Clinical Update for Resuscitation Science: 2nd Edition

A Special Issue of Life (ISSN 2075-1729) belonging to the section "Medical Research".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 3155

Editor


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Guest Editor
Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 739-8511, Japan
Interests: cardiac arrest; ARDS; ECMO; trauma
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Special Issue Information

Dear Colleagues,

We are grateful to the researchers who contributed to the first volume of this Special Issue:

Clinical Update for Resuscitation Science: https://www.mdpi.com/journal/life/special_issues/13865L573S.

Resuscitation science has advanced over the past decade, leading to improved outcomes for critically ill patients with severe acute respiratory or circulatory failure. However, despite these advancements, their outcomes remain poor. For example, the survival rates of patients with cardiac arrest are approximately 10% (varying from 0% to 18%), and even among survivors, many patients are discharged or transferred to other hospitals in a vegetative state or coma. Therefore, there is a need to develop better strategies for the management of such critically ill patients.

The objective of this Special Issue is to discuss knowledge gaps and research priorities in the field of resuscitation science, as well as to present potential novel treatment strategies that seek to improve their outcomes. The scope of this Special Issue intentionally encompasses a wide range of topics and perspectives related to resuscitation research.

This Special Issue focuses on all critically ill patients who need resuscitative interventions, such as those with severe acute respiratory or circulatory failure, requiring the support of extracorporeal membrane oxygenation, or severe trauma, as well as patients experiencing cardiac arrest. This broad scope takes in clinical and basic research and review articles related to resuscitation science.

Dr. Mitsuaki Nishikimi
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • resuscitation science
  • cardiac arrest
  • acute respiratory failure
  • acute circulatory failure
  • trauma

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Published Papers (1 paper)

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Review

12 pages, 2071 KB  
Review
Optimizing Timing and Dose of Starting Norepinephrine and Vasopressin in Septic Shock
by Gaku Hiroto, Mitsuaki Nishikimi and Nobuaki Shime
Life 2026, 16(6), 913; https://doi.org/10.3390/life16060913 - 29 May 2026
Viewed by 2643
Abstract
Despite advances in septic shock management, optimal vasopressor strategies remain understudied. Norepinephrine (NE) is recommended as the first-line vasopressor for restoring arterial pressure; however, excessive catecholamine exposure has been associated with adverse events, including arrhythmias, ischemia, and poor clinical outcomes. While the early [...] Read more.
Despite advances in septic shock management, optimal vasopressor strategies remain understudied. Norepinephrine (NE) is recommended as the first-line vasopressor for restoring arterial pressure; however, excessive catecholamine exposure has been associated with adverse events, including arrhythmias, ischemia, and poor clinical outcomes. While the early initiation of NE is increasingly recognized as important, uncertainty persists regarding the optimal starting dose and escalation strategy. In septic shock, particularly refractory septic shock, reduced vascular responsiveness may limit the effectiveness of escalating NE doses and increase the risk of dose-related complications. Vasopressin (AVP), a non-adrenergic vasopressor, provides complementary mechanisms to NE and may reduce catecholamine requirements. Randomized trials have not consistently demonstrated a survival benefit; AVP may improve hemodynamic stability and renal perfusion. Emerging evidence suggests the potential advantages of earlier AVP initiation at lower NE doses than those currently recommended. Collectively, the current evidence supports a strategy that prioritizes early and adequately dosed NE to achieve rapid hemodynamic stabilization, followed by the timely initiation of AVP once moderate NE requirements are reached, rather than the continued escalation of NE alone. Such an integrated approach may help balance efficacy and safety, and minimize catecholamine-related harm while optimizing perfusion in septic shock cases. Full article
(This article belongs to the Special Issue Clinical Update for Resuscitation Science: 2nd Edition)
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