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Pulmonary Embolism: Clinical Advances and Future Opportunities
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Pulmonary Embolism: Clinical Advances and Future Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 25 December 2025 | Viewed by 673

Special Issue Editor

Dr. James Horowitz

E-Mail Website
Guest Editor
Department of Medicine, Division of Cardiology, New York University Grossman School of Medicine, New York, NY, USA
Interests: pulmonary embolism; critical care cardiology; cardiac arrest; cardiogenic shock; mechanical circulatory support; cardiogenic shock teams

Special Issue Information

Dear Colleagues,

Pulmonary embolism(PE) is the third leading cause of cardiovascular death and a major contributor to long-term morbidity. With the evolution of catheter-based therapies, we have seen significant evolution in pulmonary embolism care over the recent years. Several recent published registries offer insight into these advances while randomized controled trials underway will inform our future practice.

In this special issue of the Journal of Clinical Medicine, “Pulmonary Embolism: Clinical Advances and Future Opportunities” we aim to highlight recent developments in the field of advanced pulmonary embolism care and future directions in the field. We hope to review developments with respect to interventional therapies, risk assessment, Pulmonary Embolism Response Teams, and pharmacologic and mechanical circulatory support for the failing right ventricle. We cordially invite cotributions from worldwide experts in the field of pulmonary embolism care exploring the aforementioned issues in this special issue.

Dr. James Horowitz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pulmonary embolism
  • risk stratification
  • pulmonary embolism response teams
  • high risk PE
  • massive PE
  • intermediate risk PE
  • sub massive PE
  • catheter directed thrombolysis
  • catheter thrombectomy
  • catheter directed embolectomy
  • extra corporeal membrane oxygenation

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Published Papers (1 paper)

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Research

14 pages, 487 KiB  
Article
Sex-Based Differences in Clinical Presentation, Management, and Outcomes in Patients Hospitalized with Pulmonary Embolism: A Retrospective Cohort Study
by Benjamin Troxler, Maria Boesing, Cedrine Kueng, Fabienne Jaun, Joerg Daniel Leuppi and Giorgia Lüthi-Corridori
J. Clin. Med. 2025, 14(15), 5287; https://doi.org/10.3390/jcm14155287 - 26 Jul 2025
Viewed by 252
Abstract
Background/Objectives: Pulmonary embolism (PE) remains a major cause of morbidity and mortality. Despite advances in care, its nonspecific symptoms pose diagnostic and therapeutic challenges. Emerging evidence suggests sex-based differences in PE presentation, management, and outcomes, yet real-world data from European settings remain [...] Read more.
Background/Objectives: Pulmonary embolism (PE) remains a major cause of morbidity and mortality. Despite advances in care, its nonspecific symptoms pose diagnostic and therapeutic challenges. Emerging evidence suggests sex-based differences in PE presentation, management, and outcomes, yet real-world data from European settings remain scarce. This study aimed to investigate sex differences in clinical presentation, diagnostic workup, therapeutic interventions, and outcomes among hospitalized PE patients. Methods: We conducted a retrospective cohort study including all adult patients (≥18 years) admitted with a main diagnosis of acute PE at the Cantonal Hospital Baselland between January 2018 and December 2020. Data were extracted from electronic medical records and included demographics, comorbidities, symptoms, diagnostics, treatments, and outcomes. Sex-based comparisons were performed using univariate analyses. Results: Among 197 patients, 54% were women. Compared to men, women were more often admitted by ambulance (42% n = 45 vs. 24% n = 22, p = 0.009), had more frequent tachycardia (38% n = 41 vs. 23% n = 21, p = 0.024), and received lysis therapy more often (10% n = 11 vs. 2% n = 2, p = 0.023). DVT was more frequently diagnosed in women when sonography was performed (82% n = 49 vs. 64% n = 34, p = 0.035). Men had higher rates of B symptoms, smoking, and family history of PE. Women had longer hospital stays and were more frequently discharged to rehabilitation facilities. No sex differences were found in in-hospital mortality, 6-month rehospitalization, or adherence to diagnostic guidelines. Conclusions: This study reveals sex-based differences in PE presentation and management, suggesting potential disparities in care pathways. Further research is needed to promote equitable, personalized treatment strategies. Full article
(This article belongs to the Special Issue Pulmonary Embolism: Clinical Advances and Future Opportunities)
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