Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances and Applications of Neuroimaging in Brain Disorder
edited by Julio Plata-Bello
submission deadline 30 Mar 2026 | 1 articles | Viewed by 3012 | Submission Open
Keywords: neuroimaging; magnetic resonance imaging; positron emission tomography; near infrared spectroscopy; brain; dementia; schizophrenia; depression; brain tumors; multiple sclerosis; autism
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
The Other Pediatric Primary Headaches: 2nd Edition
edited by , and Giuseppe Santangelo
submission deadline 30 Mar 2026 | 2 articles | Viewed by 2964 | Submission Open
Keywords: pediatric TACs; primary pediatric headaches; pediatric tension headaches; preventive treatment; acute treatment; clinical features; children; pediatric headaches in IV 3ICHD
(This special issue belongs to the Section Medical Research)
Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions
edited by
submission deadline 30 Mar 2026 | 1 articles | Viewed by 2859 | Submission Open
Keywords: psychiatric diseases; psychiatric medicine; psychiatric pharmacotherapy; psychiatric drugs
(This special issue belongs to the Section Pharmaceutical Science)
Microvascular and Macrovascular Response in Healthy and Critically Ill
edited by Andrius Pranskunas and
submission deadline 30 Mar 2026 | 3 articles | Viewed by 2671 | Submission Open
Keywords: microcirculation; glycocalyx; peripheral perfusion; systemic hemodynamic; body temperature; dynamic maneuvers; remote ischemic conditioning; exercise; adaptation
(This special issue belongs to the Section Physiology and Pathology)
Biological Insights into Drug Safety for Vulnerable Populations submission deadline 30 Mar 2026 | Viewed by 335 | Submission Open
Keywords: drug safety; vulnerable populations; pharmacotherapy; drug metabolism and efficacy; pediatric medication safety; drug pharmacokinetics and pharmacodynamics
(This special issue belongs to the Section Pharmaceutical Science)
Recent Advances in Non-Invasive Diagnosis Based on Volatile Metabolites
edited by Kiran Sankar Maiti
submission deadline 30 Mar 2026 | Viewed by 308 | Submission Open
Keywords: volatile metabolites; breath analysis; headspace analysis; biofluids; non-invasive; diagnosis
(This special issue belongs to the Section Medical Research)
Effects of Exercise Training on Muscle Function—2nd Edition
edited by and
submission deadline 30 Mar 2026 | Viewed by 171 | Submission Open
Keywords: exercise; training; muscle function; resistance training; HIIT
(This special issue belongs to the Section Physiology and Pathology)
Novel Insights into Biomarkers and Molecular Mechanisms in Heart Failure submission deadline 30 Mar 2026 | Viewed by 73 | Submission Open
Keywords: heart failure; biomarkers; molecular mechanisms
(This special issue belongs to the Section Physiology and Pathology)
Advances in the Structure and Function of Microbial Communities
edited by and
submission deadline 31 Mar 2026 | 4 articles | Viewed by 8874 | Submission Open
Keywords: microbial communities; ecosystem dynamics; community structure; functional diversity; interactions; ecological processes; sustainability
(This special issue belongs to the Section Microbiology)
New Horizons of Adipose Tissue Disorders: From Hormonal Issues to Loose Connective Disease: 2nd Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 3720 | Submission Open
Keywords: adipose tissue; lipedema; lymphedema; obesity; matrix; vascular and lymphatic disorder; connective tissue diseases; dysbiosis; inflammation; pain
(This special issue belongs to the Section Medical Research)
Enhancements in Screening Pathways for Early Detection of Lung Cancer submission deadline 31 Mar 2026 | 2 articles | Viewed by 3510 | Submission Open
Keywords: lung cancer screening; early diagnosis; multidisciplinary pathways; liquid biopsy; exhaled breath condensate; molecular imaging; sub-lobar resection; artificial intelligence
(This special issue belongs to the Section Medical Research)
Vision Science and Optometry: 2nd Edition submission deadline 31 Mar 2026 | 3 articles | Viewed by 3452 | Submission Open
Keywords: clinical optometry; eye movements and binocular vision; aberrometry; accommodation; color vision; anterior and posterior pole; circadian light
(This special issue belongs to the Section Medical Research)
Advanced Machine Learning for Disease Prediction and Prevention
edited by and
submission deadline 31 Mar 2026 | 2 articles | Viewed by 3193 | Submission Open
Keywords: advanced machine learning; disease prediction; disease prevention; biomedical data integration; multimodal data; explainable AI (XAI); AI Interpretability; algorithmic fairness; bias mitigation; predictive modeling; healthcare analytics; risk stratification; early disease detection; clinical decision support; computational health; public health informatics; AI ethics in healthcare; medical AI validation; health data science; personalized medicine
(This special issue belongs to the Section Medical Research)
New Insights into Athlete Physiology submission deadline 31 Mar 2026 | 1 articles | Viewed by 2413 | Submission Open
Keywords: sport physiology; physical performance; injury prevention; cognition; artificial intelligence; dose– response relationship
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinary Approach to Diabetes Mellitus: From Pathophysiology to Diagnosis and Therapeutic Challenges: 2nd Edition submission deadline 31 Mar 2026 | 2 articles | Viewed by 2219 | Submission Open
Keywords: hyperlipidemia; neuropathy; nephropathy; retinopathy; psychological effects; epigenetic imprinting; molecular profiling; glucose control; vascular damage and regeneration; diabetes complications
(This special issue belongs to the Section Physiology and Pathology)
Space Medicine Advancements: From Human Health to Biomedical System Design
edited by and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1783 | Submission Open
Keywords: biomedical research in extreme environments including space; effects of gravity and radiation on biological systems; multi-omics studies on astronauts and experimental models; spaceflight analogs for disease modeling and mechanistic studies (in vitro and in vivo models); computational models for astronaut health and risk assessment (simulations and AI models); mitigation of spaceflight-induced pathophysiology and health risks; development of tools; biomarkers; and interventions for remote monitoring and the implementation of countermeasures to safeguard human health; lfe support systems and biotechnology solutions for space explorations
(This special issue belongs to the Section Medical Research)
Allergies and Allergic Diseases—Perspectives in Diagnosis and Management: 2nd Edition
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1557 | Submission Open
Keywords: allergy; anaphylaxis; cross-allergies; IgE; exercise-induced anaphylaxis; component-resolved diagnosis
(This special issue belongs to the Section Medical Research)
From Vessel to Muscle—an Integrative Approach to Ischemic Heart Disease submission deadline 31 Mar 2026 | 1 articles | Viewed by 1543 | Submission Open
Keywords: ischemic heart disease; atherosclerotic plaque features; microvascular dysfunction; coronary vasospasm; percutaneous transluminal coronary angioplasty; coronary artery bypass grafting; cardiac magnetic resonance imaging; coronary computed tomography angiography
(This special issue belongs to the Section Physiology and Pathology)
Innovation and Translation in Cardiovascular Interventions
edited by Jacek Bil
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1415 | Submission Open
Keywords: cardiovascular interventions; innovation; translational research; interventional cardiology; structural heart disease; device development; percutaneous therapy; imaging guidance; physiology-guided intervention; drug– device combination; artificial intelligence; digital health; bioresorbable scaffolds; clinical translation; cardiovascular technology
(This special issue belongs to the Section Medical Research)
The Contribution of Neurogenetics in Disentangling the Pathophysiology of Neurodegenerative Diseases
edited by , Michele Salemi and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1279 | Submission Open
Keywords: neurodegenerative diseases; translational neurogenetics; early diagnosis; prevention; therapies; clinical practice; advanced genetic techniques; outcome measures
(This special issue belongs to the Section Physiology and Pathology)
Interdisciplinarity in Cardiovascular Diseases: From Pathophysiology to Diagnosis and Treatment—4th Edition submission deadline 31 Mar 2026 | 1 articles | Viewed by 817 | Submission Open
Keywords: interdisciplinarity team; cardiovascular diseases; cardiovascular complications; gastro-esophago-enterology and hepatology; metabolic-associated steatohepatitis; gut microbiota; nephrocardiology; pulmonary diseases; rheumatology diseases; endocrinology diseases
(This special issue belongs to the Section Physiology and Pathology)
Advances in the Epidemiology, Physiology, Diagnosis and Treatment of Breast Cancer
edited by , Traian Pǎtraşcu, Petronel Mustatea and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 682 | Submission Open
Keywords: epidemiology; physiology; conservative breast surgery; sentinel lymph node biopsy; artificial intelligence in breast cancer
(This special issue belongs to the Section Medical Research)
Environmental Stress and Adaptation: Molecular Mechanisms and Ecosystems Biodiversity submission deadline 31 Mar 2026 | Viewed by 389 | Submission Open
Keywords: abiotic oxidative stress; aquatic biodiversity monitoring; reactive oxygen species; riparian and mangrove vegetation management; environmental DNA (eDNA) metabarcoding
(This special issue belongs to the Section Diversity and Ecology)
Role of the Kynurenine System in Neurological Disorders
edited by and Tamás Körtési
submission deadline 31 Mar 2026 | Viewed by 317 | Submission Open
Keywords: kynurenine pathway; neurological disorders; kynurenic acid; quinolinic acid
(This special issue belongs to the Section Physiology and Pathology)
Livestock Genomics: Decoding Complex Traits Through Network Biology
edited by Ikhide Godwin Imumorin, and Olanrewaju B. Morenikeji
submission deadline 31 Mar 2026 | Viewed by 246 | Submission Open
Keywords: network biology; systems biology; computational genomics; complex phenotypes; economic traits; livestock improvement; molecular genetics
(This special issue belongs to the Section Animal Science)
New Treatment Options for Metastatic Non-Small Cell Lung Cancer and Gastrointestinal Cancer
edited by Lydia Meder and Anna M. Dmitrieva
submission deadline 31 Mar 2026 | Viewed by 184 | Submission Open
Keywords: non-small cell lung cancer; gastrointestinal cancer; metastasis; molecular mechanisms; targeted therapy; immunotherapy; chemotherapy; vaccines; cancer treatment
(This special issue belongs to the Section Medical Research)
Thyroid and Parathyroid Diseases: Advances in Molecular Imaging submission deadline 31 Mar 2026 | Viewed by 166 | Submission Open
Keywords: thyroid cancer; parathyroid imaging; hyperparathyroidism; benign thyroid diseases; molecular imaging; radioactive iodine; radioiodine-refractory thyroid cancer; theranostics
(This special issue belongs to the Section Medical Research)
Back to Basics in Palaeontology: 2nd Edition
edited by Hua Stephane
submission deadline 31 Mar 2026 | Viewed by 145 | Submission Open
Keywords: fundamentals; natural history; multidisciplinarity; firsthand bibliography; actualism
(This special issue belongs to the Section Paleobiology)
Fatty Liver Disease: From Molecular Mechanisms to Novel Therapeutics
edited by Stephen Malnick and
submission deadline 31 Mar 2026 | Viewed by 136 | Submission Open
Keywords: fatty liver disease; metabolic-associated liver disease-MAFLD; alcoholic liver disease; non-alcoholic steatohepatitis; alcohol and COVID-19; cytokine storm; microbiome
(This special issue belongs to the Section Medical Research)
New Advances in Natural Product Research for Drug Discovery and Therapeutics submission deadline 31 Mar 2026 | Viewed by 124 | Submission Open
Keywords: plant extract; natural Product; biological activity; chemical profiling; drug discovery; clinical applications
(This special issue belongs to the Section Plant Science)
Water Pollution Solutions: From Ecological Risk Assessment to Biological Restoration
edited by Lei Wang
submission deadline 31 Mar 2026 | Viewed by 114 | Submission Open
Keywords: water pollution; emerging contaminants; biological restoration; ecological risk assessment; microbial bioremediation; phytoremediation; aquatic ecosystem restoration; bio-based technologies; biomimetic technologies
(This special issue belongs to the Section Diversity and Ecology)
Stem Cell Biology, Tissue Formation, Cell Plasticity and Regenerative Medicine
edited by
submission deadline 31 Mar 2026 | Viewed by 92 | Submission Open
Keywords: stem cell biology; development and tissue formation; growth; tissue repair and regeneration; cell plasticity; model organisms and systems; clinical translation; regenerative medicine
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Cellular Responses to Hypoxia
edited by
submission deadline 31 Mar 2026 | Viewed by 67 | Submission Open
Keywords: hypoxia  ; cellular responses  ; molecular mechanisms  ; hypoxia signaling; adaptive pathways
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Neurological Disorders: Pathophysiological Mechanisms, Translational Breakthroughs, and Therapeutic Horizons submission deadline 31 Mar 2026 | Viewed by 60 | Submission Open
Keywords: neurological disorders; pathophysiological mechanisms; translational neuroscience; precision medicine; biomarkers; immunotherapy; digital health; brain– computer interfaces; regenerative medicine; nanomedicine
(This special issue belongs to the Section Medical Research)
Molecular Crossroads: Microbial Interactions and Metabolic Regulation in Livestock Health
edited by and Orsolya Palócz
submission deadline 31 Mar 2026 | Viewed by 56 | Submission Open
Keywords: livestock microbiome; metabolic regulation; host– microbe interactions; animal health; nutrient metabolism; precision livestock farming
(This special issue belongs to the Section Animal Science)
Molecular Epidemiology of Animal Viral Diseases submission deadline 31 Mar 2026 | Viewed by 47 | Submission Open
Keywords: animal health; epidemiology; molecular characterization; virology
(This special issue belongs to the Section Animal Science)
Therapeutic Potential of Natural Products in Chronic Diseases
edited by and Wen-Long Hu
submission deadline 10 Apr 2026 | 1 articles | Viewed by 717 | Submission Open
Keywords: natural products; herbs; chronic disease
(This special issue belongs to the Section Medical Research)
Innovative Soil Amendments for Food Security: Biochar, Nanoparticles and Waste Valorization
edited by
submission deadline 10 Apr 2026 | Viewed by 180 | Submission Open
Keywords: food security; soil– plant-microbiome interactions; soil amendment; waste valorization
(This special issue belongs to the Section Plant Science)
Innovation in Rheumatology: Advances in Diagnostics, Therapeutics and AI Applications
edited by
submission deadline 10 Apr 2026 | Viewed by 82 | Submission Open
Keywords: innovation; rheumatology; artificial intelligence (AI); new therapeutics; personalised therapy; wearable technologies; electronic health records; gene therapy; nanotechnology
(This special issue belongs to the Section Medical Research)
Stem Cells and Signaling Pathways in Pulmonary Biology
edited by
submission deadline 12 Apr 2026 | Viewed by 73 | Submission Open
Keywords: pulmonary biology; lung progenitor stem cells; signaling pathways; lung repair and regeneration; multi-omics
(This special issue belongs to the Section Physiology and Pathology)
Metabolic Nutrition: Diet–Microbiota Interactions in Obesity and Inflammation submission deadline 16 Apr 2026 | Viewed by 65 | Submission Open
Keywords: nutrition; dietary intake; microbiome; inflammation
(This special issue belongs to the Section Microbiology)
Advances in Endovascular Therapies and Acute Stroke Management
edited by
submission deadline 18 Apr 2026 | 4 articles | Viewed by 3665 | Submission Open
Keywords: mechanical thrombectomy; endovascular reperfusion; stroke intervention technologies; acute ischemic stroke treatment; stroke imaging biomarkers
(This special issue belongs to the Section Medical Research)
Spinal Neuromodulation: From Basic and Translational Research to Clinical Practice submission deadline 18 Apr 2026 | 1 articles | Viewed by 2569 | Submission Open
Keywords: spinal neuromodulation; translational neuroscience; spinal cord injury; neural plasticity; multi-disciplinary rehabilitation
(This special issue belongs to the Section Medical Research)
Bacterial Antibiotic Resistance: From Mechanisms to Strategies for Restoring Antibiotic Efficacy
edited by
submission deadline 20 Apr 2026 | 1 articles | Viewed by 436 | Submission Open
Keywords: membrane transport; antibiotic resistance; pathogenic bacteria; bacterial defense; therapeutic strategies
(This special issue belongs to the Section Medical Research)
Brain Disease Diagnosis and Image Recognition
edited by Shumao Xu, and Minyan Ge
submission deadline 20 Apr 2026 | Viewed by 147 | Submission Open
Keywords: artificial intelligence; brain disease diagnosis; medical image recognition; neuroimaging; computational neuroscience; deep learning; machine learning; computer vision; signal processing; biomedical image analysis; neurodegenerative disorders; brain– computer interface; sleep disorders; sleep– wake regulation; polysomnography (PSG) analysis; circadian rhythms; sleep staging automation; REM sleep detection; insomnia biomarker identification; sleep apnea detection; neuroinflammation imaging; multimodal data fusion; explainable AI (XAI); federated learning; generative adversarial networks (GANs); edge computing for healthcare; clinical decision support systems; precision neurology; biomarker discovery; sleep-related neurodegeneration; EEG signal processing; functional MRI (fMRI); diffusion tensor imaging (DTI); Alzheimer’ s disease prediction; Parkinson’ s disease biomarkers; brain tumor segmentation; stroke lesion mapping; ethical AI in healthcare; AI-driven sleep medicine; automated sleep scoring
Phase Separation in Biological Regulation and Disease
edited by and Ke Liu
submission deadline 20 Apr 2026 | Viewed by 73 | Submission Open
Keywords: biomolecular condensates; liquid– liquid phase separation (LLPS); gene regulation; disease pathogenesis; aberrant phase separation
(This special issue belongs to the Section Physiology and Pathology)
Cardiovascular Diseases: From Basic Research to Clinical Application—3rd Edition submission deadline 24 Apr 2026 | 3 articles | Viewed by 2046 | Submission Open
Keywords: CVDs; risk factors; prevention; treatment; novelties in research; artificial intelligence
(This special issue belongs to the Section Medical Research)
Chronic Respiratory Comorbidities in Sleep-Disordered Breathing: A Holistic Approach submission deadline 24 Apr 2026 | Viewed by 500 | Submission Open
Keywords: sleep-disordered breathing (SDB); obstructive sleep apnoea (OSA); asthma; chronic obstructive pulmonary disease (COPD); interstitial lung diseases (ILDs); sleep physiology; pathophysiological traits; cardio-metabolic outcomes; treatment adherence and response
(This special issue belongs to the Section Physiology and Pathology)
Body Fluid-Based Biomarkers for Cognitive Impairment
edited by Wei Li
submission deadline 24 Apr 2026 | Viewed by 458 | Submission Open
Keywords: Alzheimer’ s disease and related dementia (ADRD); body fluid-based biomarkers; cognitive impairments; early diagnosis; treatment; prognosis
(This special issue belongs to the Section Medical Research)
The Impact of Onconutraceutics as Potential Oncological Strategy submission deadline 24 Apr 2026 | Viewed by 137 | Submission Open
Keywords: nutraceuticals; oncological therapies; onconutraceuticals; molecular pathways modulated by onconutraceuticals; chemotherapy; radiotherapy; personalized therapies; non-invasive approaches
(This special issue belongs to the Section Physiology and Pathology)
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