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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights
edited by
submission deadline 25 Feb 2027 | 4 articles | Viewed by 3734 | Submission Open
Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology
(This special issue belongs to the Section Infectious Diseases)
Geriatric Cardiology: Clinical Advances and Comprehensive Management
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 3018 | Submission Open
Keywords: geriatric assessment; management of cardiovascular disease; cardiovascular health; geriatric cardiology; frailty evaluation and management
(This special issue belongs to the Section Geriatric Medicine)
Endoscopic Therapy in Gastroesophageal Reflux Disease (GERD): Current Evidence, Techniques, and Future Perspectives
edited by Pier Alberto Testoni
submission deadline 25 Feb 2027 | 1 articles | Viewed by 2907 | Submission Open
Keywords: gastroenterology; gastroesophageal reflux disease; GERD; esophageal diseases; endoscopic therapy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Clinical Advances in Cardiac Rehabilitation: 2nd Edition
edited by
submission deadline 25 Feb 2027 | 2 articles | Viewed by 2489 | Submission Open
Keywords: cardiac rehabilitation; kinesiotherapy; psychological support; lifestyle modifications; myocardial infarction; heart failure
(This special issue belongs to the Section Cardiology)
Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions
edited by and Gaetano Cantalupo
submission deadline 25 Feb 2027 | 1 articles | Viewed by 2219 | Submission Open
Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome
(This special issue belongs to the Section Clinical Pediatrics)
Cardiometabolic Disease and Atherosclerosis: Epidemiology, Prevention, Diagnosis, and Clinical Treatment—2nd Edition
edited by and Konstantinos Mourouzis
submission deadline 25 Feb 2027 | 2 articles | Viewed by 2005 | Submission Open
Keywords: atherosclerosis; obesity; cardiometabolic disease; prevention; diabetes mellitus; endothelium; arteriosclerosis; coronary artery disease
(This special issue belongs to the Section Cardiology)
Optimizing Radiotherapy in Clinical Practice: Innovation and Outcomes
edited by , and Joseph Moore
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1657 | Submission Open
Keywords: AI-assisted automated contouring and planning; AI-assisted quality assurance; AI-assisted safety and quality improvement; radiotherapy automation; radiomics; radiotherapy error detection; personalized radiopharmaceutical therapy; theranostics; online adaptive radiotherapy; real-time treatment adaptation; image-guided radiotherapy (IGRT); AI-assisted online adaptation; personalized radiotherapy; cone-beam CT adaptation
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Updates and Current Challenges in Obstetrical Anesthesia
edited by Michael Froelich
submission deadline 25 Feb 2027 | 1 articles | Viewed by 1639 | Submission Open
Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care
(This special issue belongs to the Section Obstetrics & Gynecology)
Emerging Trends and Therapeutic Innovations in Corneal and Ocular Surface Disorders
edited by and Špela Štunf Pukl
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1415 | Submission Open
Keywords: corneal diseases; ocular surface disorders; regenerative medicine; stem cell therapy; gene therapy; nanomedicine and targeted drug delivery
(This special issue belongs to the Section Ophthalmology)
Advances in Clinical Practice and Personalized Approaches in Cardiovascular Disease—2nd Edition
edited by Joseph B. Selvanayagam and
submission deadline 25 Feb 2027 | 2 articles | Viewed by 1276 | Submission Open
Keywords: personalized medicine; cardiovascular innovations; cardiac imaging; risk assessment; multimodal imaging; therapeutic strategies; data-driven decision making; clinical outcomes; translational research
(This special issue belongs to the Section Cardiovascular Medicine)
Pediatric Sleep Health: From Pathophysiology to Quality of Life submission deadline 25 Feb 2027 | 1 articles | Viewed by 938 | Submission Open
Keywords: pediatric sleep; sleep disorders; child development; cognition; quality of life; neurodevelopment; pathophysiology; sleep health interventions; academic; sleep-disordered breathing; MRI; neuroscience
(This special issue belongs to the Section Clinical Pediatrics)
Clinical Advancements in Laparoscopic Surgery for Gastrointestinal Diseases
edited by
submission deadline 25 Feb 2027 | 1 articles | Viewed by 705 | Submission Open
Keywords: laparoscopic surgery; minimally invasive surgery; gastrointestinal diseases; colorectal cancer; gastric cancer; robotic surgery; fluorescence imaging; endoscopic-laparoscopic hybrid surgery; surgical oncology; future perspectives
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Interplay of Trauma Symptoms and Cognitive Functioning: Clinical Implications
edited by and
submission deadline 25 Feb 2027 | Viewed by 396 | Submission Open
Keywords: trauma; stress; cognitive dysfunction; clinical syndromes; clinical implications
(This special issue belongs to the Section Mental Health)
Surgical Innovations in Pediatric Orthopedics
edited by
submission deadline 25 Feb 2027 | Viewed by 386 | Submission Open
Keywords: pediatric orthopedics; surgical innovation; growth modulation; absorbable implant; 3D printing
(This special issue belongs to the Section Orthopedics)
Advances in Minimally Invasive and Endoscopic Neurosurgery
edited by Shunsuke Shibao
submission deadline 25 Feb 2027 | Viewed by 372 | Submission Open
Keywords: minimally invasive; endoscopic; keyhole; endonasal; transorbital; skull base; complications; surgical outcomes; technical innovations; robotic neurosurgery
(This special issue belongs to the Section Clinical Neurology)
Exercise, Rehabilitation, and Women’s Health: Clinical Perspectives in Sports Medicine
edited by and
submission deadline 25 Feb 2027 | Viewed by 310 | Submission Open
Keywords: women’s health; exercise intervention; rehabilitation; exercise physiology; musculoskeletal health; healthy aging; resistance training; nutrition
(This special issue belongs to the Section Clinical Rehabilitation)
Cancer Prevention and Early Detection: Epidemiological Approaches and Public Health Strategies submission deadline 25 Feb 2027 | Viewed by 303 | Submission Open
Keywords: cancer prevention; cancer screening; risk factors; cancer treatment; health information systems; cancer registry; cancer inequalities
(This special issue belongs to the Section Epidemiology & Public Health)
Pelvic Floor Disorders: Emerging Perspectives on Therapeutic Approaches submission deadline 25 Feb 2027 | Viewed by 166 | Submission Open
Keywords: pelvic floor surgery; laparoscopic approach; quality of life; pelvic organ prolapse surgery; urinary and fecal incontinence; pelvic floor disorders
(This special issue belongs to the Section Obstetrics & Gynecology)
Colorectal Surgery: New Clinical Advances, Challenges and Future Directions
edited by
submission deadline 25 Feb 2027 | Viewed by 102 | Submission Open
Keywords: colon surgery; colorectal surgery; colorectal cancer; IBD surgery; proctology; diverticular disease; diverticulitis; surgical outcomes
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Immunohematology: From Pathophysiology to Tailored Treatments submission deadline 28 Feb 2027 | 1 articles | Viewed by 4500 | Submission Open
Keywords: autoimmune cytopenia; hemophagocytic lymphohistiocytosis; inborn errors of immunity; lymphoproliferative diseases; malignancy; monoclonal antibodies; secondary immunodeficiency; vaccination
(This special issue belongs to the Section Immunology & Rheumatology)
Tumor Microenvironment—Current Status and Therapeutic Targets
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 4086 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies
(This special issue belongs to the Section Oncology)
Emerging Therapies: Clinical Trials and Insights in Psoriasis
edited by and Elżbieta Krajewska-Kułak
submission deadline 28 Feb 2027 | 3 articles | Viewed by 2826 | Submission Open
Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy
(This special issue belongs to the Section Dermatology)
Clinical Rehabilitation Strategies and Exercise for Stroke Recovery submission deadline 28 Feb 2027 | 4 articles | Viewed by 2748 | Submission Open
Keywords: stroke; stroke rehabilitation; exercise; biomarkers; rehabilitation outcomes
(This special issue belongs to the Section Clinical Rehabilitation)
Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)
edited by Aikaterini Detoraki
submission deadline 28 Feb 2027 | 1 articles | Viewed by 2060 | Submission Open
Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management
(This special issue belongs to the Section Immunology & Rheumatology)
Ergonomics and Low Back Pain: Integrative Approaches to Prevention, Assessment and Management submission deadline 28 Feb 2027 | 1 articles | Viewed by 2001 | Submission Open
Keywords: advanced in diagnostic methods; therapeutic innovations; multidisciplinary and personalized care models; prevention and rehabilitation; non-pharmacological strategies; ergonomics; biomechanics
(This special issue belongs to the Section Orthopedics)
Clinical and Epidemiological Aspects of Frailty in Acute Kidney Injury: A Spotlight on Risk Factors, Prevention and Management submission deadline 28 Feb 2027 | 1 articles | Viewed by 420 | Submission Open
Keywords: sarcopenia; AKI; frailty; amyloidosis; nutrition; epidemiology
(This special issue belongs to the Section Nephrology & Urology)
Modern Challenges in Pediatric Endocrinology: From Growth Disorders to Metabolic Dysregulation
edited by Katarzyna A. Majewska and Piotr Fichna
submission deadline 2 Mar 2027 | 2 articles | Viewed by 2508 | Submission Open
Keywords: growth hormone deficiency; growth hormone therapy; short stature; obesity; obesity complications; obesity treatment; insulin resistance; prediabetes; type 1 diabetes; type 2 diabetes; hypothyroidism; hyperthyroidism; autoimmune thyroiditis; puberty disorders
(This special issue belongs to the Section Clinical Pediatrics)
Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition
edited by Alba Scerrati and Giorgio Mantovani
submission deadline 5 Mar 2027 | 3 articles | Viewed by 3656 | Submission Open
Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis
(This special issue belongs to the Section Clinical Neurology)
Integrating Artificial Intelligence into Plastic, Reconstructive, and Aesthetic Surgery: Innovations, Challenges, and Clinical Application submission deadline 5 Mar 2027 | 2 articles | Viewed by 3391 | Submission Open
Keywords: plastic; reconstructive; aesthetic surgery; artificial intelligence; AI in plastic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment submission deadline 5 Mar 2027 | 1 articles | Viewed by 2019 | Submission Open
Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine
(This special issue belongs to the Section Cardiovascular Medicine)
Emerging Biomarkers and Novel Diagnostic Tools in Respiratory Diseases: From Bench to Bedside submission deadline 10 Mar 2027 | 4 articles | Viewed by 3053 | Submission Open
Keywords: respiratory diseases; biomarkers; non-invasive approaches; novel diagnostic tests; precision medicine; personalized therapy; disease phenotyping; diagnostic tools; functional biomarkers; imaging biomarkers; molecular biomarkers
(This special issue belongs to the Section Respiratory Medicine)
Gynecologic Cancers: Integrating Established Standards and Innovative Approaches
edited by Radu Vladareanu and Liviu Bilteanu
submission deadline 10 Mar 2027 | 2 articles | Viewed by 2857 | Submission Open
Keywords: gynecological cancers; cervical cancer; ovarian cancer; endometrial cancer; vulvar and vaginal tumors; uterine sarcoma; fertility preservation; robotic surgery; image-guided radiotherapy (IGRT); brachytherapy; proton and FLASH radiotherapy; immunotherapy; radiomics; artificial intelligence; digital twin; multimodal treatment; survivorship and quality of life
(This special issue belongs to the Section Oncology)
Echocardiography in Clinical Cardiac Imaging: Advances and Emerging Applications
edited by
submission deadline 10 Mar 2027 | 2 articles | Viewed by 2756 | Submission Open
Keywords: echocardiography; cardiac Imaging; speckle-tracking echocardiography; artificial intelligence; myocardial function; valvular heart disease; precision cardiology
(This special issue belongs to the Section Cardiology)
Radiation Therapy: Recent Trends and Future Perspectives
edited by , and Jae-won Park
submission deadline 10 Mar 2027 | 1 articles | Viewed by 907 | Submission Open
Keywords: breast reconstruction & PMRT; SBRT in oligometastatic cancer; metastasis-directed therapy; trends in modern radiotherapy techniques; palliative radiotherapy optimization; quality of life (QoL) in oncology; precision radiation oncology; artificial intelligence in radiotherapy
(This special issue belongs to the Section Oncology)
Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities
edited by and Flavio Giuseppe Biccirè
submission deadline 10 Mar 2027 | 1 articles | Viewed by 805 | Submission Open
Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy
(This special issue belongs to the Section Cardiology)
Shoulder and Elbow Diseases: Advances in Diagnosis, Treatment and Rehabilitation
edited by , and Joseph A. Abboud
submission deadline 10 Mar 2027 | 1 articles | Viewed by 497 | Submission Open
Keywords: shoulder; elbow; rotator cuff; arthritis; shoulder instability; arthroscopy; arthroplasty; tendinopathy; orthobiologics; rehabilitation; imaging
(This special issue belongs to the Section Orthopedics)
Open, Hybrid and Endovascular Repair of Visceral Artery Aneurysms: State of the Art and Clinical Perspectives
edited by , Francesco Squizzato and Vincenzo Vento
submission deadline 10 Mar 2027 | Viewed by 329 | Submission Open
Keywords: visceral artery aneurysms; endovascular treatment; open surgical repair; hybrid approach; covered stents; end-organ ischemia; long-term durability; patient selection
(This special issue belongs to the Section Vascular Medicine)
Contemporary Clinical Treatment and Rehabilitation of Scoliosis
edited by and Zbigniew Śliwiński
submission deadline 10 Mar 2027 | Viewed by 163 | Submission Open
Keywords: scoliosis; adolescent idiopathic scoliosis; spinal deformity; conservative treatment; physiotherapy; rehabilitation; physi-otherapeutic scoliosis-specific exercises (PSSE); postural control; spinal alignment; biomechanics; neuromuscular reha-bilitation; surface topography; raster stereography; gait analysis; musculoskeletal disorders
(This special issue belongs to the Section Orthopedics)
Artificial Intelligence and Eye Disease: 2nd Edition submission deadline 10 Mar 2027 | Viewed by 150 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorders
(This special issue belongs to the Section Ophthalmology)
Robotic Surgery in Urologic Diseases: Multidisciplinary Research and Clinical Practice
edited by Donato Cannoletta
submission deadline 10 Mar 2027 | Viewed by 120 | Submission Open
Keywords: robotic surgery; urological surgery; robotic platforms
(This special issue belongs to the Section Nephrology & Urology)
Clinical Diagnosis and Management of Attention-Deficit/Hyperactivity Disorder (ADHD) submission deadline 10 Mar 2027 | Viewed by 116 | Submission Open
Keywords: ADHD; randomized controlled trials; clinical research; neurodevelopmental disorders; cognitive function; prefrontal cortex; diagnostic methods; therapeutic interventions; evidence-based medicine
(This special issue belongs to the Section Mental Health)
Recent Clinical Advances in Percutaneous Coronary Intervention
edited by and Luke Pickup
submission deadline 15 Mar 2027 | 2 articles | Viewed by 7072 | Submission Open
Keywords: complex PCI; calcium modification; left main stem; stent; coronary artery disease; atherectomy; mechanical circula-tory support device; Impella; DCB; intra-coronary imaging; IVUS; OCT
(This special issue belongs to the Section Cardiology)
Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs submission deadline 15 Mar 2027 | 3 articles | Viewed by 4984 | Submission Open
Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care
(This special issue belongs to the Section Cardiology)
Recent Clinical Advances in Esophageal Surgery
edited by , James Tankel and Harbi Khalayleh
submission deadline 15 Mar 2027 | 4 articles | Viewed by 4050 | Submission Open
Keywords: esophageal surgery; minimally invasive surgery; esophageal cancer; robotic surgery; endoscopic resection; benign esophageal disorders; paraesophageal hernia; anti-reflux surgery; motility disorders
(This special issue belongs to the Section General Surgery)
Visualizing Cardiac Function: Advances in Modern Imaging Diagnostics
edited by Dafni Charisopoulou and
submission deadline 15 Mar 2027 | 3 articles | Viewed by 3936 | Submission Open
Keywords: cardiac imaging; echocardiography; coronary artery disease; valve disease; heart failure
(This special issue belongs to the Section Cardiology)
Understanding Dermatitis: Symptoms and Effective Treatment Options
edited by and Shinichi Imafuku
submission deadline 15 Mar 2027 | 1 articles | Viewed by 3738 | Submission Open
Keywords: dermatitis; atopic dermatitis; psoriasis; prurigo; JAK inhibitors; real world data
(This special issue belongs to the Section Dermatology)
Redefining Hemodialysis: Beyond Diffusion to Precision Therapy
edited by and Sagar Nigwekar
submission deadline 15 Mar 2027 | 2 articles | Viewed by 3250 | Submission Open
Keywords: digitalized medical governance; precision dialysis; convective clearance; advanced membranes; hemodynamic stability; artificial intelligence; digital biomarkers; personalized prescription; cardiovascular protection; patient-reported outcome measures; clinical trial emulation
(This special issue belongs to the Section Nephrology & Urology)
Minimally Invasive Cardiothoracic Surgery: Current Status and Future Perspectives submission deadline 15 Mar 2027 | 3 articles | Viewed by 1861 | Submission Open
Keywords: aortic-preserving surgery; hybrid cardiovascular surgery; autologous tissue repair; enhanced recovery after surgery; minimally invasive cardiac surgery (MICS); geriatric surgery
(This special issue belongs to the Section Cardiovascular Medicine)
Multiple Sclerosis: Current Diagnosis, Treatment, and Future Options
edited by Przemysław Puz, and
submission deadline 15 Mar 2027 | 3 articles | Viewed by 1733 | Submission Open
Keywords: multiple sclerosis; magnetic resonance imaging (MRI); remyelination; biomarkers; neuroprotection
(This special issue belongs to the Section Clinical Neurology)
Clinical Updates on Epilepsy Research submission deadline 15 Mar 2027 | 2 articles | Viewed by 1505 | Submission Open
Keywords: epilepsy; autoimmune epilepsy; neural autoantibodies; seizure disorders; experimental epilepsy models; animal studies; neuronal excitability; immunotherapy; predictive scoring systems; epilepsy biomarkers
(This special issue belongs to the Section Clinical Neurology)
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