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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exercise, Rehabilitation, and Women’s Health: Clinical Perspectives in Sports Medicine

edited by

Do-yeon Kim

and

Dan Newmire

submission deadline 25 Feb 2027 | Viewed by 292 | Submission Open

Keywords: women’s health; exercise intervention; rehabilitation; exercise physiology; musculoskeletal health; healthy aging; resistance training; nutrition

(This special issue belongs to the Section Clinical Rehabilitation)

Cancer Prevention and Early Detection: Epidemiological Approaches and Public Health Strategies

edited by

Carmen Martos

and

Francesco Giusti

submission deadline 25 Feb 2027 | Viewed by 284 | Submission Open

Keywords: cancer prevention; cancer screening; risk factors; cancer treatment; health information systems; cancer registry; cancer inequalities

(This special issue belongs to the Section Epidemiology & Public Health)

Pelvic Floor Disorders: Emerging Perspectives on Therapeutic Approaches

edited by

María Luísa Sánchez-Ferrer

submission deadline 25 Feb 2027 | Viewed by 159 | Submission Open

Keywords: pelvic floor surgery; laparoscopic approach; quality of life; pelvic organ prolapse surgery; urinary and fecal incontinence; pelvic floor disorders

(This special issue belongs to the Section Obstetrics & Gynecology)

Colorectal Surgery: New Clinical Advances, Challenges and Future Directions

edited by

Lior Segev

submission deadline 25 Feb 2027 | Viewed by 89 | Submission Open

Keywords: colon surgery; colorectal surgery; colorectal cancer; IBD surgery; proctology; diverticular disease; diverticulitis; surgical outcomes

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Immunohematology: From Pathophysiology to Tailored Treatments

edited by

Giorgio Costagliola

submission deadline 28 Feb 2027 | 1 articles | Viewed by 4403 | Submission Open

Keywords: autoimmune cytopenia; hemophagocytic lymphohistiocytosis; inborn errors of immunity; lymphoproliferative diseases; malignancy; monoclonal antibodies; secondary immunodeficiency; vaccination

(This special issue belongs to the Section Immunology & Rheumatology)

Tumor Microenvironment—Current Status and Therapeutic Targets

edited by

Rashi Kalra

submission deadline 28 Feb 2027 | 2 articles | Viewed by 3919 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies

(This special issue belongs to the Section Oncology)

Clinical Rehabilitation Strategies and Exercise for Stroke Recovery

edited by

Dimitrios I. Tsiptsios

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2383 | Submission Open

Keywords: stroke; stroke rehabilitation; exercise; biomarkers; rehabilitation outcomes

(This special issue belongs to the Section Clinical Rehabilitation)

Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)

edited by Aikaterini Detoraki

submission deadline 28 Feb 2027 | 1 articles | Viewed by 2002 | Submission Open

Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management

(This special issue belongs to the Section Immunology & Rheumatology)

Ergonomics and Low Back Pain: Integrative Approaches to Prevention, Assessment and Management

edited by

Janan Abbas

and

Deborah Alperovitch

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1937 | Submission Open

Keywords: advanced in diagnostic methods; therapeutic innovations; multidisciplinary and personalized care models; prevention and rehabilitation; non-pharmacological strategies; ergonomics; biomechanics

(This special issue belongs to the Section Orthopedics)

Clinical and Epidemiological Aspects of Frailty in Acute Kidney Injury: A Spotlight on Risk Factors, Prevention and Management

edited by

Alberto Parise

and

Marco Allinovi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 352 | Submission Open

Keywords: sarcopenia; AKI; frailty; amyloidosis; nutrition; epidemiology

(This special issue belongs to the Section Nephrology & Urology)

Modern Challenges in Pediatric Endocrinology: From Growth Disorders to Metabolic Dysregulation

edited by Katarzyna A. Majewska and Piotr Fichna

submission deadline 2 Mar 2027 | 2 articles | Viewed by 2327 | Submission Open

Keywords: growth hormone deficiency; growth hormone therapy; short stature; obesity; obesity complications; obesity treatment; insulin resistance; prediabetes; type 1 diabetes; type 2 diabetes; hypothyroidism; hyperthyroidism; autoimmune thyroiditis; puberty disorders

(This special issue belongs to the Section Clinical Pediatrics)

Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition

edited by Alba Scerrati and Giorgio Mantovani

submission deadline 5 Mar 2027 | 3 articles | Viewed by 3528 | Submission Open

Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis

(This special issue belongs to the Section Clinical Neurology)

Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application

edited by

Roberto Cuomo

and

Gianluca Marcaccini

submission deadline 5 Mar 2027 | 2 articles | Viewed by 3278 | Submission Open

Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment

edited by

Roberto De Ponti

and

Michele Golino

submission deadline 5 Mar 2027 | 1 articles | Viewed by 1967 | Submission Open

Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine

(This special issue belongs to the Section Cardiovascular Medicine)

Emerging Biomarkers and Novel Diagnostic Tools in Respiratory Diseases: From Bench to Bedside

edited by

Silvano Dragonieri

and

Andras Bikov

submission deadline 10 Mar 2027 | 4 articles | Viewed by 2703 | Submission Open

Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests; precision medicine; personalized therapy; disease phenotyping; diagnostic tools; functional biomarkers; imaging biomarkers; molecular biomarkers

(This special issue belongs to the Section Respiratory Medicine)

Echocardiography in Clinical Cardiac Imaging: Advances and Emerging Applications

edited by

Marina Leitman

submission deadline 10 Mar 2027 | 2 articles | Viewed by 2644 | Submission Open

Keywords: echocardiography; cardiac Imaging; speckle-tracking echocardiography; artificial intelligence; myocardial function; valvular heart disease; precision cardiology

(This special issue belongs to the Section Cardiology)

Radiation Therapy: Recent Trends and Future Perspectives

edited by

Jongmoo Park

Jaehyeon Park

and Jae-won Park

submission deadline 10 Mar 2027 | 1 articles | Viewed by 864 | Submission Open

Keywords: breast reconstruction & PMRT; SBRT in oligometastatic cancer; metastasis-directed therapy; trends in modern radiotherapy techniques; palliative radiotherapy optimization; quality of life (QoL) in oncology; precision radiation oncology; artificial intelligence in radiotherapy

(This special issue belongs to the Section Oncology)

Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities

edited by

Danilo Menichelli

and Flavio Giuseppe Biccirè

submission deadline 10 Mar 2027 | 1 articles | Viewed by 769 | Submission Open

Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy

(This special issue belongs to the Section Cardiology)

Shoulder and Elbow Diseases: Advances in Diagnosis, Treatment and Rehabilitation

edited by

Mohammad Daher

Hafiz F. Kassam

and Joseph A. Abboud

submission deadline 10 Mar 2027 | 1 articles | Viewed by 439 | Submission Open

Keywords: shoulder; elbow; rotator cuff; arthritis; shoulder instability; arthroscopy; arthroplasty; tendinopathy; orthobiologics; rehabilitation; imaging

(This special issue belongs to the Section Orthopedics)

Open, Hybrid and Endovascular Repair of Visceral Artery Aneurysms: State of the Art and Clinical Perspectives

edited by

Andrea Xodo

, Francesco Squizzato and Vincenzo Vento

submission deadline 10 Mar 2027 | Viewed by 318 | Submission Open

Keywords: visceral artery aneurysms; endovascular treatment; open surgical repair; hybrid approach; covered stents; end-organ ischemia; long-term durability; patient selection

(This special issue belongs to the Section Vascular Medicine)

Contemporary Clinical Treatment and Rehabilitation of Scoliosis

edited by

Jacek Wilczyński

and Zbigniew Śliwiński

submission deadline 10 Mar 2027 | Viewed by 149 | Submission Open

Keywords: scoliosis; adolescent idiopathic scoliosis; spinal deformity; conservative treatment; physiotherapy; rehabilitation; physi-otherapeutic scoliosis-specific exercises (PSSE); postural control; spinal alignment; biomechanics; neuromuscular reha-bilitation; surface topography; raster stereography; gait analysis; musculoskeletal disorders

(This special issue belongs to the Section Orthopedics)

Artificial Intelligence and Eye Disease: 2nd Edition

edited by

Andrzej Grzybowski

Louis Arnould

and

Haoyu Chen

submission deadline 10 Mar 2027 | Viewed by 138 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorders

(This special issue belongs to the Section Ophthalmology)

Clinical Diagnosis and Management of Attention-Deficit/Hyperactivity Disorder (ADHD)

edited by

Francisco Gonzalez-Lima

submission deadline 10 Mar 2027 | Viewed by 109 | Submission Open

Keywords: ADHD; randomized controlled trials; clinical research; neurodevelopmental disorders; cognitive function; prefrontal cortex; diagnostic methods; therapeutic interventions; evidence-based medicine

(This special issue belongs to the Section Mental Health)

Robotic Surgery in Urologic Diseases: Multidisciplinary Research and Clinical Practice

edited by Donato Cannoletta

submission deadline 10 Mar 2027 | Viewed by 87 | Submission Open

Keywords: robotic surgery; urological surgery; robotic platforms

(This special issue belongs to the Section Nephrology & Urology)

Recent Clinical Advances in Percutaneous Coronary Intervention

edited by

Lampson Fan

and Luke Pickup

submission deadline 15 Mar 2027 | 2 articles | Viewed by 6957 | Submission Open

Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT

(This special issue belongs to the Section Cardiology)

Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs

edited by

Silvius Alexandru Pescariu

Felix Bratosin

and

Cristian Mornos

submission deadline 15 Mar 2027 | 3 articles | Viewed by 4829 | Submission Open

Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care

(This special issue belongs to the Section Cardiology)

Recent Clinical Advances in Esophageal Surgery

edited by

Guy Pines

, James Tankel and Harbi Khalayleh

submission deadline 15 Mar 2027 | 4 articles | Viewed by 3885 | Submission Open

Keywords: esophageal surgery; minimally invasive surgery; esophageal cancer; robotic surgery; endoscopic resection; benign esophageal disorders; paraesophageal hernia; anti-reflux surgery; motility disorders

(This special issue belongs to the Section General Surgery)

Visualizing Cardiac Function: Advances in Modern Imaging Diagnostics

edited by Dafni Charisopoulou and

Michael Henein

submission deadline 15 Mar 2027 | 3 articles | Viewed by 3770 | Submission Open

Keywords: cardiac imaging; echocardiography; coronary artery disease; valve disease; heart failure

(This special issue belongs to the Section Cardiology)

Understanding Dermatitis: Symptoms and Effective Treatment Options

edited by

Emi Sato

and Shinichi Imafuku

submission deadline 15 Mar 2027 | 1 articles | Viewed by 3698 | Submission Open

Keywords: dermatitis; atopic dermatitis; psoriasis; prurigo; JAK inhibitors; real world data

(This special issue belongs to the Section Dermatology)

Redefining Hemodialysis: Beyond Diffusion to Precision Therapy

edited by

Stefano Stuard

and Sagar Nigwekar

submission deadline 15 Mar 2027 | 1 articles | Viewed by 2705 | Submission Open

Keywords: digitalized medical governance; precision dialysis; convective clearance; advanced membranes; hemodynamic stability; artificial intelligence; digital biomarkers; personalized prescription; cardiovascular protection; patient-reported outcome measures; clinical trial emulation

(This special issue belongs to the Section Nephrology & Urology)

Minimally Invasive Cardiothoracic Surgery: Current Status and Future Perspectives

edited by

Shun-Ichiro Sakamoto

submission deadline 15 Mar 2027 | 3 articles | Viewed by 1748 | Submission Open

Keywords: aortic-preserving surgery; hybrid cardiovascular surgery; autologous tissue repair; enhanced recovery after surgery; minimally invasive cardiac surgery (MICS); geriatric surgery

(This special issue belongs to the Section Cardiovascular Medicine)

Multiple Sclerosis: Current Diagnosis, Treatment, and Future Options

edited by Przemysław Puz,

Nikolaos Grigoriadis

and

Eduardo Agüera-Morales

submission deadline 15 Mar 2027 | 3 articles | Viewed by 1636 | Submission Open

Keywords: multiple sclerosis; magnetic resonance imaging (MRI); remyelination; biomarkers; neuroprotection

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Epilepsy Research

edited by

Guillermo Estivill-Torrús

submission deadline 15 Mar 2027 | 2 articles | Viewed by 1445 | Submission Open

Keywords: epilepsy; autoimmune epilepsy; neural autoantibodies; seizure disorders; experimental epilepsy models; animal studies; neuronal excitability; immunotherapy; predictive scoring systems; epilepsy biomarkers

(This special issue belongs to the Section Clinical Neurology)

Glaucoma: Advances in Diagnosis, Management, and Vision Preservation

edited by

Masaki Tanito

and

Takuhei Shoji

submission deadline 15 Mar 2027 | 2 articles | Viewed by 1334 | Submission Open

Keywords: glaucoma diagnosis; OCT and OCT angiography; laser therapies (SLT, micropulse, cyclophotocoagulation, etc.); minimally invasive glaucoma surgery (MIGS); long-tube devices; artificial intelligence and imaging; pharmacological therapy; visual field and retinal ganglion cell function

(This special issue belongs to the Section Ophthalmology)

Measuring Recovery After Arthroplasty: Optimal Tools and Timing of Outcome Assessment

edited by

Nicholas David Clement

submission deadline 15 Mar 2027 | 1 articles | Viewed by 840 | Submission Open

Keywords: arthroplasty; hip; knee; recovery; outcomes; assessment

(This special issue belongs to the Section Orthopedics)

Delaying the Progression to Castration Resistance: Integrating Multidisciplinary Strategies and Tumor Survival Mechanisms in High-Risk Prostate Cancer

edited by Tag Keun Yoo

submission deadline 15 Mar 2027 | 1 articles | Viewed by 558 | Submission Open

Keywords: high-risk prostate cancer; oligometastasis; cytoreductive prostatectomy; multidisciplinary therapy; ADT; ARPI; docetaxel resistance; tumor survival mechanisms; CRPC progression

(This special issue belongs to the Section Oncology)

Outcomes in Pediatric Neurosurgery

edited by

Petra Klinge

and Konstantina Svokos

submission deadline 15 Mar 2027 | 1 articles | Viewed by 541 | Submission Open

Keywords: functional outcomes; pediatric neurosurgery; quality of life; innovative technologies; global neurosurgery

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Advances and Emerging Trends in Neuropsychology

edited by

Sharon Vaisvaser

and

Tal Shafir

submission deadline 15 Mar 2027 | 1 articles | Viewed by 383 | Submission Open

Keywords: neuropsychology; affective neuroscience; social neuroscience; brain–behavior relationship; emotional processing; emotion regulation; memory; personalized mental health; therapeutic factors

(This special issue belongs to the Section Mental Health)

From Gastritis to Gastric Cancer: Challenges in Diagnosis and Long-Term Management

edited by

Zuzanna Pelc

and

Karol Rawicz-Pruszyński

submission deadline 15 Mar 2027 | Viewed by 323 | Submission Open

Keywords: gastric cancer; gastritis and H. pylori; early detection and endoscopy; multimodal treatment; molecular profiling (MSI/MMR, PD-L1, CLDN18.2, HER2)

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Diagnostic and Rehabilitation of Vestibular Disorders

edited by

Ingrida Ulozienė

submission deadline 15 Mar 2027 | Viewed by 184 | Submission Open

Keywords: persistent postural-perceptual dizziness; vestibular migraine; vestibular disorders; motion perception; vestibular reha-bilitation; visually induced dizziness and visual dependence

(This special issue belongs to the Section Otolaryngology)

Technology-Enhanced Clinical Rehabilitation: Innovations, Applications and Outcomes

edited by Adam Wrzeciono and Joanna Szczepańska-Gieracha

submission deadline 15 Mar 2027 | Viewed by 143 | Submission Open

Keywords: clinical rehabilitation; digital health; virtual reality; augmented reality; artificial intelligence; tele-rehabilitation; wearable technologies; rehabilitation robotics; digital therapeutics; technology-assisted rehabilitation; psychosocial aspects; remote monitoring

(This special issue belongs to the Section Clinical Rehabilitation)

Biological Therapies in Psoriasis: Cardiovascular Aspects, Biomarkers, and the Patient Perspective

edited by

Ilona Hartmane

and

Reinhart M. Speeckaert

submission deadline 15 Mar 2027 | Viewed by 142 | Submission Open

Keywords: psoriasis; comorbidities; quality of life; biomarkers; pathogenesis; systemic immunosuppressive treatment; biologics; patient outcomes

(This special issue belongs to the Section Dermatology)

Advances in Transcatheter and Surgical Aortic Valve Replacement

edited by

Anna Olasińska-Wiśniewska

and

Tomasz Urbanowicz

submission deadline 15 Mar 2027 | Viewed by 95 | Submission Open

Keywords: aortic stenosis; TAVI; SAVR; minimally invasive; biomarker

(This special issue belongs to the Section Cardiology)

Personalized Medicine: Future Perspectives on Personalized Oral and Maxillofacial Surgery

edited by

Cosmin Ioan Faur

, Rareș Calin Roman and Mihaela Carmen Hedeşiu

submission deadline 19 Mar 2027 | 1 articles | Viewed by 2370 | Submission Open

Keywords: head and neck surgery; head and neck oncology; head and neck reconstructions; personalized medicine; artificial intelligence; head and neck trauma; integrative medicine

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pulmonary Hypertension: From Pathophysiology to Clinical Management

edited by

Dirk Bandorski

and

Lukas Ley

submission deadline 19 Mar 2027 | 1 articles | Viewed by 1415 | Submission Open

Keywords: pulmonary hypertension; pulmonary arterial hypertension; chronic thromboembolic pulmonary hypertension; pulmonary endarterectomy; balloon pulmonary angioplasty; pharmacological treatment; pathophysiology

(This special issue belongs to the Section Respiratory Medicine)

Insights and Innovations in Sports Cardiology

edited by

Garyfallia K. Pepera

submission deadline 20 Mar 2027 | 7 articles | Viewed by 15201 | Submission Open

Keywords: sports cardiology; athlete heart; cardiovascular screening; arrhythmias; sudden cardiac death; cardiac rehabilitation; exercise prescription; mobile health; preventive cardiology; personalized medicine; pediatric fitness

(This special issue belongs to the Section Sports Medicine)

Acute Myocardial Infarction: Diagnosis, Treatment, and Rehabilitation

edited by

Francesca Giordana

submission deadline 20 Mar 2027 | 9 articles | Viewed by 12228 | Submission Open

Keywords: acute myocardial infarction; coronary angioplasty; acute heart failure; cardiogenic shock; rehabilitation programs

(This special issue belongs to the Section Cardiovascular Medicine)

Acute Coronary Syndrome(ACS): From Emergency Intervention to Long-Term Prevention

edited by Marco Ciardetti and Alessio Mattesini

submission deadline 20 Mar 2027 | 4 articles | Viewed by 9230 | Submission Open

Keywords: acute coronary syndrome; primary percutaneous coronary intervention; antithrombotic therapy; secondary prevention; risk stratification

(This special issue belongs to the Section Cardiology)

Sarcopenia, Musculoskeletal, and Neuromuscular Disorders: Physical Therapy and Rehabilitation Perspectives

edited by

Do-youn Lee

and

Myoung-Kwon Kim

submission deadline 20 Mar 2027 | 2 articles | Viewed by 7583 | Submission Open

Keywords: sarcopenia; musculoskeletal diseases; neuromuscular disorders; muscle mass; low back pain; neck pain; gait and balance; physical therapy; rehabilitation medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Artificial Intelligence in Gastrointestinal Disorders: Current Updates from Theory to Clinical Practice

edited by