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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Acute Myeloid Leukemia: From Molecular Complexity to Precision Medicine

edited by Matteo Molica

submission deadline 20 Jan 2027 | 1 articles | Viewed by 868 | Submission Open

Keywords: acute myeloid leukemia; molecular diagnostics; targeted therapy; measurable residual disease; risk stratification

(This special issue belongs to the Section Hematology)

Neuroinflammation and Neuroimmunology in Neurological Disorders

edited by Łukasz A. Poniatowski

submission deadline 20 Jan 2027 | 1 articles | Viewed by 841 | Submission Open

Keywords: neuroinflammation; neuroimmunology; neurodegenerative diseases; Parkinson’s disease; multiple sclerosis; stroke; traumatic brain injury; hydrocephalus; neurosurgical disorders; neurological disorders; biomarkers; clinical diagnosis; management strategies

(This special issue belongs to the Section Clinical Neurology)

Symptoms, Diagnosis and Treatments of Tricuspid Regurgitation

edited by

Diana Ruxandra Hădăreanu

and Cristina Florescu

submission deadline 20 Jan 2027 | 1 articles | Viewed by 789 | Submission Open

Keywords: tricuspid regurgitation; right heart failure; echocardiography; multimodality cardiac imaging; valvular heart disease; tricuspid valve surgery; transcatheter edge-to-edge repair

(This special issue belongs to the Section Cardiology)

Contemporary Management of Acute and Chronic Liver Disease: Advances in Diagnosis and Therapy

edited by Manisha Verma

submission deadline 20 Jan 2027 | 2 articles | Viewed by 758 | Submission Open

Keywords: acute and chronic liver disease; cirrhosis; risk stratification; emerging therapies; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Oral Autoimmune Diseases: Diagnosis and Clinical Management

edited by Zuzanna Ślebioda

submission deadline 20 Jan 2027 | 1 articles | Viewed by 688 | Submission Open

Keywords: Sjögren syndrome; lupus erythematous; lichen planus; Behçet’s disease; recurrent aphthous stomatitis; pemphigus vulgaris; mucous membrane pemphigoid; autoimmune disease; oral mucosa

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Hysterectomy Surgery—Recent Developments and Emerging Trends

edited by

Anastasia Prodromidou

Themos Grigoriadis

and Dimitrios Zacharakis

submission deadline 20 Jan 2027 | Viewed by 641 | Submission Open

Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care

(This special issue belongs to the Section Obstetrics & Gynecology)

Foot and Ankle Fracture Management and Complication Insights

edited by Jaeho Cho

submission deadline 20 Jan 2027 | 1 articles | Viewed by 595 | Submission Open

Keywords: foot and ankle fractures; clinical anatomy; trauma management; post-traumatic arthritis; surgical techniques

(This special issue belongs to the Section Orthopedics)

Clinical Research Progress in Atrial Fibrillation

edited by

Roddy Hiram

submission deadline 20 Jan 2027 | Viewed by 529 | Submission Open

Keywords: atrial fibrillation; atrial arrhythmias; cardiac fibrosis; inflammation; electrical remodeling

(This special issue belongs to the Section Cardiology)

Innovations, Biomarkers, and Challenges in Cancer Immunotherapy

edited by

Mohammad Mousaei Ghasroldasht

and Mahzad Akbarpour

submission deadline 20 Jan 2027 | Viewed by 491 | Submission Open

Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms

(This special issue belongs to the Section Oncology)

Prevention, Treatment, and Prognosis of Cerebral Aneurysms

edited by

Murai Yasuo

submission deadline 20 Jan 2027 | Viewed by 412 | Submission Open

Keywords: cerebral aneurysm; subarachnoid hemorrhage; clipping; interventional surgery; mortarity; long-term; surgical complication; bypass

(This special issue belongs to the Section Clinical Neurology)

Current Perspectives and Emerging Trends in Cardiothoracic Surgery

edited by Zsolt Szabo and

Zsolt Molnar

submission deadline 20 Jan 2027 | Viewed by 392 | Submission Open

Keywords: minimally invasive cardiac surgery; minimally invasive thoracic surgery; minimally invasive valve surgery; non-intubated and spontaneous ventilation techniques; thymus surgery; prehabilitation; chronic comorbidities (DM, COPD); cardiopulmonary bypass outcomes; extracorporeal life support (ECLS); emerging trends in cardiothoracic surgery

(This special issue belongs to the Section General Surgery)

Clinical Advances in Hemodialysis: 2nd Edition

edited by Maurizio Bossola

submission deadline 20 Jan 2027 | Viewed by 364 | Submission Open

Keywords: hemodialysis; interdialytic weight gain; symptom burden and quality of life; impaired cognitive function; fatigue; dietary restrictions; depression; anxiety; frailty; polypharmacy

(This special issue belongs to the Section Nephrology & Urology)

Myocardial Infarction: Current Status and Future Challenges—2nd Edition

edited by Isaac Pascual and

Rebeca Lorca

submission deadline 20 Jan 2027 | Viewed by 358 | Submission Open

Keywords: myocardial infarction; acute coronary syndrome (ACS); ischemic heart disease; coronary artery disease (CAD); percutaneous coronary intervention; pharmacological therapy; cardiovascular risk factors

(This special issue belongs to the Section Cardiology)

Human Immunodeficiency Virus: From Clinical Studies to Patient Outcomes

edited by Vítor Duque

submission deadline 20 Jan 2027 | Viewed by 329 | Submission Open

Keywords: HIV/AIDS; clinical trials; patient outcomes; clinical translational research

(This special issue belongs to the Section Infectious Diseases)

Current Advances and Unmet Needs in Autoimmune Inflammatory Rheumatic Diseases

edited by

Shunsuke Mori

submission deadline 20 Jan 2027 | Viewed by 253 | Submission Open

Keywords: autoimmune inflammatory rheumatic diseases; rheumatoid arthritis; connective tissue disorders; comorbidities; unmet medical needs; immune-targeted therapies

(This special issue belongs to the Section Immunology & Rheumatology)

Recent Advances in the Treatment of Chronic Kidney Disease (CKD)

edited by

Giacomo Garibotto

and

Elisa Russo

submission deadline 20 Jan 2027 | Viewed by 209 | Submission Open

Keywords: chronic kidney disease; therapy; diabetic nephropathy; obesity; hypertension; MRA; incretins; SGLT2i; kidney fibrosis; hyperkalemia; cardiovascular

(This special issue belongs to the Section Nephrology & Urology)

Anterior Cruciate Ligament Injury Reconstruction and Rehabilitation

edited by Andrea Volpin and Nicholas Colyvas

submission deadline 20 Jan 2027 | Viewed by 192 | Submission Open

Keywords: anterior cruciate ligament; ACL reconstruction; ACL rehabilitation; sports knee injuries; graft selection; return to sport; revision ACL reconstruction; knee biomechanics; meniscal injury; injury prevention

(This special issue belongs to the Section Orthopedics)

Towards Precision Oncology in Bone Sarcomas: New Insights into Osteosarcoma and Chondrosarcoma

edited by Andrea Sambri and Alessandro Bruschi

submission deadline 20 Jan 2027 | Viewed by 187 | Submission Open

Keywords: osteosarcoma; chondrosarcoma; bone sarcoma; molecular diagnostics; tumor microenvironment; precision oncology; surgical oncology; limb-salvage surgery; targeted therapy; prognostic biomarkers

(This special issue belongs to the Section Oncology)

Cardiac Rehabilitation: Current Strategies and Future Directions

edited by Andrzej Kleinrok and

Marlena Krawczyk-Suszek

submission deadline 20 Jan 2027 | Viewed by 183 | Submission Open

Keywords: cardiac rehabilitation; secondary prevention; cardiovascular disease; cardiovascular risk; exercise training; telerehabilitation; digital health; patient adherence; personalised medicine; wearable technologies; artificial intelligence; quality of life; multidisciplinary care; mental support

(This special issue belongs to the Section Cardiology)

Takotsubo Syndrome: From Diagnosis to Treatment

edited by Gregor Poglajen and Christian Templin

submission deadline 20 Jan 2027 | Viewed by 149 | Submission Open

Keywords: Takotsubo syndrome; stress cardiomyopathy; acute heart failure; catecholamines; myocardial stunning; microvascular dysfunction; cardiac imaging; cardiogenic shock; biomarkers; personalized therapy

(This special issue belongs to the Section Cardiology)

Pancreatic Diseases Through the Lens of EUS and ERCP: From Risk Stratification to Intervention

edited by

Maria Cristina Conti-Bellocchi

submission deadline 20 Jan 2027 | Viewed by 131 | Submission Open

Keywords: endosonography; endoscopic retrograde cholangiopancreatography; pancreatic diseases; risk assessment; fine‑needle biopsy; stents; minimally invasive procedures; advanced imaging; artificial intelligence in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Ablation, Embolization, and Stenting: Current Trends in Interventional Radiology

edited by Praveen Peddu

submission deadline 22 Jan 2027 | 4 articles | Viewed by 5135 | Submission Open

Keywords: interventional radiology; ablation; embolization; stenting; minimally invasive therapy

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome

edited by

Maria Amicone

and

Antonio Pisani

submission deadline 22 Jan 2027 | 1 articles | Viewed by 1586 | Submission Open

Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet

(This special issue belongs to the Section Nephrology & Urology)

Spine Surgery Innovations: Treatments and Technologies

edited by

Marco D. Burkhard

and

Tomoyuki Asada

submission deadline 22 Jan 2027 | 2 articles | Viewed by 1580 | Submission Open

Keywords: AI; robotics; navigation; muscle preservation; minimally invasive surgery; motion preservation; alignment targets; implant materials; bone growth factors; custom-made implants

(This special issue belongs to the Section Orthopedics)

Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition

edited by

Paul Immanuel Heidekrueger

, Peter Niclas Broer and Denis C. Ehrl

submission deadline 24 Jan 2027 | 5 articles | Viewed by 5165 | Submission Open

Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Updates in the Diagnosis, Imaging, and Treatment of Retinal and Macular Diseases

edited by

Makoto Inoue

submission deadline 24 Jan 2027 | 4 articles | Viewed by 4475 | Submission Open

Keywords: retinal diseases; macular degeneration; diagnostic imaging; OCT/OCTA; artificial intelligence; deep learning; clinical ophthalmology; gene therapy; treatment innovations

(This special issue belongs to the Section Ophthalmology)

Current Insights into Atopic Dermatitis

edited by Francisco José Navarro-Trivino

submission deadline 24 Jan 2027 | Viewed by 160 | Submission Open

Keywords: atopic dermatitis; type 2 inflammation; skin barrier; biologics; JAK inhibitors; precision medicine; chronic pruritus

(This special issue belongs to the Section Dermatology)

Artificial Intelligence (AI) and Deep Learning (DL) in Medical Imaging

edited by

Francesco Pucciarelli

submission deadline 25 Jan 2027 | 6 articles | Viewed by 16186 | Submission Open

Keywords: artificial intelligence; deep learning; imaging; diagnosis; precision medicine; oncologic

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition

edited by

Francesca Lodato

submission deadline 25 Jan 2027 | 11 articles | Viewed by 13651 | Submission Open

Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Cardiogenic Shock and Cardiac Arrest: Updates, Challenges and Opportunities

edited by

Torben K. Becker

submission deadline 25 Jan 2027 | 5 articles | Viewed by 9447 | Submission Open

Keywords: cardiac arrest; extracorporeal membrane oxygenation; extracorporeal CPR; cardiopulmonary resuscitation; cardiogenic shock; resuscitation; prognostication

(This special issue belongs to the Section Cardiology)

Non-Small Cell Lung Cancer (NSCLC): Recent Advances in Clinical Diagnosis and Treatment

edited by

Cesare Guida

submission deadline 25 Jan 2027 | 12 articles | Viewed by 9074 | Submission Open

Keywords: novel screening tool; cancer biomarkers; predictive marker of immunotherapy; targeted therapy; radiotherapy; non-small cell lung cancer

(This special issue belongs to the Section Oncology)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 25 Jan 2027 | 6 articles | Viewed by 8713 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut–brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Spinal Neurosurgery

edited by Jang-Won Yoon

submission deadline 25 Jan 2027 | 7 articles | Viewed by 7996 | Submission Open

Keywords: minimally invasive spine surgery; lateral lumbar interbody fusion; endoscopic spine surgery; patient-reported out-comes; functional assessment; perioperative care; surgical decision-making

(This special issue belongs to the Section Clinical Neurology)

Autoimmune-Induced Alopecia and Emerging Therapies in Hair Loss—2nd Edition

edited by David Saceda-Corralo

submission deadline 25 Jan 2027 | 2 articles | Viewed by 7687 | Submission Open

Keywords: autoimmune-induced alopecia; alopecia areata; cicatricial alopecia; occurs; hair loss; frontal fibrosing alopecia

(This special issue belongs to the Section Dermatology)

Current Advances in General and Regional Anesthesia

edited by Eleni Laou, Eleana Garini and

Giolanda Varvarousi

submission deadline 25 Jan 2027 | 3 articles | Viewed by 6773 | Submission Open

Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety

(This special issue belongs to the Section Anesthesiology)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 25 Jan 2027 | 4 articles | Viewed by 5596 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment

edited by

Camilla Gesi

submission deadline 25 Jan 2027 | 1 articles | Viewed by 5133 | Submission Open

Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted

(This special issue belongs to the Section Mental Health)

Surgical Oncology: Clinical Application of Translational Medicine

edited by Domenico Parmeggiani

submission deadline 25 Jan 2027 | 4 articles | Viewed by 4964 | Submission Open

Keywords: surgical oncology; drug safety; adverse events; nanovesicles; targeted drug delivery; cancer biomarkers; precision oncology; tumor microenvironment; nanomedicine; personalized medicine; diagnostics; prognosis; innovative therapies; translational research

(This special issue belongs to the Section Oncology)

Current Perspectives on the Clinical Management of Respiratory Diseases

edited by

Pradeesh Sivapalan

and

Alexandr Ceasovschih

submission deadline 25 Jan 2027 | 3 articles | Viewed by 4552 | Submission Open

Keywords: COPD; acute exacerbations; biomarkers; clinical trials; bronchiectasis; respiratory infections

(This special issue belongs to the Section Respiratory Medicine)

Clinical Updates in Reproductive Endocrinology: 2nd Edition

edited by Iwona Bojar and

Dorota Raczkiewicz

submission deadline 25 Jan 2027 | 3 articles | Viewed by 4323 | Submission Open

Keywords: reproductive endocrinology; endocrine diseases in pregnancy; infertility; endocrine diagnostics in infertility; long-term consequences of endocrine disorders; therapy for endocrine disorders

(This special issue belongs to the Section Obstetrics & Gynecology)

Multiple Sclerosis and Demyelinating Disease: Clinical Treatment and Management

edited by Sotirios Giannopoulos

submission deadline 25 Jan 2027 | 3 articles | Viewed by 4307 | Submission Open

Keywords: multiple sclerosis; demyelinating disease; comorbidities; disease modifying treatments; neuromuscular disorder; myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 25 Jan 2027 | 4 articles | Viewed by 3927 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Advances in Clinical Management of Temporomandibular Joint Diseases

edited by

João Luiz Monteiro

submission deadline 25 Jan 2027 | 3 articles | Viewed by 3600 | Submission Open

Keywords: minimally invasive surgical procedure; artificial intelligence; temporomandibular joint disorders; temporomandibular disorders; temporomandibular joint

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Clinical Advances in Reconstructive Urology and Prosthetic Surgery

edited by Elisa Berdondini and

Esaú Fenández-Pascual

submission deadline 25 Jan 2027 | 1 articles | Viewed by 3076 | Submission Open

Keywords: reconstructive urology; penile prosthesis; artificial urinary sphincter; urethral stricture; reconstructive surgery; minimally invasive procedures

(This special issue belongs to the Section Nephrology & Urology)

High-Risk Pregnancy Management: From Prenatal Care to Postpartum Outcomes

edited by

Angela Vinturache

submission deadline 25 Jan 2027 | 2 articles | Viewed by 2543 | Submission Open

Keywords: high-risk pregnancy; prenatal care; postpartum outcomes; postpartum mental health; birth trauma; AI in obstetrics; medico-legal liability; equity & culturally safe care; indigenous and rural/remote care; EMR-enabled decision support; quality trend monitoring; maternal morbidity and mortality; perinatal morbidity; standardized care bundles & pathways

(This special issue belongs to the Section Obstetrics & Gynecology)

Advancing Trends and Strategies in Vascular and Endovascular Surgery

edited by Karin Pfister and Fiona Rohlffs

submission deadline 25 Jan 2027 | 2 articles | Viewed by 1394 | Submission Open

Keywords: vascular surgery; endovascular surgery; carotid endarterectomy; peripheral vascular diseases; vascular imaging; aortic diseases; aortic aneurysm; arteriovenous malformation; pelvic venous disorder; endovenous procedures; pal-liative therapy concept

(This special issue belongs to the Section Vascular Medicine)

Interaction Between Systemic Diseases and Oral Diseases: 2nd Edition

edited by

Henk S. Brand

submission deadline 25 Jan 2027 | 2 articles | Viewed by 1301 | Submission Open

Keywords: medical dental interaction; saliva; xerostomia; diagnostics; inflammatory bowel disease; cancer survivors; dental erosion; Sjögren’s disease; liver transplantation

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management and Update of Aortic Dissection and Aortic Aneurysm Diseases

edited by

Makoto Hibino

submission deadline 25 Jan 2027 | 1 articles | Viewed by 1175 | Submission Open

Keywords: aortic aneurysm; aortic dissection; aortic surgery; endovascular procedures

(This special issue belongs to the Section Cardiovascular Medicine)

Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders: 2nd Edition

edited by

Paweł T. Matusik

submission deadline 25 Jan 2027 | 1 articles | Viewed by 1146 | Submission Open

Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Musculoskeletal Imaging and Intervention: 2nd Edition

edited by

Miguel Malo-Urriés

and

Jacobo Rodríguez-Sanz

submission deadline 25 Jan 2027 | 2 articles | Viewed by 1076 | Submission Open

Keywords: ultrasound; invasive physiotherapy; minimally invasive surgical procedures; magnetic resonance; image analysis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Displaying special issue 851-900 on page 18 of 30.

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