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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Therapeutic Advances of Mitral Regurgitation

edited by Angelo Squeri

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1312 | Submission Open

Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography

(This special issue belongs to the Section Cardiovascular Medicine)

Current and Emerging Treatment Options in Chronic Liver Diseases

edited by Chandana B. Herath and Michael Praktiknjo

submission deadline 28 Feb 2026 | 2 articles | Viewed by 1239 | Submission Open

Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advances and Clinical Outcomes of Pediatric Endocrinology

edited by

Gerdi Tuli

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1026 | Submission Open

Keywords: congenital hypothyroidism; rare bone diseases; growth hormone deficiency; endocrine sequelae of cancer treatments; disorders of sex development; central diabetes insipidus; gender dysphoria

(This special issue belongs to the Section Clinical Pediatrics)

Current Trends in Urogynecology: 3rd Edition

edited by

Tomasz Rechberger

submission deadline 28 Feb 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: urogynecological surgery (uterovaginal prolapse; urinary incontinence; fistulas); OAB; pharmacology; physiotherapy; LUTS

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Therapies: Clinical Trials and Insights in Psoriasis

edited by

Beata Kowalewska

and Elżbieta Krajewska-Kułak

submission deadline 28 Feb 2026 | 1 articles | Viewed by 562 | Submission Open

Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy

(This special issue belongs to the Section Dermatology)

Inflammatory Bowel Disease: Clinical Pathogenesis and Management Strategies

edited by

Francesco Colombo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 524 | Submission Open

Keywords: epithelial barrier dysfunction; intestinal microbiota dysbiosis; minimally invasive surgery in IBDs; disease monitoring; perianal disease treatment; surgical complications in IBD; prehabilitation; stoma formation and management; timing of surgery in IBDs; risk stratification for IBD surgery; patient-reported outcomes post-surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Epidemiology Associated Risks and Intervention Strategies of Childhood Obesity

edited by

María M. Morales Suárez-Varela

Antonio Castillo-Paredes

and Eduardo Guzmán-Muñoz

submission deadline 28 Feb 2026 | Viewed by 342 | Submission Open

Keywords: childhood obesity; overweight; eating disorders; nutritional programs; psychological interventions; physical activity exercise; sport; physical well-being; mental well-being; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Hysterectomy Surgery—Recent Developments and Emerging Trends

edited by

Anastasia Prodromidou

Themos Grigoriadis

and Dimitrios Zacharakis

submission deadline 28 Feb 2026 | Viewed by 220 | Submission Open

Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care

(This special issue belongs to the Section Obstetrics & Gynecology)

Recent Advances in Prevention, Management, and Rehabilitation of Head and Neck Injuries

edited by

Giovanni Barassi

, Pier Enrico Gallenga and

Roberta Di Pietro

submission deadline 5 Mar 2026 | 2 articles | Viewed by 3253 | Submission Open

Keywords: neck injuries; whiplash injuries; head injuries; concussion; neck pain; cervicalgia; post-concussive syndrome; post-concussive symptoms; vision disorders; hearing disorders; emergency care; emergency therapies; physical medicine and rehabilitation; musculoskeletal rehabilitation; sports medicine

(This special issue belongs to the Section Sports Medicine)

Sleep and Circadian Rhythms in Patients with Physical and Mental Disorders

edited by

Argyro Pachi

Ioannis Ilias

and

Athanassios Tselebis

submission deadline 10 Mar 2026 | 5 articles | Viewed by 16287 | Submission Open

Keywords: sleep; circadian rhythms; insomnia; depression; physical health; mental health; circadian medicine; chronotype; chronotherapy; melatonin

(This special issue belongs to the Section Mental Health)

Clinical Advancements in Kidney Transplantation

edited by Louise Benning

submission deadline 10 Mar 2026 | 6 articles | Viewed by 12933 | Submission Open

Keywords: kidney transplantation; immunosuppression; immune monitoring; biomarkers; rejection; machine perfusion; graft survival

(This special issue belongs to the Section Nephrology & Urology)

New Insights in the Endovascular Treatment of Aortic Type A Dissection

edited by

Markus Kofler

submission deadline 10 Mar 2026 | 2 articles | Viewed by 5379 | Submission Open

Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection

(This special issue belongs to the Section Cardiology)

Clinical Diagnosis and Management of Corneal Diseases

edited by

Eirini-Kanella Panagiotopoulou

Georgios Labiris

and Panagiota Ntonti

submission deadline 10 Mar 2026 | 2 articles | Viewed by 1481 | Submission Open

Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty

(This special issue belongs to the Section Ophthalmology)

Bladder Cancer: Clinical Diagnosis and Treatment

edited by Răzvan Bardan and

Bogdan Petrut

submission deadline 10 Mar 2026 | 1 articles | Viewed by 626 | Submission Open

Keywords: bladder cancer; non-muscle invasive bladder cancer (NMIBC); muscle-invasive bladder cancer (MIBC); urinary biomarkers; immunotherapy; risk stratification; surgical treatment; AI in urology; personalized medicine

(This special issue belongs to the Section Nephrology & Urology)

Current Trends and Future Challenges in Coronary Artery Disease

edited by Federica Agnello

submission deadline 10 Mar 2026 | 1 articles | Viewed by 259 | Submission Open

Keywords: coronary artery disease; cardiovascular prevention; coronary computed tomography angiography (CCTA); CT-derived fractional flow reserve (FFR-CT); intracoronary imaging; residual risk; functional assessment; artificial intelligence in cardiology; percutaneous coronary intervention

(This special issue belongs to the Section Cardiology)

Prevention, Diagnosis, and Clinical Treatment of Corneal Diseases

edited by Rossella Anna Maria Colabelli-Gisoldi and

Fabio Scarinci

submission deadline 10 Mar 2026 | 1 articles | Viewed by 221 | Submission Open

Keywords: dry eye disease; cornea transplant; stem cell therapy; corneal imaging; cornea disease; deep anterior lamellar keratoplasty; descemet stripping automated endothelial keratoplasty; descemet membrane endothelial keratoplasty; keratoconus; eye bank

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Minimally Invasive Gynecologic Surgery

edited by

Giulia Bonavina

submission deadline 10 Mar 2026 | Viewed by 128 | Submission Open

Keywords: minimally invasive gynecological surgery; MIGS; laparoscopy; robotics; natural orifice transluminal endoscopic surgery; endometriosis; endometrial cancer; vaginal hysterectomy; leiomyomas; fibroids; vNOTES

(This special issue belongs to the Section Obstetrics & Gynecology)

Neurological Injury After Cardiac Arrest: Mechanisms, Prognostication, and Emerging Therapies

edited by

Marco Mion

and Nikos Gorgoraptis

submission deadline 10 Mar 2026 | Viewed by 107 | Submission Open

Keywords: cardiac arrest; hypoxic– ischaemic brain injury; neuroprognostication; neuroprotection; biomarkers; targeted tem-perature management; multimodal monitoring; neurorehabilitation

(This special issue belongs to the Section Emergency Medicine)

Latest Advances and Prospects in Valvular Heart Diseases

edited by Konstantinos M. Lampropoulos

submission deadline 10 Mar 2026 | Viewed by 95 | Submission Open

Keywords: valvular heart disease (VHD); diagnostic advances; minimally invasive surgery; transcatheter valve interventions; valve repair techniques; patient management strategies

(This special issue belongs to the Section Cardiology)

Rehabilitation and Management of Stroke

edited by Thomas Platz

submission deadline 15 Mar 2026 | 6 articles | Viewed by 23318 | Submission Open

Keywords: stroke; rehabilitation; evidence; implementation; neurology; neurorehabilitation

(This special issue belongs to the Section Clinical Rehabilitation)

Targeted Diagnosis and Treatment of Coronary Artery Disease: 2nd Edition

edited by

Antonio Nenna

submission deadline 15 Mar 2026 | 3 articles | Viewed by 6849 | Submission Open

Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis

(This special issue belongs to the Section Cardiology)

Updates on Brain Tumors: Diagnosis and Treatment

edited by Jigisha P. Thakkar and

Rimas V Lukas

submission deadline 15 Mar 2026 | 1 articles | Viewed by 5840 | Submission Open

Keywords: primary brain tumors; glioblastoma; IDH mutant glioma; meningioma; brain metastases; leptomeningeal disease

(This special issue belongs to the Section Clinical Neurology)

Clinical Applications of Endoscopic Technology in Gastroenterology

edited by

Naim Abu-Freha

submission deadline 15 Mar 2026 | 2 articles | Viewed by 2800 | Submission Open

Keywords: gastroscopy; colonoscopy; sedation; polyps; early detection; endoscopic submucosal dissection; mucosal resection; artificial intelligence in endoscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Oral Hygiene: Updates and Clinical Progress: 2nd Edition

edited by

Frédéric Denis

submission deadline 15 Mar 2026 | 3 articles | Viewed by 2306 | Submission Open

Keywords: periodontal disease; dental caries; plaque control; oral hygiene practices; gingivitis; dental prophylaxis; oral health education

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Novel Developments in Dental and Oral Surgery

edited by

Antonio Rapani

Teresa Lombardi

and

Federico Berton

submission deadline 15 Mar 2026 | 2 articles | Viewed by 2044 | Submission Open

Keywords: guided bone regeneration; dental implant osseointegration; laser dentistry; maxillofacial reconstruction; sinus lift techniques

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Robot-Assisted Surgery: Current Trends and Future Perspectives

edited by

Francisco Miguel Sanchez-Margallo

and

Juan Alberto Sánchez-Margallo

submission deadline 15 Mar 2026 | 1 articles | Viewed by 1689 | Submission Open

Keywords: robot-assisted surgery; surgical robotics; artificial intelligence in surgery; augmented reality; surgical ergonomics; minimally invasive surgery; haptic feedback

(This special issue belongs to the Section General Surgery)

Thyroid Disease: Updates from Diagnosis to Treatment: 2nd Edition

edited by

Luca Giovanella

and

Petra Petranović Ovčariček

submission deadline 15 Mar 2026 | 2 articles | Viewed by 1611 | Submission Open

Keywords: autoimmune thyroid diseases; thyroiditis; thyroid cancers; PET/CT; hyperthyroidism

(This special issue belongs to the Section Endocrinology & Metabolism)

Risk Prediction in Mechanical Circulatory Support (MCS) and Cardiac Transplantation

edited by

Nandini Nair

submission deadline 15 Mar 2026 | 1 articles | Viewed by 1336 | Submission Open

Keywords: advanced heart failure; mechanical circulatory support (MCS); cardiac transplantation; heart transplantation; risk prediction

(This special issue belongs to the Section Cardiology)

Latest Advances in Thoracic Surgery: 2nd Edition

edited by

Hideki Ujiie

submission deadline 15 Mar 2026 | 2 articles | Viewed by 1251 | Submission Open

Keywords: lung cancer; surgical oncology; robotic surgery; thoracic surgery; lung diseases; minimally invasive surgery

(This special issue belongs to the Section Respiratory Medicine)

Current Challenges and Future Directions in Lung Resections in Thoracic Surgery

edited by Vasileios K. Kouritas and Emmanuel Michael Kefaloyannis

submission deadline 15 Mar 2026 | 1 articles | Viewed by 1098 | Submission Open

Keywords: robotic-assisted thoracic surgery (RATS); robotic; sublobar; 3D; emphysema; endobronchial valves; lung volume reduction surgery (LVRS); high-risk; AI; research; lung; screening; lung cancer

(This special issue belongs to the Section General Surgery)

Research Progress in Kawasaki Disease: Epidemiology, Treatment and Cardiovascular Outcomes

edited by Andre Jakob

submission deadline 15 Mar 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: Kawasaki disease; immune pathogenesis; immunomodulatory treatment; coronary artery pathology; cardiovascular outcomes

(This special issue belongs to the Section Clinical Pediatrics)

Cardiovascular Disease in MASLD: New Advances in Therapeutic Targets

edited by

Alfredo Caturano

submission deadline 15 Mar 2026 | Viewed by 137 | Submission Open

Keywords: MASLD; cardiovascular disease (CVD); metabolic dysfunction; steatotic liver disease; insulin resistance; dyslipidemia; atherosclerosis; inflammation; GLP-1 receptor agonists; SGLT2 inhibitors; lipid-lowering therapies; cardiometabolic risk; clinical trials; therapeutic targets

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Diagnosis and Treatment of Uveitis

edited by

Nenad Vukojević

submission deadline 15 Mar 2026 | Viewed by 119 | Submission Open

Keywords: uveitis; intraocular tumors; medical retina; pediatric retina

(This special issue belongs to the Section Ophthalmology)

Advances in Antithrombotic Therapy in Cardiovascular Medicine

edited by Daniele Giacoppo and Antonio Greco

submission deadline 15 Mar 2026 | Viewed by 109 | Submission Open

Keywords: anticoagulant; antiplatelet; antithrombotic therapy; cardiovascular pharmacotherapy; coronary artery disease; in-flammation; lipid-lowering drugs; lipid metabolism; residual cardiovascular risk; thrombosis

(This special issue belongs to the Section Cardiovascular Medicine)

Urologic Oncology: From Diagnosis to Treatment

edited by Matteo Vittori and Valerio Iacovelli

submission deadline 15 Mar 2026 | Viewed by 101 | Submission Open

Keywords: prostate cancer; kidney cancer; bladder cancer; testicular cancer

(This special issue belongs to the Section Nephrology & Urology)

Early-Stage Non-Small Cell Lung Cancer: Diagnostic Challenges and Therapeutic Innovations

edited by Efimia Boutsikou, Georgia F. Hardavella and

Kelly Domvri

submission deadline 15 Mar 2026 | Viewed by 89 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); early-stage lung cancer; diagnostic imaging; stereotactic ablative radiotherapy (SABR); molecular profiling; adjuvant targeted therapy; immunotherapy in early-stage NSCLC

(This special issue belongs to the Section Respiratory Medicine)

Progress in Clinical Diagnosis and Therapy in Ophthalmology

edited by

Edward Wylegala

submission deadline 16 Mar 2026 | 3 articles | Viewed by 1684 | Submission Open

Keywords: ophthalmic imaging; artificial intelligence in ophthalmology; retinal diseases; corneal transplantation; glaucoma diagnostics; ocular therapeutics; personalized medicine; ocular genetics

(This special issue belongs to the Section Ophthalmology)

Movement Analysis in Rehabilitation

edited by Paola Contessa

submission deadline 16 Mar 2026 | Viewed by 118 | Submission Open

Keywords: clinical biomechanics; engineering methods; human movement; motor control; muscle force; musculoskeletal disorders; neuromuscular diseases; posture and balance; rehabilitation

(This special issue belongs to the Section Orthopedics)

Clinical Practices of Critical Care in Emergency Medicine

edited by

Gianni Turcato

submission deadline 17 Mar 2026 | 1 articles | Viewed by 1320 | Submission Open

Keywords: non-invasiveness; non-ICU critically ill patient; organ replacement versus organ support; prognostic assessment; vasopressors; inotropes; and vasoactive agents; emergency department

(This special issue belongs to the Section Intensive Care)

Neurocritical Care: Clinical Advances and Practice Updates: 2nd Edition

edited by Ali Seifi

submission deadline 18 Mar 2026 | Viewed by 208 | Submission Open

Keywords: traumatic brain injury (TBI); intracerebral hemorrhage (ICH); neurocritical care practice; neurocritical care; neurosurgical innovations; artificial intelligence; medical device and technology innovation in neurocritical care; stroke management; subarachnoid hemorrhage (SAH); status epilepticus

(This special issue belongs to the Section Clinical Neurology)

Clinical Perspectives in Stroke Rehabilitation

edited by Krystyna Jaracz,

Karolina Filipska-Blejder

and Robert Ślusarz

submission deadline 20 Mar 2026 | 9 articles | Viewed by 27080 | Submission Open

Keywords: stroke; clinical perspectives; therapy; functional outcome predictors; rehabilitation; quality of life

(This special issue belongs to the Section Clinical Rehabilitation)

Sleep in Neurology—Sleep Disorders and Dysfunction of the Nervous System

edited by

Mariusz Siemiński

submission deadline 20 Mar 2026 | 6 articles | Viewed by 20900 | Submission Open

Keywords: sleep; neurology; insomnia; restless leg syndrome; REM sleep behavior disorder; parasomnia; somnambulism; neurodegenerative disorders; brain injury; sleep-related movement disorders

(This special issue belongs to the Section Clinical Neurology)

Current Trends in Implant Dentistry

edited by Marco Toia

submission deadline 20 Mar 2026 | 7 articles | Viewed by 19331 | Submission Open

Keywords: digital implant planning; osseointegration; guided surgery (static and dynamic); bone regeneration; zygomatic and pterygoid implants; 3D previsualization; craniofacial analysis; peri-implant diseases; immediate loading

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Musculoskeletal Rehabilitation and Regenerative Medicine: Current Challenges and New Perspectives

edited by

Raffaele Vitiello

and Gianpaolo P. Ronconi

submission deadline 20 Mar 2026 | 5 articles | Viewed by 19072 | Submission Open

Keywords: musculoskeletal diseases; rehabilitation; enhanced recovery after surgery; chronic pain; disability; regenerative medicine; personalized medicine

(This special issue belongs to the Section Clinical Rehabilitation)

Moving Forward to New Trends in Pulmonary Diseases

edited by

Ramona Cioboata

and

Costin Teodor Streba

submission deadline 20 Mar 2026 | 6 articles | Viewed by 18063 | Submission Open

Keywords: pulmonary tuberculosis; chronic obstructive airway diseases; bronchiectasis; COVID-19; sleep apnea; ultrasound; lung cancer; pulmonary rehabilitation

(This special issue belongs to the Section Respiratory Medicine)

Risk Prediction for Gynecological Cancer

edited by

Federico Ferrari

submission deadline 20 Mar 2026 | 9 articles | Viewed by 16828 | Submission Open

Keywords: cervical cancer; endometrial cancer; tubo-ovarian cancer; diagnosis; treatment; prognosis

(This special issue belongs to the Section Obstetrics & Gynecology)

Anterior Cruciate Ligament (ACL) Injuries: Clinical Treatment and Rehabilitation

edited by Young-Jin Seo

submission deadline 20 Mar 2026 | 9 articles | Viewed by 14692 | Submission Open

Keywords: anterior cruciate ligament (ACL); reconstruction; lateral extra-articular procedures; all-inside technique; internal bracing; slope reducing osteotomy; biologic augmentation; rehabilitation

(This special issue belongs to the Section Orthopedics)

Innovation in Hand Surgery

edited by Rocco De Vitis and Marco Passiatore

submission deadline 20 Mar 2026 | 7 articles | Viewed by 11447 | Submission Open

Keywords: hand surgery; hand reconstruction; hand deformities; reconstructive surgery; peripheral nerve surgery; hand tumors; thumb arthritis; wrist arthritis; arthroscopy; prosthesis

(This special issue belongs to the Section Orthopedics)

New Advances in Musculoskeletal Physiotherapy: Exercise, Manual Therapy and Invasive Physiotherapy

edited by

Marcos José Navarro-Santana

and Ignacio Cancela-Cilleruelo

submission deadline 20 Mar 2026 | 5 articles | Viewed by 11339 | Submission Open

Keywords: musculoskeletal disorders; exercise therapy; manual therapy; invasive physical therapy; rehabilitation

(This special issue belongs to the Section Orthopedics)

Chronic Kidney Disease: Clinical Challenges and Management

edited by