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Special Issue "Approach to Male Infertility and Induction of Spermatogenesis"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cell Biology".

Deadline for manuscript submissions: 31 December 2019

Special Issue Editors

Guest Editor
Dr. Alice Luddi

Università degli Studi di Siena, Department of Molecular and Developmental Medicine, Siena, Italy
Website | E-Mail
Interests: male infertility; spermatogenesis; female infertility; endometrial receptivity; gene expression
Guest Editor
Prof. Paola Piomboni

Dept. of Molecular and Developmental Medicine, University of Siena, Siena, Italy
Website | E-Mail
Interests: male infertility; spermatogenesis; female infertility; endometrial receptivity; gene expression

Special Issue Information

Dear Colleagues,

Infertility is defined by the World Health Organization as the inability to conceive naturally after one year of regular unprotected intercourse. Both males and females are equally responsible for the causes. It has been estimated that approximately 7% of the male population is affected by infertility, mainly due to the alteration of spermatogenesis, a complex and tightly coordinated process taking place in the seminiferous tubules that leads to sperm production starting from puberty. The last decade has witnessed huge advances in the understanding of the molecular basis of several pathological conditions affecting sperm production and maturation, thus providing new interesting clues that impact most recent reproductive technologies. In this Special Issue, we want to provide a global overview of human male infertility ranging from the genetic causes to the molecular and endocrine aspects of disease pathogenesis. This Issue will also cover new advances in preclinical therapeutic strategies, including the in vitro recapitulation of the spermatogenesis process to the pharmacological management of infertile patients.

On behalf of the Journal of Clinical Medicine you are cordially invited to contribute an article to the Special Issue “Approach to Male Infertility and Induction of Spermatogenesis”. Research articles, Reviews, Mini Reviews, Case Reports, and Clinical Cases will be considered for publication.

Dr. Alice Luddi
Prof. Paola Piomboni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • human male infertility
  • sperm
  • spermatogenesis
  • apoptosis
  • genetic of male infertility
  • translational research
  • assisted reproductive techniques (ARTs)
  • HPG axis (hypothalamic–pituitary–gonadal axis)
  • pharmacologic treatment
  • fertilization

Published Papers

This special issue is now open for submission.
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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