Drug Delivery Carriers and Application of Nanomaterials

Dear Colleagues,

Advances in nanomaterials sciences have contributed to drug delivery carriers that can work on the site of disease. Stimulus-responsive nanomaterials, with a combination of therapeutic agents, impact every branch of medicine, and several stimulus-active nanomaterials have been developed that can be controlled using pH and temperature or both. However, creating stimulus-trigger delivery carriers with a specific release site for targeted therapeutic activity is challenging. To this end, there is an excellent opportunity to combine the stimulus-trigger nanomaterials carriers with therapeutic agents to control therapeutic release rationally.

Drug release from the carriers complies with the predetermined rate irrespective of patient need or changing physiologic condition. In the physiologic system, the temperature increases blood flow that can play a significant role in releasing drugs from carriers. Furthermore, the average body temperature is about 98.6° Fahrenheit, but various conditions, illnesses, and medicines can raise body temperature. Additionally, heat can be remotely generated in the skin by various typical tools such as hot air, NIR light, focus ultrasound (FUS), microwave (MW), etc. Moreover, the in vivo pH staying at 7.4 most of the time may increase or decrease based on pathological conditions. Understanding these temperature and pH effects and designing meaningful thermo- and pH-dependent nanomaterials are significant to developing and evaluating the controlled-release drug delivery system.

Dr. Shazid Md. Sharker
Guest Editor

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