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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Joint Repair and Replacement: Current Challenges and Opportunities
edited by Bartosz Gonera and Kacper Ruzik
submission deadline 20 Dec 2026 | 3 articles | Viewed by 3227 | Submission Open
Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants
(This special issue belongs to the Section Orthopedics)
Transcatheter Aortic Valve Implantation and Replacement: Prospects and Challenges—2nd Edition
edited by Konstantinos Toutouzas and
submission deadline 20 Dec 2026 | 4 articles | Viewed by 3158 | Submission Open
Keywords: TAVI; aortic stenosis; valve-in-valve; structural heart disease; TAVI-in-TAVI
(This special issue belongs to the Section Cardiology)
Carotid Artery Disease (CAD) and Its Complications: A Comprehensive Update
edited by Yacob G. Tedla
submission deadline 20 Dec 2026 | 3 articles | Viewed by 3040 | Submission Open
Keywords: carotid artery disease; ischemic stroke; vascular dementia; transient ischemic attack; vascular imaging; carotid endarterectomy; carotid stent placement; risk stratification
(This special issue belongs to the Section Vascular Medicine)
Clinical Advances in Risk Minimization Through Robot-Assisted Surgery
edited by Radko Komadina
submission deadline 20 Dec 2026 | 6 articles | Viewed by 3010 | Submission Open
Keywords: robot-assisted technology; robotic surgery; laparoscopic surgery; spinal surgery; robot-assisted gynecological operations; robot-assisted operations in urology; robot-assisted prostatectomy
(This special issue belongs to the Section General Surgery)
Applications of Artificial Intelligence in Cardiology: New Tools to Transform Care submission deadline 20 Dec 2026 | 1 articles | Viewed by 2853 | Submission Open
Keywords: artificial intelligence in cardiology; machine learning; deep learning; AI-driven ECG analysis; cardiovas-cular imaging and AI; predictive analytics in cardiology; mHealth and wearables; clinical decision support systems; ethics and AI in healthcare; digital health and remote monitoring
(This special issue belongs to the Section Cardiology)
Recent Advancements in Nuclear Medicine and Radiology: 2nd Edition
edited by Adriaan A. Lammertsma
submission deadline 20 Dec 2026 | 3 articles | Viewed by 2719 | Submission Open
Keywords: PET; SPECT; CT; MRI; AI; image analysis; kinetic analysis
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advanced Applications of Magnetic Resonance Imaging (MRI) in Clinical Diagnosis
edited by Francescamaria Donati
submission deadline 20 Dec 2026 | 4 articles | Viewed by 2603 | Submission Open
Keywords: magnetic resonance imaging (MRI); clinical diagnosis; high-field MRI; diffusion-weighted imaging (DWI); perfusion MRI (pMRI); artificial intelligence in imaging; diagnostic imaging; early disease detection; disease monitoring; treatment planning
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Cardiac Rehabilitation: Integrating Multidimensional Approaches for Enhanced Cardiovascular Health
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 2539 | Submission Open
Keywords: cardiac rehabilitation; multidimensional approach; integrating approach; cardiovascular health; primary and secondary prevention
(This special issue belongs to the Section Clinical Rehabilitation)
State-of-the-Art Advances in Bloodstream Infections submission deadline 20 Dec 2026 | 2 articles | Viewed by 2335 | Submission Open
Keywords: bloodstream infections; sepsis; antimicrobial resistance; rapid diagnostics; metagenomics; antimicrobial treatment; antimicrobial stewardship; artificial intelligence; precision medicine
(This special issue belongs to the Section Infectious Diseases)
Clinical Applications of Artificial Intelligence and Machine Learning in Diagnosis and Therapy
edited by Christian Salvatore, Valentina Chiappa and Gennaro D’Anna
submission deadline 20 Dec 2026 | 4 articles | Viewed by 2125 | Submission Open
Keywords: artificial intelligence in clinical medicine; machine learning in clinical medicine; medical imaging analysis; digital biomarkers; explainable artificial intelligence (XAI); precision medicine; human–AI interaction in healthcare
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
The New Era of Urological Surgery: Technology-Enhanced Clinical Outcomes submission deadline 20 Dec 2026 | 1 articles | Viewed by 2123 | Submission Open
Keywords: urology; surgery; robotic surgery; artificial intelligence; urological cancer
(This special issue belongs to the Section Nephrology & Urology)
Atrial Fibrillation and Heart Failure: Diagnosis, Risk Stratification, and Clinical Management
edited by Christian Grebmer
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1981 | Submission Open
Keywords: atrial fibrillation; heart failure; clinical management; risk stratification; anticoagulation; catheter ablation; guide-line-directed therapy; clinical outcomes
(This special issue belongs to the Section Cardiology)
Advances in Spinal Deformity: Current Challenges and Future Directions
edited by and Sam Yeol Chang
submission deadline 20 Dec 2026 | 4 articles | Viewed by 1893 | Submission Open
Keywords: spinal deformity; adult spinal deformity; pediatric scoliosis; minimally invasive spine surgery; navigation and robotics; spinal alignment; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Pharmacotherapy of Mental Diseases: Latest Developments submission deadline 20 Dec 2026 | 2 articles | Viewed by 1880 | Submission Open
Keywords: brain stimulation; mental health; novel intervention; pharmacotherapy; psychotherapy; quality of life; psychologi-cal well-being; treatment personalization in mental diseases
(This special issue belongs to the Section Mental Health)
Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives submission deadline 20 Dec 2026 | 1 articles | Viewed by 1693 | Submission Open
Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery
(This special issue belongs to the Section Respiratory Medicine)
Advancements in Diagnosing, Management and Treatment of Gynecologic Oncology submission deadline 20 Dec 2026 | 3 articles | Viewed by 1643 | Submission Open
Keywords: gynecologic oncology; ovarian cancer; endometrial cancer; cervical cancer; breast cancer; peritoneal metastasis; biomarkers; cytoreductive surgery; HIPEC; targeted therapy; immunotherapy; artificial intelligence
(This special issue belongs to the Section Obstetrics & Gynecology)
New Insights into Regional Anesthesia and Pain Management submission deadline 20 Dec 2026 | 3 articles | Viewed by 1630 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided techniques; erector spinae plane block; pericapsular nerve group (PENG) block; interfascial plane blocks; multimodal analgesia; opioid-sparing analgesia; postoperative pain; inflammatory response; enhanced recovery after surgery (ERAS); pediatric anesthesia; geriatric anesthesia; orthopedic anesthesia; randomized controlled trials
(This special issue belongs to the Section Anesthesiology)
Advancing Personalized and Precision Medicine with Large Language Models
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1490 | Submission Open
Keywords: large language models; precision medicine; clinical decision support; electronic health records; phenotyping; multimodal data integration; explainable artificial intelligence; clinical summarization; biomedical data interpretation; digital health
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Advances in Laparoscopic, Robotic, and Minimally Invasive Gastrointestinal Surgery submission deadline 20 Dec 2026 | 2 articles | Viewed by 1281 | Submission Open
Keywords: minimally invasive surgery; laparoscopy; robotic surgery; gastrointestinal surgery; surgical innovation; patient outcomes; enhanced recovery; clinical research
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)
edited by Diana Alecsandru
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1275 | Submission Open
Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Beyond Full Weight-Bearing Alone: Innovative, Individualized and Holistic Rehabilitation in Geriatric Orthopedic Trauma submission deadline 20 Dec 2026 | Viewed by 1190 | Submission Open
Keywords: geriatric trauma; orthogeriatrics; rehabilitation; weight-bearing; partial weight-bearing; full weight-bearing; fracture healing; frailty; sarcopenia; mobilization; tele-rehabilitation; digital health; wearable sensors; biofeedback; exoskeleton; robotics; neuromuscular electrical stimulation; multimodal rehabilitation; individualized care; postoperative aftercare
(This special issue belongs to the Section Clinical Rehabilitation)
Schizophrenia and Psychotic Disorders: Clinical Updates submission deadline 20 Dec 2026 | 1 articles | Viewed by 1115 | Submission Open
Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities
(This special issue belongs to the Section Mental Health)
Clinical Diagnosis and Treatment of Demyelinating Diseases
edited by and John S. Tzartos
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1107 | Submission Open
Keywords: demyelinating diseases of the CNS; demyelinating diseases of the PNS; multiple sclerosis; neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); clinical diagnosis; biomarkers; therapeutics
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Obstructive Sleep Apnea submission deadline 20 Dec 2026 | 1 articles | Viewed by 914 | Submission Open
Keywords: obstructive sleep apnea; sleep apnea syndromes; precision medicine; treatment outcome; diagnosis
(This special issue belongs to the Section Respiratory Medicine)
Moving Forward to New Trends in Pulmonary Diseases: 2nd Edition submission deadline 20 Dec 2026 | 1 articles | Viewed by 909 | Submission Open
Keywords: pulmonary tuberculosis; chronic obstructive airway diseases; bronchiectasis; COVID-19; sleep apnea; ultrasound; lung cancer; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Advances in Endoscopy for the Diagnosis and Treatment of Gastrointestinal Diseases submission deadline 20 Dec 2026 | 1 articles | Viewed by 833 | Submission Open
Keywords: gastrointestinal endoscopy; early gastrointestinal neoplasia; endoscopic imaging; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic full-thickness resection (EFTR); pancreatic and biliary diseas-es; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); small bowel pathology; video capsule endoscopy (VCE); artificial intelligence (AI)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Critical Care Cardiology
edited by Marc-Olivier Fischer
submission deadline 20 Dec 2026 | 1 articles | Viewed by 821 | Submission Open
Keywords: antiplatelets drugs; arrhythmia ablations; cardiology; catecholamines; sodium-glucose cotransporter type 2 inhibitors; critical care; cardiogenic shock; echocardiography; ECLS; ECMO; inotropic drugs; vasopressors drugs
(This special issue belongs to the Section Intensive Care)
Kidney Cancer: From Diagnostic to Therapy—2nd Edition
edited by Devin N. Patel, Ithaar H. Derweesh and
submission deadline 20 Dec 2026 | 2 articles | Viewed by 811 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Colorectal Disorder: Latest Advances and Prospects
edited by Pietro Fransvea
submission deadline 20 Dec 2026 | 1 articles | Viewed by 809 | Submission Open
Keywords: colorectal surgery; emergency surgery; artificial intelligence; minimally invasive surgery; colorectal cancer; sepsis; gut microbiome; intestinal failure
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Hip Surgery: Recent Clinical Advances
edited by Sujith Konan
submission deadline 20 Dec 2026 | 1 articles | Viewed by 711 | Submission Open
Keywords: total hip replacement; revision hip replacement; bearing surfaces; instability; dislocation; fixation of hip implants; large heads; dual mobility; aces in hip surgery
(This special issue belongs to the Section Orthopedics)
Heart Failure in the Elderly: Diagnosis, Treatment and Prognosis
edited by Francesco Curcio and Francesco Cacciatore
submission deadline 20 Dec 2026 | 1 articles | Viewed by 695 | Submission Open
Keywords: heart failure; elderly; aging; frailty; HFpEF; multimorbidity; biomarkers; precision medicine; aortic stenosis; trans-thyretin amyloidosis; cardiac amyloidosis
(This special issue belongs to the Section Cardiology)
Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)—Second Edition
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 668 | Submission Open
Keywords: obstructive sleep apnea syndrome; diagnosis; obesity; treatment; CPAP; comorbidities; cardiovascular risk
(This special issue belongs to the Section Respiratory Medicine)
Chronic Kidney Disease: Treatment, Nutritional Intervention and Renal Transplantation
edited by Hülya Taşkapan
submission deadline 20 Dec 2026 | 1 articles | Viewed by 619 | Submission Open
Keywords: chronic kidney disease; renal insufficiency; nutritional therapy; dietary intervention; CKD management; treatment strategies; nephrology; dialysis; kidney transplantation
(This special issue belongs to the Section Nephrology & Urology)
Artificial Intelligence in Craniofacial Surgery: An Emerging Challenge submission deadline 20 Dec 2026 | 1 articles | Viewed by 601 | Submission Open
Keywords: artificial intelligence; craniofacial surgery; surgical simulation; machine learning; deep learning; predictive modeling; 3D reconstruction; intraoperative guidance; patient-specific planning; clinical validation; surgical innovation; precision medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 4th Edition
edited by and Panagiota Christia
submission deadline 20 Dec 2026 | 1 articles | Viewed by 600 | Submission Open
Keywords: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease
(This special issue belongs to the Section Cardiology)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 20 Dec 2026 | Viewed by 588 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Vulnerability and Resilience in the Perinatal Period: Focus on Maternal and Paternal Mental Health
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 552 | Submission Open
Keywords: perinatal mental health; maternal mental health; paternal mental health; resilience; perinatal wellbeing; dyadic processes; parent–infant relationship; perinatal affective disorders; perinatal psychiatry
(This special issue belongs to the Section Mental Health)
Pulmonary Embolism and Pulmonary Hypertension: From Diagnosis to Treatment
edited by Remigiusz Kazimierczyk
submission deadline 20 Dec 2026 | 1 articles | Viewed by 519 | Submission Open
Keywords: pulmonary hypertension; pulmonary embolism; CTEPH; PET/MRI; catheter-directed therapies
(This special issue belongs to the Section Cardiology)
Liver Failure: Current Status and Future Opportunities
edited by
submission deadline 20 Dec 2026 | Viewed by 515 | Submission Open
Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Artificial Intelligence in Orthopedics: Current Advancements and Future Perspectives
edited by Koroush Kabir
submission deadline 20 Dec 2026 | 1 articles | Viewed by 513 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; orthopedics; trauma surgery; spinal surgery; arthroplasty; clin-ical guidelines
(This special issue belongs to the Section Orthopedics)
Surgical Treatment of Urinary System Cancers
edited by Roderick K. Clark and Matthew G. Kaag
submission deadline 20 Dec 2026 | 1 articles | Viewed by 510 | Submission Open
Keywords: urologic oncology; multimodal cancer treatment; perioperative management; oncologic outcomes; surgical innovation; minimally invasive surgery
(This special issue belongs to the Section Nephrology & Urology)
Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century
edited by Reinhardt T. Grundmann
submission deadline 20 Dec 2026 | Viewed by 386 | Submission Open
Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation
(This special issue belongs to the Section Cardiovascular Medicine)
The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century
edited by Tomer Ziv-Baran and Elena Izkhakov
submission deadline 20 Dec 2026 | Viewed by 385 | Submission Open
Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach
(This special issue belongs to the Section Epidemiology & Public Health)
Transcatheter Strategies for Mitral and Tricuspid Valve Treatment
edited by , Magdalena Erlebach and Marco Gennari
submission deadline 20 Dec 2026 | 1 articles | Viewed by 377 | Submission Open
Keywords: TEER; tricuspid valve; mitral valve; remodeling; durability
(This special issue belongs to the Section Cardiology)
Skin Cancer: From Diagnosis to Personalized Treatment
edited by
submission deadline 20 Dec 2026 | Viewed by 376 | Submission Open
Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery
(This special issue belongs to the Section Dermatology)
Advances in Orthopedic Trauma Surgery: From Surgical Techniques to Patient Outcomes submission deadline 20 Dec 2026 | Viewed by 337 | Submission Open
Keywords: trauma; fractures; clinical outcome; surgical techniques; complications; innovation; patient management
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Cardio-Obstetrics on Labor and Delivery
edited by Diana S. Wolfe
submission deadline 20 Dec 2026 | Viewed by 328 | Submission Open
Keywords: cardio-obstetrics; maternal medicine; high risk pregnancy; perinatology; cardiology
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Management and Advances in Hereditary Hemorrhagic Telangiectasia
edited by Hanny Al-Samkari
submission deadline 20 Dec 2026 | Viewed by 314 | Submission Open
Keywords: hereditary hemorrhagic telangiectasia; epistaxis; gastrointestinal bleeding; women’s health; arteriovenous mal-formation; AVM; anemia; iron deficiency; vasculopathy; angiogenesis; novel therapy
(This special issue belongs to the Section Hematology)
Thoracic Organ Transplantation: From Diagnosis to Long-Term Outcomes
edited by Sławomir Zeglen
submission deadline 20 Dec 2026 | 1 articles | Viewed by 300 | Submission Open
Keywords: lung transplantation; heart transplantation; thoracic organ transplantation; transplantation candidate evaluation; transplant out-comes; immunosuppressive therapy; graft dysfunction; chronic lung allograft dysfunction (CLAD); artificial intelligence in preopera-tive medicine; physical activity in transplant candidates and recipients
(This special issue belongs to the Section General Surgery)
Cardiogenic Shock: Multidisciplinary Approaches in Acute Cardiac Care submission deadline 20 Dec 2026 | Viewed by 296 | Submission Open
Keywords: cardiogenic shock; acute cardiac care; emergency department; intensive care unit; acute coronary syndromes; shock team; mechanical circulatory support; ECMO; hemodynamic monitoring
(This special issue belongs to the Section Emergency Medicine)
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