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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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PET Imaging in Bone and Non-Bone Diseases
edited by and
submission deadline 19 May 2026 | 2 articles | Viewed by 5973
Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges submission deadline 20 May 2026 | 27 articles | Viewed by 83900 | Submission Open
Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiovascular Disease in the Elderly: Prevention and Diagnosis
edited by Ioana Dana Alexa, Gabriel Ioan Prada and
submission deadline 20 May 2026 | 10 articles | Viewed by 33265 | Submission Open
Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction
(This special issue belongs to the Section Cardiovascular Medicine)
Novel Insights into the Prevention and Treatment of Contact Dermatitis
edited by , Christoph Skudlik, Swen Malte John and
submission deadline 20 May 2026 | 5 articles | Viewed by 17216 | Submission Open
Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment
(This special issue belongs to the Section Dermatology)
Endometriosis: Clinical Challenges and Prognosis submission deadline 20 May 2026 | 5 articles | Viewed by 15289 | Submission Open
Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis
(This special issue belongs to the Section Obstetrics & Gynecology)
Ischemic Stroke: Diagnosis and Treatment submission deadline 20 May 2026 | 5 articles | Viewed by 13936 | Submission Open
Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy
(This special issue belongs to the Section Clinical Neurology)
State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy
edited by Marco Mercieri
submission deadline 20 May 2026 | 4 articles | Viewed by 13827 | Submission Open
Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets
(This special issue belongs to the Section Clinical Neurology)
Cardiac Imaging in the Diagnosis and Management of Heart Failure
edited by Mahi Lakshmi Ashwath and Allen S. Anderson
submission deadline 20 May 2026 | 2 articles | Viewed by 13379 | Submission Open
Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain
(This special issue belongs to the Section Cardiology)
Chronic Lung Conditions: Integrative Approaches to Long-Term Care submission deadline 20 May 2026 | 5 articles | Viewed by 13292 | Submission Open
Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes
(This special issue belongs to the Section Respiratory Medicine)
Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions
edited by and Pablo Codner
submission deadline 20 May 2026 | 9 articles | Viewed by 11779 | Submission Open
Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies
edited by
submission deadline 20 May 2026 | 9 articles | Viewed by 10925 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
Updates on Cardiac Pacing and Electrophysiology
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 8930 | Submission Open
Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation
(This special issue belongs to the Section Cardiology)
Neural Application of Artificial Intelligence in Clinical Neuroscience
edited by Saurabh J. Singhal
submission deadline 20 May 2026 | 4 articles | Viewed by 8454 | Submission Open
Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction
(This special issue belongs to the Section Clinical Neurology)
New Advances in Myasthenia Gravis
edited by Shingo Konno
submission deadline 20 May 2026 | 3 articles | Viewed by 8366 | Submission Open
Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis
(This special issue belongs to the Section Clinical Neurology)
Clinical Application of Knee Arthroscopy
edited by and Alessandro Carrozzo
submission deadline 20 May 2026 | 6 articles | Viewed by 7331 | Submission Open
Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation
(This special issue belongs to the Section Orthopedics)
Cirrhosis and Its Complications: Prognosis and Clinical Management
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 7220 | Submission Open
Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 May 2026 | 4 articles | Viewed by 7205 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition submission deadline 20 May 2026 | 4 articles | Viewed by 6635 | Submission Open
Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses
(This special issue belongs to the Section Orthopedics)
Prostate Cancer: Diagnosis, Clinical Management and Prognosis
edited by Giovanni Muto
submission deadline 20 May 2026 | 6 articles | Viewed by 6600 | Submission Open
Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments
(This special issue belongs to the Section Nephrology & Urology)
New Advances in Uterus and Ovarian Transplantation: 2nd Edition submission deadline 20 May 2026 | 3 articles | Viewed by 5991 | Submission Open
Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Challenges in Reproductive Health
edited by and Guido Ambrosini
submission deadline 20 May 2026 | 2 articles | Viewed by 5931 | Submission Open
Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 5636 | Submission Open
Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke
(This special issue belongs to the Section Clinical Neurology)
Clinical Update in Pulmonary Rehabilitation
edited by Akira Tamaki
submission deadline 20 May 2026 | 3 articles | Viewed by 4691 | Submission Open
Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention
(This special issue belongs to the Section Respiratory Medicine)
Research Progress in Pediatric Endocrinology
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 4686 | Submission Open
Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening
(This special issue belongs to the Section Clinical Pediatrics)
Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 3451 | Submission Open
Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants
(This special issue belongs to the Section Clinical Neurology)
Surgical Management of Complex Spinal Pathologies: Challenges and Innovations
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 3429 | Submission Open
Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Diagnosis and Treatment of Ocular Surface Diseases submission deadline 20 May 2026 | 3 articles | Viewed by 3251 | Submission Open
Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care
(This special issue belongs to the Section Ophthalmology)
Physiotherapy in Clinical Practice: From Assessment to Rehabilitation submission deadline 20 May 2026 | 4 articles | Viewed by 3231 | Submission Open
Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 3113 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Advances in Fertility Preservation
edited by Dunja Maria Baston-Büst
submission deadline 20 May 2026 | 3 articles | Viewed by 3095 | Submission Open
Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex
(This special issue belongs to the Section Obstetrics & Gynecology)
New Updates in Pediatric Gastroenterology
edited by , Alina Stanescu-Popp and Oana Belei
submission deadline 20 May 2026 | 2 articles | Viewed by 2958 | Submission Open
Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2345 | Submission Open
Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies
(This special issue belongs to the Section Cardiovascular Medicine)
New Therapies for Diabetic Foot Ulcer Management submission deadline 20 May 2026 | 1 articles | Viewed by 2345 | Submission Open
Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments
(This special issue belongs to the Section Endocrinology & Metabolism)
Total Joint Arthroplasty: Innovations, Outcomes, and Challenges—Second Edition
edited by Hendrik Kohlhof
submission deadline 20 May 2026 | 2 articles | Viewed by 2153 | Submission Open
Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management
(This special issue belongs to the Section Orthopedics)
Current Challenges in Oral and Maxillofacial Surgery
edited by and Lucia Memé
submission deadline 20 May 2026 | 2 articles | Viewed by 2047 | Submission Open
Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Percutaneous Coronary Intervention: Latest Advances and Future Prospects submission deadline 20 May 2026 | 1 articles | Viewed by 1996 | Submission Open
Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease
(This special issue belongs to the Section Cardiology)
Recent Advances in Adverse Pregnancy and Neonatal Outcomes
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 1994 | Submission Open
Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section
(This special issue belongs to the Section Obstetrics & Gynecology)
Neurovascular Interventions: Evolving Techniques and Insights
edited by Delia Cannizzaro
submission deadline 20 May 2026 | 2 articles | Viewed by 1798 | Submission Open
Keywords: endovascular treatment; intracranial aneurysms; AI in neurointerventional surgery; intracranial vascular malformation; new endovascular device
(This special issue belongs to the Section Clinical Neurology)
Cardiac Imaging in Cardiovascular Disorders
edited by Leif-Christopher Engel
submission deadline 20 May 2026 | 1 articles | Viewed by 1575 | Submission Open
Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging
(This special issue belongs to the Section Cardiology)
Presbyopia, Laser, Cataract and Refractive Surgery: State-of-the-Art Research: Second Edition
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1482 | Submission Open
Keywords: presbyopia; cataract surgery; refractive surgery; femtosecond laser; intraocular lenses; corneal refractive procedures; phakic intraocular lenses; visual outcomes; patient-reported outcomes; surgical innovations
(This special issue belongs to the Section Ophthalmology)
Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1256 | Submission Open
Keywords: quality of life (QOL); cognition; behavior; stigma; seizure severity; interictal epileptiform discharge (IED); social
(This special issue belongs to the Section Clinical Neurology)
New Horizons in Aortic Valve Replacement
edited by Abdellaziz Dahou
submission deadline 20 May 2026 | 1 articles | Viewed by 1150 | Submission Open
Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement
(This special issue belongs to the Section Cardiology)
Clinical Progress in Oral and Maxillofacial Surgery
edited by Luis M. Junquera and Giuseppe Consorti
submission deadline 20 May 2026 | 1 articles | Viewed by 978 | Submission Open
Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Updates in Transfusion Medicine and Patient Blood Management submission deadline 20 May 2026 | 1 articles | Viewed by 959 | Submission Open
Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine
(This special issue belongs to the Section Hematology)
Spine Surgery and Rehabilitation: Technical Nuances and Outcomes
edited by Sehan Park and Dong-Ho Lee
submission deadline 20 May 2026 | 1 articles | Viewed by 831 | Submission Open
Keywords: spine surgery; rehabilitation; postoperative outcomes; surgical techniques; patient centered perspective
(This special issue belongs to the Section Orthopedics)
Clinical Trends and Prospects in Urology Surgery: 2nd Edition
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 746 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Advances in Demyelinating and Neuroinflammatory Disorders submission deadline 20 May 2026 | 1 articles | Viewed by 678 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica spectrum disorder; MOG antibody– associated disease; neuroinflammation; biomarkers; advanced imaging; disease-modifying therapies; clinical outcomes
(This special issue belongs to the Section Clinical Neurology)
Anesthesia in Head and Neck Surgery
edited by Antonino Maniaci
submission deadline 20 May 2026 | 1 articles | Viewed by 656 | Submission Open
Keywords: airway management; hemodynamic stability; perioperative monitoring; head and neck surgery; anesthesia
(This special issue belongs to the Section Anesthesiology)
Interventional Cardiology: Clinical Advances and Future Perspectives
edited by Antonio Landi and
submission deadline 20 May 2026 | 1 articles | Viewed by 655 | Submission Open
Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome
(This special issue belongs to the Section Cardiology)
Audiology and Phoniatrics in Head and Neck Surgery: Functional Assessment, Rehabilitation Strategies, and Quality of Life Outcomes
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 646 | Submission Open
Keywords: audiology; phoniatrics; voice disorders; hearing preservation; speech rehabilitation; head and neck surgery; functional outcomes; quality of life; voice analysis; audiometry; cochlear implants; dysphagia; laryngeal surgery
(This special issue belongs to the Section Otolaryngology)
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