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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanism of Circadian Rhythm
edited by Rosângela Vieira de Andrade
submission deadline 20 Nov 2025 | 1 articles | Viewed by 10743 | Submission Open
Keywords: circadian cycle; exercise; aging; clock genes; health
(This special issue belongs to the Section Molecular Biology)
Molecular Metabolism of Ameloblasts in Tooth Development
edited by Maiko Suzuki and Yong Hee Patricia Chun
submission deadline 20 Nov 2025 | 6 articles | Viewed by 8983 | Submission Open
Keywords: ameloblasts; amelogenesis; metabolism; gene regulation; amelogenesis imperfecta; SCPP; enamel hypomineralization; tooth epithelial stem cells
(This special issue belongs to the Section Molecular Biology)
Omics Science and Research in Human Health and Disease
edited by Elisa De Paolis
submission deadline 20 Nov 2025 | 4 articles | Viewed by 6514 | Submission Open
Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics
(This special issue belongs to the Section Molecular Biology)
Physiology and Molecular Medicine of Molecular Hydrogen
edited by and John Nagi Kheir
submission deadline 20 Nov 2025 | 2 articles | Viewed by 6150 | Submission Open
Keywords: molecular hydrogen; reactive oxygen species; nitric oxide; inflammation; cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
The Role of Autophagy in Disease and Cancer submission deadline 20 Nov 2025 | 3 articles | Viewed by 5493 | Submission Open
Keywords: autophagy; autophagy-related proteins; target therapy; cancer; neurodegenerative disease; infections; aging; metabolic disease; autoimmunity
(This special issue belongs to the Section Molecular Biology)
Molecular Aspects of Hematological Malignancies and Benign Hematological Disorders—3rd Edition submission deadline 20 Nov 2025 | 3 articles | Viewed by 4252 | Submission Open
Keywords: myeloproliferative neoplasms; leukemia; lymphoma; multiple myeloma; oxidative stress; inflammation; microbiome; genetics; molecular biology
(This special issue belongs to the Section Molecular Biology)
Drosophila: A Versatile Model in Biology and Medicine—2nd Edition submission deadline 20 Nov 2025 | 5 articles | Viewed by 3664 | Submission Open
Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics
(This special issue belongs to the Section Molecular Biology)
Genetic Testing in Molecular Pathology and Diagnosis
edited by
submission deadline 20 Nov 2025 | 3 articles | Viewed by 2198 | Submission Open
Keywords: genetic testing; molecular pathology; personalized medicine; genetic diagnostics; disease mechanisms; novel genetic tests; clinical integration; patient management
(This special issue belongs to the Section Molecular Biology)
New Advances in Germ Cell Research
edited by
submission deadline 20 Nov 2025 | 2 articles | Viewed by 1796 | Submission Open
Keywords: spermatogenesis; sperm capacitation; oogenesis; oocyte maturation; cumulus cells; fertilization; gene expression; biomarkers; exosomes; infertility
(This special issue belongs to the Section Molecular Biology)
Computational Design and Therapeutic Applications of Peptide-Based Drugs submission deadline 20 Nov 2025 | 1 articles | Viewed by 1770 | Submission Open
Keywords: peptide drug design; in silico drug discovery; peptide– protein interactions; therapeutic peptides
(This special issue belongs to the Section Molecular Biology)
Research on Intracellular Signal Transduction Systems
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1375 | Submission Open
Keywords: signal transduction; receptor; G protein; kinase; second messenger; gene expression; cytoskeleton; human disease
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Animal Reproduction
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 1262 | Submission Open
Keywords: spermatogenesis; follicular atresia; oocyte maturation; granulosa cells; hormone regulation; autophagy; apoptosis; miRNA; signaling regulation
(This special issue belongs to the Section Molecular Biology)
Reproductive Physiology and miRNA-Mediated Gene Regulation in Domestic Animals submission deadline 20 Nov 2025 | 1 articles | Viewed by 1050 | Submission Open
Keywords: reproductive physiology; microRNAs; miRNAs; gene regulation; domestic animals
(This special issue belongs to the Section Molecular Biology)
Endothelial-to-Mesenchymal Transition: A Key Driver of Tumor Progression and Therapeutic Resistance
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 986 | Submission Open
Keywords: Endothelial-to-Mesenchymal Transition; wound healing and fibrosis; tumor progression; abnormal blood vessel formation; cancer therapy
(This special issue belongs to the Section Molecular Biology)
Endothelial Dysfunction, Inflammation and Cognition
edited by Christelle Basset and Anne S. Prigent-Tessier
submission deadline 20 Nov 2025 | Viewed by 608 | Submission Open
Keywords: inflammation; endothelial dysfunction; cognition; nitric oxide (NO); BDNF; physical exercise
(This special issue belongs to the Section Molecular Biology)
Biomarkers in Precision Medicine
edited by
submission deadline 20 Nov 2025 | 1 articles | Viewed by 565 | Submission Open
Keywords: biomarkers; precision medicine; novel techniques; artificial intelligence
(This special issue belongs to the Section Molecular Biology)
Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments submission deadline 20 Nov 2025 | Viewed by 477 | Submission Open
Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms
(This special issue belongs to the Section Molecular Biology)
Stem Cell Biology & Regenerative Medicine—2nd Edition
edited by
submission deadline 20 Nov 2025 | Viewed by 293 | Submission Open
Keywords: hiPSC; hES; Crispr; BBB; disease in a dish; neuro-regeneration; pain reliever; scaffold
(This special issue belongs to the Section Molecular Biology)
Mesenteric Adipose Tissue: The New Player in Health and Disease
edited by Eva Pardina and Jose M. Balibrea
submission deadline 20 Nov 2025 | Viewed by 280 | Submission Open
Keywords: mesenteric adipose tissue; obesity; inflammatory bowel diseases; Chron’ s disease; MASLD; metabolic inflammation; metabolic syndrome; mesenteric resections
(This special issue belongs to the Section Molecular Biology)
Nucleic Acid Aptamers in Molecular Medicine
edited by
submission deadline 20 Nov 2025 | Viewed by 264 | Submission Open
Keywords: aptamers; SELEX; targeted therapy; drug delivery; diagnosis; biomarker discovery
(This special issue belongs to the Section Molecular Biology)
Allosteric Modulation of Kinases in Cancer Therapeutic Strategies and Challenges
edited by
submission deadline 20 Nov 2025 | Viewed by 255 | Submission Open
Keywords: kinase signaling; allosteric modulators; cancer therapy; drug resistance; molecular mechanisms; protein– protein interactions; targeted therapy; conformational changes; ATP-competitive inhibitors; drug design
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Sprouty Proteins in Cancer
edited by Barbara Hausott and
submission deadline 20 Nov 2025 | Viewed by 241 | Submission Open
Keywords: sprouty; tumor growth; apoptosis; migration; signaling
(This special issue belongs to the Section Molecular Biology)
Molecular Science of Anesthesia
edited by Jose Luis Guerrero Orriach and Maria Dolores Carmona-Luque
submission deadline 20 Nov 2025 | Viewed by 224 | Submission Open
Keywords: anesthesia; nervous system; signal; receptor
(This special issue belongs to the Section Molecular Biology)
Recent Advances in the Biological Function of Tyrosinase
edited by
submission deadline 20 Nov 2025 | Viewed by 223 | Submission Open
Keywords: tyrosinase-related proteins; tyrosinase; melanogenesis; copper; zinc; metal enzymes; tyrosinase inhibitor; pigmentation disorders
(This special issue belongs to the Section Molecular Biology)
Mechanism(s) of HFpEF and HFrEF
edited by
submission deadline 20 Nov 2025 | Viewed by 213 | Submission Open
Keywords: HFpEF; HFrEF; diabetes; hypertension; obesity; microbiota; epigenetics; probiotics; postbiotics
(This special issue belongs to the Section Molecular Biology)
The Role of Embryonic Stem Cells in Human Disease and Health
edited by Fahad Kidwai
submission deadline 20 Nov 2025 | Viewed by 160 | Submission Open
Keywords: emrbryonic stem cells; human disease and health; regenerative therapy
(This special issue belongs to the Section Molecular Biology)
Unveiling the Complexity of TRPC Channels: From Molecular Mechanisms to Clinical Applications
edited by Oleksandra Tiapko
submission deadline 20 Nov 2025 | Viewed by 156 | Submission Open
Keywords: TRPC channels; TRPC– lipid interactions; TRPC– protein interactions; cellular homeostasis; TRPC-dependent disorders; (photo)pharmacology; TRPC in native tissue
(This special issue belongs to the Section Molecular Biology)
Regenerative Medicine: Molecular Mechanisms Driving Tissue Regeneration and Repair
edited by and Paul Jordan Christo
submission deadline 20 Nov 2025 | Viewed by 95 | Submission Open
Keywords: stem cell; cell signaling; immune modulation; extracellular matrix; remodeling; gene regulation; gene editing; growth factors; extracellular vesicles; small molecules
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms Underlying Taste and Smell submission deadline 20 Nov 2025 | Viewed by 44 | Submission Open
Keywords: olfaction; anosmia; hyposmia; ageusia; dysgeusia; gustation; chemesthesis; receptors; chemosensory processing; epigenome
(This special issue belongs to the Section Molecular Biology)
Redox, Antioxidant and Mitochondrial Signaling
edited by
submission deadline 20 Nov 2025 | Viewed by 40 | Submission Open
Keywords: oxygen; reactive oxygen species; antioxidants; signal transduction
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms in Organ Transplantation
edited by Hirofumi Hirao
submission deadline 25 Nov 2025 | 4 articles | Viewed by 3895 | Submission Open
Keywords: organ transplantation; cellular-specific response to perioperative stress; cold/warm ischemia; innate/adaptive immunity; microcirculatory disturbance
(This special issue belongs to the Section Molecular Biology)
Oxidative Stress and Disease: Basic and Biochemical Approaches submission deadline 25 Nov 2025 | 1 articles | Viewed by 436 | Submission Open
Keywords: aging; antioxidant mechanisms; cancer; cytokines; enzymatic pathways; inflammatory processes; oxidative stress; reactive oxygen species (ROS)
(This special issue belongs to the Section Molecular Biology)
Nuclear Receptors in Diseases
edited by Roberto Palacios-Ramirez
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5632 | Submission Open
Keywords: nuclear receptors; hormone receptors; orphan receptors; retinoid receptors; metabolic diseases; cancers; drug metabolism
(This special issue belongs to the Section Molecular Biology)
Exploring the Cytoskeleton and Its Regulators: From Structure to Function
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2792 | Submission Open
Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology
(This special issue belongs to the Section Molecular Biology)
Mast Cells in Human Health and Diseases—3rd Edition
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1725 | Submission Open
Keywords: mast cells; human diseases; pain; cardiovascular diseases; microbiome; food allergy; stress; cancer
(This special issue belongs to the Section Molecular Biology)
Latest Insights into Glycobiology submission deadline 30 Nov 2025 | Viewed by 361 | Submission Open
Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis
(This special issue belongs to the Section Molecular Biology)
Current Research in Membrane Transporters, Channels, and Receptors
edited by Ivana Vrhovac Madunic
submission deadline 30 Nov 2025 | Viewed by 349 | Submission Open
Keywords: membrane transporters; cell membrane; transmembrane proteins; glucose transport; ion channels; cellular receptors; signal tranduction; pathophysiology; diabetes; aging
(This special issue belongs to the Section Molecular Biology)
Genomic and Proteomic Advances in Tracking Antibiotic Resistance Evolution
edited by
submission deadline 30 Nov 2025 | Viewed by 253 | Submission Open
Keywords: antibiotic resistance; genomic; proteomic; one health
(This special issue belongs to the Section Molecular Biology)
Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 224 | Submission Open
Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence
edited by and Inês Bártolo
submission deadline 30 Nov 2025 | Viewed by 140 | Submission Open
Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Nematodes Management
edited by
submission deadline 30 Nov 2025 | Viewed by 75 | Submission Open
Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation
(This special issue belongs to the Section Molecular Biology)
Molecular Perspectives in Tissue Engineering and Regenerative Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 65 | Submission Open
Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell– scaffold interactions; nanomaterials
(This special issue belongs to the Section Molecular Biology)
New Insights into Intercellular Communication and Signal Transduction
edited by
submission deadline 30 Nov 2025 | Viewed by 58 | Submission Open
Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Lipopolysaccharides submission deadline 30 Nov 2025 | Viewed by 56 | Submission Open
Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases
(This special issue belongs to the Section Molecular Biology)
Cellular Memory in Response to Environmental Conditions
edited by
submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: cellular memory; cellular environment; embryonic development; epigenetics; transgenerational inheritance; mammals; DOHaD
(This special issue belongs to the Section Molecular Biology)
Eukaryotic Cells Under Stress: Biochemical and Physiological Mechanisms of Resistance and Resilience submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: cellular stress response; oxidative stress; bioactive compounds; ROS; DNA damage/repair; environmental stressors; molecular chaperones; antioxidant in human diseases
(This special issue belongs to the Section Molecular Biology)
Stem Cell and Epigenetic Regulation in Regenerative Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: mesenchymal stem cells; regenerative medicine; stemness genes; stem cell differentiation; molecular regulation; gene expression; cell– environment interactions; conditioned medium; secreted factors; epigenetic modification
(This special issue belongs to the Section Molecular Biology)
Bioactive Small Molecules in Tissue Repair and Regeneration submission deadline 30 Nov 2025 | Viewed by 43 | Submission Open
Keywords: small molecules; organ and tissue regeneration; development; aging
(This special issue belongs to the Section Molecular Biology)
Advances in Tau Protein Research submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open
Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’ s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics
(This special issue belongs to the Section Molecular Biology)
Understanding and Combating Antimicrobial Resistance: Molecular Insights and Innovative Approaches submission deadline 30 Nov 2025 | Viewed by 39 | Submission Open
Keywords: genetic mutations; horizontal gene transfer; efflux pump mechanisms; biofilm formation; novel antibiotic development; antimicrobial peptides; phage therapy; CRISPR-based tools; antimicrobial stewardship programs
(This special issue belongs to the Section Molecular Biology)
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