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Clinical Updates in Reproductive Endocrinology: 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 25 November 2025 | Viewed by 627

Special Issue Editors


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Guest Editor
Department of Women’s Health, Institute of Rural Health in Lublin, Lublin, Poland
Interests: endocrine gynecology; reproductive endocrinology; endocrine diseases in pregnancy; infertility; menopause; antiaging medicine
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Guest Editor
1. Department of Medical Statistics, School of Public Health, Center of Postgraduate Medical Education, 01-826 Warsaw, Poland
2. Department of Demography, Institute of Statistics and Demography, Collegium of Economic Analyses, SGH Warsaw School of Economics, 02-554 Warsaw, Poland
Interests: public health; health promotion and biostatistics; infertility and endocrinology problems; mental health and quality of life
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to invite you to contribute to this Special Issue, entitled “Clinical Updates in Reproductive Endocrinology: 2nd Edition”. We are launching this edition following the success of the first edition, in which we published six papers. For more details, please visit https://www.mdpi.com/journal/jcm/special_issues/BBG85TAK79

Several problems persist in reproductive endocrinology, mainly linked to the continued search for better diagnostic and therapeutic methods that enable patients to go on to have healthy children. We have observed increasing problems with fertility, especially in highly developed countries. One of the reasons for this is that reproductive endocrinology has not yet been sufficiently researched. There are a number of endocrine disorders that make it difficult to become pregnant and that complicate the course of pregnancy. Furthermore, an underestimated number of patients with endocrine disorders suffer from mental health problems that affect their reproduction ability. An equally important issue concerns the improvement of quality of life for people struggling with endocrine problems while trying to conceive and managing the late consequences (metabolic and psychological) of treatments for endocrine disorders during the reproductive period. Despite international guidelines and consensus updates around the world, there are still gaps in the literature regarding all of the abovementioned areas. This Special Issue will present a comprehensive review of advances in the diagnosis and treatment of reproductive endocrine disorders, with a particular emphasis on the clinical application of the latest findings regarding the treatment of infertility and other consequences of endocrine diseases. Researchers in the field of reproductive endocrinology are encouraged to contribute their research findings in the form of original articles, meta-analyses, or reviews to this Special Issue.

Prof. Dr. Iwona Bojar
Prof. Dr. Dorota Raczkiewicz
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive endocrinology
  • endocrine diseases in pregnancy
  • infertility
  • endocrine diagnostics in infertility
  • long-term consequences of endocrine disorders
  • therapy for endocrine disorders

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Published Papers (1 paper)

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Research

15 pages, 962 KB  
Article
Clinical Investigation of Recurrence, Oncological, and Obstetrical Outcomes in Patients with Ovarian Atypical Endometriosis
by Su Hyeon Choi, So Hyun Shim, Seyeon Won, Nara Lee, Mi Kyoung Kim, Bo Wook Kim, Yong Wook Jung, Seok Ju Seong, Songmi Noh and Mi-La Kim
J. Clin. Med. 2025, 14(16), 5656; https://doi.org/10.3390/jcm14165656 - 10 Aug 2025
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Abstract
Objectives: The objective of this study was to evaluate the safety of postoperative in vitro fertilization (IVF) for atypical endometriosis (AE) in terms of ovarian endometrioma recurrence and development of endometriosis-related ovarian cancer (EAOC). Methods: Premenopausal women with AE who had [...] Read more.
Objectives: The objective of this study was to evaluate the safety of postoperative in vitro fertilization (IVF) for atypical endometriosis (AE) in terms of ovarian endometrioma recurrence and development of endometriosis-related ovarian cancer (EAOC). Methods: Premenopausal women with AE who had undergone ovarian surgery between 2008 and 2022 and had attended follow-up appointments for at least 3 months were included in this retrospective study. The recurrence of endometriosis, postoperative pregnancy rate, occurrence of postoperative EAOC in cases of AE, and independent risk factors of AE recurrence were analyzed. Results: A total of 105 patients were included in the study with a median age of 33 years (range, 16–50 years) and a median follow-up duration of 29.0 months (range, 3–143 months). Most of the patients were treated with cyst enucleation (96.2%). Recurrent ovarian endometrioma was detected in 19 patients (18.1%), 4 of whom (19.0%) underwent reoperation, and there were no cases of EAOC. The cumulative recurrence rate at 12, 24, and 50 months was 7.4, 15.8, and 26.3%, respectively. Among the 105 patients, 36 wanted to become pregnant; of these, 12 underwent IVF, which, according to a univariable analysis, did not increase their risk of recurrent ovarian endometrioma. According to a subsequent multivariable analysis, previous history of ovarian endometrioma operation was the sole significant risk factor for AE recurrence (HR, 4.246; 95% CI, 1.262–14.285; p = 0.020). Conclusions: IVF trials for pregnancy did not represent a risk factor for recurrence, as treated AE showed a low possibility of malignant transformation, and IVF was not a risk factor for recurrence. Full article
(This article belongs to the Special Issue Clinical Updates in Reproductive Endocrinology: 2nd Edition)
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