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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Impact of Diet on the Metabolism and Body Composition of Patients with Skin Diseases

edited by

Giuseppe Annunziata

Luigi Barrea

and Matteo Megna

submission deadline 25 Mar 2027 | 1 articles | Viewed by 2978 | Submission Open

Keywords: diet–skin axis; body composition; inflammatory skin diseases; nutritional interventions; metabolomics; adipose tissue dysfunction; nutraceutical

(This special issue belongs to the Section Nutrition and Metabolism)

Advances in Immune Metabolism: Lipid Regulation and Disease Outcomes

edited by Hui Yang

submission deadline 25 Mar 2027 | 3 articles | Viewed by 2826 | Submission Open

Keywords: immune cell; lipid metabolism; immune disease; inflammation; autoimmune; tumour

(This special issue belongs to the Section Lipid Metabolism)

State-of-the-Art NMR-Based Metabolomics and Its Applications

edited by

Pau Nolis

submission deadline 25 Mar 2027 | 1 articles | Viewed by 1495 | Submission Open

Keywords: NMR spectroscopy; metabolomics; metabolic profiling; biomarker; multivariate analysis; high-throughput data analysis

Linking Environmental Exposures to Metabolic Syndrome Risk

edited by

Emily P. Laveriano Santos

and Esther Herrera-Luis

submission deadline 25 Mar 2027 | Viewed by 175 | Submission Open

Keywords: metabolic syndrome; exposome; environmental exposure; cardiometabolic risk factors; life course

(This special issue belongs to the Section Environmental Metabolomics)

Metabolic Responses to Feed and Nutrition in Livestock

edited by

Arda Yıldırım

and

Baichuan Deng

submission deadline 31 Mar 2027 | 4 articles | Viewed by 3393 | Submission Open

Keywords: animal nutrition; feed metabolomics; livestock metabolism; feed ingredients; biochemical characterization of feeds; functional feed additives; metabolic profiling; gut microbiota–host metabolism; precision nutrition

(This special issue belongs to the Section Animal Metabolism)

Metabolites and Plant Stress Resistance

edited by

Nan Gao

submission deadline 31 Mar 2027 | 3 articles | Viewed by 2228 | Submission Open

Keywords: metabolomics; mass spectrometry; abiotic stresses; biotic stresses; biomarkers; biostimulants; biofertilizers; exogenous metabolites

(This special issue belongs to the Section Plant Metabolism)

Environmental Exposures and Metabolic Health in Vulnerable Populations

edited by

Sandra India-Aldana

and Lauren Petrick

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1960 | Submission Open

Keywords: exposomics; metabolic health; metabolic diseases; metabolomics; metabolome; susceptible populations; susceptible windows; children; women’s health; minorities

(This special issue belongs to the Section Environmental Metabolomics)

Recent Advances in Metabolomics (IECM2026)

edited by

and

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1789 | Submission Open

Keywords: lipidomics; nutrition metabolomics; environmental metabolomics; clinical metabolomics; metabolic modeling; metabolomics technology; data analysis and integration; drug metabolism

(This special issue belongs to the Section Advances in Metabolomics)

New Findings on Microbial Metabolism and Its Effects on Human Health

edited by

Ulrike E. Rolle-Kampczyk

Beatrice Engelmann

and

Sven-Bastiaan Haange

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1659 | Submission Open

Keywords: metabolomics; microbial metabolism; microbial crosstalk; cross-feeding; xenobiotic and microbial metabolism; multi-omics integration; system biology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Natural Products in Metabolic Perspective: Isolation, Profiling and Bioactivities

edited by

Ebubekir İzol

and

Chuanying Fang

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1110 | Submission Open

Keywords: natural products; metabolomics; phytochemical profiling; bioactive compounds; biological activities; medicinal and aromatic plants; bee products; LC–MS/MS; UHPLC-HRMS; enzyme inhibition

(This special issue belongs to the Section Plant Metabolism)

Natural Products and Metabolic Regulation: Redox Signaling, Inflammation, and Metabolic Reprogramming in Health and Disease

edited by

Hasan Gencoglu

submission deadline 31 Mar 2027 | 1 articles | Viewed by 546 | Submission Open

Keywords: natural products; metabolic regulation; redox signaling; oxidative stress; inflammation; metabolic reprogramming; nutraceuticals; phytochemicals; bioactive compounds; chronic diseases

(This special issue belongs to the Section Nutrition and Metabolism)

Veterinary Metabolomics: Emerging Tools for Animal Health

edited by

Ionela Hotea

Adrian Maximilian Macri

and Emil Tirziu

submission deadline 31 Mar 2027 | Viewed by 531 | Submission Open

Keywords: veterinary metabolomics; animal nutrition; nutrient utilization; feed efficiency; precision nutrition; metabolic health; microbiome–metabolome interactions; sustainable livestock production; multi-omics integration; animal welfare; one health

(This special issue belongs to the Section Animal Metabolism)

Integrative Metabolomics: Pathway Dynamics, Exposure Analysis and Precision Health

edited by Soundara Viveka Thangaraj and

Wei Sha

submission deadline 31 Mar 2027 | Viewed by 355 | Submission Open

Keywords: metabolomics; toxicology; biomarkers; pathway modeling; personalized medicine

(This special issue belongs to the Section Integrative Metabolomics)

Food Microbiome and Metabolome

edited by

Talita Pimenta Do Nascimento

Cecilia Zanin Palchetti

Weidong Dai

and

Mateus Kawata Salgaço

submission deadline 31 Mar 2027 | Viewed by 297 | Submission Open

Keywords: foodomics; fermented foods; probiotics, postbiotics, and prebiotics; biopreservation; microbiome–gut–brain axis; bioactive compounds; next-generation sequencing (NGS); food safety and quality

(This special issue belongs to the Section Food Metabolomics)

Oxidative-ER Stress in Disease: Metabolic Biomarkers and Therapeutic Opportunities

edited by

Tolga Mercantepe

and Adnan Yılmaz

submission deadline 31 Mar 2027 | Viewed by 220 | Submission Open

Keywords: endoplazmik reticulum (ER) stress; oxidative stress; redox metabolism; systemic diseases; toxicology and environmental exposures

(This special issue belongs to the Section Cell Metabolism)

Circadian Regulation of Metabolic Health: From Molecular Mechanisms to Human Physiology

edited by Stuart J. Hesketh and

Ben J. Edwards

submission deadline 31 Mar 2027 | Viewed by 204 | Submission Open

Keywords: circadian rhythms; metabolic health; endocrine regulation; skeletal muscle; exercise timing; circadian misalignment; metabolomics; ageing; human physiology; energy balance

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Application of Metabolomics, Lipidomics and Exposomics Based on LC-MS

edited by

Zhiqiang Pang

and

Jianguo (Jeff) Xia

submission deadline 31 Mar 2027 | Viewed by 185 | Submission Open

Keywords: metabolomics; lipidomics; exposomics; multi-omics; LC-MS

(This special issue belongs to the Section Advances in Metabolomics)

Cytochrome Enzymes: Roles in Drug Response, Interactions and Therapeutic Targeting

edited by

Asaf Evrim Evren

and

İsmail Çelik

submission deadline 31 Mar 2027 | Viewed by 183 | Submission Open

Keywords: pharmacoinformatics; therapeutic targeting; cytochrome P450; molecular modelling; drug metabolism; drug–drug interactions; food–drug interactions

(This special issue belongs to the Section Bioinformatics and Data Analysis)

New Development Trends of Mass Spectrometry-Driven Metabolomics

edited by Xiaosuo Wang

submission deadline 31 Mar 2027 | Viewed by 140 | Submission Open

Keywords: mass spectrometry; metabolomics; lipidomics; spatial metabolomics; imaging mass spectrometry; miniature mass spectrometry; multi-omics integration; biomarker discovery; precision medicine; artificial intelligence; systems biology

(This special issue belongs to the Section Advances in Metabolomics)

Perspectives on Metabolomics, Quality Control, and Pharmacovigilance of Medicinal Plants and Herbal Medicines

edited by

Mary Anne Medeiros Bandeira

submission deadline 31 Mar 2027 | Viewed by 139 | Submission Open

Keywords: medicinal plants; herbal medicines; plant metabolism; metabolomics; quality control; NMR; natural products; plant secondary metabolites; metabolic profiling; botanical products

(This special issue belongs to the Section Plant Metabolism)

Associations Between Lifestyle, Nutrition Intake and Metabolic Health

edited by José Francisco López-Gil,

Camila Miño

and Rodrigo Yánez-Sepúlveda

submission deadline 31 Mar 2027 | Viewed by 138 | Submission Open

Keywords: lifestyle factors; nutritional intake; dietary patterns; metabolic health; metabolic biomarkers; nutritional epidemiology; multi-omics; gene–diet interactions; precision nutrition; cardiometabolic risk

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Brain Energy Metabolism and Substrate Utilization in Neuroinflammation and Neurodegenerative Diseases

edited by

Chandan Sona

submission deadline 1 Apr 2027 | Viewed by 321 | Submission Open

Keywords: brain energy metabolism; neurodegenerative diseases; mitochondrial dysfunction; substrate utilization; neuron–glia metabolic coupling; metabolic reprogramming

(This special issue belongs to the Section Cell Metabolism)

Inflammation and Oxidative Stress in the Metabolic Syndrome

edited by

Dalia Dop

and

Vlad Pădureanu

submission deadline 10 Apr 2027 | 1 articles | Viewed by 372 | Submission Open

Keywords: obesity; dyslipidemia; increased insulin resistance; diabetes mellitus; inflammatory markers; ROS (reactive oxygen species); nitric oxide; antioxidants

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Responses to Exercise Training

edited by

Hee-Tae Roh

submission deadline 15 Apr 2027 | 3 articles | Viewed by 1720 | Submission Open

Keywords: exercise metabolism; exercise training; physical activity; acute exercise responses; environmental exercise physiology; metabolomics; metabolic pathways; myokines and adipokines; metabolic flexibility; chronic disease

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics in Plant–Microbe Interactions: Advances and Applications

edited by

Nabil Radouane

and Salima Boutahiri

submission deadline 15 Apr 2027 | 2 articles | Viewed by 1586 | Submission Open

Keywords: metabolomics; plant–microbe interactions; sustainable agriculture; biocontrol; disease resistance; LC-MS; GC-MS; metagenomics

(This special issue belongs to the Section Plant Metabolism)

Metabolic Characteristics of Microbial Cells and Enzymes

edited by

Hao Wu

and

Wei Zeng

submission deadline 15 Apr 2027 | 2 articles | Viewed by 1557 | Submission Open

Keywords: microbial cell; enzyme; metabolic property; metabolites; metabolic engineering; enzyme engineering; synthetic biology

(This special issue belongs to the Section Microbiology and Ecological Metabolomics)

Precision Exercise, Metabolic Health and Personalized Performance

edited by

Levent Ceylan

Zacharias Papadakis

and

Hamza Küçük

submission deadline 15 Apr 2027 | 1 articles | Viewed by 1162 | Submission Open

Keywords: precision exercise; personalized health; exercise physiology; exercise metabolism; human perfor-mance; recovery; metabolic adaptation; nutrition; healthy aging; physical activity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

The Effects of Trace Elements and Endocrine-Disrupting Compounds on Metabolic Health

edited by

Kamila Pokorska-Niewiada

and

Agata Witczak

submission deadline 15 Apr 2027 | 1 articles | Viewed by 944 | Submission Open

Keywords: the role of trace elements and/or EDCs in the development of metabolic syndrome; trace elements and endocrine-active substances in biological samples, their potential use as biomarkers of metabolic disorders; progress in research on multifactorial relationships determining metabolic health/development of metabolic diseases; progress in clinical research on the importance of elements and EDCs in metabolic pathways; the impact of genetic and environmental disorders on metabolite levels and fluxes

(This special issue belongs to the Section Environmental Metabolomics)

Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Ambrin Farizah Babu and

Ze Xiang

submission deadline 15 Apr 2027 | 1 articles | Viewed by 929 | Submission Open

Keywords: MASLD; biomarkers; diet and lifestyle; molecular mechanisms; drug development

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Control of Inflammatory Responses

edited by

Xin Li

submission deadline 15 Apr 2027 | 1 articles | Viewed by 717 | Submission Open

Keywords: immunometabolism; inflammation; metabolic reprogramming; macrophages; metabolites; immune signaling; metabolomics; metabolic pathways; tissue microenvironment; chronic inflammation

(This special issue belongs to the Section Cell Metabolism)

Cellular Metabolic Adaptation to Environmental Stressors

edited by

Lu Kang

Yujiao Jia

and

Canping Pan

submission deadline 15 Apr 2027 | Viewed by 153 | Submission Open

Keywords: ecotoxicology; environmental safety; metabolomics; abiotic stress; stress adaptation

(This special issue belongs to the Section Environmental Metabolomics)

Metabolomics and Plant Defence, 3rd Edition

edited by

Shitou Xia

and

Junxing Lu

submission deadline 15 Apr 2027 | Viewed by 120 | Submission Open

Keywords: metabolomics; plant defence; biotic and abiotic stresses; phytohormone; metabolites and metabolic homeostasis; metabolomic profiling methodology

(This special issue belongs to the Section Plant Metabolism)

Emerging Inflammatory and Metabolic Biomarkers in Hayfever

edited by

Moneisha Gokhale

Serap Azizoǧlu

and

Elena Planells

submission deadline 19 Apr 2027 | 1 articles | Viewed by 471 | Submission Open

Keywords: IgE sensitisation; allergic rhinitis; allergenic capacity; thunderstorm asthma; asthma; immunotherapy; indoor air quality; questionnaire survey; quality of life; lived experience; hayfever; allergic rhinitis; ocular allergy

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Metabolomic Analysis in Food Science

edited by

Ryota Mabuchi

submission deadline 20 Apr 2027 | Viewed by 139 | Submission Open

Keywords: foods; metabolomics; metabolomic analysis; metabolic profiling; analytical methods; quality assessment; functional; taste; flavor

(This special issue belongs to the Section Food Metabolomics)

Metabolic Signatures of Pediatric Endocrine and Metabolic Disorders

edited by

Tiago Jeronimo dos Santos

submission deadline 25 Apr 2027 | 2 articles | Viewed by 1740 | Submission Open

Keywords: pediatric metabolomics; endocrine disorders; type 1 diabetes; type 2 diabetes; childhood obesity; insulin resistance; metabolic pathways; MASLD/MASH; biomarkers; environmental metabolic perturbations; multi-omics

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Responses in Plants Under Abiotic Stress

edited by

Ghulam Hasnain

submission deadline 25 Apr 2027 | 2 articles | Viewed by 983 | Submission Open

Keywords: abiotic stress; plant metabolism; compatible solutes; antioxidant systems; energy metabolism; lipid metabolism; osmotic stress; drought stress; heat stress; salinity stress; heavy metal stress; crop productivity; stress tolerance; gene expression; proteomics; metabolomics; signaling pathways; transcription factors; reactive oxygen species

(This special issue belongs to the Section Plant Metabolism)

Biological Markers of Chronic Inflammatory Diseases

edited by

Elena Cojocaru

and Marcel Costuleanu

submission deadline 25 Apr 2027 | 1 articles | Viewed by 789 | Submission Open

Keywords: chronic inflammation; biological markers; inflammatory mediators; cytokines; immune dysregulation; oxidative stress; metabolic pathways; chronic inflammatory diseases; precision medicine; translational research

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Cancer and Cardiovascular Diseases: Molecular Mechanisms, Metabolic Reprogramming and Therapeutic Perspectives

edited by

Alfredo Cruz-Gregorio

submission deadline 26 Apr 2027 | Viewed by 43 | Submission Open

Keywords: cancer; cardiovascular diseases; cardio-oncology; cancer-associated cardiovascular dysfunction; metabolic reprogramming; oncometabolites; mitochondrial dysfunction; inflammation; redox signaling; cardiotoxicity

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomics for Clinical Biomarkers Discovery

edited by

Cecília R.C. Calado

submission deadline 30 Apr 2027 | 2 articles | Viewed by 1951 | Submission Open

Keywords: metabolomics; biomarkers discovery; precision medicine

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Pharmacometabolomics in Drug Mechanism, Efficacy and Toxicity

edited by Christian Giommi and Camilla Morresi

submission deadline 30 Apr 2027 | 1 articles | Viewed by 1206 | Submission Open

Keywords: pharmacometabolomics; drug mechanisms; metabolic biomarkers; drug efficacy; drug toxicity; metabolic flux analysis; lipidomics and metabolomics profiling; computational metabolomics; systems pharmacology; precision medicine

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

Analysis and Function of Metabolites in Medicinal Plants

edited by Gunes Ak and

Stefano Dall'Acqua

submission deadline 30 Apr 2027 | Viewed by 168 | Submission Open

Keywords: medicinal plants; secondary metabolites; phytochemistry; metabolomics; LC-MS/GC-MS analysis; bioactive compounds; pharmacological activity; antioxidant activity; plant metabolite profiling; natural products

(This special issue belongs to the Section Plant Metabolism)

Dietary Fiber, Gut Microbiota, and Metabolic Regulation

edited by Xi Wang

submission deadline 30 Apr 2027 | 1 articles | Viewed by 140 | Submission Open

Keywords: dietary fiber; gut microbiota; metabolic regulation; metabolomics; microbiome–metabolome interactions

(This special issue belongs to the Section Food Metabolomics)

Metabolite Profiles in Inflammatory Diseases, 2nd Edition

edited by Rodica Pădureanu and Ionut Donoiu

submission deadline 30 Apr 2027 | Viewed by 108 | Submission Open

Keywords: gut; inflammation; markers; metabolomics; multiple sclerosis; rheumatoid arthritis; lung disease; osteoarthritis

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Food Fermentation Metabolomics: From Microbial Metabolism to Flavor and Function

edited by

Sastia Prama Putri

and Rifqi Ahmad Riyanto

submission deadline 30 Apr 2027 | Viewed by 29 | Submission Open

Keywords: fermented foods metabolomics; microbial metabolic pathways in fermentation; flavor compound formation; volatile metabolomics; functional metabolites produced during fermentation; MS-based metabolomics approaches

(This special issue belongs to the Section Food Metabolomics)

Metabolites and Metabolic Interactions in Plant–Fungal Symbioses

edited by

Łukasz Furmanek

and

Tomasz Oszako

submission deadline 30 Apr 2027 | Viewed by 10 | Submission Open

Keywords: application of metabolites; endophytic fungi and fungal symbionts; biological control and ecological role of metabolites; metabolism; metabolomics; mycorrhizal interactions; plant–fungal interaction; primary and secondary metabolites of fungi and lichens; symbiosis; volatile organic compounds

(This special issue belongs to the Section Plant Metabolism)

Interactions Between Exercise Physiology and Metabolism (2nd Edition)

edited by

Lijing Gong

and Enming Zhang

submission deadline 10 May 2027 | Viewed by 96 | Submission Open

Keywords: exercise; metabolism; physical activity; chronic disease prevention; exerkines

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Exercise, Inflammation, and Metabolic Diseases: An Interdisciplinary Perspective

edited by Shujuan Hu and Xianwang Wang

submission deadline 15 May 2027 | 1 articles | Viewed by 481 | Submission Open

Keywords: exercise; inflammation; metabolic diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

From Environmental Exposures to Health: Metabolic Signatures in Exposome Research

edited by Xiangping Lin,

Xinyu Liu

and

Guozhu Ye

submission deadline 15 May 2027 | Viewed by 395 | Submission Open

Keywords: exposome; metabolomics; environmental exposure; air pollution; biomarker discovery; multi-omics integration; environmental epidemiology; metabolic signatures

(This special issue belongs to the Section Environmental Metabolomics)

Metabolite Profiling and Metabolic Pathways in the Food Industry

edited by

Menekşe Bulut

submission deadline 15 May 2027 | Viewed by 155 | Submission Open

Keywords: food metabolites; metabolite profiling; functional foods; food quality; bioactive compounds; food authenticity; food processing; LC‑MS; GC‑MS; sustainable food systems

(This special issue belongs to the Section Food Metabolomics)

Metabolic and Mitochondrial Remodeling in Cardiac Disease

edited by Pedro E. Antunes and Diana Santos

submission deadline 15 May 2027 | Viewed by 96 | Submission Open

Keywords: cardiovascular diseases; heart failure; mitochondria; myocardium; dysfunction-associated fatty liver disease; obesity; diabetes

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

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