Oxidative-ER Stress in Disease: Metabolic Biomarkers and Therapeutic Opportunities

Dear Colleagues,

This Special Issue aims to provide an integrated view of how oxidative stress disrupts cellular–metabolic networks in systemic diseases and toxic exposures, shapes disease phenotypes, and reveals treatable targets, with a particular emphasis on the bidirectional crosstalk between endoplasmic reticulum (ER) stress and oxidative stress.

The scope encompasses biochemical and cellular foundations of oxidative stress, including redox signaling, metabolic reprogramming, and inter-organelle crosstalk, as well as ER stress responses and their associated inflammation and cell death pathways. The systemic disease focus includes cardiometabolic diseases, neurodegenerative and neuropsychiatric disorders, chronic inflammatory/autoimmune conditions and aging, along with kidney, lung, and gastrointestinal diseases. Toxicological aspects cover redox-active effects of environmental exposures and xenobiotic metabolism, alongside detoxification pathways.

On the topic of diagnostics and therapeutics, we invite studies on circulating and tissue-specific biomarkers, targeted antioxidants and redox modulators, lifestyle interventions, and methodological approaches involving advanced omics, systems biology, and computational modeling. Translational studies, clinical evidence, and risk assessment frameworks are also encouraged. Article types may include original research, comprehensive reviews, perspectives, and methodological papers.

In summary, we seek high-impact contributions that elucidate the roles of oxidative and ER stress across systemic and toxicological diseases, bridging basic science and clinical translation, with priority given to interdisciplinary and multi-omics studies.

Dr. Tolga Mercantepe
Prof. Dr. Adnan Yılmaz
Guest Editors

Manuscript Submission Information

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