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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Key Challenges in Heart Transplantation and Their Solutions
edited by Elizabeth J. Maynes
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1302 | Submission Open
Keywords: heart transplantation; heart failure; cardiac surgery; minimally invasive techniques; general surgery; heart diseases
(This special issue belongs to the Section Cardiology)
Current Challenges and Perspectives in Liver Transplantation
edited by Bogdan Dorobanţu, and Waldo Concepcion
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1250 | Submission Open
Keywords: liver transplantation; liver surgery; liver cirrhosis; liver disease; alcoholic and non-alcoholic steatohepatitis; cholangiocarcinoma; hepatocellular carcinoma; auxiliary liver transplantation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes
edited by Thomas Mokrusch and Frank Kirchhoff
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1186 | Submission Open
Keywords: neurorehabilitation; therapeutic approaches; repair mechanism; plasticity; neurology
(This special issue belongs to the Section Clinical Neurology)
New Perspectives in Maternal–Fetal Medicine
edited by Catalina de Paco-Matallana
submission deadline 20 Dec 2025 | 1 articles | Viewed by 890 | Submission Open
Keywords: maternal– fetal medicine; prenatal diagnostics; fetal therapy; precision medicine; neonatal outcomes; maternal health
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Perspectives and Innovations in Urogynecology
edited by Stavros Athanasiou
submission deadline 20 Dec 2025 | 1 articles | Viewed by 873 | Submission Open
Keywords: urogynecology; pelvic organ prolapse; urinary incontinence; overactive bladder; pelvic floor surgery; reconstructive surgery; minimally invasive surgery; pelvic floor disorders; innovative surgical techniques; quality of life
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiovascular Imaging: Diagnosis and Therapeutic Guidance in Clinical Practice
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 733 | Submission Open
Keywords: cardiovascular magnetic resonance; cardiac imaging; T1 and T2 mapping; myocardial tissue characterization; late gadolinium enhancement; ischemic heart disease; cardiomyopathies; valvular heart disease; therapeutic guidance; precision medicine; mitral valve prolapse
(This special issue belongs to the Section Cardiology)
New Clinical Advances in Breast Reconstruction
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 490 | Submission Open
Keywords: breast reconstruction; autologous (flap) reconstruction; implant-based reconstruction; microsurgery and perforator flaps; robotic surgery/endoscopic surgery; fat grafting (lipofilling); patient-reported outcomes; reconstructive surgical innovation
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Novel Diagnostic and Therapeutic Strategies in Vitreoretinal Disease
edited by Jerzy Mackiewicz and
submission deadline 20 Dec 2025 | Viewed by 359 | Submission Open
Keywords: retinal detachment; vitreoretinal diseases; PPV; vitrectomy; macular edema; uveitis; AMD; retinal imaging; retinal pathology; diabetic retinopathy; optical coherent tomography; OCT
(This special issue belongs to the Section Ophthalmology)
Innovative Treatment and Management Strategies for Inflammatory Bowel Disease
edited by Syed Adeel Hassan and
submission deadline 20 Dec 2025 | Viewed by 321 | Submission Open
Keywords: Crohn’ s disease; ulcerative colitis; efficacy; safety; nutrition; surgery; biomarkers
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Parkinson's Disease: Recent Advances in Diagnosis and Treatment submission deadline 20 Dec 2025 | Viewed by 282 | Submission Open
Keywords: Parkinson’ s disease; disease-modifying therapies; artificial intelligence; microbiome; alpha-synuclein; neuroimaging
(This special issue belongs to the Section Clinical Neurology)
Transformative Research in Hydrocephalus: Clinical Advances
edited by Afroditi D. Lalou, Zofia Helena Czosnyka and Marek Czosnyka
submission deadline 20 Dec 2025 | Viewed by 279 | Submission Open
Keywords: cerebrospinal fluid dynamics; CSF shunt; intracranial pressure monitoring; telemetric ICP; hydrocephalus pathophysiology; neuroimaging; paediatric hydrocephalus; adult hydrocephalus; translational neuroscience
(This special issue belongs to the Section Clinical Neurology)
Risk Factors in Neonatal Intensive Care submission deadline 20 Dec 2025 | Viewed by 274 | Submission Open
Keywords: neonatal intensive care; infant birth; preterm; neonatal resuscitation; neonatal outcome; growth restriction; prenatal diagnosis; severe maternal pathology and its effects on a newborn; therapeutical hypothermia; parenteral nutrition; neonatal infection; retinopathy of prematurity
(This special issue belongs to the Section Clinical Pediatrics)
Applications of Artificial Intelligence in Cardiology: New Tools to Transform Care submission deadline 20 Dec 2025 | Viewed by 229 | Submission Open
Keywords: artificial intelligence in cardiology; machine learning; deep learning; AI-driven ECG analysis; cardiovas-cular imaging and AI; predictive analytics in cardiology; mHealth and wearables; clinical decision support systems; ethics and AI in healthcare; digital health and remote monitoring
(This special issue belongs to the Section Cardiology)
Recent Developments in Urinary Incontinence
edited by
submission deadline 20 Dec 2025 | Viewed by 185 | Submission Open
Keywords: urinary incontinence; overactive bladder; stress urinary incontinence; pelvic floor dysfunction; urodynamics; minimally invasive treatment; neuromodulation; regenerative medicine; conservative management; digital health in urology
(This special issue belongs to the Section Nephrology & Urology)
Hospital-Acquired Infections: Insights, Prevention, and Control Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 184 | Submission Open
Keywords: healthcare-acquired infections; bloodstream infections; hospital‐acquired pneumonia; intestinal infections; clostridium difficile; surgical site infections; urinary tract infections; emergency department
(This special issue belongs to the Section Epidemiology & Public Health)
Surgical Oncology: Clinical Application of Translational Medicine
edited by Domenico Parmeggiani
submission deadline 20 Dec 2025 | Viewed by 178 | Submission Open
Keywords: surgical oncology; drug safety; adverse events; nanovesicles; targeted drug delivery; cancer biomarkers; precision oncology; tumor microenvironment; nanomedicine; personalized medicine; diagnostics; prognosis; innovative therapies; translational research
(This special issue belongs to the Section Oncology)
Laparoscopy and Surgery in Gynecologic Oncology: 2nd Edition
edited by Zoltan Novak
submission deadline 20 Dec 2025 | Viewed by 160 | Submission Open
Keywords: gynecologic cancers; ovarian; uterine; cervical; laparoscopy; diagnosis; staging; treatment; palliative care; fertility preservation
(This special issue belongs to the Section Obstetrics & Gynecology)
Current and Emerging Treatment Options in Intestinal and Stomach Neoplasms
edited by Alexandros E. Giakoustidis and
submission deadline 20 Dec 2025 | Viewed by 154 | Submission Open
Keywords: colorectal cancer; colon cancer; gastric carcinoma; malignancy; gastroenterology; endoscopic techniques; therapeutic advancements; intestinal neoplasms
(This special issue belongs to the Section Oncology)
Clinical Research and Insights in Endometriosis
edited by
submission deadline 20 Dec 2025 | Viewed by 150 | Submission Open
Keywords: endometriosis; pelvic pain; infertility; inflammation; minimal access surgery; laparoscopy; hysteroscopy; robotics
(This special issue belongs to the Section Obstetrics & Gynecology)
The Treatment of BPO with Minimal Invasive Approach
edited by
submission deadline 20 Dec 2025 | Viewed by 146 | Submission Open
Keywords: benign prostatic obstruction (BPO); prostatectomy; non-muscle invasive bladder cancer; muscle invasive bladder cancer; robotic surgery
(This special issue belongs to the Section Nephrology & Urology)
Advances in Clinical Management of Temporomandibular Joint Diseases submission deadline 20 Dec 2025 | Viewed by 145 | Submission Open
Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Advanced Image-Enhanced Endoscopy and Colonoscopy
edited by , and Simona Di Caro
submission deadline 20 Dec 2025 | Viewed by 144 | Submission Open
Keywords: gastrointestinal endoscopy; colorectal cancer; endoscopic screening; artificial intelligence; chromoendoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Lung Transplantation and Interventional Pulmonology
edited by Anupam Kumar and Frye Laura
submission deadline 20 Dec 2025 | Viewed by 141 | Submission Open
Keywords: lung transplantation; interventional pulmonology; immunosuppressive therapies; organ rejection; pulmonary rehabilitation; surgical innovations; post-transplant complications; diagnostic advancements; donor lung shortage; thoracic surgery
(This special issue belongs to the Section Respiratory Medicine)
Advanced Technologies, Concepts, and Topics in Modern Neurosurgery
edited by and Ralf Stroop
submission deadline 20 Dec 2025 | Viewed by 138 | Submission Open
Keywords: modern neurosurgery; virtual reality; augmented reality; intraoperative imaging; neuronavigation; artificial intelligence; machine learning; robotic surgery; 3D printing; neurovascular interventions; neuro-oncology; skull base surgery; functional neurosurgery; spinal neurosurgery; surgical innovation; image-guided surgery; personalized neurosurgical planning
(This special issue belongs to the Section General Surgery)
Status, Application and Future Directions of Artificial Urinary Sphincters
edited by JiSung Shim
submission deadline 20 Dec 2025 | Viewed by 136 | Submission Open
Keywords: ISD; robot surgery; neurogenic SUI; female AUS; complication; erosion; urethroplasty; malfunction; PPI; BOO
(This special issue belongs to the Section Nephrology & Urology)
Gastric Cancer: Epidemiology, Clinical Management and Emerging Biomarkers submission deadline 20 Dec 2025 | Viewed by 101 | Submission Open
Keywords: gastric cancer; metabolism; biomarkers; surgical stress; adjuvant therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Innovations in Preeclampsia
edited by Jeffrey M. Denney and
submission deadline 22 Dec 2025 | 3 articles | Viewed by 14255 | Submission Open
Keywords: preeclampsia; pathophysiology; renin; SFlt-1; PlGF; hypertensive disorders of pregnancy; imitators of preeclampsia; vascular reactivity
(This special issue belongs to the Section Obstetrics & Gynecology)
Scoliosis: Advances in Diagnosis and Management
edited by Michal Latalski
submission deadline 22 Dec 2025 | 3 articles | Viewed by 3949 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; adult scoliosis; congenital scoliosis; neuromuscular scoliosis; diagnosis; imaging; treatment; surgery; bracing; rehabilitation; patient-reported outcomes; quality of life
(This special issue belongs to the Section Orthopedics)
Clinical Advances of Adolescent Idiopathic Scoliosis: Current Status and Prospects
edited by Maria Chiara Maccarone and
submission deadline 22 Dec 2025 | 2 articles | Viewed by 3604 | Submission Open
Keywords: adolescent idiopathic scoliosis; treatment; non-invasive therapies; surgery; neurophisiology; imaging; motion analysis; personalized medicine
(This special issue belongs to the Section Orthopedics)
Oral Surgery: Recent Advances and Future Perspectives submission deadline 22 Dec 2025 | 1 articles | Viewed by 3269 | Submission Open
Keywords: oral surgery; implant dentistry; atrophic jaws; bone regeneration; digital dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Ablation, Embolization, and Stenting: Current Trends in Interventional Radiology
edited by Praveen Peddu
submission deadline 22 Dec 2025 | 1 articles | Viewed by 597 | Submission Open
Keywords: interventional radiology; ablation; embolization; stenting; minimally invasive therapy
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Innovative Aspects in Dental Implantology and Related Clinical Research (Second Edition) submission deadline 22 Dec 2025 | 1 articles | Viewed by 311 | Submission Open
Keywords: dental implants; implantology; bone regeneration; implant-supported prosthesis; zygomatic implants; reconstructive surgery; pre-implant surgery; short implants
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Advances in Stereotactic Radiosurgery
edited by Shafak S. Aluwini
submission deadline 24 Dec 2025 | 1 articles | Viewed by 592 | Submission Open
Keywords: stereotactic radiosurgery; clinical outcomes; brachytherapy; IMRT; brain metastases; arteriovenous malformations; functional disorders; radiosurgery
(This special issue belongs to the Section Oncology)
Sports Injury: Clinical Prevention and Treatment
edited by , Susana Pulgar and
submission deadline 25 Dec 2025 | 4 articles | Viewed by 22148 | Submission Open
Keywords: injury prevention; team sports; talent identification; biobanding; injury burden; muscle injury; PHV
(This special issue belongs to the Section Sports Medicine)
Skin Diseases: From Diagnosis to Treatment
edited by
submission deadline 25 Dec 2025 | 6 articles | Viewed by 17025 | Submission Open
Keywords: skin; melanoma; NMSC; CTCL; mesenchymal
(This special issue belongs to the Section Dermatology)
Pathogenesis, Diagnosis, and Management of Upper Gastrointestinal Disease
edited by
submission deadline 25 Dec 2025 | 6 articles | Viewed by 12989 | Submission Open
Keywords: esophagus; stomach; duodenum; DGBI; FGIDs; Helicobacter; eosinophilic esophagitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Technological Advances, Innovative Applications, and New Clinical Benefits of Computed Tomography submission deadline 25 Dec 2025 | 3 articles | Viewed by 11239 | Submission Open
Keywords: computed tomography (CT); spectral CT; dual-energy CT; dual-source spectral CT; dual-layer spectral CT; pho-ton-counting CT; photon-counting detector CT; spectral photon-counting CT; artificial intelligence; radiomics
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Headache: Updates on the Assessment, Diagnosis and Treatment submission deadline 25 Dec 2025 | 7 articles | Viewed by 11140 | Submission Open
Keywords: headache; migraine; tension-type headache; cervicogenic headache; therapeutic exercise
(This special issue belongs to the Section Clinical Neurology)
Targeted Treatment of Kidney Stones
edited by Carmen Gonzalez-Enguita and
submission deadline 25 Dec 2025 | 4 articles | Viewed by 10272 | Submission Open
Keywords: shockwave lithotripsy; ureteroscopy; percutaneous nephrolithotomy; laser lithotripsy; minimally invasive techniques; stone recurrence prevention
(This special issue belongs to the Section Nephrology & Urology)
Thyroid Cancer: Clinical Diagnosis and Treatment
edited by Alfred A. Simental
submission deadline 25 Dec 2025 | 5 articles | Viewed by 10202 | Submission Open
Keywords: thyroid nodule; thyroid ultrasound; radiofrequency ablation; molecular analysis; thyroid surgery
(This special issue belongs to the Section Oncology)
Clinical Epidemiology in Chronic Kidney Disease
edited by and Claudia Torino
submission deadline 25 Dec 2025 | 7 articles | Viewed by 9954 | Submission Open
Keywords: chronic kidney disease; end-stage kidney disease; dialysis; hypertension; renal disease; clinical nephrology; chronic renal failure
(This special issue belongs to the Section Nephrology & Urology)
New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias
edited by
submission deadline 25 Dec 2025 | 5 articles | Viewed by 9454 | Submission Open
Keywords: cardiac arrest; defibrillation; ventricular tachycardia; ventricular fibrillation; catheter ablation; non-invasive ablation; neuromodulation; stellate ganglion block
(This special issue belongs to the Section Cardiology)
Anterior Cruciate Ligament (ACL): Innovations in Clinical Management
edited by Xaver Feichtinger, and Georg Brandl
submission deadline 25 Dec 2025 | 4 articles | Viewed by 8489 | Submission Open
Keywords: ACL; graft choice; ACL repair; ALL; tibial slope
(This special issue belongs to the Section Orthopedics)
Innovations in Maxillofacial Surgery
edited by , and Ignacio Navarro Cuéllar
submission deadline 25 Dec 2025 | 5 articles | Viewed by 7794 | Submission Open
Keywords: orthognathic surgery; sleep apnea; 3D technologies; regenerative medicine; reconstructive surgery; facial trauma; minimally invasive surgery; oncology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Recent Advances in Inflammatory and Infectious Skin Diseases (Second Edition)
edited by , Astrid Herzum and Paolo Romita
submission deadline 25 Dec 2025 | 4 articles | Viewed by 7226 | Submission Open
Keywords: atopic dermatitis; eczematous diseases; inflammatory skin diseases; chronic skin diseases; human herpesvirus; roseola syphilitica; psoriasis
(This special issue belongs to the Section Dermatology)
Recent Research Progress in Pediatric Orthopedic Surgery
edited by and Madeleine Willegger
submission deadline 25 Dec 2025 | 4 articles | Viewed by 4776 | Submission Open
Keywords: pediatric orthopedics; deformity correction; pediatric hip; pediatric trauma; basic research in pediatric orthopedics; clubfoot; pediatric foot and ankle deformities; pediatric hand
(This special issue belongs to the Section Clinical Pediatrics)
Exploring Artificial Intelligence in Precision Medicine for Gastrointestinal Diseases
edited by Vincenzo Davide Palumbo
submission deadline 25 Dec 2025 | 3 articles | Viewed by 4604 | Submission Open
Keywords: cholangiocarcinoma; biliary tree stenoses; colorectal cancer; endoscopic image analysis; IBD; gastrointestinal disorders
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Pulmonary Embolism: Clinical Advances and Future Opportunities
edited by James Horowitz
submission deadline 25 Dec 2025 | 4 articles | Viewed by 4453 | Submission Open
Keywords: pulmonary embolism; risk stratification; pulmonary embolism response teams; high risk PE; massive PE; intermediate risk PE; sub massive PE; catheter directed thrombolysis; catheter thrombectomy; catheter directed embolectomy; extra corporeal membrane oxygenation
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Radiation Therapy for Cancers submission deadline 25 Dec 2025 | 2 articles | Viewed by 3315 | Submission Open
Keywords: radiation oncology; radiotherapy; cancer radiotherapy; cancer radiation therapy; radiobiology; predictive and prognostic biomarkers; cancer treatment; heavy ions radiation oncology; protontherapy; cancer biolology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
New Insights in Skin Tumors: From Pathogenesis to Therapy
edited by Loredana Ungureanu and Simona C. Şenilǎ
submission deadline 25 Dec 2025 | 3 articles | Viewed by 2375 | Submission Open
Keywords: skin tumors; pathogenesis; diagnosis; personalized medicine; therapeutic strategies; dermato-oncology
(This special issue belongs to the Section Dermatology)
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