Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endocrinology and Metabolic Syndrome: Epidemiology
edited by Roman Junik and
submission deadline 30 Nov 2025 | Viewed by 62 | Submission Open
Keywords: metabolic syndrome; obesity; hypertension; diabetes; dyslipidemia; endocrinology
(This special issue belongs to the Section Epidemiology)
Update on Obstructive Sleep Apnea (OSA) submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open
Keywords: obstructive sleep apnea; snoring; sleep-disordered breathing; adult sleep apnea; pediatric sleep apnea
(This special issue belongs to the Section Physiology and Pathology)
Environment, Genetics, and Cardiovascular Disease
edited by
submission deadline 30 Nov 2025 | Viewed by 61 | Submission Open
Keywords: cardiovascular disease; environmental exposure; genetics; epigenetics
(This special issue belongs to the Section Medical Research)
Advances in Biomedical Frontier Technologies and Disease Diagnosis
edited by
submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open
Keywords: nanomedicine  ; biomaterials  ; gene therapy  ; drug delivery  ; bacteriotherapy  ; nanobiotechnology  ; hereditary diseases  ; bioinformatics  ; personalized medicine  ; smart biomaterials
(This special issue belongs to the Section Medical Research)
Coagulation and Its Disorders: Physiology and Pathological Mechanisms submission deadline 30 Nov 2025 | Viewed by 53 | Submission Open
Keywords: coagulation; bleeding disorders; thrombotic mechanisms; animal models; molecular mechanisms; disseminated intravascular coagulation; fibrinolysis; new diagnostic tools and treatment; inflammatory response; thrombin generation; coagulation alterations induced by hepatic and metabolic disorders; drug-induced coagulation alterations
(This special issue belongs to the Section Physiology and Pathology)
Etiology, Diagnosis, and Treatment of Coeliac Diseases
edited by Paul J Ciclitira
submission deadline 30 Nov 2025 | Viewed by 48 | Submission Open
Keywords: coeliac disease; blood tests; dietary treatment; etiology
(This special issue belongs to the Section Medical Research)
Prosthetic Joint Infections: A Multidisciplinary Approach
edited by
submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open
Keywords: orthoplastic approach; prosthetic joint infection; diagnosis and management of PJI; antibiotic therapy in periprosthetic infections
Advances in Millimeter-Wave-Based Pain Therapy
edited by and David Crouzier
submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open
Keywords: millimetric waves; pain therapy; pain management; electromagnetic radiations; biophysics
Innovative Cardiovascular Interventions: From Imaging to Precision Therapies submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open
Keywords: cardiovascular diseases (CVDs); diagnostic imaging; minimally invasive interventions; precision medicine; 3D/4D imaging; gene therapy; cell-based therapies
(This special issue belongs to the Section Physiology and Pathology)
Investigations of Circular RNAs in Plants submission deadline 1 Dec 2025 | Viewed by 69 | Submission Open
Keywords: plant circRNAs; miRNAs; stress responses; abiotic; biotic; translation; gene regulation; growth; development
(This special issue belongs to the Section Plant Science)
Neurological Diseases: Prevention, Diagnostics, Treatment and Rehabilitation
edited by and Gelu Onose
submission deadline 2 Dec 2025 | 4 articles | Viewed by 5413 | Submission Open
Keywords: neurological diseases; stroke prevention; stroke treatment; rehabilitation; artificial intelligence; cellular therapy; molecular therapy; interdisciplinary approaches; therapeutic interventions
(This special issue belongs to the Section Medical Research)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 258 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
Microvascular Dynamics: Insights and Applications
edited by and Friedrich Jung
submission deadline 15 Dec 2025 | 6 articles | Viewed by 11005 | Submission Open
Keywords: microvessels; dynamics; velocity; flow; rheology; in vitro; animals; humans; biomarkers; imaging; simulations; models; preclinical; clinical
(This special issue belongs to the Section Physiology and Pathology)
Unusual Genomic Traits in Their Evolutionary Context
edited by Miguel Naranjo-Ortiz
submission deadline 15 Dec 2025 | Viewed by 103 | Submission Open
Keywords: unusual genomes; genomic traits; comparative genomics; descriptive genomics; evolutionary genomics; non-model organisms; methodological limitations in genomics
(This special issue belongs to the Section Genetics and Genomics)
2nd Edition—Featured Papers on the Origins of Life
edited by James R. Lyons
submission deadline 17 Dec 2025 | 3 articles | Viewed by 2062 | Submission Open
Keywords: astrobiology; astrochemistry; planetary science; prebiotic chemistry; chirality; chemical evolution; protocells; synthetic biology; complex systems
(This special issue belongs to the Section Origin of Life)
Unravelling the Molecular Mechanisms of Different Stress Responses in Plants
edited by
submission deadline 18 Dec 2025 | 1 articles | Viewed by 1065 | Submission Open
Keywords: biotic stresses; abiotic stresses; plant growth and development; crop productivity; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Innovative Approaches in Dermatological Therapies and Diagnostics submission deadline 26 Dec 2025 | 4 articles | Viewed by 3222 | Submission Open
Keywords: dermatology; inflammatory diseases; skin cancer; non-invasive diagnosis; dermoscopy; confocal dermoscopy; targeted therapy; JAK inhibitors; biologics; artificial intelligence
(This special issue belongs to the Section Medical Research)
Advances in Diagnostic Imaging for Systemic Disorders
edited by Christoph Strolz
submission deadline 29 Dec 2025 | Viewed by 78 | Submission Open
Keywords: high-resolution computed tomography (HRCT); diffusion-weighted imaging (DWI); dual-energy CT in musculoskeletal imaging; high-resolution ultrasonography; SPECT/CT; PET/CT modalities
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Current Views on Knee Osteoarthritis: 3rd Edition submission deadline 30 Dec 2025 | Viewed by 121 | Submission Open
Keywords: knee osteoarthritis; metabolic syndrome; obesity; pathogenesis; adipokines; disease-modifying; treatment; personalized medicine
(This special issue belongs to the Section Medical Research)
Advances in the Pathology of Dialysis: Insights into Peritoneal and Hemodialysis-Related Complications
edited by
submission deadline 30 Dec 2025 | Viewed by 38 | Submission Open
Keywords: peritoneal dialysis; hemodialysis; acute kidney injury (AKI); chronic kidney disease; pathology; complication
(This special issue belongs to the Section Physiology and Pathology)
Advances in Neural Stem Cell Medicine
edited by Kiminobu Sugaya
submission deadline 30 Dec 2025 | Viewed by 18 | Submission Open
Keywords: neural stem cell; neurodegenerative diseases; cell therapy; exosomes
(This special issue belongs to the Section Physiology and Pathology)
Plant Biotic and Abiotic Stresses 2024
edited by and
submission deadline 31 Dec 2025 | 21 articles | Viewed by 23734 | Submission Open
Keywords: plant stress; abiotic stress; biotic stress
(This special issue belongs to the Section Plant Science)
Gastrointestinal Health: Clinical Research and Therapeutic Innovations
edited by
submission deadline 31 Dec 2025 | 16 articles | Viewed by 19523 | Submission Open
Keywords: gut microbiota; inflammatory bowel diseases; irritable bowel syndrome; gastroesophageal reflux disease; fatty liver disease; liver cirrhosis; probiotics; mediterranean diet; epidemiology; diagnosis; treatment; artificial intelligence
(This special issue belongs to the Section Medical Research)
New Trends in Otorhinolaryngology submission deadline 31 Dec 2025 | 6 articles | Viewed by 11964 | Submission Open
Keywords: head and neck; otolaryngology; hearing loss; speech disorders; swallowing disorders; cancer; microRNA; nose; plastic surgery
(This special issue belongs to the Section Medical Research)
Clinical Management and Prevention of Adverse Pregnancy Outcomes submission deadline 31 Dec 2025 | 5 articles | Viewed by 8297 | Submission Open
Keywords: pathologic pregnancies; ultrasound; clinical and molecular characteristics; fetal pathologies
(This special issue belongs to the Section Reproductive and Developmental Biology)
New Diagnostic and Therapeutic Developments in Eye and Systemic Diseases
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 6964 | Submission Open
Keywords: eye diseases; systemic diseases; oculomics; ocular imaging; eye surgery; retina; cornea; glaucoma; refractive surgery; OCT; OCTA
(This special issue belongs to the Section Medical Research)
Ecology and Conservation of Small Mammals: Exploring Biodiversity, Climate Resilience, and Ecosystem Dynamics Through Small Mammal Monitoring and Research: 2nd Edition submission deadline 31 Dec 2025 | 7 articles | Viewed by 6622 | Submission Open
Keywords: small mammals; biodiversity; indicators; monitoring; assessment; communities
(This special issue belongs to the Section Diversity and Ecology)
Recent Advances in Functional Genomics
edited by Katerina R. Katsani and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4870 | Submission Open
Keywords: chromatin profiling; CRISPR screens; crop genomics; epigenome editing; epigenomics; interactomes; metagenomics; pharmacogenomics; phenomics
(This special issue belongs to the Section Genetics and Genomics)
New Insights into Breast Cancer: Current Controversies and Future Perspectives
edited by , Angela Bucaro and Flavia de Lauretis
submission deadline 31 Dec 2025 | 5 articles | Viewed by 4505 | Submission Open
Keywords: breast cancer treatment; oncoplastic surgery; conservative mastectomy; breast reconstruction; sentinel node biopsy; chemotherapy; radiotherapy; integrated therapies
(This special issue belongs to the Section Medical Research)
Molecular Mechanisms and Therapeutic Effects of Drugs in Cancer—2nd Edition submission deadline 31 Dec 2025 | 3 articles | Viewed by 4275 | Submission Open
Keywords: cancer; therapy; cancer drug; molecular mechanism; signaling pathways; targeted therapy; in silico drug response studies; innovative cancer treatment
(This special issue belongs to the Section Medical Research)
Advances in Non-Invasive Brain Stimulation submission deadline 31 Dec 2025 | 2 articles | Viewed by 3643 | Submission Open
Keywords: translational neuroscience; clinical neurophysiology; neurodegeneration; neural plasticity; neurosonology; sleep disorders; cognitive decline; non-invasive brain stimulation; nutraceuticals; neurogenetics; transcranial magnetic stimulation; dementia; vascular cognitive impairment; stroke; depression; metaplasticity; motor cortex; motor learning; neurotrophins; transcranial-focused ultrasound
(This special issue belongs to the Section Medical Research)
Trends in Clinical Research 2025 submission deadline 31 Dec 2025 | 3 articles | Viewed by 3371 | Submission Open
Keywords: artificial intelligence; biomedical research; digital health; evidence-based medicine; health policy; new therapies; new drugs; patient-centered research; personalized medicine; translational medicine
(This special issue belongs to the Section Medical Research)
Advances in Non-Alcoholic Fatty Liver Disease: Pathophysiology, Diagnosis, and Emerging Therapies submission deadline 31 Dec 2025 | 2 articles | Viewed by 3129 | Submission Open
Keywords: non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated fatty liver disease (MAFLD); steatohepatitis; metabolic syndrome; insulin resistance; apoptosis/cell death
(This special issue belongs to the Section Medical Research)
Plant Physiology: From Omic Analysis Toward Physiological Mechanism Research: 2nd Edition
edited by and Fang He
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2075 | Submission Open
Keywords: plant physiology; transcriptome; proteomics; gene regulatory network; bioinformation; omics; molecular mechanisms
(This special issue belongs to the Section Plant Science)
Molecular Mechanisms of Preeclampsia
edited by Feng Li
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2074 | Submission Open
Keywords: preeclampsia; hypertension; proteinuria; placenta; fetal growth restriction; pregnancy com-plications; implantation
(This special issue belongs to the Section Reproductive and Developmental Biology)
Antimicrobial Innovations
edited by and Miho Nakamura
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1602 | Submission Open
Keywords: antimicrobial resistance; biopreservation; lactic acid bacteria; bacteriocins; bacteriophages; natural antimicrobials; antimicrobial peptides; foodborne pathogens; antimicrobial biomaterials; race for the surface; microbial growth models; food safety
(This special issue belongs to the Section Microbiology)
From Muscle to Fascia: Current Trends and Future Perspectives submission deadline 31 Dec 2025 | 1 articles | Viewed by 1421 | Submission Open
Keywords: connective tissue; deep fascia; superficial fascia; retinacula; muscle stiffness; hyaluronan; densification; biomechanics; therapies
(This special issue belongs to the Section Physiology and Pathology)
Obstetrics and Gynecology Medicine: From Bench to Bedside—2nd Edition submission deadline 31 Dec 2025 | 1 articles | Viewed by 1231 | Submission Open
Keywords: obstetrics; gynecology; translational research; translational medicine
(This special issue belongs to the Section Medical Research)
Feature Papers in Animal Science: 4th Edition
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1128 | Submission Open
Keywords: fish; microbial ecology; lipid nutrition; electron microscopy; gut microbiota; proteomics; next-generation sequencing; arthropod parasites; protease inhibitors; disease vectors; cystatin; serpin; Kunitz; tick; insect; vector– host interaction; innate immunity; shellfish immunology; bivalve molluscs; transcriptomics; diseases; hemocytes; microscopy
(This special issue belongs to the Section Animal Science)
Neurobiological and Neuroepigenetic Factors in Childhood Disorders: Autism Spectrum Disorder and Obesity
edited by Elisa Na
submission deadline 31 Dec 2025 | 1 articles | Viewed by 852 | Submission Open
Keywords: obesity; autism spectrum disorder; hypothalamus; cerebellum; frontal cortex; epigenetics
(This special issue belongs to the Section Physiology and Pathology)
Diagnosis and Treatment of Erectile Dysfunction
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 636 | Submission Open
Keywords: erectile dysfunction; non-invasive methods; surgical strategies
(This special issue belongs to the Section Physiology and Pathology)
Conservation Ecology and Management of Mammalian Predators submission deadline 31 Dec 2025 | Viewed by 588 | Submission Open
Keywords: mammalian predators; mesocarnivores; terrestrial predators; predator– prey interactions
(This special issue belongs to the Section Animal Science)
Pain: New Insights into Mechanisms, Diagnosis, Therapy, and Management
edited by and I-Han Hsiao
submission deadline 31 Dec 2025 | Viewed by 536 | Submission Open
Keywords: pain; mechanisms; signaling pathways; diagnosis
(This special issue belongs to the Section Physiology and Pathology)
Advances in Research on Motor Deficits Caused by Neurological Disorders: From Mechanism to Treatment
edited by and Hans Hultborn
submission deadline 31 Dec 2025 | Viewed by 516 | Submission Open
Keywords: neurological disorders; neurodegenerative diseases; brain injury; spinal cord injury; stroke; cerebral palsy; peripheral nerve injury; paralysis; spasticity; contracture; muscle weakness; postural asymmetry; gate pattern changes; uncontrolled movements
(This special issue belongs to the Section Medical Research)
Advancing Cancer Radiodiagnostics Through Artificial Intelligence: Techniques, Applications, and Challenges
edited by Pei-Ju Chao, , and
submission deadline 31 Dec 2025 | Viewed by 364 | Submission Open
Keywords: artificial intelligence; cancer radiodiagnostics; machine learning; tumor detection; radiomics integration
(This special issue belongs to the Section Medical Research)
The Interactions Between Cells and Their Microenvironment
edited by and
submission deadline 31 Dec 2025 | Viewed by 338 | Submission Open
Keywords: cell microenvironment; extracellular matrix; interstitial cells
(This special issue belongs to the Section Cell Biology and Tissue Engineering)
The Emerging Clinical Relevance of Artificial Intelligence, Data Science, and Wearable Devices in Headache
edited by , , Muneto Tatsumoto and Shingo Shimoda
submission deadline 31 Dec 2025 | Viewed by 290 | Submission Open
Keywords: headache; migraine; tension-type headache; trigeminal autonomic cephalalgias; medication-overuse headache; primary headaches; secondary headaches; raising awareness; calcitonin gene-related peptide (CGRP) monoclonal antibodies; artificial intelligence; wearable devices; data sciences
(This special issue belongs to the Section Medical Research)
Characterization, Bioactivity Evaluation and Utilization of Plant Polysaccharides
edited by and
submission deadline 31 Dec 2025 | Viewed by 288 | Submission Open
Keywords: plant polysaccharides; identification; characterization; functional property; biological activity; health benefit; food packaging
(This special issue belongs to the Section Pharmaceutical Science)
Radiological Diagnosis of Cervical Spondylosis and Carotid Artery Disease
edited by Anusha Vaddi
submission deadline 31 Dec 2025 | Viewed by 287 | Submission Open
Keywords: carotid artery disease; atherosclerosis; cervical spondylosis; c-spine; radiological diagnosis; diagnostic accuracy; AI in radiology
(This special issue belongs to the Section Medical Research)
Endocrine Mechanisms and Cellular Dynamics in Obesity: Insights and Innovations
edited by Manuel Gil Lozano and Marina Romaní-Pérez
submission deadline 31 Dec 2025 | Viewed by 152 | Submission Open
Keywords: gastrointestinal peptides; adipokines; food intake regulation; hypothalamus; orexigenic; anorexigenic; adipocytes; pancreatic islets; leptin; insulin
(This special issue belongs to the Section Physiology and Pathology)
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