Metabolic Insights and Therapeutic Strategies in Hematologic Disorders
A Special Issue of Metabolites (ISSN 2218-1989) belonging to the section "Cell Metabolism".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 682
Editor
2. German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Interests: myelodysplastic neoplasms; clonal hematopoiesis; metabolomics; microbiome; inflammation
Special Issue Information
Dear Colleagues,
In recent years, the understanding of cellular metabolism has emerged as a cornerstone in deciphering the pathophysiology of hematologic disorders. Aberrant metabolic pathways critically influence the behavior of hematopoietic stem and progenitor cells, the tumor microenvironment, and immune regulation, thereby shaping disease onset, progression, and therapeutic response. Metabolic reprogramming, encompassing altered glycolysis, mitochondrial function, lipid metabolism, and redox homeostasis, has been recognized not only as a hallmark of malignant hematologic diseases such as leukemia, lymphoma, and multiple myeloma but also as a key player in non-malignant conditions including anemia, hemoglobinopathies, and bone marrow failure syndromes.
This Special Issue, Metabolic Insights and Therapeutic Strategies in Hematologic Disorders, will provide a platform for integrating basic, translational, and clinical research that explores the metabolic underpinnings of hematologic diseases. We invite contributions that elucidate metabolic pathways driving disease pathogenesis, identify metabolic biomarkers for diagnosis or prognosis, and highlight novel metabolism-targeted therapeutic strategies. Studies employing cutting-edge technologies, such as metabolomics, single-cell analysis, and systems biology approaches, are particularly encouraged, along with studies that bridge metabolic research with pharmacological innovation and clinical outcomes.
By uniting multidisciplinary perspectives, this Special Issue will advance our understanding of how metabolic alterations can be leveraged for precision medicine in hematology. Ultimately, our goal is to foster the development of innovative, metabolism-based interventions that improve patient care and transform the therapeutic landscape of hematologic disorders.
Dr. Ekaterina Balaian
Guest Editor
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hematological malignancies
- leukemia
- lymphoma
- metabolomics
- drug resistance
- tumor biology
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