Nutrition and Metabolic Diseases: Mechanistic Insights and Personalized Dietary Strategies

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 15 July 2026 | Viewed by 1270

Special Issue Editors


E-Mail Website
Guest Editor
Department of Agricultural Sciences, University of Naples “Federico II”, 80055 Portici, Italy
Interests: human nutrition; personalized nutrition; postprandial response; food digestion; metabolomics; biomarkers; food science

E-Mail Website
Guest Editor
Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo 03828-000, Brazil
Interests: inflammation; nutrigenomics; nutrigenetics; obesity; exercise; protein metabolism; fatty acid metabolism
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metabolic diseases, including obesity, type 2 diabetes, and cardiovascular disorders, remain a major global health challenge. Nutrition plays a central role in both their prevention and management. However, inter-individual differences in digestion, absorption, and metabolic responses mean that dietary interventions are often not equally effective across populations. Advances in metabolomics and other high-throughput technologies now allow researchers to measure individual metabolomes and identify biomarkers that reflect personal responses to specific foods and nutrients. This opens the way for personalized nutrition strategies tailored to prevent or mitigate metabolic diseases.

Despite these opportunities, several challenges remain, including understanding the mechanistic basis of postprandial metabolism, accounting for variability due to digestion, genetics, or gut microbiota, selecting appropriate analytical platforms, ensuring reproducibility, and integrating multi-omics data for predictive modeling. Therefore, this special issue aims to bring together research addressing the role of nutrition in metabolic disease, with a particular focus on individualized metabolic responses and personalized dietary strategies. Contributions are welcome that explore food digestion, postprandial metabolic profiling, biomarker discovery, computational modeling, and integrative multi-omics approaches. 

Dr. Silvia Tagliamonte
Prof. Dr. Marcelo Macedo Rogero
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized nutrition
  • metabolic diseases
  • metabolomics
  • food digestion
  • postprandial metabolism
  • biomarkers
  • gut microbiome
  • precision medicine
  • systems biology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 1107 KB  
Article
Time Exposure and Fat Mass Reduction Drive Trimethylamine N-Oxide Modulation During a Very-Low-Energy Ketogenic Therapy (VLEKT) in Women with Obesity
by Giuseppe Annunziata, Ludovica Verde, Maria Maisto, Martina Galasso, Giulia De Alteriis, Vincenzo Piccolo, Gian Carlo Tenore, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri and Luigi Barrea
Metabolites 2026, 16(3), 150; https://doi.org/10.3390/metabo16030150 - 24 Feb 2026
Viewed by 851
Abstract
Background/Objectives: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite increasingly recognized as a pro-atherogenic factor and a biomarker of cardiometabolic risk. Dietary patterns and adiposity are key modulators of circulating TMAO levels; however, evidence on the impact of very-low-energy ketogenic therapy (VLEKT) [...] Read more.
Background/Objectives: Trimethylamine N-oxide (TMAO) is a gut microbiota-derived metabolite increasingly recognized as a pro-atherogenic factor and a biomarker of cardiometabolic risk. Dietary patterns and adiposity are key modulators of circulating TMAO levels; however, evidence on the impact of very-low-energy ketogenic therapy (VLEKT) on TMAO metabolism, particularly in women with obesity, remains limited. This study aimed to investigate the effects of VLEKT on circulating TMAO concentrations, with specific focus on treatment duration and body composition (BC) changes. Methods: This study included 43 adult women with obesity eligible for VLEKT based on meal replacements. Anthropometric measurements and BC were assessed using standardized protocols and bioelectrical impedance analysis at baseline and post-intervention. Serum TMAO concentrations were quantified by validated HPLC–ESI–MS/MS. Results: After VLEKT, participants exhibited significant reductions in body weight, BMI, waist girth, fat mass (FM), and circulating TMAO levels. Greater reductions in TMAO were observed in women with longer ketogenic exposure and more pronounced FM loss. Changes in TMAO levels correlated negatively with VLEKT duration and positively with FM variations. In multivariate models, treatment duration and FM reduction emerged as independent predictors of TMAO decrease. A Receiver Operating Characteristic (ROC) analysis identified a FM reduction ≥14.25% as the optimal threshold associated with clinically relevant TMAO lowering. Conclusions: VLEKT reduces circulating TMAO levels in women with obesity. This effect appears to be primarily driven by the duration of ketogenic exposure and the magnitude of FM loss, rather than total weight reduction alone, highlighting the relevance of BC-targeted interventions in modulating gut microbiota-derived cardiometabolic risk markers. Full article
Show Figures

Figure 1

Back to TopTop