G Protein-Coupled Receptors and Their Kinases in Cell Biology and Disease

Dear Colleagues,

Over the past three decades, since Nobel prize winners Robert Lefkowitz and Brian Kobilka characterized the structure of G protein-coupled receptors (GPCRs), a great deal of clinical and pharmacological evidence has advanced our knowledge of how these receptors and their signaling pathways influence almost every aspect of mammals’ physiology. GPCRs can transduce cellular signals from neurohormones, sensory stimuli, and ions, and their activity is directly modulated by GPCR kinases (GRKs), phosphorylation, and subsequent desensitization. Nevertheless, an alteration in GRKs’ expression, with subsequent GPCR dysfunction, may induce—or at least influence—the development and progression of different systemic disorders. Thus, several drugs which are able to directly inhibit or enhance GPCR signaling have been developed and are currently used in clinical practice.

This Topical Collection calls for both original articles and reviews providing readers of IJMS with a comprehensive elucidation of the GPCR and GRK functions in cell biology that is necessary for developing novel research approaches as well as therapeutic strategies.

Dr. Alessandro Cannavo
Collection Editor

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