Omics Technologies in Bladder Cancer

Dear Colleagues,

The surfaces of bladders and ureters are covered mainly by urothelium. Urinary bladder urothelial carcinoma has a high frequency of local recurrence followed by lethal distal spreading. Cystoscopy and urine cytology offer high specificity and acceptable sensitivity for high-grade urinary bladder urothelial carcinoma diagnosis but lack sensitivity in low-grade lesions. Furthermore, a subset of patients with tumor metastasis might not demonstrate detectable urinary bladder cancer recurrence, especially those who have received radical cystectomy. Therefore, identifying prognostic biomarkers by uncovering the molecular carcinogenesis of urinary bladder urothelial carcinoma may give valuable insights that help to interpret better diagnosis/prognosis and novel targeted therapeutic strategies.

Proteomics covers many platform techniques for protein separation and identification, determining their functions and interactions, and annotation. Proteomic techniques that can examine the whole proteome or a fraction comprise two-dimensional gel electrophoresis or liquid chromatography, combined with mass spectrometry.

Genetic and, ultimately, protein alterations are primary determinants controlling neoplastic transformation and tumor progression. Thus, comparison of in vitro or clinical samples by proteomics technology allows molecular characterization of the proteins involved in urinary bladder urothelial carcinoma progression and searching for potential biomarkers for early detection and prognosis.

Prof. Dr. Ting-Feng Wu
Guest Editor

Prof. Dr. Chien-Feng Li
Co-Guest Editor

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