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Physiology and Molecular Medicine of Molecular Hydrogen

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 3587

Special Issue Editors


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Guest Editor
1. Department of Kinesiology and Outdoor Recreation, Southern Utah University, Cedar City, UT 84720, USA
2. Molecular Hydrogen Institute, Cedar City, UT 84720, USA
Interests: molecular hydrogen; reactive oxygen species; nitric oxide; inflammation; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Department of Pediatrics, Harvard Medical School, Boston, MA, USA
2. Staff Physician, Boston Children’s Hospital, Boston, MA, USA
Interests: molecular hydrogen; ischemia-reperfusion; hypoxia; ECMO; oxygen microparticles

Special Issue Information

Dear Colleagues,

Molecular hydrogen (H2 gas) has emerged as a fascinating molecule with the ability to penetrate biomembranes and access subcellular compartments. Recent research has unveiled its diverse therapeutic effects, spanning its antioxidant, anti-inflammatory, and antiapoptotic activities. Moreover, H2 has been shown to influence microRNA expression, protein phosphorylation cascades, and various signal transduction pathways. Demonstrating its versatility, hydrogen’s therapeutic potential has been explored in over 170 different animal/human disease models, encompassing a wide array of human physiological systems. Yet, despite these advancements, significant gaps persist within our understanding of the mechanistic actions of molecular hydrogen, its clinical viability, and the optimal dosage, frequency, and treatment duration.

In light of this, our Special Issue aims to gather contributions that advance the exploration of molecular hydrogen’s therapeutic utility. We welcome submissions encompassing both in vitro cellular mechanistic studies and in vivo investigations in animal models and human clinical settings. Original research articles, reviews, perspectives, and short communications are all encouraged, provided they contribute to our understanding of the pharmacokinetics, pharmacodynamics, and therapeutic applications of molecular hydrogen.

We invite you to join us in this endeavor to delve deeper into the potential of molecular hydrogen as a therapeutic agent.

In the meantime, the H2 Summit hosted by me and Dr. John Nagi Kheir is being prepared. The link to the meeting is as follows: https://h2mhisummit.org/h2-summit/. We sincerely invite you to attend and forward to let more scholars know about molecular hydrogen.

Dr. Tyler W. LeBaron
Dr. John Nagi Kheir
Guest Editors

Manuscript Submission Information

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Keywords

  • molecular hydrogen
  • reactive oxygen species
  • nitric oxide
  • inflammation
  • cardiovascular disease

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Published Papers (2 papers)

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Research

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22 pages, 18508 KiB  
Article
The Role of Mast Cells in the Remodeling Effects of Molecular Hydrogen on the Lung Local Tissue Microenvironment under Simulated Pulmonary Hypertension
by Dmitrii Atiakshin, Andrey Kostin, Alexander Alekhnovich, Artem Volodkin, Michael Ignatyuk, Ilya Klabukov, Denis Baranovskii, Igor Buchwalow, Markus Tiemann, Marina Artemieva, Nataliya Medvedeva, Tyler W. LeBaron, Mami Noda and Oleg Medvedev
Int. J. Mol. Sci. 2024, 25(20), 11010; https://doi.org/10.3390/ijms252011010 - 13 Oct 2024
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Abstract
Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation and blood pressure. In this [...] Read more.
Molecular hydrogen (H2) has antioxidant, anti-inflammatory, and anti-fibrotic effects. In a rat model simulating pulmonary fibrotic changes induced by monocrotaline-induced pulmonary hypertension (MPH), we had previously explored the impact of inhaled H2 on lung inflammation and blood pressure. In this study, we further focused the biological effects of H2 on mast cells (MCs) and the parameters of the fibrotic phenotype of the local tissue microenvironment. MPH resulted in a significantly increased number of MCs in both the pneumatic and respiratory parts of the lungs, an increased number of tryptase-positive MCs with increased expression of TGF-β, activated interaction with immunocompetent cells (macrophages and plasma cells) and fibroblasts, and increased MC colocalization with a fibrous component of the extracellular matrix of connective tissue. The alteration in the properties of the MC population occurred together with intensified collagen fibrillogenesis and an increase in the integral volume of collagen and elastic fibers of the extracellular matrix of the pulmonary connective tissue. The exposure of H2 together with monocrotaline (MCT), despite individual differences between animals, tended to decrease the intrapulmonary MC population and the severity of the fibrotic phenotype of the local tissue microenvironment compared to changes in animals exposed to the MCT effect alone. In addition, the activity of collagen fibrillogenesis associated with MCs and the expression of TGF-β and tryptase in MCs decreased, accompanied by a reduction in the absolute and relative content of reticular and elastic fibers in the lung stroma. Thus, with MCT exposure, inhaled H2 has antifibrotic effects involving MCs in the lungs of rats. This reveals the unknown development mechanisms of the biological effects of H2 on the remodeling features of the extracellular matrix under inflammatory background conditions of the tissue microenvironment. Full article
(This article belongs to the Special Issue Physiology and Molecular Medicine of Molecular Hydrogen)
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Review

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27 pages, 1367 KiB  
Review
Molecular Hydrogen in the Treatment of Respiratory Diseases
by Dominika Zajac, Monika Jampolska and Piotr Wojciechowski
Int. J. Mol. Sci. 2025, 26(9), 4116; https://doi.org/10.3390/ijms26094116 - 26 Apr 2025
Viewed by 553
Abstract
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current therapeutic potential among others in inflammatory diseases, cancer, and sports medicine, among others. The present review aims to provide a consistent summary [...] Read more.
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current therapeutic potential among others in inflammatory diseases, cancer, and sports medicine, among others. The present review aims to provide a consistent summary of the findings of the last twenty years on the use of molecular hydrogen in major respiratory diseases, including allergies, asthma, COPD, pulmonary fibrosis, lung injury of various origins, as well as cancer and infections of the respiratory tract. In addition, the basic mechanisms through which molecular hydrogen exercises its biological activity on the respiratory system are described. Full article
(This article belongs to the Special Issue Physiology and Molecular Medicine of Molecular Hydrogen)
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