Innovations, Utilization, and Safety of Psychiatric Drugs: Current Trends and Future Directions

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: 30 March 2026 | Viewed by 1238

Special Issue Editor


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Guest Editor
Department of Pharmacy, University of Split School of Medicine, 21000 Split, Croatia
Interests: psychiatric medicine; community pharmacies; pharmacology; a dverse drug reaction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Basic biology and pharmacology research in the field of psychiatric diseases has witnessed significant advancements in recent decades, yet challenges remain in clinical practice, especially concerning the efficacy and safety of marketed psychiatric medicine. The aim of this Special Issue, therefore, is to provide a comprehensive platform for exploring the latest developments in psychiatric pharmacotherapy, addressing the critical need for safe and effective treatment options for a variety of psychiatric patients, ranging from the spectrum of depressive disorders to psychotic disorders. By gathering insights from these critical areas, the aim of this Special Issue is to foster a deeper understanding of the current status and future directions of psychiatric drug research and practice. Thus, we welcome submissions from researchers, clinicians, and scholars who are working to advance the field and improve patient care in all fields related to psychiatric disorders.

Dr. Josipa Bukić
Guest Editor

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Keywords

  • psychiatric diseases
  • psychiatric medicine
  • psychiatric pharmacotherapy
  • psychiatric drugs

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Published Papers (1 paper)

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Review

20 pages, 1178 KiB  
Review
Following the Action of Atypical Antipsychotic Clozapine and Possible Prediction of Treatment Response in Schizophrenia
by Mihai-Gabriel Năstase, Antonia Ioana Vasile, Arina Cipriana Pietreanu and Simona Trifu
Life 2025, 15(6), 830; https://doi.org/10.3390/life15060830 - 22 May 2025
Viewed by 864
Abstract
We tried to synthesize the possibilities of predicting the response to clozapine treatment, which can significantly improve the efficacy of the active substance and reduce adverse reactions, and how the active substance acts at the D1 dopaminergic receptors D2, D3, D4, and D5, [...] Read more.
We tried to synthesize the possibilities of predicting the response to clozapine treatment, which can significantly improve the efficacy of the active substance and reduce adverse reactions, and how the active substance acts at the D1 dopaminergic receptors D2, D3, D4, and D5, muscarinic M1, M2, M3, and M5, and the histamine and alpha 1 adrenergic receptor, as well as how it contributes to increased cerebral blood flow, the effect on ribosomal protein S6 function, or the effect on kynurenine 3-monooxygenase function. Clozapine is one of the most effective antipsychotics, and there is potential to improve performance by combining it with different compounds to limit adverse effects or by augmenting it with other antipsychotics (amisulpride, paliperidone), other active substances with different properties (minocycline, N-acetylcysteine, memantine), or alternative therapies (electroconvulsive therapy, repetitive transcranial magnetic stimulation). There are also significant steps in optimizing clozapine efficacy by predicting treatment response, which could be determined by testing the following: plasma levels of clozapine N-oxide and N-desmethylclozapine, serum levels of neurotrophins and glutamate, genetic testing, the polygenic risk score, morphometry, or even the identification and accurate determination of persistent negative symptoms. Full article
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