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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Head and Neck Cancer: Clinical Diagnosis and Treatment
edited by Enrique Sanz-Garcia, Nicole Chau and Neus Baste
submission deadline 15 May 2026 | Viewed by 42 | Submission Open
Keywords: head and neck; multidisciplinary approaches; biomarkers; early detection; therapies
(This special issue belongs to the Section Otolaryngology)
Hypertrophic Cardiomyopathy: Lights and Shadows of Structural Pharmacological Treatment
edited by Daniel Dalos
submission deadline 15 May 2026 | Viewed by 39 | Submission Open
Keywords: hypertrophic cardiomyopathy; treatment; myosin inhibition; ventricular arrhythmia; atrial fibrillation
(This special issue belongs to the Section Cardiology)
Comprehensive Hernia Surgery: From Clinical Diagnosis to Postoperative Care
edited by Luca Regusci
submission deadline 15 May 2026 | Viewed by 28 | Submission Open
Keywords: ventral hernia; complexe hernias; botox treatment; laparoscopic surgery; robotic surgery
(This special issue belongs to the Section General Surgery)
Spinal Disorders: Current Treatment and Future Opportunities: Part III
edited by
submission deadline 15 May 2026 | Viewed by 7 | Submission Open
Keywords: spine; spine surgery; spondylolisthesis; scoliosis; cervical myelopathy; spine surgery training; disc replacement; spine trauma; spine infection; spine fracture; spinal epidural abscess
(This special issue belongs to the Section Orthopedics)
PET Imaging in Bone and Non-Bone Diseases
edited by and
submission deadline 19 May 2026 | 2 articles | Viewed by 4104 | Submission Open
Keywords: PET; bone metabolism; bone diseases; metabolic bone diseases; image analysis; radiomics; artificial intelligence
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Cardiovascular Disease in the Elderly: Prevention and Diagnosis
edited by Ioana Dana Alexa, Gabriel Ioan Prada and
submission deadline 20 May 2026 | 7 articles | Viewed by 19549 | Submission Open
Keywords: cardiovascular risk factors; elderly patients; frailty; sarcopenia; heart rate variability; insulin resistance; physical resilience; intrinsic capacity; diastolic dysfunction
(This special issue belongs to the Section Cardiovascular Medicine)
New Advances in Wound Healing and Skin Wound Treatment
edited by Hajime Matsumura
submission deadline 20 May 2026 | 8 articles | Viewed by 13681 | Submission Open
Keywords: trauma wound; burns; chronic wound; DFU; VLU; ischemic wound; regenerative medicine in wound care; debridement; biofilm; wound dressing; antimicrobial treatment  
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Endometriosis: Clinical Challenges and Prognosis submission deadline 20 May 2026 | 5 articles | Viewed by 8457 | Submission Open
Keywords: endometriosis; therapy; rehabilitation; psychology; diagnostics; ultrasound imaging; metabolomics; prognosis
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiac Imaging in the Diagnosis and Management of Heart Failure
edited by Mahi Lakshmi Ashwath and Allen S. Anderson
submission deadline 20 May 2026 | 2 articles | Viewed by 8156 | Submission Open
Keywords: echocardiography; cardiac MRI; myocardial viability; tissue characterization; ischemic and non-ischemic cardiomyopathy; HFpEF; myocardial strain
(This special issue belongs to the Section Cardiology)
Chronic Lung Conditions: Integrative Approaches to Long-Term Care submission deadline 20 May 2026 | 4 articles | Viewed by 8146 | Submission Open
Keywords: chronic lung conditions: chronic non-infectious lung disease and post-respiratory infectious syndromes; including TB sequelae; TB MDR; post-COVID-19; and bronchiectasis; long-term care; integrative approach; multidisciplinary; multimorbidity; outcomes
(This special issue belongs to the Section Respiratory Medicine)
Novel Insights into the Prevention and Treatment of Contact Dermatitis
edited by , Christoph Skudlik, Swen Malte John and
submission deadline 20 May 2026 | 3 articles | Viewed by 7291 | Submission Open
Keywords: allergic; allergy; contact dermatitis; irritant; occupation; prevention; sensitization; skin; therapy; treatment
(This special issue belongs to the Section Dermatology)
Effect of Long-Term Insomnia on Mental Health—2nd Edition submission deadline 20 May 2026 | 1 articles | Viewed by 7064 | Submission Open
Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress
(This special issue belongs to the Section Mental Health)
New Advances in Myasthenia Gravis
edited by Shingo Konno
submission deadline 20 May 2026 | 3 articles | Viewed by 4972 | Submission Open
Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis
(This special issue belongs to the Section Clinical Neurology)
Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3559 | Submission Open
Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment
(This special issue belongs to the Section Ophthalmology)
New Advances in Uterus and Ovarian Transplantation: 2nd Edition submission deadline 20 May 2026 | 2 articles | Viewed by 3506 | Submission Open
Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Updates on Cardiac Pacing and Electrophysiology
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3417 | Submission Open
Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation
(This special issue belongs to the Section Cardiology)
Prostate Cancer: Diagnosis, Clinical Management and Prognosis
edited by Giovanni Muto
submission deadline 20 May 2026 | 3 articles | Viewed by 3284 | Submission Open
Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments
(This special issue belongs to the Section Nephrology & Urology)
Clinical Update in Pulmonary Rehabilitation
edited by Akira Tamaki
submission deadline 20 May 2026 | 3 articles | Viewed by 3030 | Submission Open
Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention
(This special issue belongs to the Section Respiratory Medicine)
Cirrhosis and Its Complications: Prognosis and Clinical Management
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2088 | Submission Open
Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Application of Knee Arthroscopy
edited by and Alessandro Carrozzo
submission deadline 20 May 2026 | 3 articles | Viewed by 1991 | Submission Open
Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation
(This special issue belongs to the Section Orthopedics)
Research Progress in Pediatric Endocrinology
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 1166 | Submission Open
Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening
(This special issue belongs to the Section Clinical Pediatrics)
Advances in Fertility Preservation
edited by Dunja Maria Baston-Büst
submission deadline 20 May 2026 | 1 articles | Viewed by 1075 | Submission Open
Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex
(This special issue belongs to the Section Obstetrics & Gynecology)
Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 959 | Submission Open
Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants
(This special issue belongs to the Section Clinical Neurology)
Recent Advances in Adverse Pregnancy and Neonatal Outcomes
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 956 | Submission Open
Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes
edited by Giovanni Colombo and
submission deadline 20 May 2026 | 2 articles | Viewed by 714 | Submission Open
Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life
(This special issue belongs to the Section Otolaryngology)
Clinical Management and Long-Term Prognosis in Intensive Care submission deadline 20 May 2026 | 2 articles | Viewed by 565 | Submission Open
Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation
(This special issue belongs to the Section Intensive Care)
Cardiac Imaging in Cardiovascular Disorders
edited by Leif-Christopher Engel
submission deadline 20 May 2026 | Viewed by 547 | Submission Open
Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging
(This special issue belongs to the Section Cardiology)
Surgical Management of Complex Spinal Pathologies: Challenges and Innovations
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 525 | Submission Open
Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Percutaneous Coronary Intervention: Latest Advances and Future Prospects submission deadline 20 May 2026 | 1 articles | Viewed by 482 | Submission Open
Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease
(This special issue belongs to the Section Cardiology)
Physiotherapy in Clinical Practice: From Assessment to Rehabilitation submission deadline 20 May 2026 | 1 articles | Viewed by 478 | Submission Open
Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Advances in Clinical Rheumatology—2nd Edition
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 468 | Submission Open
Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome
(This special issue belongs to the Section Immunology & Rheumatology)
Cutting Edge Research on Total Knee Arthroplasty
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 441 | Submission Open
Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery
(This special issue belongs to the Section Orthopedics)
Total Joint Arthroplasty: Innovations, Outcomes, and Challenges—Second Edition
edited by Hendrik Kohlhof
submission deadline 20 May 2026 | 1 articles | Viewed by 341 | Submission Open
Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management
(This special issue belongs to the Section Orthopedics)
Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome submission deadline 20 May 2026 | 1 articles | Viewed by 304 | Submission Open
Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
New Therapies for Diabetic Foot Ulcer Management submission deadline 20 May 2026 | Viewed by 300 | Submission Open
Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Updates of Physical Therapy in Rehabilitation
edited by
submission deadline 20 May 2026 | Viewed by 263 | Submission Open
Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy
(This special issue belongs to the Section Clinical Rehabilitation)
Clinical Updates in Transfusion Medicine and Patient Blood Management submission deadline 20 May 2026 | Viewed by 234 | Submission Open
Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine
(This special issue belongs to the Section Hematology)
New Horizons in Aortic Valve Replacement
edited by Abdellaziz Dahou
submission deadline 20 May 2026 | Viewed by 192 | Submission Open
Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement
(This special issue belongs to the Section Cardiology)
Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives
edited by Balakrishnan M. Mahesh
submission deadline 20 May 2026 | Viewed by 176 | Submission Open
Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion
(This special issue belongs to the Section Cardiology)
Novel Approaches in Cataract and Refractive Surgery
edited by Stephen T. Armenti
submission deadline 20 May 2026 | Viewed by 161 | Submission Open
Keywords: cataract surgery; complex cataract surgery; secondary intraocular lens surgery; refractive surgery (LASIK; PRK; SMILE); astigmatism correction; multifocal intraocular lenses; femtosecond laser; dropless cataract surgery
(This special issue belongs to the Section Ophthalmology)
Surgery in the Era of Neoadjuvant Immune Checkpoint Inhibitors Therapy for Thoracic Oncology
edited by
submission deadline 20 May 2026 | Viewed by 121 | Submission Open
Keywords: neoadjuvant therapy; immune checkpoint inhibitors; unresectable disease; lung cancer; locally advanced lung cancer
(This special issue belongs to the Section General Surgery)
Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective
edited by and
submission deadline 20 May 2026 | Viewed by 117 | Submission Open
Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics
(This special issue belongs to the Section Sports Medicine)
Spine Surgery: Current Challenges and Opportunities
edited by Kambiz Sarahrudi
submission deadline 20 May 2026 | Viewed by 102 | Submission Open
Keywords: vertebral fracture; spine trauma; spinal cord injury; adjacent segment degeneration; infection; spondylodiscitis; verte-bral metastasis; osteoporotic fracture; fracture of sacrum; disk degeneration; degenerative spine surgery; minimally invasive spine surgery
(This special issue belongs to the Section Orthopedics)
Current Challenges in Oral and Maxillofacial Surgery
edited by and Lucia Memé
submission deadline 20 May 2026 | Viewed by 84 | Submission Open
Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Challenges in Pancreatitis Management
edited by
submission deadline 20 May 2026 | Viewed by 81 | Submission Open
Keywords: acute pancreatitis; chronic pancreatitis; medical management; surgical management; nutritional support; pancreatic diabetes; clinical research; reviews
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Progress in Oral and Maxillofacial Surgery
edited by Luis M. Junquera and Giuseppe Consorti
submission deadline 20 May 2026 | Viewed by 80 | Submission Open
Keywords: oral and maxillofacial surgery; craniofacial surgery; facial deformity; cleft lip and palate; TMJ surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Neurovascular Interventions: Evolving Techniques and Insights
edited by Delia Cannizzaro
submission deadline 20 May 2026 | Viewed by 79 | Submission Open
Keywords: endovascular treatment; intracranial aneurysms; AI in neurointerventional surgery; intracranial vascular malformation; new endovascular device
(This special issue belongs to the Section Clinical Neurology)
Strategies in Complex Hand Trauma: Bridging Orthopedics, Plastic Surgery and Rehabilitation
edited by Clarisa Simón-Pérez and
submission deadline 20 May 2026 | Viewed by 72 | Submission Open
Keywords: complex hand trauma; orthopedics; plastic surgery; microsurgery; rehabilitation; functional reconstruction; multidis-ciplinary management
(This special issue belongs to the Section General Surgery)
Anesthesia in Head and Neck Surgery
edited by and Antonino Maniaci
submission deadline 20 May 2026 | Viewed by 71 | Submission Open
Keywords: airway management; hemodynamic stability; perioperative monitoring; head and neck surgery; anesthesia
(This special issue belongs to the Section Anesthesiology)
Diagnosis and Treatment of Connective Tissue Diseases: A Clinician's Perspective: 2nd Edition
edited by , and Aleksandra Dańczak-Pazdrowska
submission deadline 20 May 2026 | Viewed by 70 | Submission Open
Keywords: connective tissue diseases; lupus erythematosus; scleroderma; dermatomyositis; MCTD; clinical picture; spectrum of clinical symptoms; treatment; complications; clinical follow-up
(This special issue belongs to the Section Immunology & Rheumatology)
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