Review Special Issue Series: Old and New Challenges in the Management of Male Factor Infertility

Dear Colleagues,

This Review Special Issue Series, entitled “Review Special Issue Series: Old and New Challenges in the Management of Male Factor Infertility”, is committed to presenting an exclusive collection of comprehensive reviews.

Although the infertility of couples is caused by a male factor in 30–50% of cases, an adequate (or even any) andrological assessment of the male partner is seldom obtained, the assumption being that only the male gamete, and not the human subject, matters in the achievement of oocyte fertilization and pregnancy, regardless of the man’s health condition. This represents a clear case of gender discrimination. The reproductive ability of couples with severe male factor infertility may be significantly impaired without the appropriate medical or surgical management of the severe spermatogenic dysfunction; on the other hand, couples are referred to donor sperm IUI or IVF when the male partner is azoospermic, without attempting to individuate the cause and the possible medical or surgical treatment applicable to such a condition. Managing infertile couples in such a way may expose couples to an increased risk of treatment failure; in addition, since male infertility has been proposed as an independent risk factor for poor health status and early mortality, if infertile men are evaluated early in life, there is an opportunity for health assessment, counseling, and disease prevention. Clinical training in male infertility is most commonly an aspect of andrology training; however, some urologists or endocrinologists may have little experience in the counseling and management of infertile men. The purpose of the present Special Issue is, therefore, thanks to the contribution of internationally renowned experts in the field, to provide the readers with a comprehensive and evidence-based update on the challenges faced in the management of male factor infertility.

Prof. Dr. Giovanni M. Colpi
Guest Editor

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