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Updates on Brain Tumors: Diagnosis and Treatment
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Updates on Brain Tumors: Diagnosis and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1418

Special Issue Editors

Dr. Jigisha P. Thakkar

E-Mail Website
Guest Editor
Department of Neurology of Loyola University Stritch School of Medicine, Maywood, IL, USA
Interests: neurology; neuro-oncology; brain tumors (primary and metastatic); neurologic complications of cancer and cancer therapies
Dr. Rimas V Lukas

E-Mail Website
Guest Editor
Lou Malnati Brain Tumor Institute, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Interests: neurology; neuro-oncology; brain tumors (primary and metastatic); neurologic complications of cancer and cancer therapies

Special Issue Information

Dear Colleagues,

In the last decade, there have been great advancements in the diagnosis and treatment of brain tumors, and the WHO classification has changed twice. Next-generation sequencing has revolutionized our understating of brain tumors, aiding in accurate diagnosis and opening up new avenues for targeted therapies. Multiple CNS-penetrating agents, including targeted therapies, as well as immunotherapy, have been FDA-approved for primary and metastatic brain tumors. An understanding of the molecular biology of tumors has provided experimental therapeutic insights. Innovative treatment approaches including oncolytic virus therapy and tumor vaccines, as well as the penetration of the BBB with implantable ultrasound devices, hold promise for future improvements in prognosis. This Special Issue will focus on the clinical advances in the diagnosis and management of primary and metastatic brain tumors that are driving modern neuro-oncological care.
We look forward to receiving your submissions for this Special Issue.

Dr. Jigisha P. Thakkar
Dr. Rimas V Lukas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • primary brain tumors
  • glioblastoma
  • IDH mutant glioma
  • meningioma
  • brain metastases
  • leptomeningeal disease

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Published Papers (1 paper)

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Review

21 pages, 2812 KiB  
Review
Advances in the Management of Craniopharyngioma: A Narrative Review of Recent Developments and Clinical Strategies
by Mousa Javidialsaadi, Diego D. Luy, Heather L. Smith, Arba Cecia, Seunghyuk Daniel Yang and Anand V. Germanwala
J. Clin. Med. 2025, 14(4), 1101; https://doi.org/10.3390/jcm14041101 - 9 Feb 2025
Viewed by 1053
Abstract
Craniopharyngiomas (CPs) are rare intracranial tumors arising from remnants of Rathke’s pouch. Despite their benign histology, CPs present considerable clinical challenges due to their tendency to exert mass effect and adherence to critical neurovascular structures. There remains no clear consensus on the most [...] Read more.
Craniopharyngiomas (CPs) are rare intracranial tumors arising from remnants of Rathke’s pouch. Despite their benign histology, CPs present considerable clinical challenges due to their tendency to exert mass effect and adherence to critical neurovascular structures. There remains no clear consensus on the most effective management of CPs. We explore the latest developments in targeted treatment approaches, examining how innovations in surgery, radiation therapy, and emerging therapies are improving outcomes and management for these challenging tumors. In addition to providing our experience, we reviewed previously reported case series and reviews relevant to CPs. Studies show a bimodal age distribution for CP diagnosis, with peak incidence occurring in children aged 5–14 years and in adults aged 50–74 years. Surgical resection is the typical initial treatment for CPs, and adjuncts, including radiation therapy and intracavitary treatments, have been proven effective for tumor control. Additionally, genetic mutations associated with CPs offer an opportunity for novel strategies that address the underlying molecular mechanisms driving tumor growth through targeting the Wnt/β-catenin and/or MAPK/ERK pathways to disrupt the aberrant signaling that promotes tumor proliferation and survival. Survival rates for CPs are generally favorable (five-year survival of 80%), with recent studies showing improved outcomes and higher survival rates in children. CPs remain rare and challenging tumors. Although surgical resection is the main treatment, surgeons must weigh the benefits of achieving a gross total resection with the risks of iatrogenic injury. Adjuncts, including intracavitary and radiation treatments, may assist with subtotal resections and recurrences, as well as approved BRAF inhibitor therapy for the papillary variant. Many improvements in diagnostic and therapeutic methods were made after Dr. Cushing coined the term “craniopharyngioma”. Ongoing experiments, investigations, and advances in radiation techniques and molecular targeted therapies will provide patients with promise for safer and more effective treatments. Full article
(This article belongs to the Special Issue Updates on Brain Tumors: Diagnosis and Treatment)
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