle metabolism; metabolomics and multi-omics approaches

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exploring Pathological Mechanisms in Obesity, Diabetes, and Metabolic Syndrome: 2nd Edition

edited by

Tiemin Liu

Hongmei Yan

and

Qiongyue Zhang

submission deadline 31 Dec 2026 | 7 articles | Viewed by 8115 | Submission Open

Keywords: metabolic diseases: obesity, diabetes, NAFLD, MAFLD, NASH, metabolic syndrome, etc.; multi-omics: metabolomics, lipidomics, proteomics, etc.; pathogenesis: genetic predispositions, lifestyle factors, microbiome and environmental exposures, etc.

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Muscle Metabolic Response and Adaptation to Exercise, Diet, and Environment: 2nd Edition

edited by

Susumu Muroya

submission deadline 31 Dec 2026 | 4 articles | Viewed by 5564 | Submission Open

Keywords: skeletal muscle; metabolomics; mitochondria; energy metabolism; lipid metabolism; nutrition; feeding; environment; exercise; stress

(This special issue belongs to the Section Animal Metabolism)

Advances on Metabolomics: Driving Innovation in Bio-Analysis and Natural Products Research

edited by

Natalia Drabińska-Fois

Daria Cicha-Wojciechowicz

Patrycja Mojsak

Eliza Matuszewska-Mach

and Martyna Pajewska-Szmyt

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3309 | Submission Open

Keywords: metabolomics; bioanalysis; biomedical research; biomarkers; foodomics; lipidomics; volatilomics; natural products; clinical diagnosis; biomarker discovery; analytical approaches; method development; mass spectrometry; disease detection; microorganisms

(This special issue belongs to the Section Advances in Metabolomics)

Open-Source Software in Metabolomics, 2nd Edition

edited by

Seongho Kim

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3085 | Submission Open

Keywords: GC- MS; LC-MS; mass spectrometry; metabolomics; open-source software

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Biomarkers in Obesity, Metabolic Syndrome, and Weight Loss: Advances in Diagnosis, Risk Stratification, and Personalized Management

edited by

Martina Gažarová

Petra Lenártová

and

Magdalena Górnicka

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3068 | Submission Open

Keywords: obesity biomarkers; metabolic risk stratification; adipose tissue dysfunction; nutritional biomarkers; personalized nutrition; nutrition interventions; weight loss interventions; body composition analysis; emerging anthropometric indices

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Research in Dairy Cattle Health

edited by

Wei Yang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2449 | Submission Open

Keywords: dairy cow; nutrient metabolism; feed ingredients; additives; disease; microbes; metabolite biomarkers

(This special issue belongs to the Section Animal Metabolism)

Bioactive Compounds: Plant Stress Responses, Metabolic Regulation, and Therapeutic Insights

edited by

Periyasamy Rathinapriya

and

Theivanayagam Maharajan

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1822 | Submission Open

Keywords: abiotic stress adaptation; antioxidant potential; cytotoxic and therapeutic activity; plant-derived elicitors; plant metabolism

(This special issue belongs to the Section Plant Metabolism)

Bioactive Secondary Metabolites from Marine Macro- and Microorganisms

edited by

Xiaowei Luo

and

Yonghong Liu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1745 | Submission Open

Keywords: secondary metabolites; bioactivity; marine natural products; marine microorganisms; marine organisms; drug discovery; lead compounds; pharmacological mechanism; marine drugs

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Regulation in Cancer Development and Progression

edited by Ovidiu Nicolae Pop and Carmen Pantiș

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1437 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor progression; glycolysis; lipid metabolism; amino acid metabolism; mitochondrial metabolism; tumor microenvironment; immunometabolism; therapeutic resistance

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Biomarkers and Metabolites in Clinical Practice and Research

edited by

Mina Hur

submission deadline 31 Dec 2026 | 2 articles | Viewed by 996 | Submission Open

Keywords: identification of disease and non-disease biomarkers and metabolites; understanding the pathogenesis of the diseases through metabolites; physiological response against environmental stress or stimuli; clinical and translational researches; exposure to toxin or chemical drugs; lifestyle, nutrition, and genetic or epigenetic factors

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Microbial and Nutrition Metabolism in Animals

edited by

Zhiming Xu

and Xiaoge Sun

submission deadline 31 Dec 2026 | 1 articles | Viewed by 520 | Submission Open

Keywords: ruminant nutrition; microbial metabolism; lipid metabolism; rumen microbiota; microbial fermentation; microbiome; microbe–host; microorganisms and the environment

(This special issue belongs to the Section Animal Metabolism)

Plant-Derived Bioactive Metabolites and Their Applications

edited by

Irina Ielciu

and

Ramona Paltinean

submission deadline 31 Dec 2026 | Viewed by 318 | Submission Open

Keywords: plant metabolites; characterization methods; biological activities

(This special issue belongs to the Section Plant Metabolism)

Integrative OMICs Analyses of Cardiometabolic Dysfunction

edited by

Rui Wang-Sattler

and Makoto Harada

submission deadline 31 Dec 2026 | Viewed by 278 | Submission Open

Keywords: cardiometabolic disease; metabolic syndrome; OMICs integration; metabolomics; biomarker discovery; machine learning; explainable AI; metabolic stress; inflammation; fibrosis

(This special issue belongs to the Section Integrative Metabolomics)

Fat and Glucose Metabolism: Mechanisms and Regulation

edited by

Getachew D. Belew

submission deadline 31 Dec 2026 | Viewed by 227 | Submission Open

Keywords: fat metabolism; glucose metabolism; intermediary metabolism; energy homeostasis; cardiometabolic diseases; obesity; MASLD/MASH; type 2 diabetes; metabolic regulation; therapeutic targets

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Effects of Functional Foods on Human Metabolism

edited by

Boqun Liu

submission deadline 31 Dec 2026 | Viewed by 227 | Submission Open

Keywords: functional foods; human metabolism; metabolic pathways; bioactive components; gut microbiota

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Factors in Neurodegenerative Diseases: Mechanisms, Biomarkers, and Therapy

edited by

Anna Serefko

and

Aleksandra Szopa

submission deadline 31 Dec 2026 | Viewed by 195 | Submission Open

Keywords: neurodegenerative diseases; metabolic dysfunction; insulin resistance; obesity; dyslipidemia; oxida-tive stress; glucose metabolism; lipid metabolism; gut–brain axis; biomarkers; therapeutic strategies

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Influence of Dietary Lipids on Cancer: Effects on Carcinogen Metabolism and Oxidative Stress

edited by

Noemí Cárdenas-Rodríguez

and Daniel Ortega-Cuellar

submission deadline 31 Dec 2026 | Viewed by 168 | Submission Open

Keywords: dietary lipids; cancer metabolism; carcinogen metabolism; oxidative stress; lipidomics; lipid peroxidation; metabolomics; fatty acids; redox signaling; nutritional oncology; high fat diet; cytochrome P450; reactive oxygen species

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolism of Ectotherms: Insights from Amphibians and Reptiles

edited by

Lana Pađen

and Jasna Aladrović

submission deadline 1 Jan 2027 | 2 articles | Viewed by 1843 | Submission Open

Keywords: ectotherm; metabolic processes; amphibians; reptiles

(This special issue belongs to the Section Animal Metabolism)

Functional Foods and Metabolic Health

edited by

Lucas Fornari Laurindo

submission deadline 10 Jan 2027 | Viewed by 507 | Submission Open

Keywords: metabolomics; metabolic analyses; functional foods; metabolic health; chronic disease prevention; bioactive compounds; antioxidants; soluble fiber; probiotics; omega-3 fatty acids; diabetes; dyslipidemia; gut microbiota; obesity; cardiovascular disease; metabolic syndrome; personalized nutrition; nutritional interventions

(This special issue belongs to the Section Plant Metabolism)

Interplay Between Metabolism, Oxidative Stress, and Cellular Signaling in Health and Disease

edited by

Serena Castelli

and

Laura Mosca

submission deadline 15 Jan 2027 | 5 articles | Viewed by 7484 | Submission Open

Keywords: oxidative stress; metabolism; cellular signaling; lipid metabolism; ROS

(This special issue belongs to the Section Lipid Metabolism)

The Role of Lipid Metabolism in Health and Disease

edited by

Mónica Narváez-Rivas

submission deadline 15 Jan 2027 | 5 articles | Viewed by 5781 | Submission Open

Keywords: lipid metabolism; lipidomics; dyslipidemia; mass spectrometry; lipid biomarkers; lipid signaling; therapeutic targets; bioinformatics; clinical lipidomics

(This special issue belongs to the Section Lipid Metabolism)

The Role of Diet and Nutrition in Relation to Metabolic Health

edited by

Ivana Šarac

Marija Paunovic

and

Marija Takić

submission deadline 15 Jan 2027 | 2 articles | Viewed by 5127 | Submission Open

Keywords: dietary patterns; nutrients; metabolic syndrome; diet; metabolic health; nutritional biochemistry; dietotherapy; functional food; nutraceuticals

(This special issue belongs to the Section Nutrition and Metabolism)

Multi-Omics Insights into Stress-Induced Metabolism of Bioactive Plant Compounds

edited by

Dan Gao

and

Junsong Wang

submission deadline 15 Jan 2027 | 2 articles | Viewed by 2069 | Submission Open

Keywords: stress-induced metabolism; plant secondary metabolites; bioactive phytochemicals; medicinal plant compounds; multi-omics integration; comparative metabolomics; plant stress biology; metabolic and regulatory networks; network pharmacology

(This special issue belongs to the Section Plant Metabolism)

Nutritional Epidemiology and Metabolic Disorders, Second Edition

edited by

Kijoon Kim

submission deadline 15 Jan 2027 | Viewed by 376 | Submission Open

Keywords: nutritional epidemiology; antioxidants; medicinal herbs; functional ingredients; public health

(This special issue belongs to the Section Nutrition and Metabolism)

Nutrition, Metabolism and Clinical Management of Liver Diseases

edited by Miguel Suárez Matías

submission deadline 15 Jan 2027 | Viewed by 138 | Submission Open

Keywords: MASLD; MASH; cirrhosis; sarcopenia; malnutrition; alcohol-associated liver disease; liver trans-plantation; gut–liver axis; hepatocellular carcinoma; artificial intelligence

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mycotoxins and Fungal Secondary Metabolism

edited by

Guohua Yin

and Kayla K. Pennerman

submission deadline 20 Jan 2027 | 2 articles | Viewed by 3093 | Submission Open

Keywords: mycotoxins; aflatoxin; patulin; biocontrol; metabolites; fungi

(This special issue belongs to the Section Plant Metabolism)

Bioactive Compounds in Obesity and Its Metabolic Complications

edited by

Patricia Rios Chavez

and Héctor Eduardo Martínez-Flores

submission deadline 20 Jan 2027 | 2 articles | Viewed by 2698 | Submission Open

Keywords: antioxidant; obesity; inflammation; oxidative stress; metabolic syndrome

(This special issue belongs to the Section Plant Metabolism)

Mass Spectrometry Imaging and Spatial Metabolomics—2nd Edition

edited by

Zhonghua Wang

and Chenglong Sun

submission deadline 20 Jan 2027 | 2 articles | Viewed by 1962 | Submission Open

Keywords: mass spectrometry imaging (MSI); spatial metabolomics; biomarker discovery; disease diagnostics; drug development; technical advancements; interdisciplinary approaches; imaging techniques

(This special issue belongs to the Section Metabolomic Profiling Technology)

Advancements in Mass Spectrometry Techniques for Metabolomic and Pharmaceutical Analysis

edited by

Xiaowei Song

and Fangling Wu

submission deadline 29 Jan 2027 | 1 articles | Viewed by 1373 | Submission Open

Keywords: ambient ionization; mass spectrometry imaging; sample pretreatment; isomer analysis; marker discovery; ion annotation; structural identification; artificial intelligence; multi-omics

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Novel Methods of Mass Spectrometry Imaging Towards Biomedical and Environmental Applications

edited by

Xiaoxiao Ma

Zhaoying Wang

and

Yanhua Chen

submission deadline 31 Jan 2027 | 2 articles | Viewed by 2171 | Submission Open

Keywords: mass spectrometry imaging; molecular mapping; new techniques; biomedicine; materials science; environmental research; pharmaceutics

(This special issue belongs to the Section Advances in Metabolomics)

Mechanism-Aware Machine Learning in Metabolomics and Clinical Translation: Signatures, Pathways, and Patient Impact

edited by

Vasuk Gautam

submission deadline 31 Jan 2027 | 2 articles | Viewed by 1687 | Submission Open

Keywords: bioinformatics; machine learning; metabolomics; integrative omics; multi-omics; translational research; data analysis; clinical research

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Metabolomics: The Role of Natural Products in Drugs

edited by

Jeysson Sanchez-Suarez

and

Jennyfer Andrea Aldana Mejía

submission deadline 31 Jan 2027 | 1 articles | Viewed by 996 | Submission Open

Keywords: metabolomics; natural products; drug discovery; bioactive compounds; computational metabolism; pharmacology; secondary metabolites; therapeutic development

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Metabolic Insights and Therapeutic Strategies in Hematologic Disorders

edited by Ekaterina Balaian

submission deadline 31 Jan 2027 | 1 articles | Viewed by 413 | Submission Open

Keywords: hematological malignancies; leukemia; lymphoma; metabolomics; drug resistance; tumor biology

(This special issue belongs to the Section Cell Metabolism)

NMR Metabolomics in Nutrition Research

edited by Aaryani Tipirneni-Sajja

submission deadline 31 Jan 2027 | Viewed by 409 | Submission Open

Keywords: nutritional metabolomics; NMR metabolomics; nutrients; diet; metabolism

(This special issue belongs to the Section Nutrition and Metabolism)

Integrating Metabolism and Molecular Biology in Cancer Research and Therapeutics

edited by

Susmita Barman

submission deadline 31 Jan 2027 | Viewed by 386 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; tumor microenvironment; oncometabolites; immunometabolism; therapeutic resistance; microbiome-derived metabolites; metabolomics; molecular signaling pathways

(This special issue belongs to the Section Integrative Metabolomics)

Amino Acid Metabolism Affecting Obesity and Energy Balance

edited by Xuchao Lyu and

Teruo Miyazaki

submission deadline 31 Jan 2027 | Viewed by 381 | Submission Open

Keywords: metabolomics; enzymes; obesity; amino acids; non-protein amino acids; biomarkers; cell signals

(This special issue belongs to the Section Cell Metabolism)

Beyond Metabolism: The Expanding Role of GLP-1 Receptor Agonists in Modern Medicine

edited by Alessandro Conforti,

Davide Francomano

and

Marco Marchetti

submission deadline 31 Jan 2027 | Viewed by 186 | Submission Open

Keywords: GLP-1 receptor agonists; type 2 diabetes mellitus; obesity; pleiotropic effects; cardiovascular risk; nephroprotection; central nervous system; satiety; chronic inflammation; bone metabolism; musculoskeletal system; osteoarticular; osteoarthritis; weight loss; innovative therapy; integrated medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Lipid Metabolism Dysregulation in Metabolic Disorders: Unraveling the Molecular Complexity: 2nd Edition

edited by

Joshua De Leon

submission deadline 31 Jan 2027 | Viewed by 182 | Submission Open

Keywords: lipid metabolism; dyslipidemia; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Nutrition and Metabolic Diseases: Mechanistic Insights and Personalized Dietary Strategies

edited by

Silvia Tagliamonte

and

Marcelo Macedo Rogero

submission deadline 5 Feb 2027 | 2 articles | Viewed by 2776 | Submission Open

Keywords: personalized nutrition; metabolic diseases; metabolomics; food digestion; postprandial metabolism; biomarkers; gut microbiome; precision medicine; systems biology

(This special issue belongs to the Section Nutrition and Metabolism)

Lipids and Fatty Acid Metabolism in Cardiovascular Diseases

edited by

Jasmina Debeljak Martacic

and Tamara Popović

submission deadline 10 Feb 2027 | 4 articles | Viewed by 3322 | Submission Open

Keywords: lipid metabolism; lipidomics; cardiovascular diseases; prevention strategies

(This special issue belongs to the Section Lipid Metabolism)

Novel Insights into Lipid Metabolism in Health and Diseases

edited by

Hartmut Kühn

and

Astrid Borchert

submission deadline 15 Feb 2027 | 1 articles | Viewed by 528 | Submission Open

Keywords: neutral lipids; phospholipids; lysophosphatides; sphingolipids; cholesterol; cholesterol esters; eicosanoids; endocannabinoids; diacylglycerols; polyunsaturated fatty acids; lipid peroxidation; antioxidants

(This special issue belongs to the Section Lipid Metabolism)

Pharmacological Modulation of Metabolic Pathways: Impact on Drug Development and Therapeutic Outcomes

edited by Marina Nikolić and

Jovana Joksimovic Jovic

submission deadline 15 Feb 2027 | Viewed by 203 | Submission Open

Keywords: biomarker discovery; pharmacometabolomics; therapeutic targets; drug response; metabolic reprogramming; cardiometabolic diseases; pharmacological modulation; therapeutic outcomes; translational research

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Advances in Metabolomics and Lipidomics for Health and Disease

edited by Vannuruswamy Garikapati,

Silvia Radrezza

and Ziying Xu

submission deadline 15 Feb 2027 | Viewed by 197 | Submission Open

Keywords: metabolomics; lipidomics; biomarkers; clinical research; shotgun; LC-MS; IMS; MALDI MS imaging; NMR; bioinformatics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism and Nutrition in Aquatic Animals

edited by

Lei Wang

, Peng Tan and Rantao Zuo

submission deadline 15 Feb 2027 | Viewed by 163 | Submission Open

Keywords: nutrition; metabolism; aquatic animals; multi-omics; growth; health

(This special issue belongs to the Section Animal Metabolism)

Parasites and Microorganisms Faces Metabolomics: A Key Tool to Understanding Their Host Interactions

edited by

Mario Augusto Izidoro

and Sérgio Schenkman

submission deadline 15 Feb 2027 | Viewed by 109 | Submission Open

Keywords: metabolomics; mass spectrometry; bioinformatics; parasite and microorganism metabolome; biomarkers; pathogen metabolism; multiplatform metabolomics; targeted and untargeted metabolomics

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Nutritional Modulation of Brain Metabolism: Dietary Interventions, Metabolomics and Neuroprotection

edited by

Marta Balog

and

Hikaru Hori

submission deadline 17 Feb 2027 | Viewed by 100 | Submission Open

Keywords: nutritional metabolomics; brain metabolism; ketogenic diet; mediterranean diet; neuronutraceuticals; gut–brain axis; lipidomics; neuroinflammation; sex differences; personalized nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

Current Research in Metabolic Syndrome and Cardiometabolic Disorders

edited by

Ciprian Ilie Rosca

and

Yunping Qiu

submission deadline 20 Feb 2027 | 6 articles | Viewed by 7959 | Submission Open

Keywords: metabolic syndrome; obesity; dyslipidemias; hyperuricemia; diabetes mellitus; cardiovascular diseases; heart failure; arrythmias; acute or chronic coronary syndromes; SGLT2-inhibitors; metabolic liver diseases; COVID-19 infection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

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