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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Surgical Management of Complex Spinal Pathologies: Challenges and Innovations
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 770 | Submission Open
Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 762 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Physiotherapy in Clinical Practice: From Assessment to Rehabilitation submission deadline 20 May 2026 | 1 articles | Viewed by 700 | Submission Open
Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 May 2026 | 1 articles | Viewed by 605 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiac Imaging in Cardiovascular Disorders
edited by Leif-Christopher Engel
submission deadline 20 May 2026 | Viewed by 572 | Submission Open
Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging
(This special issue belongs to the Section Cardiology)
Cutting Edge Research on Total Knee Arthroplasty
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 538 | Submission Open
Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery
(This special issue belongs to the Section Orthopedics)
Total Joint Arthroplasty: Innovations, Outcomes, and Challenges—Second Edition
edited by Hendrik Kohlhof
submission deadline 20 May 2026 | 1 articles | Viewed by 501 | Submission Open
Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management
(This special issue belongs to the Section Orthopedics)
Clinical Updates of Physical Therapy in Rehabilitation
edited by
submission deadline 20 May 2026 | Viewed by 375 | Submission Open
Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects
edited by
submission deadline 20 May 2026 | Viewed by 366 | Submission Open
Keywords: quality of life (QOL); cognition; behavior; stigma; seizure severity; interictal epileptiform discharge (IED); social
(This special issue belongs to the Section Clinical Neurology)
New Therapies for Diabetic Foot Ulcer Management submission deadline 20 May 2026 | Viewed by 332 | Submission Open
Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Updates in Transfusion Medicine and Patient Blood Management submission deadline 20 May 2026 | Viewed by 263 | Submission Open
Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine
(This special issue belongs to the Section Hematology)
Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest
edited by
submission deadline 20 May 2026 | Viewed by 262 | Submission Open
Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Research in Vascular Access Devices
edited by
submission deadline 20 May 2026 | Viewed by 256 | Submission Open
Keywords: short peripheral catheters; long peripheral catheters; midline; peripherally inserted central catheters (PICCs); femoral-inserted central catheters (FICCs); centrally inserted central catheters (CICCs); totally implantable venous access devices (TIVAD); catheter-related bloodstream infection (CRBSI); catheter-associated bloodstream infection (CABSI); central line-associated bloodstream infection (CLABSI); catheter-related thrombosis (CRT); fibroblastic sleeve; infiltration; extravasation
(This special issue belongs to the Section Vascular Medicine)
Interventional Cardiology: Clinical Advances and Future Perspectives
edited by Antonio Landi and
submission deadline 20 May 2026 | Viewed by 214 | Submission Open
Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome
(This special issue belongs to the Section Cardiology)
Key Quality Indicators in Diagnosis and Treatment of Respiratory Diseases
edited by
submission deadline 20 May 2026 | Viewed by 213 | Submission Open
Keywords: key quality indicators; respiratory disorders; audit; quality improvement; real-life data
(This special issue belongs to the Section Respiratory Medicine)
New Horizons in Aortic Valve Replacement
edited by Abdellaziz Dahou
submission deadline 20 May 2026 | Viewed by 204 | Submission Open
Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement
(This special issue belongs to the Section Cardiology)
Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives
edited by Balakrishnan M. Mahesh
submission deadline 20 May 2026 | Viewed by 190 | Submission Open
Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion
(This special issue belongs to the Section Cardiology)
The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease submission deadline 20 May 2026 | Viewed by 181 | Submission Open
Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy
(This special issue belongs to the Section Clinical Laboratory Medicine)
Novel Approaches in Cataract and Refractive Surgery
edited by Stephen T. Armenti
submission deadline 20 May 2026 | Viewed by 180 | Submission Open
Keywords: cataract surgery; complex cataract surgery; secondary intraocular lens surgery; refractive surgery (LASIK; PRK; SMILE); astigmatism correction; multifocal intraocular lenses; femtosecond laser; dropless cataract surgery
(This special issue belongs to the Section Ophthalmology)
Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective
edited by and
submission deadline 20 May 2026 | Viewed by 132 | Submission Open
Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics
(This special issue belongs to the Section Sports Medicine)
Surgery in the Era of Neoadjuvant Immune Checkpoint Inhibitors Therapy for Thoracic Oncology
edited by
submission deadline 20 May 2026 | Viewed by 127 | Submission Open
Keywords: neoadjuvant therapy; immune checkpoint inhibitors; unresectable disease; lung cancer; locally advanced lung cancer
(This special issue belongs to the Section General Surgery)
Spine Surgery: Current Challenges and Opportunities
edited by Kambiz Sarahrudi
submission deadline 20 May 2026 | Viewed by 118 | Submission Open
Keywords: vertebral fracture; spine trauma; spinal cord injury; adjacent segment degeneration; infection; spondylodiscitis; verte-bral metastasis; osteoporotic fracture; fracture of sacrum; disk degeneration; degenerative spine surgery; minimally invasive spine surgery
(This special issue belongs to the Section Orthopedics)
Current Challenges in Oral and Maxillofacial Surgery
edited by and Lucia Memé
submission deadline 20 May 2026 | Viewed by 114 | Submission Open
Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Neurovascular Interventions: Evolving Techniques and Insights
edited by Delia Cannizzaro
submission deadline 20 May 2026 | Viewed by 104 | Submission Open
Keywords: endovascular treatment; intracranial aneurysms; AI in neurointerventional surgery; intracranial vascular malformation; new endovascular device
(This special issue belongs to the Section Clinical Neurology)
Anesthesia in Head and Neck Surgery
edited by and Antonino Maniaci
submission deadline 20 May 2026 | Viewed by 103 | Submission Open
Keywords: airway management; hemodynamic stability; perioperative monitoring; head and neck surgery; anesthesia
(This special issue belongs to the Section Anesthesiology)
Clinical Updates on Perioperative Pain Management: 3rd Edition submission deadline 20 May 2026 | Viewed by 100 | Submission Open
Keywords: anesthesia and intensive care; pain management; spinal anesthesia; postoperative pain; breast surgery; fascial plane blocks; abdominal surgery; cardiac surgery; thoracotomy; knee surgery; orthopedic surgery; hip surgery; ultrasound
(This special issue belongs to the Section Anesthesiology)
Clinical Progress in Oral and Maxillofacial Surgery
edited by Luis M. Junquera and Giuseppe Consorti
submission deadline 20 May 2026 | Viewed by 99 | Submission Open
Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Challenges in Pancreatitis Management
edited by
submission deadline 20 May 2026 | Viewed by 99 | Submission Open
Keywords: acute pancreatitis; chronic pancreatitis; medical management; surgical management; nutritional support; pancreatic diabetes; clinical research; reviews
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Diagnosis and Treatment of Connective Tissue Diseases: A Clinician's Perspective: 2nd Edition
edited by , and Aleksandra Dańczak-Pazdrowska
submission deadline 20 May 2026 | Viewed by 97 | Submission Open
Keywords: connective tissue diseases; lupus erythematosus; scleroderma; dermatomyositis; MCTD; clinical picture; spectrum of clinical symptoms; treatment; complications; clinical follow-up
(This special issue belongs to the Section Immunology & Rheumatology)
Clinical Trends and Prospects in Urology Surgery: 2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 94 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; minimally invasive surgery; artificial intelligence
(This special issue belongs to the Section Nephrology & Urology)
Clinical Research Progress in Atrial Fibrillation
edited by
submission deadline 20 May 2026 | Viewed by 93 | Submission Open
Keywords: atrial fibrillation; atrial arrhythmias; cardiac fibrosis; inflammation; electrical remodeling
(This special issue belongs to the Section Cardiology)
Strategies in Complex Hand Trauma: Bridging Orthopedics, Plastic Surgery and Rehabilitation
edited by Clarisa Simón-Pérez and
submission deadline 20 May 2026 | Viewed by 89 | Submission Open
Keywords: complex hand trauma; orthopedics; plastic surgery; microsurgery; rehabilitation; functional reconstruction; multidis-ciplinary management
(This special issue belongs to the Section General Surgery)
Cardiomyopathies: A Contemporary Review of Advances and Clinical Strategies
edited by Carla Contaldi
submission deadline 20 May 2026 | Viewed by 89 | Submission Open
Keywords: cardiomyopathies; heart failure; genetic mutations; molecular mechanisms; advanced cardiac imaging; cardiac MRI; precision medicine; risk stratification
(This special issue belongs to the Section Cardiology)
Prevention, Treatment, and Prognosis of Cerebral Aneurysms
edited by
submission deadline 20 May 2026 | Viewed by 89 | Submission Open
Keywords: cerebral aneurysm; subarachnoid hemorrhage; clipping; interventional surgery; mortarity; long-term; surgical com-plication; bypass
(This special issue belongs to the Section Clinical Neurology)
Advances in Demyelinating and Neuroinflammatory Disorders submission deadline 20 May 2026 | Viewed by 87 | Submission Open
Keywords: multiple sclerosis; neuromyelitis optica spectrum disorder; MOG antibody– associated disease; neuroinflammation; biomarkers; advanced imaging; disease-modifying therapies; clinical outcomes
(This special issue belongs to the Section Clinical Neurology)
Alcohol-Associated Liver Disease: Diagnosis and Treatment of Acute and Chronic Conditions
edited by Halina Cichoz-Lach and
submission deadline 20 May 2026 | Viewed by 86 | Submission Open
Keywords: alcohol-associated liver disease; alcohol-associated hepatitis; alcohol-associated liver cirrhosis; excessive alcohol intake; oxidative liver damage; gut– liver axis; organ-to-organ crosstalk
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Perspectives on Obesity and Bariatric Surgery: Outcomes and Complications
edited by Dilhana S. Badurdeen
submission deadline 20 May 2026 | Viewed by 85 | Submission Open
Keywords: obesity; bariatric surgery; metabolic surgery; Roux-en-Y Gastric Bypass (RYGB); sleeve gastrectomy; revisional bariatric surgery; complications; outcomes; weight loss maintenance; metabolic syndrome; type 2 diabetes remission; nutritional deficiencies; gastrointestinal adaptation; quality of life; long-term follow-up
(This special issue belongs to the Section General Surgery)
The Current Trend in the Management of Bruxism and Temporomandibular Disorders, 2nd Edition submission deadline 20 May 2026 | Viewed by 84 | Submission Open
Keywords: bruxism; temporomandibular disorders (TMDs); dental health; treatment modalities; diagnosis; clinical interventions
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Presbyopia, Laser, Cataract and Refractive Surgery: State-of-the-Art Research: Second Edition
edited by
submission deadline 20 May 2026 | Viewed by 82 | Submission Open
Keywords: presbyopia; cataract surgery; refractive surgery; femtosecond laser; intraocular lenses; corneal refractive procedures; phakic intraocular lenses; visual outcomes; patient-reported outcomes; surgical innovations
(This special issue belongs to the Section Ophthalmology)
Acute Coronary Syndromes | Circulation Research submission deadline 20 May 2026 | Viewed by 82 | Submission Open
Keywords: acute coronary syndromes; cardiovascular risk; individualized therapy; STEMI; risk factors
(This special issue belongs to the Section Cardiology)
Clinical Aspects of Return to Sport After Injuries: 2nd Edition
edited by and
submission deadline 20 May 2026 | Viewed by 81 | Submission Open
Keywords: musculoskeletal system; tissue overload; diagnostic methods; rehabilitation; treatment; injury prevention; return to sport; rehabilitation medicine; sports medicine
(This special issue belongs to the Section Sports Medicine)
Clinical Advances in Ocular Surgeries: Innovations in Cataract, Retinal, and Beyond
edited by and Yu Cheol Kim
submission deadline 20 May 2026 | Viewed by 80 | Submission Open
Keywords: cataract surgery; retinal surgery; intraocular lenses; femtosecond laser; minimally invasive vitrectomy; ocular imaging; surgical innovation; ocular trauma; corneal transplantation; glaucoma surgery
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Hemodialysis: 2nd Edition
edited by Maurizio Bossola
submission deadline 20 May 2026 | Viewed by 79 | Submission Open
Keywords: hemodialysis; interdialytic weight gain; symptom burden and quality of life; impaired cognitive function; fatigue; dietary restrictions; depression; anxiety; frailty; polypharmacy
(This special issue belongs to the Section Nephrology & Urology)
Diagnosis, Monitoring, and Treatment of Myocardial Infarction: 2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 78 | Submission Open
Keywords: myocardial infarction; diagnosis; monitoring; treatment; acute MI
(This special issue belongs to the Section Cardiovascular Medicine)
Foot and Ankle Surgery: Clinical Challenges and New Insights: 2nd Edition
edited by
submission deadline 20 May 2026 | Viewed by 77 | Submission Open
Keywords: hallux valgus; minimal invasive correction; chronic ankle instability; arthroscopic Brostrom procedure; suture-tape augmentation; ankle arthritis; total ankle arthroplasty; ankle arthrodesis
(This special issue belongs to the Section Orthopedics)
Neurological Surgery: Clinical Advances and AI-Driven Innovations
edited by Ali A. Alattar
submission deadline 20 May 2026 | Viewed by 70 | Submission Open
Keywords: neurosurgery; artificial intelligence; machine learning; deep learning; radiomics; image segmentation; surgical video analytics; navigation and robotics; predictive modeling; clinical decision support
(This special issue belongs to the Section Clinical Neurology)
Advances in Diagnosis and Management of Scoliosis
edited by
submission deadline 20 May 2026 | Viewed by 70 | Submission Open
Keywords: scoliosis; spinal deformities; therapeutic strategies; personalized care; quality of life
(This special issue belongs to the Section Orthopedics)
The Interplay of Trauma Symptoms and Cognitive Functioning: Clinical Implications
edited by and
submission deadline 20 May 2026 | Viewed by 68 | Submission Open
Keywords: trauma; stress; cognitive dysfunction; clinical syndromes; clinical implications
(This special issue belongs to the Section Mental Health)
Acute Medical Threats: Evidence-Driven Strategies in Emergency Medicine submission deadline 20 May 2026 | Viewed by 64 | Submission Open
Keywords: emergency medicine protocols; acute medical care; trauma management; resuscitation; critical care; infectious disease preparedness
(This special issue belongs to the Section Emergency Medicine)
Spine Surgery and Rehabilitation: Technical Nuances and Outcomes
edited by Sehan Park and Dong-Ho Lee
submission deadline 20 May 2026 | Viewed by 64 | Submission Open
Keywords: spine surgery; rehabilitation; postoperative outcomes; surgical techniques; patient centered perspective
(This special issue belongs to the Section Orthopedics)
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