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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in the Management of Chronic Lymphocytic Leukemia submission deadline 12 May 2026 | 2 articles | Viewed by 5096
Keywords: chronic lymphocytic leukemia; lymphoproliferative disorders; prognostic factors; targeted therapy; CAR T cell; elderly patients; comorbidities
(This special issue belongs to the Section Hematology)
Gastroesophageal Cancer: Advances in Clinical Diagnosis and Management
edited by and Maximos Frountzas
submission deadline 15 May 2026 | 8 articles | Viewed by 16250 | Submission Open
Keywords: gastroesophageal cancer; endoscopic therapy; minimally invasive surgery; multimodality treatment; immunotherapy
(This special issue belongs to the Section Oncology)
Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies
edited by
submission deadline 15 May 2026 | 4 articles | Viewed by 9018 | Submission Open
Keywords: heart; lung; kidney; liver; bone; brain
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD) submission deadline 15 May 2026 | 4 articles | Viewed by 8144 | Submission Open
Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone
(This special issue belongs to the Section Mental Health)
Clinical Advances in Trauma and Emergency Medicine
edited by Viktoria Bogner-Flatz
submission deadline 15 May 2026 | 5 articles | Viewed by 7869 | Submission Open
Keywords: resuscitation; trauma emergency management; disaster response; mild traumatic brain injury emergency management; critical emergency care
(This special issue belongs to the Section Emergency Medicine)
Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes
edited by
submission deadline 15 May 2026 | 6 articles | Viewed by 5751 | Submission Open
Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment
(This special issue belongs to the Section Nephrology & Urology)
Thyroid Disorders: New Clinical Diagnosis and Management submission deadline 15 May 2026 | 1 articles | Viewed by 3179 | Submission Open
Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging
(This special issue belongs to the Section Endocrinology & Metabolism)
Heart Failure: Challenges and Future Options
edited by Pedro Caravaca-Pérez and Marta Farrero-Torres
submission deadline 15 May 2026 | 6 articles | Viewed by 3168 | Submission Open
Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care
(This special issue belongs to the Section Cardiovascular Medicine)
Damage Control Surgery: New Insights into Resuscitation, Operative Strategies and Complications submission deadline 15 May 2026 | 2 articles | Viewed by 1867 | Submission Open
Keywords: damage control surgery; damage control resuscitation; polytrauma management; massive transfusion protocol; hemorrhagic shock; trauma laparotomy; staged laparotomy; temporary abdominal closure; multidisciplinary trauma care
(This special issue belongs to the Section General Surgery)
Clinical Research in Management of Corneal Diseases
edited by Massimo Busin and Angeli Christy Yu
submission deadline 15 May 2026 | 2 articles | Viewed by 1416 | Submission Open
Keywords: corneal surgery; corneal transplant; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty; corneal neurotization
(This special issue belongs to the Section Ophthalmology)
Clinical Updates on Maternal Fetal Medicine: 2nd Edition submission deadline 15 May 2026 | 1 articles | Viewed by 1355 | Submission Open
Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Updates on Pediatric Surgery
edited by Carlos Theodore Huerta and Eduardo Alfonso Perez
submission deadline 15 May 2026 | 1 articles | Viewed by 1195 | Submission Open
Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality
(This special issue belongs to the Section Clinical Pediatrics)
Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies
edited by
submission deadline 15 May 2026 | 1 articles | Viewed by 865 | Submission Open
Keywords: neuroendocrine neoplasms (NENs); epidemiology; biomarkers for NENs; targeted therapies for NENs; carcinoid syndrome; precision medicine; gastrointestinal NENs; advanced endoscopic approaches to NEN treatment; imaging modalities for NENs; survival risk factors in NENs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery submission deadline 15 May 2026 | 1 articles | Viewed by 810 | Submission Open
Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology
(This special issue belongs to the Section Otolaryngology)
Spinal Disorders: Current Treatment and Future Opportunities: Third Edition
edited by
submission deadline 15 May 2026 | 1 articles | Viewed by 720 | Submission Open
Keywords: spine; spine surgery; spondylolisthesis; scoliosis; cervical myelopathy; spine surgery training; disc replacement; spine trauma; spine infection; spine fracture; spinal epidural abscess
(This special issue belongs to the Section Orthopedics)
Head and Neck Cancer: Clinical Diagnosis and Treatment
edited by Enrique Sanz-Garcia, Nicole Chau and Neus Baste
submission deadline 15 May 2026 | 1 articles | Viewed by 681 | Submission Open
Keywords: head and neck; multidisciplinary approaches; biomarkers; early detection; therapies
(This special issue belongs to the Section Otolaryngology)
Mechanisms and Management of Intracerebral Hemorrhage
edited by Emanuela Crobeddu
submission deadline 15 May 2026 | Viewed by 373 | Submission Open
Keywords: intracerebral hemorrhage; arteriovenous malformation (AVM); dural arteriovenous fistula (DAVF); cavernoma; neuroinflammation; blood– brain barrier; hematoma evacuation; neuroprotection; imaging technologies; vascular lesions
(This special issue belongs to the Section Clinical Neurology)
Comprehensive Hernia Surgery: From Clinical Diagnosis to Postoperative Care
edited by Luca Regusci
submission deadline 15 May 2026 | Viewed by 205 | Submission Open
Keywords: ventral hernia; complexe hernias; botox treatment; laparoscopic surgery; robotic surgery
(This special issue belongs to the Section General Surgery)
Hypertrophic Cardiomyopathy: Lights and Shadows of Structural Pharmacological Treatment
edited by Daniel Dalos
submission deadline 15 May 2026 | Viewed by 159 | Submission Open
Keywords: hypertrophic cardiomyopathy; treatment; myosin inhibition; ventricular arrhythmia; atrial fibrillation
(This special issue belongs to the Section Cardiology)
PET Imaging in Bone and Non-Bone Diseases
edited by and
submission deadline 19 May 2026 | 2 articles | Viewed by 5903 | Submission Open
Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges submission deadline 20 May 2026 | 27 articles | Viewed by 83152 | Submission Open
Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiovascular Disease in the Elderly: Prevention and Diagnosis
edited by Ioana Dana Alexa, Gabriel Ioan Prada and
submission deadline 20 May 2026 | 10 articles | Viewed by 32883 | Submission Open
Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction
(This special issue belongs to the Section Cardiovascular Medicine)
New Advances in Wound Healing and Skin Wound Treatment
edited by Hajime Matsumura
submission deadline 20 May 2026 | 11 articles | Viewed by 28797 | Submission Open
Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment  
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges submission deadline 20 May 2026 | 7 articles | Viewed by 22274 | Submission Open
Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Novel Insights into the Prevention and Treatment of Contact Dermatitis
edited by , Christoph Skudlik, Swen Malte John and
submission deadline 20 May 2026 | 5 articles | Viewed by 17040 | Submission Open
Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment
(This special issue belongs to the Section Dermatology)
Endometriosis: Clinical Challenges and Prognosis submission deadline 20 May 2026 | 5 articles | Viewed by 15072 | Submission Open
Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis
(This special issue belongs to the Section Obstetrics & Gynecology)
Ischemic Stroke: Diagnosis and Treatment submission deadline 20 May 2026 | 5 articles | Viewed by 13768 | Submission Open
Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy
(This special issue belongs to the Section Clinical Neurology)
State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy
edited by Marco Mercieri
submission deadline 20 May 2026 | 3 articles | Viewed by 13678 | Submission Open
Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets
(This special issue belongs to the Section Clinical Neurology)
Cardiac Imaging in the Diagnosis and Management of Heart Failure
edited by Mahi Lakshmi Ashwath and Allen S. Anderson
submission deadline 20 May 2026 | 2 articles | Viewed by 13259 | Submission Open
Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain
(This special issue belongs to the Section Cardiology)
Chronic Lung Conditions: Integrative Approaches to Long-Term Care submission deadline 20 May 2026 | 5 articles | Viewed by 13180 | Submission Open
Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes
(This special issue belongs to the Section Respiratory Medicine)
Advances in Spine Surgery: Best Practices and Future Directions
edited by Martin N. Stienen and
submission deadline 20 May 2026 | 7 articles | Viewed by 13012 | Submission Open
Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction
(This special issue belongs to the Section Clinical Neurology)
Effect of Long-Term Insomnia on Mental Health—2nd Edition submission deadline 20 May 2026 | 2 articles | Viewed by 12188 | Submission Open
Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress
(This special issue belongs to the Section Mental Health)
Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions
edited by and Pablo Codner
submission deadline 20 May 2026 | 9 articles | Viewed by 11632 | Submission Open
Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies
edited by
submission deadline 20 May 2026 | 9 articles | Viewed by 10549 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
Updates on Cardiac Pacing and Electrophysiology
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 8782 | Submission Open
Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation
(This special issue belongs to the Section Cardiology)
Neural Application of Artificial Intelligence in Clinical Neuroscience
edited by Saurabh J. Singhal
submission deadline 20 May 2026 | 4 articles | Viewed by 8320 | Submission Open
Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction
(This special issue belongs to the Section Clinical Neurology)
New Advances in Myasthenia Gravis
edited by Shingo Konno
submission deadline 20 May 2026 | 3 articles | Viewed by 8305 | Submission Open
Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis
(This special issue belongs to the Section Clinical Neurology)
Clinical Application of Knee Arthroscopy
edited by and Alessandro Carrozzo
submission deadline 20 May 2026 | 5 articles | Viewed by 7075 | Submission Open
Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation
(This special issue belongs to the Section Orthopedics)
Cirrhosis and Its Complications: Prognosis and Clinical Management
edited by
submission deadline 20 May 2026 | 6 articles | Viewed by 6993 | Submission Open
Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 May 2026 | 4 articles | Viewed by 6988 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition submission deadline 20 May 2026 | 4 articles | Viewed by 6519 | Submission Open
Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses
(This special issue belongs to the Section Orthopedics)
Prostate Cancer: Diagnosis, Clinical Management and Prognosis
edited by Giovanni Muto
submission deadline 20 May 2026 | 6 articles | Viewed by 6446 | Submission Open
Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments
(This special issue belongs to the Section Nephrology & Urology)
New Advances in Uterus and Ovarian Transplantation: 2nd Edition submission deadline 20 May 2026 | 3 articles | Viewed by 5913 | Submission Open
Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Challenges in Reproductive Health
edited by and Guido Ambrosini
submission deadline 20 May 2026 | 2 articles | Viewed by 5888 | Submission Open
Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 5583 | Submission Open
Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke
(This special issue belongs to the Section Clinical Neurology)
Clinical Update in Pulmonary Rehabilitation
edited by Akira Tamaki
submission deadline 20 May 2026 | 3 articles | Viewed by 4633 | Submission Open
Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention
(This special issue belongs to the Section Respiratory Medicine)
Research Progress in Pediatric Endocrinology
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 4589 | Submission Open
Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening
(This special issue belongs to the Section Clinical Pediatrics)
Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine submission deadline 20 May 2026 | 4 articles | Viewed by 4242 | Submission Open
Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness
(This special issue belongs to the Section Emergency Medicine)
Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes
edited by Giovanni Colombo and
submission deadline 20 May 2026 | 4 articles | Viewed by 3593 | Submission Open
Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life
(This special issue belongs to the Section Otolaryngology)
Surgical Management of Complex Spinal Pathologies: Challenges and Innovations
edited by
submission deadline 20 May 2026 | 4 articles | Viewed by 3350 | Submission Open
Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes
(This special issue belongs to the Section Orthopedics)
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