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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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PET Imaging in Bone and Non-Bone Diseases

edited by

Tanuj Puri

and

Glen Blake

submission deadline 19 May 2026 | 2 articles | Viewed by 5964 | Submission Open

Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 20 May 2026 | 27 articles | Viewed by 83768 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiovascular Disease in the Elderly: Prevention and Diagnosis

edited by Ioana Dana Alexa, Gabriel Ioan Prada and

Ciprian Rezus

submission deadline 20 May 2026 | 10 articles | Viewed by 33206 | Submission Open

Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction

(This special issue belongs to the Section Cardiovascular Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 20 May 2026 | 7 articles | Viewed by 22436 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Novel Insights into the Prevention and Treatment of Contact Dermatitis

edited by

Cara Bieck

, Christoph Skudlik, Swen Malte John and

Albert Nienhaus

submission deadline 20 May 2026 | 5 articles | Viewed by 17193 | Submission Open

Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment

(This special issue belongs to the Section Dermatology)

Endometriosis: Clinical Challenges and Prognosis

edited by

Francisco Artacho-Cordon

submission deadline 20 May 2026 | 5 articles | Viewed by 15247 | Submission Open

Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 20 May 2026 | 5 articles | Viewed by 13912 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

edited by Marco Mercieri

submission deadline 20 May 2026 | 4 articles | Viewed by 13793 | Submission Open

Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets

(This special issue belongs to the Section Clinical Neurology)

Cardiac Imaging in the Diagnosis and Management of Heart Failure

edited by Mahi Lakshmi Ashwath and Allen S. Anderson

submission deadline 20 May 2026 | 2 articles | Viewed by 13362 | Submission Open

Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain

(This special issue belongs to the Section Cardiology)

Chronic Lung Conditions: Integrative Approaches to Long-Term Care

edited by

Antigona Carmen Trofor

submission deadline 20 May 2026 | 5 articles | Viewed by 13268 | Submission Open

Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes

(This special issue belongs to the Section Respiratory Medicine)

Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions

edited by

Alon Shechter

and Pablo Codner

submission deadline 20 May 2026 | 9 articles | Viewed by 11755 | Submission Open

Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies

edited by

Minzhong Yu

submission deadline 20 May 2026 | 9 articles | Viewed by 10874 | Submission Open

Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment

(This special issue belongs to the Section Ophthalmology)

Updates on Cardiac Pacing and Electrophysiology

edited by

Axel Brandes

submission deadline 20 May 2026 | 6 articles | Viewed by 8911 | Submission Open

Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation

(This special issue belongs to the Section Cardiology)

Neural Application of Artificial Intelligence in Clinical Neuroscience

edited by Saurabh J. Singhal

submission deadline 20 May 2026 | 4 articles | Viewed by 8434 | Submission Open

Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction

(This special issue belongs to the Section Clinical Neurology)

New Advances in Myasthenia Gravis

edited by Shingo Konno

submission deadline 20 May 2026 | 3 articles | Viewed by 8354 | Submission Open

Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 20 May 2026 | 5 articles | Viewed by 7315 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 20 May 2026 | 6 articles | Viewed by 7178 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome

edited by

Graziano Montaruli

Domenico Ciavarella

and

Michele Tepedino

submission deadline 20 May 2026 | 4 articles | Viewed by 7173 | Submission Open

Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 May 2026 | 4 articles | Viewed by 6626 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 May 2026 | 6 articles | Viewed by 6583 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

New Advances in Uterus and Ovarian Transplantation: 2nd Edition

edited by

Elliott G. Richards

submission deadline 20 May 2026 | 3 articles | Viewed by 5979 | Submission Open

Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenges in Reproductive Health

edited by

Loris Marin

and Guido Ambrosini

submission deadline 20 May 2026 | 2 articles | Viewed by 5926 | Submission Open

Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke

edited by

Fusao Ikawa

submission deadline 20 May 2026 | 3 articles | Viewed by 5628 | Submission Open

Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke

(This special issue belongs to the Section Clinical Neurology)

Clinical Update in Pulmonary Rehabilitation

edited by Akira Tamaki

submission deadline 20 May 2026 | 3 articles | Viewed by 4683 | Submission Open

Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention

(This special issue belongs to the Section Respiratory Medicine)

Research Progress in Pediatric Endocrinology

edited by

Federico Baronio

submission deadline 20 May 2026 | 2 articles | Viewed by 4674 | Submission Open

Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening

(This special issue belongs to the Section Clinical Pediatrics)

Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition

edited by

Lucio D'Anna

submission deadline 20 May 2026 | 3 articles | Viewed by 3438 | Submission Open

Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants

(This special issue belongs to the Section Clinical Neurology)

Surgical Management of Complex Spinal Pathologies: Challenges and Innovations

edited by

Spyridon Komaitis

submission deadline 20 May 2026 | 4 articles | Viewed by 3414 | Submission Open

Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes

(This special issue belongs to the Section Orthopedics)

Diagnosis and Treatment of Ocular Surface Diseases

edited by

Stuti Misra

and

Sònia Travé-Huarte

submission deadline 20 May 2026 | 3 articles | Viewed by 3247 | Submission Open

Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care

(This special issue belongs to the Section Ophthalmology)

Physiotherapy in Clinical Practice: From Assessment to Rehabilitation

edited by

Inés Llamas Ramos

and

Rocío Llamas-Ramos

submission deadline 20 May 2026 | 4 articles | Viewed by 3219 | Submission Open

Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Clinical Rheumatology—2nd Edition

edited by

Jacopo Ciaffi

submission deadline 20 May 2026 | 3 articles | Viewed by 3101 | Submission Open

Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome

(This special issue belongs to the Section Immunology & Rheumatology)

Advances in Fertility Preservation

edited by Dunja Maria Baston-Büst

submission deadline 20 May 2026 | 3 articles | Viewed by 3086 | Submission Open

Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex

(This special issue belongs to the Section Obstetrics & Gynecology)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 20 May 2026 | 2 articles | Viewed by 2947 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Therapies for Diabetic Foot Ulcer Management

edited by

Irene Sanz-Corbalan

and

Raúl J. Molines Barroso

submission deadline 20 May 2026 | 1 articles | Viewed by 2340 | Submission Open

Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest

edited by

Erik Roman-Pognuz

submission deadline 20 May 2026 | 2 articles | Viewed by 2263 | Submission Open

Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Total Joint Arthroplasty: Innovations, Outcomes, and Challenges—Second Edition

edited by Hendrik Kohlhof

submission deadline 20 May 2026 | 2 articles | Viewed by 2142 | Submission Open

Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management

(This special issue belongs to the Section Orthopedics)

Current Challenges in Oral and Maxillofacial Surgery

edited by

Federica Canfora

and Lucia Memé

submission deadline 20 May 2026 | 2 articles | Viewed by 2035 | Submission Open

Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Percutaneous Coronary Intervention: Latest Advances and Future Prospects

edited by

Alessandro Mandurino-Mirizzi

submission deadline 20 May 2026 | 1 articles | Viewed by 1994 | Submission Open

Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease

(This special issue belongs to the Section Cardiology)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 20 May 2026 | 2 articles | Viewed by 1984 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Aspects of Return to Sport After Injuries: 2nd Edition

edited by

Anna Mika

and

Łukasz Oleksy

submission deadline 20 May 2026 | 2 articles | Viewed by 1865 | Submission Open

Keywords: musculoskeletal system; tissue overload; diagnostic methods; rehabilitation; treatment; injury prevention; return to sport; rehabilitation medicine; sports medicine

(This special issue belongs to the Section Sports Medicine)

Diagnosis and Treatment of Connective Tissue Diseases: A Clinician's Perspective: 2nd Edition

edited by

Agnieszka Żebrowska

Adam Reich

and Aleksandra Dańczak-Pazdrowska

submission deadline 20 May 2026 | 2 articles | Viewed by 1807 | Submission Open

Keywords: connective tissue diseases; lupus erythematosus; scleroderma; dermatomyositis; MCTD; clinical picture; spectrum of clinical symptoms; treatment; complications; clinical follow-up

(This special issue belongs to the Section Immunology & Rheumatology)

Neurovascular Interventions: Evolving Techniques and Insights

edited by Delia Cannizzaro

submission deadline 20 May 2026 | 2 articles | Viewed by 1789 | Submission Open

Keywords: endovascular treatment; intracranial aneurysms; AI in neurointerventional surgery; intracranial vascular malformation; new endovascular device

(This special issue belongs to the Section Clinical Neurology)

Cardiac Imaging in Cardiovascular Disorders

edited by Leif-Christopher Engel

submission deadline 20 May 2026 | 1 articles | Viewed by 1571 | Submission Open

Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging

(This special issue belongs to the Section Cardiology)

Foot and Ankle Surgery: Clinical Challenges and New Insights: 2nd Edition

edited by

Byung-Ki Cho

submission deadline 20 May 2026 | 3 articles | Viewed by 1496 | Submission Open

Keywords: hallux valgus; minimal invasive correction; chronic ankle instability; arthroscopic Brostrom procedure; suture-tape augmentation; ankle arthritis; total ankle arthroplasty; ankle arthrodesis

(This special issue belongs to the Section Orthopedics)

Presbyopia, Laser, Cataract and Refractive Surgery: State-of-the-Art Research: Second Edition

edited by

Ivo Guber

submission deadline 20 May 2026 | 1 articles | Viewed by 1478 | Submission Open

Keywords: presbyopia; cataract surgery; refractive surgery; femtosecond laser; intraocular lenses; corneal refractive procedures; phakic intraocular lenses; visual outcomes; patient-reported outcomes; surgical innovations

(This special issue belongs to the Section Ophthalmology)

Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects

edited by

Hideaki Kanemura

submission deadline 20 May 2026 | 1 articles | Viewed by 1249 | Submission Open

Keywords: quality of life (QOL); cognition; behavior; stigma; seizure severity; interictal epileptiform discharge (IED); social

(This special issue belongs to the Section Clinical Neurology)

New Horizons in Aortic Valve Replacement

edited by Abdellaziz Dahou

submission deadline 20 May 2026 | 1 articles | Viewed by 1144 | Submission Open

Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement

(This special issue belongs to the Section Cardiology)

Clinical Progress in Oral and Maxillofacial Surgery

edited by Luis M. Junquera and Giuseppe Consorti

submission deadline 20 May 2026 | 1 articles | Viewed by 972 | Submission Open

Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Updates in Transfusion Medicine and Patient Blood Management

edited by

Carlos Jerico

and

José Antonio García-Erce

submission deadline 20 May 2026 | 1 articles | Viewed by 935 | Submission Open

Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine

(This special issue belongs to the Section Hematology)

Clinical Updates on Perioperative Pain Management: 3rd Edition

edited by

Felice Eugenio Agro

Giuseppe Pascarella

and

Fabio Costa

submission deadline 20 May 2026 | 2 articles | Viewed by 900 | Submission Open

Keywords: anesthesia and intensive care; pain management; spinal anesthesia; postoperative pain; breast surgery; fascial plane blocks; abdominal surgery; cardiac surgery; thoracotomy; knee surgery; orthopedic surgery; hip surgery; ultrasound

(This special issue belongs to the Section Anesthesiology)

Spine Surgery and Rehabilitation: Technical Nuances and Outcomes

edited by Sehan Park and Dong-Ho Lee

submission deadline 20 May 2026 | 1 articles | Viewed by 829 | Submission Open

Keywords: spine surgery; rehabilitation; postoperative outcomes; surgical techniques; patient centered perspective

(This special issue belongs to the Section Orthopedics)

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