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New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias
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New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 4741

Special Issue Editor

Dr. Simone Savastano

E-Mail Website
Guest Editor
Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy
Interests: cardiac arrest; sudden death; ventricular arrhythmias
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiac arrest and ventricular arrhythmia remain two of the main challenges for modern medicine: survival after cardiac arrest is still low and the best way to prevent and treat ventricular arrhythmias can be improved.

Research on cardiac arrest and ventricular arrhythmia should focus on the prevention, diagnosis and treatment of these life-threatening conditions.

We would like to cover all the above-mentioned topics, from prevention to diagnosis and treatment, to enhance the knowledge on cardiac arrest and ventricular arrhythmias in order to improve patient outcome. Particular attention will be paid to new technology and strategies, such as non-invasive ablation and neuromodulation.

Dr. Simone Savastano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac arrest
  • defibrillation
  • ventricular tachycardia
  • ventricular fibrillation
  • catheter ablation
  • non-invasive ablation
  • neuromodulation
  • stellate ganglion block

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Published Papers (3 papers)

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Research

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12 pages, 793 KiB  
Article
Cangrelor in Patients Undergoing Percutaneous Coronary Intervention After Out-of-Hospital Cardiac Arrest
by Marco Ferlini, Luca Raone, Sara Bendotti, Alessia Currao, Roberto Primi, Andrea Bongiorno, Cristian Fava, Laura Dall’Oglio, Marianna Adamo, Daniele Ghiraldin, Marcello Marino, Cinzia Dossena, Andrea Baldo, Diego Maffeo, Vilma Kajana, Silvia Affinito, Enrico Baldi, Leonardo De Luca and Simone Savastano
J. Clin. Med. 2025, 14(1), 76; https://doi.org/10.3390/jcm14010076 - 27 Dec 2024
Cited by 1 | Viewed by 942
Abstract
Background: Cangrelor provides rapid platelet inhibition, making it a potential option for out-of-hospital cardiac arrest (OHCA) survivors undergoing percutaneous coronary intervention (PCI). However, clinical data on its use after OHCA are limited. This study investigates in-hospital outcomes of cangrelor use in this [...] Read more.
Background: Cangrelor provides rapid platelet inhibition, making it a potential option for out-of-hospital cardiac arrest (OHCA) survivors undergoing percutaneous coronary intervention (PCI). However, clinical data on its use after OHCA are limited. This study investigates in-hospital outcomes of cangrelor use in this population. Methods: We conducted a prospective, observational study involving OHCA patients from the Lombardia CARe Registry (January 2015–December 2022) who underwent PCI in seven centers in Northern Italy. Propensity score (PS) matching compared patients who received cangrelor to those who did not. Logistic regression tested associations between cangrelor and discharge outcomes. Results: Of 612 OHCA patients admitted, 414 (67.4%) underwent PCI with known antithrombotic therapy, of whom 34 (8.2%) received cangrelor. Radial access was more common in the cangrelor group, which also had a higher troponin peak and a final TIMI flow grade of 3. Survival at discharge was 82.4% in the cangrelor group, compared to 65.3% in the no-cangrelor group (p = 0.043). Univariable logistic regression showed that cangrelor use was associated with higher survival at discharge (OR 2.5; 95% CI: 1.1–6.1, p = 0.049). After multiple PS matchings, cangrelor remained associated with better survival (OR 2.07; 95% CI: 1.16–2.98). Major bleeding rates were higher in the cangrelor group, even after adjusting for baseline bleeding risk (OR: 7.0; 95% CI: 2.9–17.0; p < 0.001). Conclusions: In OHCA patients undergoing PCI, cangrelor use was linked to improved in-hospital survival but higher major bleeding, suggesting a potential net clinical benefit. Full article
(This article belongs to the Special Issue New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias)
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14 pages, 1506 KiB  
Article
Actions Taken by Bystanders During Sudden Cardiac Arrest: Analysis of Emergency Medical Service Documentation in Poland
by Rafał Milewski, Jolanta Lewko, Gabriela Milewska, Anna Baranowska, Agnieszka Lankau, Magda Orzechowska and Elżbieta Krajewska-Kułak
J. Clin. Med. 2024, 13(24), 7765; https://doi.org/10.3390/jcm13247765 - 19 Dec 2024
Viewed by 740
Abstract
Background/Objectives: Sudden cardiac arrest (SCA) is a severe medical condition involving the cessation of the heart’s mechanical activity. Following the chain of survival, which includes early recognition and calling for help, early initiation of cardiopulmonary resuscitation (CPR), early defibrillation, and post-resuscitation care, [...] Read more.
Background/Objectives: Sudden cardiac arrest (SCA) is a severe medical condition involving the cessation of the heart’s mechanical activity. Following the chain of survival, which includes early recognition and calling for help, early initiation of cardiopulmonary resuscitation (CPR), early defibrillation, and post-resuscitation care, offers the greatest chances of saving a person who has experienced SCA. The aim of this study was to analyze cases of out-of-hospital cardiac arrest (OHCA) and assess the actions taken by bystanders. Methods: The input for analysis consisted of 49,649 dispatch records from the emergency medical team (EMT) at the Voivodeship Emergency Medical Station in Bialystok in 2018–2019. Results: Among the patients where bystanders performed CPR, the return of spontaneous circulation (ROSC) occurred in 30.53% of cases, whereas in the cases where the bystander did not perform CPR, ROSC occurred in 2.35% of cases. When cardiac arrest rhythm was ventricular fibrillation (VF) or pulseless ventricular tachycardia (pVT), ROSC occurred in 58.62% of cases, while there was asystole or pulseless electrical activity (PEA) present, ROSC occurred in 26.56% of cases. In patients who experienced OHCA in a VF/pVT rhythm and who underwent intubation, ROSC occurred in 58.73% of cases, whereas in patients who underwent alternative procedures for airway management, ROSC occurred in 83.33% of cases. Conclusions: The most significant factor influencing the occurrence of ROSC in patients is CPR initiation by bystanders. The presence of a rhythm that requires defibrillation increases the likelihood of achieving ROSC in the patient. Alternative methods for airway management appear to be more beneficial in VF/pVT rhythms. Full article
(This article belongs to the Special Issue New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias)
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Review

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13 pages, 281 KiB  
Review
Tailored Basic Life Support Training for Specific Layperson Populations—A Scoping Review
by Sebastian Schnaubelt, Christoph Veigl, Erwin Snijders, Cristian Abelairas Gómez, Marco Neymayer, Natalie Anderson, Sabine Nabecker and Robert Greif
J. Clin. Med. 2024, 13(14), 4032; https://doi.org/10.3390/jcm13144032 - 10 Jul 2024
Cited by 3 | Viewed by 2530
Abstract
Background: Basic life support (BLS) is a life-saving link in the out-of-hospital cardiac arrest chain of survival. Most members of the public are capable of providing BLS but are more likely to do so confidently and effectively if they undertake BLS training. Lay [...] Read more.
Background: Basic life support (BLS) is a life-saving link in the out-of-hospital cardiac arrest chain of survival. Most members of the public are capable of providing BLS but are more likely to do so confidently and effectively if they undertake BLS training. Lay members of the public comprise diverse and specific populations and may benefit from tailored BLS training. Data on this topic are scarce, and it is completely unknown if there are any benefits arising from tailored courses or for whom course adaptations should be developed. Methods: The primary objective of this scoping review was to identify and describe differences in patient, clinical, and educational outcomes when comparing tailored versus standard BLS courses for specific layperson populations. This review was undertaken as part of the continuous evidence evaluation process of the International Liaison Committee on Resuscitation. Results: A primary search identified 1307 studies and after title, abstract, and full-text screening, we included eight publications reporting on tailored courses for specific populations. There were no studies reporting direct comparisons between tailored and standardized training. Seven (88%) studies investigated courses tailored for individuals with a disability, and only one study covered another specific population group (refugees). Overall, the quality of evidence was low as the studies did not compare tailored vs. non-tailored approaches or consisted of observational or pre–post-designed investigations. Conclusions: Tailored BLS education for specific populations is likely feasible and can include such groups into the pool of potential bystander resuscitation providers. Research into comparing tailored vs. standard courses, their cost-to-benefit ratio, how to best adapt courses, and how to involve members of the respective communities should be conducted. Additionally, tailored courses for first responders with and without a duty to respond could be explored. Full article
(This article belongs to the Special Issue New Clinical Advances in Sudden Cardiac Arrest and Ventricular Arrhythmias)
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