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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Updates on Metabolic and Bariatric Surgery
edited by Maria-Jose Barahona
submission deadline 27 Dec 2025 | 1 articles | Viewed by 694 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; weight loss; obesity treatment; metabolic disorders
(This special issue belongs to the Section General Surgery)
Atrial Fibrillation Rhythm Management: Outcomes, Innovations, and Future Directions
edited by Roberto Scacciavillani and Gemma Pelargonio
submission deadline 28 Dec 2025 | 5 articles | Viewed by 4774 | Submission Open
Keywords: atrial fibrillation; catheter ablation; radiofrequency; cryoablation; pulsed field ablation; cardioneuroablation; left bundle branch area pacing
(This special issue belongs to the Section Cardiology)
Lung Transplantation: Current Strategies and Future Directions
edited by Omer Senbaklavaci and György Lang
submission deadline 28 Dec 2025 | 1 articles | Viewed by 1412 | Submission Open
Keywords: lung transplantation; graft optimization; immunosuppression; artificial lung; xenotransplantation; end-stage lung disease; donor lung preservation; chronic lung allograft dysfunction
(This special issue belongs to the Section Respiratory Medicine)
Imaging and Molecular Biomarkers: The New Approach to Degenerative Retinal Diseases submission deadline 28 Dec 2025 | 1 articles | Viewed by 161 | Submission Open
Keywords: ophthalmology; degenerative retinal diseases; imaging biomarkers; multimodal imaging; OCT; OCT angiography; molecular biomarkers; precision medicine; translational ophthalmic research
(This special issue belongs to the Section Ophthalmology)
Managements of Venous Thromboembolism submission deadline 29 Dec 2025 | 3 articles | Viewed by 1830 | Submission Open
Keywords: venous thromboembolism; deep vein thrombosis; pulmonary embolism; anticoagulation therapy; direct oral anticoagulants; risk stratification; bleeding risk; artificial intelligence; personalized medicine
(This special issue belongs to the Section Vascular Medicine)
Pediatric Neurosurgery: Clinical Advances in Diagnostics and Perioperative Management
edited by Kara Leigh Krajewski and Ulrich-Wilhelm Thomale
submission deadline 29 Dec 2025 | 1 articles | Viewed by 717 | Submission Open
Keywords: rapid sequence MRI; intraoperative MRI; perioperative management; neurocritical care; patient selection; M&M conferences; surgical team; rehabilitation
(This special issue belongs to the Section Clinical Pediatrics)
Current Concepts and Clinical Application of Echocardiography
edited by
submission deadline 29 Dec 2025 | Viewed by 160 | Submission Open
Keywords: echocardiography; clinical echocardiography; advanced echocardiography; cardiovascular disease; clinical cardiology
(This special issue belongs to the Section Cardiology)
Treatment of Atopic Dermatitis
edited by and Ricardo Ruíz-Villaverde
submission deadline 30 Dec 2025 | 6 articles | Viewed by 19297 | Submission Open
Keywords: atopic dermatitis; eczema; topical treatment; systemic treatment; biological therapy; JAK inhibitor; antipruritic treatment
(This special issue belongs to the Section Dermatology)
Chronic Pain: Non-Pharmacological Treatments and Rehabilitation Strategies
edited by Matteo Ponzano
submission deadline 30 Dec 2025 | 8 articles | Viewed by 12790 | Submission Open
Keywords: pain; neuropathies; musculoskeletal health; biopsychosocial management; physical therapy; cognitive behavioral therapies
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies
edited by
submission deadline 30 Dec 2025 | 7 articles | Viewed by 10773 | Submission Open
Keywords: endometriosis; ovarian endometrioma; polycystic ovary syndrome; reproductive health; cervical; postmenopausal women; hormone replacement therapy; sarcopenia
(This special issue belongs to the Section Obstetrics & Gynecology)
Current Challenges in Inflammatory Bowel Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 7047 | Submission Open
Keywords: ulcerative colitis; Chron’ s disease; inflammatory bowel disease; colitis-associated cancer; novel pharmaceutics
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The State of Breast Reconstruction: From Surgical Methods to Patient-Reported Outcomes
edited by Geoffroy C. Sisk
submission deadline 30 Dec 2025 | 2 articles | Viewed by 4439 | Submission Open
Keywords: breast reconstruction; implant based; autologous tissue; oncoplastic; breast cancer reconstruction; patient-reported outcomes; acellular dermal matrix; prepectoral; lymphedema; microsurgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Recent Advances in Glaucoma Management
edited by Bogomil Voykov
submission deadline 30 Dec 2025 | 3 articles | Viewed by 4303 | Submission Open
Keywords: glaucoma; MIGS; microinvasive glaucoma surgery; quality of life; sustained-release drugs; wound healing modula-tion; intraocular pressure; intraocular pressure-lowering medication; microstent-supported bleb surgery; MIBS; neuroprotection
(This special issue belongs to the Section Ophthalmology)
Clinical Management for Coronary Artery Disease and Revascularization
edited by Mohammad Reza Movahed
submission deadline 30 Dec 2025 | 3 articles | Viewed by 3739 | Submission Open
Keywords: coronary artery disease; coronary syndrome; stenting; revascularization; cardiovascular
(This special issue belongs to the Section Cardiovascular Medicine)
Advancements in Emergency Medicine Practices and Protocols
edited by Vincenzo G. Menditto and Beatrice Gasperini
submission deadline 30 Dec 2025 | 4 articles | Viewed by 3558 | Submission Open
Keywords: emergency; pulmonary embolism; trauma; management; guidelines; frailty; emergency department observation unit
(This special issue belongs to the Section Emergency Medicine)
Ultrasound-Guided Biopsy of Gynecologic Tumors: Technique and Clinical Application
edited by and Alexandros Daponte
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2057 | Submission Open
Keywords: ultrasound-guided biopsy; gynecologic tumors; ovarian cancer; biopsy technique; precision diagnosis; endometrial lesions
(This special issue belongs to the Section Obstetrics & Gynecology)
Augmented and Artificial Intelligence in Ophthalmology
edited by Tina Felfeli, Edsel B. Ing, David Jose Mathew and Michael Balas
submission deadline 30 Dec 2025 | 2 articles | Viewed by 1995 | Submission Open
Keywords: artificial intelligence; ophthalmology; eye health; vision; teleophthalmology
(This special issue belongs to the Section Ophthalmology)
Inflammatory Bowel Disease: From Diagnosis to Treatment—2nd Edition
edited by Laura Maria Minordi and Daniela Pugliese
submission deadline 30 Dec 2025 | 2 articles | Viewed by 1776 | Submission Open
Keywords: Crohn’ s disease; ulcerative colitis; imaging; endoscopy; complications; advanced therapies; surgery
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Shoulder Arthroplasty: Clinical Advances and Future Perspectives
edited by Vani J. Sabesan
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1040 | Submission Open
Keywords: shoulder arthroplasty; reverse shoulder arthroplasty; perioperative optimization; multimodal pain management; rehabilitation protocols; outpatient shoulder arthroplasty; implant longevity; complication management; disparities in outcomes
(This special issue belongs to the Section Orthopedics)
Cerebral Palsy: Recent Advances in Clinical Management
edited by Laurie J. Glader and M. Wade Shrader
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1009 | Submission Open
Keywords: cerebral palsy; pediatric; neurology; complex care; clinical management
(This special issue belongs to the Section Clinical Pediatrics)
Autoimmune Diseases and Multisystem Inflammation: Pathophysiology and Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 967 | Submission Open
Keywords: autoimmune diseases; cardiovascular diseases; cutaneous diseases; gastrointestinal diseases; pulmonary diseases; renal diseases; systemic manifestation; rheumatoid arthritis; systemic lupus erythematosus; vasculitis
(This special issue belongs to the Section Immunology & Rheumatology)
Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance
edited by Radu Andy Sascau and
submission deadline 30 Dec 2025 | 1 articles | Viewed by 913 | Submission Open
Keywords: cardiac magnetic resonance; cardiomyopathy; tissue characterization; stress perfusion; 4D flow; heart failure; ischemic heart disease; multi-modality imaging; valvular heart disease; T1 mapping; T2 mapping; myocarditis
(This special issue belongs to the Section Cardiovascular Medicine)
Joint Repair and Replacement: Current Challenges and Opportunities
edited by Bartosz Gonera and Kacper Ruzik
submission deadline 30 Dec 2025 | 1 articles | Viewed by 869 | Submission Open
Keywords: orthopedic biomechanics; knee injuries; joint replacement; anterior cruciate ligament; arthroscopy; sports medicine; prosthetic implants
(This special issue belongs to the Section Orthopedics)
Innovations and Challenges in Cardiovascular Surgery
edited by Marc Leon
submission deadline 30 Dec 2025 | 1 articles | Viewed by 819 | Submission Open
Keywords: cardiovascular surgery; minimally invasive surgery; robotic surgery; hybrid; 3D printing; artificial intelligence; mechanical circulatory support; heart transplantation; valve disease; aortic dissection; ischemic heart disease; heart failure
(This special issue belongs to the Section Cardiovascular Medicine)
Regional Anesthesia and Pain Management: Mastering Clinical Art for Optimal Patient Satisfaction
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 665 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided nerve blocks; fascial plane blocks; multimodal analgesia; postoperative analgesia; chronic pain management; opioid-sparing strategies; non-opioid analgesics; patient satisfaction; anesthesia techniques; perioperative care; pain interventions; nerve block techniques; clinical outcomes
(This special issue belongs to the Section Anesthesiology)
State of the Art in Management of Aortic Aneurysm in Vascular Surgery
edited by Rana O. Afifi and Eanas Yassa
submission deadline 30 Dec 2025 | 1 articles | Viewed by 590 | Submission Open
Keywords: aortic dissection; complex aortic surgery; endovascular aortic repair; aortic imaging; aortic aneurysm
(This special issue belongs to the Section Vascular Medicine)
Interventional Cardiology: Recent Developments and Future Challenges
edited by and George Kassimis
submission deadline 30 Dec 2025 | Viewed by 231 | Submission Open
Keywords: percutaneous coronary intervention (PCI); drug-eluting stents (DES); high risk percutaneous coronary intervention (CHIP); chronic total occlusions (CTO); intravascular imaging (IVUS; OCT); coronary physiology (FFR; iFR); antiplatelet therapy; complex coronary interventions; mechanical circulatory support (MCS)
(This special issue belongs to the Section Cardiology)
Advancing Neonatal Seizures and Epilepsy: New Perspectives and Interventions
edited by and Gaetano Cantalupo
submission deadline 30 Dec 2025 | Viewed by 209 | Submission Open
Keywords: neonatal seizures; neonatal epilepsy; neonatal EEG; automated EEG analysis; neonatal brain monitoring; genetic; precision medicine; genetic epilepsies; genome; exome
(This special issue belongs to the Section Clinical Pediatrics)
Pulmonary Critical Care: Integrating Bedside Physiology and Advanced Monitoring in the Management of Severe Respiratory Diseases
edited by
submission deadline 30 Dec 2025 | Viewed by 187 | Submission Open
Keywords: lung monitoring; ARDS; ARF; biomarkers; lung physiology; pneumonia; lung ultrasound; artificial intelligence; COPD; EIT
(This special issue belongs to the Section Respiratory Medicine)
New Developments in Hematopoietic Stem Cell Transplantation in Clinical Practice
edited by Mattia Algeri
submission deadline 30 Dec 2025 | Viewed by 157 | Submission Open
Keywords: hematopoietic stem cell transplantation; graft-versus-host disease (GVHD); conditioning regimens; immune reconstitution; donor selection; post-transplant complications; long-term survivorship
(This special issue belongs to the Section Hematology)
Plastic and Reconstructive Surgery of the Face: Chances and Challenges
edited by and Bogdan Andrei Suciu
submission deadline 30 Dec 2025 | Viewed by 154 | Submission Open
Keywords: facial plastic surgery; facial reconstruction procedures; tissue regeneration; esthetic facial procedures; digital imaging and customization; biomaterials in reconstructive surgery; flap surgery innovations; microsurgical precision techniques
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Advances in Antiphospholipid Syndrome (APS)
edited by
submission deadline 30 Dec 2025 | Viewed by 154 | Submission Open
Keywords: thrombosis; pregnancy; antiphospholipid syndrome; lupus anticoagulant; antiphospholipid antibodies
(This special issue belongs to the Section Immunology & Rheumatology)
Current and Emerging Treatment Options in Colorectal Cancer
edited by Michael Osseis
submission deadline 30 Dec 2025 | Viewed by 137 | Submission Open
Keywords: colorectal cancer (CRC); emerging treatment options; targeted therapies; new surgical technologies; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Challenges and Opportunities in Colorectal Cancer
edited by
submission deadline 30 Dec 2025 | Viewed by 118 | Submission Open
Keywords: colorectal cancer; screening; staging; treatment of colorectal cancer (CRC); high-risk patients; fecal occult testing; colonoscopy; lynch syndrome
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cutting-Edge Technologies and Unconventional Therapies in Heart Failure
edited by and Pablo Díez-Villanueva
submission deadline 30 Dec 2025 | Viewed by 107 | Submission Open
Keywords: heart failure; new technologies; artificial intelligence; treatment; advanced heart failure
(This special issue belongs to the Section Cardiology)
Advances in Diagnosis and Treatment of Amyloidosis
edited by Michael Rosenzweig
submission deadline 31 Dec 2025 | 9 articles | Viewed by 20709 | Submission Open
Keywords: amyloidosis; transthyretin (TTR); autologous stem cell transplantation (ASCT); chemotherapy; immunotherapy; cardiomyopathy; nephropathy; neuropathy
(This special issue belongs to the Section Cardiology)
Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions
edited by Cosmin Sinescu, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 18340 | Submission Open
Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Symptoms and Treatment of Parkinson’s Disease
edited by and Nikolaos Papagiannakis
submission deadline 31 Dec 2025 | 5 articles | Viewed by 15984 | Submission Open
Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies
(This special issue belongs to the Section Clinical Neurology)
Oral Health and Dental Care: Current Advances and Future Options
edited by , and Alessia Bramanti
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6223 | Submission Open
Keywords: oral health; dental care; technologies; innovation; dental materials
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Challenges in the Field of Psycho-Oncology: Insights from Research
edited by , , Tânia Brandão and Ricardo Teixeira
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6200 | Submission Open
Keywords: cancer; psycho-oncology; survivorship care; psychological distress; quality of life; sustainable development goals; global health; health disparities
(This special issue belongs to the Section Oncology)
New Trends and Challenges in Critical Care Management
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3690 | Submission Open
Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19
(This special issue belongs to the Section Intensive Care)
Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3680 | Submission Open
Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension
(This special issue belongs to the Section Respiratory Medicine)
Acute Kidney Injury: Latest Advances and Prospects
edited by and Kianoush Kashani
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3449 | Submission Open
Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach
(This special issue belongs to the Section Nephrology & Urology)
Evidence-Based Diagnosis and Clinical Management of Low Back Pain submission deadline 31 Dec 2025 | 2 articles | Viewed by 3394 | Submission Open
Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Updates on Knee and Hip Arthroplasty
edited by Amarildo Smakaj and Elena Gasbarra
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3051 | Submission Open
Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening
(This special issue belongs to the Section Orthopedics)
Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2885 | Submission Open
Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy
(This special issue belongs to the Section Oncology)
Clinical Therapeutic Advances in Bone Fractures
edited by Simon Hackl and Eva Simone Steinhausen
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2788 | Submission Open
Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection
(This special issue belongs to the Section Orthopedics)
Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine submission deadline 31 Dec 2025 | 2 articles | Viewed by 2465 | Submission Open
Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Children and Adolescent Mood Disorders: Risks and Treatment submission deadline 31 Dec 2025 | Viewed by 1491 | Submission Open
Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs
(This special issue belongs to the Section Mental Health)
Pregnancy Complications and Maternal-Perinatal Outcomes
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 1464 | Submission Open
Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound
(This special issue belongs to the Section Obstetrics & Gynecology)
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