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Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes
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Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 771

Special Issue Editors

Prof. Dr. Thomas Mokrusch

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Guest Editor
German Brain Council, University of Erlangen-Nürnberg, Friedrichstr. 88, 10117 Berlin, Germany
Interests: neurorehabilitation; mechanical ventilation; brain
Prof. Dr. Frank Kirchhoff

E-Mail Website
Guest Editor
1. Molecular Physiology, Center for Integrative Physiology and Molecular Medicine (CIPMM), University of Saarland, 66421 Homburg, Germany
2. Center for Gender-specific Biology and Medicine (CGBM), University of Saarland, 66421 Homburg, Germany
Interests: neuroscience; synaptic transmission; astrocytes; neuroglia; molecular and cellular mechanisms of neuron-glia interaction in the central nervous system

Special Issue Information

Dear Colleagues,

"There is no health ­without brain health" is the guiding principle behind neurological rehabilitation (which, of course, includes not only diseases of the CNS but also those of the peripheral nervous system). Currently, 15 percent of people world­wide suffer from a neurological condition, and this results in enormous costs, including more than EUR 800 billion annually in Europe alone. Research in neurological rehabilitation is therefore crucial in enhancing future public health.

Neurological rehabilitation plays an important role in the overall structure of health care, as this period of treatment is usually the longest period during which patients receive and participate in restorative therapies.

This Special Issue will showcase therapeutic options currently available for neurological rehabilitation, what is known about their mechanisms of action, and what further developments can be expected in the future. This will be demonstrated using examples from vascular diseases, traumatic lesions, tumors, infectious and immunological diseases, and degenerative processes. In addition, this Special Issue will provide examples of how prevention and specific therapeutic measures can increase overall therapeutic success.

Prof. Dr. Thomas Mokrusch
Prof. Dr. Frank Kirchhoff
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurorehabilitation
  • therapeutic approaches
  • repair mechanism
  • plasticity
  • neurology

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Published Papers (1 paper)

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Research

15 pages, 414 KB  
Article
The Effect of Aerobic Exercise Training on Patients with Type III Spinal Muscular Atrophy
by Sezan Mergen Kilic, Fatma Mutluay, Arman Cakar, Murat Giris, Hacer Durmus, Ilknur Bingul, Asuman Gedikbasi, Canan Kucukgergin, Zehra Oya Uyguner and Yesim Parman
J. Clin. Med. 2025, 14(17), 6087; https://doi.org/10.3390/jcm14176087 - 28 Aug 2025
Viewed by 603
Abstract
Background: Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by variants in the SMN1 gene. This study investigates the functional and biochemical effects of moderate-intensity aerobic exercise in SMA Type III patients. Methods: Twenty-three patients aged 18–57 years were included in this [...] Read more.
Background: Spinal muscular atrophy (SMA) is a neurodegenerative disorder caused by variants in the SMN1 gene. This study investigates the functional and biochemical effects of moderate-intensity aerobic exercise in SMA Type III patients. Methods: Twenty-three patients aged 18–57 years were included in this study. The training group underwent a 12-week aerobic exercise program using a bicycle ergometer at 60–70% of their maximum heart rate three times per week for 30 min per session. The training continued for an additional four months. The primary outcome measures were the six-minute walk distance and oxygen uptake, both reflecting exercise capacity. Secondary outcome measures included muscle strength with dynamometer, functional performance, and fatigue with different scales. Furthermore, serum survival motor neuron (SMN) protein and insulin-like growth factor-1 (IGF-1) hormone levels were measured at baseline, post-training first measurement (after 12 weeks), and post-training second measurement (after 28 weeks). Results: The exercise group showed a significant increase in exercise capacity (p < 0.001) and 6MWT walking distance (p = 0.003). Furthermore, reduction in walking time in the 10-m walk test (p = 0.019) and improvements in strength of the right and left quadriceps (p = 0.004, p = 0.031) and right gastrocnemius (p = 0.034) muscles were identified. Furthermore, an improvement in the Fatigue Severity Scale (FSS) (p = 0.037) was found. SMN protein and IGF-1 levels were increased in the second measurement in the training group (p = 0.022 and p = 0.016, respectively). Conclusions: An aerobic exercise program improved physical function and muscle strength and reduced fatigue in SMA Type III patients, with sustained biochemical improvements. Aerobic exercise may serve as a beneficial adjunct therapy for this population. Full article
(This article belongs to the Special Issue Neurological Rehabilitation: Repair Mechanisms, Plasticity, and Connectomes)
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