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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research of Natural Products in Cancer Diseases

edited by

Angeliki Tiptiri-Kourpeti

submission deadline 20 Sep 2025 | Viewed by 1001 | Submission Open

Keywords: cancer; natural products; drug resistance; side effects; bioactive compounds; prevention; treatment; signaling pathways; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Novel Nanoparticle Composites: Functionalization and Application

edited by

Jovan M. Nedeljković

and

Vesna Lazić

submission deadline 20 Sep 2025 | 1 articles | Viewed by 990 | Submission Open

Keywords: nanoparticles; nanocomposites; synthesis; functionalization; interface; photocatalysis; antimicrobial nanoparticles; nanomedicine; theoretical modelling; computer simulations

(This special issue belongs to the Section Molecular Nanoscience)

Human Hereditary Diseases: Advances in Molecular Genetics, Genomics and Therapeutic Strategies

edited by Yulin Jin and

Yujing Li

submission deadline 20 Sep 2025 | 1 articles | Viewed by 927 | Submission Open

Keywords: hereditary diseases; genetics and genomics; molecular mechanism; gene regulation; therapeutic approach

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unraveling the Genetic Background of Neurological Disorders: 2nd Edition

edited by

Vasileios Siokas

Efthimios Dardiotis

and

Ioannis Liampas

submission deadline 20 Sep 2025 | 1 articles | Viewed by 920 | Submission Open

Keywords: neurological disorders; neurogenetics; personalized treatments; gene-association studies; genetics; genome-wide association studies; genetic linkage studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Tumor Metastasis and Inhibition

edited by

Yu-Chan Chang

submission deadline 20 Sep 2025 | 1 articles | Viewed by 907 | Submission Open

Keywords: metastasis; epithelial– mesenchymal transition; small-molecule compounds; animal imaging; signal transduction

(This special issue belongs to the Section Molecular Oncology)

Personalized Nanomedicine in Oncology

edited by Sajid Ali

submission deadline 20 Sep 2025 | Viewed by 893 | Submission Open

Keywords: drug/gene delivery; biomaterials; stimuli-responsive systems; lipid– polymer nanoparticles; lipodendriplexes; dual delivery; inorganic nanoparticles; targeted delivery system

(This special issue belongs to the Section Molecular Nanoscience)

The Blood–Brain Barrier and Neuroprotection

edited by Aruna Sharma and Hari Shanker Sharma

submission deadline 20 Sep 2025 | 1 articles | Viewed by 885 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Omics in Agriculture

edited by

Sebastian Wojciech Przemieniecki

submission deadline 20 Sep 2025 | 1 articles | Viewed by 874 | Submission Open

Keywords: agronomy; plant production; animal production; genome; microbiome; metagenomics; RNAseq; molecular mechnisms; molecular pest diagnostics; molecular interactions; gene editing

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Electrochemical Materials

edited by

Raj Karthik

submission deadline 20 Sep 2025 | 1 articles | Viewed by 863 | Submission Open

Keywords: electrochemical materials; molecular design; energy storage; electrocatalysis; sensing applications; nanomaterials; sustainable materials; hybrid systems; interface engineering; green chemistry

(This special issue belongs to the Section Materials Science)

Mitochondria as a Therapeutic Target for Anti-Cancer Drugs

edited by

Dalia Marija Kopustinskiene

submission deadline 20 Sep 2025 | Viewed by 832 | Submission Open

Keywords: mitochondria; cancer; apoptosis; oxidative phosphorylation; Warburg effect; cardiolipin; inflammation

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathophysiology of Cystic Fibrosis

edited by

Stefanie Krick

and George M. Solomon

submission deadline 20 Sep 2025 | 1 articles | Viewed by 831 | Submission Open

Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Extracellular Vesicles: Functions and Therapeutic Applications

edited by Deepshikha Tewari

submission deadline 20 Sep 2025 | Viewed by 802 | Submission Open

Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Therapeutics for HIV Co-Infections

edited by

Vishwanath Venketaraman

and

Selvakumar Subbian

submission deadline 20 Sep 2025 | 1 articles | Viewed by 779 | Submission Open

Keywords: HIV co-infections; molecular therapeutics; Mtb; ART; immune responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Targeted Therapies in Ischemic Stroke

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 20 Sep 2025 | 1 articles | Viewed by 777 | Submission Open

Keywords: ischemic stroke; cerebral protection; repair treatments; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 20 Sep 2025 | 1 articles | Viewed by 770 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

Bioconjugates and Application

edited by

Gábor Mező

submission deadline 20 Sep 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: bioconjugates; targeted therapy; homing moieties; drug delivery; bioconjugates as diagnostic tools; targeted nanoparticles; antibody– drug conjugates; linkage systems

(This special issue belongs to the Section Macromolecules)

Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach

edited by Preeti Chhabra

submission deadline 20 Sep 2025 | 1 articles | Viewed by 724 | Submission Open

Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Amyotrophic Lateral Sclerosis Behind Motor Neurons

edited by

Patrizia Longone

and Ezia Guatteo

submission deadline 20 Sep 2025 | 1 articles | Viewed by 706 | Submission Open

Keywords: non-neuronal cells; neurotransmitters; systemic disease; motor system; neuronal circuitry; skeletal muscle metabolism; muscle oxidative metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Apoptosis and Autophagy in Osteosarcoma

edited by

Hyung-Mun Yun

and

Kyung-Ran Park

submission deadline 20 Sep 2025 | 1 articles | Viewed by 697 | Submission Open

Keywords: apoptosis; autophagy; bioactive molecule; cancer; necroptosis; osteosarcoma; osteoclast; osteoblast

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Intestinal Microbiome and Its Function

edited by

Simone Baldi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 691 | Submission Open

Keywords: human microbiome; gut microbiome; microbiota-derived metabolites; SCFAs; gut– organ axis

(This special issue belongs to the Section Molecular Microbiology)

Advances in Diabetic Ischemic Heart Failure

edited by Branko Beleslin

submission deadline 20 Sep 2025 | 1 articles | Viewed by 673 | Submission Open

Keywords: diabetes; ischemic cardiomyopathy; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Epigenetic Insights into Extracellular Vesicles

edited by

Dimitrios Vlachakis

and

George P. Chrousos

submission deadline 20 Sep 2025 | Viewed by 671 | Submission Open

Keywords: exosomes; extracellular vesicles; cell– cell communication; endocrinology

(This special issue belongs to the Section Biochemistry)

Mitochondria and Energy Metabolism Reprogramming in Diseases

edited by

Nadège Bellance

submission deadline 20 Sep 2025 | 1 articles | Viewed by 665 | Submission Open

Keywords: mitochondrial dysfunctions; energy metabolism; pathophysiological mechanisms; therapeutic targets; physiology of organelle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition

edited by

Zhidong Zhou

submission deadline 20 Sep 2025 | 1 articles | Viewed by 653 | Submission Open

Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies

(This special issue belongs to the Section Molecular Neurobiology)

Cell Biology and Biochemistry Regulation Mediated by Natural Compounds

edited by

Amélia M. Silva

submission deadline 20 Sep 2025 | Viewed by 647 | Submission Open

Keywords: cellular targets; natural compounds; nutraceuticals; health-promoting effects; enzymatic activity; cell-based assays; in vivo; nanoencapsulation; delivery of natural compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Research Progresses on Multifaceted Cholinergic Signaling

edited by Taher Darreh-Shori

submission deadline 20 Sep 2025 | Viewed by 638 | Submission Open

Keywords: cholinergic signaling; choline acetyltransferase (ChAT); nicotinic acetylcholine receptors (AChRs); muscarinic acetylcholine receptors (mAChRs); mitochondrial acetylcholine receptors; cholinergic anti-inflammatory pathway; cholinergic signaling in cancer; cholinergic signaling in mitochondria; cholinergic signaling in ALS; cholinergic signaling in dementia; cholinergic signaling in COVID-19

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition

edited by

Jolanta Neubauer-Geryk

submission deadline 20 Sep 2025 | 1 articles | Viewed by 622 | Submission Open

Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Statistical Methods in Gene Expression Analysis, Functional Genomics, Genetics, and Biochemistry

edited by Łukasz Huminiecki

submission deadline 20 Sep 2025 | 1 articles | Viewed by 619 | Submission Open

Keywords: multi-omics; statistics; gene expression analysis

(This special issue belongs to the Section Molecular Informatics)

Nanostructures: From Synthesis, Modification to Biomedical Applications

edited by Kleoniki Giannousi and

Catherine Dendrinou-Samara

submission deadline 20 Sep 2025 | 1 articles | Viewed by 611 | Submission Open

Keywords: nanostructures; post-synthetic methods; multi-drug resistant bacteria; amyloidopathies; neurodegeneration; photocatalysis; biosensors

(This special issue belongs to the Section Molecular Nanoscience)

Gestational Diabetes Mellitus: Molecular Insights into Pathophysiology, Management and Therapy

edited by

Paweł Jan Stanirowski

submission deadline 20 Sep 2025 | 1 articles | Viewed by 554 | Submission Open

Keywords: GDM pathogenesis; health programming; pharmacogenomics; life-style interventions; fetal growth disorders; preeclampsia; polyhydramnios; placental origin of disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Roles and Function of Extracellular Vesicles in Diseases: 3rd Edition

edited by

Won Jong Rhee

submission deadline 20 Sep 2025 | Viewed by 467 | Submission Open

Keywords: extracellular vesicle; exosome; disease; roles and function

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifunctional Nanocomposites for Bioapplications

edited by

Athina Angelopoulou

submission deadline 20 Sep 2025 | 1 articles | Viewed by 461 | Submission Open

Keywords: nanocomposites; biomedical applications; molecular characteristics; metabolic pathways; biomarkers; external stimuli

(This special issue belongs to the Section Molecular Nanoscience)

Lipoproteins—Opportunities for the Development of Nanotherapeutics in Chronic Disease

edited by

Thomas Grewal

submission deadline 20 Sep 2025 | Viewed by 458 | Submission Open

Keywords: lipoproteins; LDL; HDL; nanotherapeutics; chronic disease; targeted therapy; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Natural Products in Human Health and Disease

edited by

Sung-Joon Lee

and Ji Hae Lee

submission deadline 20 Sep 2025 | Viewed by 454 | Submission Open

Keywords: natural substances; phytochemicals; chronic diseases; aging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

miRNAs in Cancers: From Molecular Biology to Treatment

edited by

Laura Mosca

submission deadline 20 Sep 2025 | Viewed by 450 | Submission Open

Keywords: cancer; miRNA; epigenetic

(This special issue belongs to the Section Molecular Biology)

The Medicinal Mechanism and Application of Biologically Active Compounds in Melanoma

edited by Rosanna Avola and Adriana C. E. Graziano

submission deadline 20 Sep 2025 | Viewed by 444 | Submission Open

Keywords: biologically active compounds; medicinal mechanism; cancer; melanoma; chemoprevention; anticancer effect; immunomodulation; apoptosis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Glioma Knowledge: From Genome to Signal Pathways Alterations

edited by

Sabrina Di Bartolomeo

and Giuseppina D'Alessandro

submission deadline 20 Sep 2025 | Viewed by 443 | Submission Open

Keywords: gliomas; signalling pathways; genetic alterations; epigenetics; metabolic alterations; drug resistance; glioma stem cells

(This special issue belongs to the Section Molecular Neurobiology)

Fiber Plants: Genetics and Genomics, Molecular Mechanisms and Potential Applications—Novel Materials, Functional Foods and Beyond

edited by

Jian Zhang

and

Michael Deyholos

submission deadline 20 Sep 2025 | 1 articles | Viewed by 432 | Submission Open

Keywords: fiber plant; genetics; genomics; bioactive products; natural fibers; fatty acids; medical products; environmental and ecological effects of fiber plants

(This special issue belongs to the Section Molecular Plant Sciences)

Novel Therapeutic Advances in Pancreatic Cancer

edited by

Enza Lonardo

submission deadline 20 Sep 2025 | Viewed by 421 | Submission Open

Keywords: pancreatic cancer; therapeutic advancements; tumor microenvironment; personalized medicine; biomarkers; liquid biopsy; targeted therapies; immunotherapy; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Chemicals Impacts on the Reproductive System

edited by

Giovanna Liguori

and

Anna Costagliola

submission deadline 20 Sep 2025 | Viewed by 413 | Submission Open

Keywords: endocrine disruptors; environmental pollution; female reproduction; male reproduction

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Choroid Plexus in Neurological Health

edited by

Telma Quintela

submission deadline 20 Sep 2025 | Viewed by 409 | Submission Open

Keywords: choroid plexus; cerebrospinal fluid; neurological health; blood– CSF barrier; central nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Epilepsy and Antiepileptic Drugs, 3rd Edition

edited by

Jarogniew J. Luszczki

submission deadline 20 Sep 2025 | Viewed by 408 | Submission Open

Keywords: antiepileptic drugs: classic; novel; second and third generations; antiseizure medications: novel therapeutic options; cannabinoids in epilepsy; animal models of epilepsy: from animals to humans; clinical trials in epilepsy: novel potentially efficacious drugs; interactions between antiepileptic drugs: pharmacodynamic and pharmacokinetic aspects; interactions of antiepileptic drugs with other drugs: pharmacodynamic and pharmacokinetic aspects; adverse effects of antiseizure medication; treatment of epilepsy in specific populations (elderly; childbearing women; children); drug-resistant epilepsy in preclinical conditions; epileptogenesis: all pathophysiological and molecular aspects

(This special issue belongs to the Section Molecular Pharmacology)

Drug Resistance Mechanisms in Human Cancer Cells to Anticancer Drugs

edited by

Daekyu Sun

submission deadline 20 Sep 2025 | Viewed by 401 | Submission Open

Keywords: cancer therapy; targeted therapy; combination therapy; drug resistance; resensitization; DNA repair; DNA damage response; DNA repair inhibitors; synthetic lethality; chemoradiation

(This special issue belongs to the Section Molecular Pharmacology)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 20 Sep 2025 | Viewed by 400 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Translational Research of Non-Small Cell Lung Cancer

edited by

Xabier Mielgo Rubio

submission deadline 20 Sep 2025 | Viewed by 399 | Submission Open

Keywords: non-small cell lung cancer; precision medicine; targeted therapy; resistance mechanisms; immunotherapy; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Research of Human Fertility

edited by

Angeliki Tiptiri-Kourpeti

and Byron Asimakopoulos

submission deadline 20 Sep 2025 | Viewed by 387 | Submission Open

Keywords: human reproduction; fertility preservation; ART; infertility; IVF

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into Reproductive Toxicology

edited by Maria Cristina Budani

submission deadline 20 Sep 2025 | Viewed by 378 | Submission Open

Keywords: endocrine disruptors; environmental toxicants; fertility; heavy metals; lifestyle habits; molecular mechanisms; pregnancy; teratology; teratogenic compounds; reproductive toxicology

(This special issue belongs to the Section Molecular Toxicology)

New Biomarkers in Pancreatic Diseases

edited by