Special Issue "Surface Modification of Nanoparticles"
A special issue of Materials (ISSN 1996-1944).
Deadline for manuscript submissions: closed (16 March 2018)
Nanotechnology has provided novel tools for engineering inorganic and organic nanomaterials with special properties, due to the intrinsic physicho-chemical properties of the material, and tunable features, such as size, shape, and surface chemistry. A plethora of existing surface nanoparticle functionalization strategies allows designing multifunctional platform as promising solutions for diagnostics and therapeutics. Surface modification with different polymers, ligands, biomolecules, etc., enable to increase the solubility and stability properties, avoid nonspecific biomolecules adsorption, and develop multifunctional nanomaterials introducing targeting motives (such as peptides, sugars, nucleic acids, or proteins), as well as decorating with fluorescent labels or incorporating drugs.
Nevertheless, independently of the surface functionality, when nanomaterials are in contact with biological fluids, the surface is immediately covered and modified by endogenous biomolecules giving them a new identity, which dictates the final biological response. The organization of certain biomolecules and the exposure of specific protein domains or sequences on the nanoparticle surface can trigger specific cellular recognition pathways, therefore, the environment plays a key role in the recognition event itself and has to be taken into account. It is imperative to seek for characterization techniques capable of assessing the availability and accessibility of the active target on the nanoparticle surface giving insights on the surface geometry and functionality, and for methodologies that enable to acquire molecular information in a realistic biological scenario.
New emerging design strategies move towards functionality biomimetic designs, by using nature components from cells to introduce natural targeting specificities on the nanoparticle surface. It then becomes possible to design the nanoparticles surface to engineer predicable biological responses avoiding undesirable effects.
A complete understanding of the molecular interactions at the nanointerface would provide the tools to design smart nanoscale materials that efficiently regulate their interactions with complex biological systems (cells and biological barriers)
Dr. Pablo del Pino
Dr. Beatriz Pelaz
Dr. Ester Polo
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- multifuncional nanocapsules
- protein corona