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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 28 Aug 2025 | Viewed by 57 | Submission Open

Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants

edited by

Sheila Leone

and

Lucia Recinella

submission deadline 29 Aug 2025 | 1 articles | Viewed by 749 | Submission Open

Keywords: oxidative stress; inflammation; herbal extracts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application and Formulation of Therapeutic Natural Deep Eutectic Solvents

edited by

Kunn Hadinoto Ong

submission deadline 29 Aug 2025 | Viewed by 104 | Submission Open

Keywords: deep eutectic solvent; ionic liquid drug; eutectic mixture; green solvent; pharmaceutical salts

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Thrombosis

edited by

J. Kh. Khizroeva

submission deadline 30 Aug 2025 | 6 articles | Viewed by 16031 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on the Role of the Gut Microbiota in Human Diseases and Health

edited by

Sanda Cretoiu

submission deadline 30 Aug 2025 | 5 articles | Viewed by 12782 | Submission Open

Keywords: microbiota; microbiome; gut microbiome metabolites; dysbiosis; gut– organ axis; gut microbiota pathogens; diet

(This special issue belongs to the Section Molecular Microbiology)

The Role of Extracellular Vesicles in Cancer Diagnosis and Therapy, 2nd Edition

edited by

Nils Ludwig

submission deadline 30 Aug 2025 | 3 articles | Viewed by 7145 | Submission Open

Keywords: extracellular vesicles; exosomes; intercellular communication; liquid biopsy; cancer therapeutics; nanotherapeutics

(This special issue belongs to the Section Molecular Oncology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 30 Aug 2025 | 4 articles | Viewed by 5247 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

From Bench to Bedside: Well-Established and Emerging Preclinical Models in Cardiovascular Research

edited by

Laura Calvillo

and Veronica Dusi

submission deadline 30 Aug 2025 | 1 articles | Viewed by 4979 | Submission Open

Keywords: myocardial infarction; organ ischemia and reperfusion injury; hypertension; cardiovascular dysfunction; cardio-renal syndrome; stroke; arrhythmias; heart disease; heart failure; genetic disorders; translational medicine; organoids; bioreactors; organs on a chip; omics sciences; pharmacology; molecular biology; gene therapy; quantum biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 30 Aug 2025 | 1 articles | Viewed by 4187 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Immunology of Infectious Disease and Transplantation: A Symbiotic Dance

edited by

Alessandro Perrella

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3908 | Submission Open

Keywords: organ transplantation; infectious disease; immune responses; immunology; personalized medicine; transplantation medicine

(This special issue belongs to the Section Molecular Immunology)

Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition

edited by

Yong-Gu Cho

and

Kwon-Kyoo Kang

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3330 | Submission Open

Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Transition Metal Catalysis: From Synthesis to Late-Stage Functionalization of Aromatics and Heterocycles

edited by

Antonio Del Vecchio

and

Fabio Bellina

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3109 | Submission Open

Keywords: transition metal catalysis; homogeneous catalysis; heterogeneous catalysis; cross-couplings; synthesis of aromatics and heteroaromatics; late-stage functionalization; photo-; electro-; flow; mechanochemistry; medicinal chemistry; material sciences; bioinorganic chemistry; industrial processes

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2196 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Oral Soft Tissue Repair and Oral Diseases: 2nd Edition

edited by

Jacek Matys

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1982 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Biology)

The Extracellular Matrix in Physiopathology

edited by

Eric Huet

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1946 | Submission Open

Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 30 Aug 2025 | 2 articles | Viewed by 1393 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1273 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Advances in the Genetics, Epidemiology and Management of Myopathies

edited by

Efthimios Dardiotis

and

Vasileios Siokas

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1248 | Submission Open

Keywords: myopathies; muscle disorders; muscle weakness; muscle pain; myalgia

(This special issue belongs to the Section Molecular Biology)

Intracellular Trafficking and Catabolism of Free Heme: Physiological Roles and Relevance to Pathological Mechanisms

edited by Junichi Taira

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1121 | Submission Open

Keywords: heme oxygenase; heme metabolism; heme chaperon; free heme (labile heme); cytochrome P450 reductase; reactive oxygen species; carbon monoxide

(This special issue belongs to the Section Biochemistry)

Beyond the Known: Molecular Insights into the World of New Psychoactive Compounds

edited by

Helena Gaspar

and

Rita Pacheco

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1102 | Submission Open

Keywords: new psychoactive substances; synthetic drugs; metabolism; toxicology; drug checking; designer drugs

(This special issue belongs to the Section Macromolecules)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 30 Aug 2025 | 1 articles | Viewed by 948 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Plants Redox Biology

edited by

Xin Li

submission deadline 30 Aug 2025 | 1 articles | Viewed by 919 | Submission Open

Keywords: plant– environment interaction; stress physiology; plant redox signaling; plant hormones; plant– pathogen interaction; reactive oxygen species (ROS); reactive nitrogen species (RNS); ascorbate; flavonoid; glutathione

(This special issue belongs to the Section Molecular Plant Sciences)

Plant-Microbe Interaction: Current Status and Future Directions

edited by

Juan Manuel Ruiz Lozano

submission deadline 30 Aug 2025 | Viewed by 826 | Submission Open

Keywords: beneficial micro-organism; climate change; crop productivity; environmental stress; food production; plant growth; stress mitigation; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 30 Aug 2025 | 1 articles | Viewed by 818 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Technologies in the Study and Understanding of Colorectal Tumorigenesis: Challenges and Opportunities

edited by

Paola Sena

submission deadline 30 Aug 2025 | 1 articles | Viewed by 774 | Submission Open

Keywords: colorectal cancer; genetic analysis; gut microbiome; tumor; circulating components; medicine; immunotherapy; proteomics

(This special issue belongs to the Section Molecular Oncology)

Biodegradable Polymers: From Chemical Synthesis to Biodegradable Mechanism

edited by

Ling-Ping Xiao

Oana Lelia Pop

and

Gabrijel Ondrasek

submission deadline 30 Aug 2025 | Viewed by 757 | Submission Open

Keywords: biodegradable polymers; polyolefins; molecular structures; synthesis; chemical modification; hydrolysis kinetics

(This special issue belongs to the Section Macromolecules)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 30 Aug 2025 | 1 articles | Viewed by 687 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Computer-Aided Drug Design Strategies

edited by

Alexandre G. De Brevern

submission deadline 30 Aug 2025 | 1 articles | Viewed by 651 | Submission Open

Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques

(This special issue belongs to the Section Molecular Informatics)

Gastrointestinal Microbes: Implications for Health and Disease

edited by Suqin Hang

submission deadline 30 Aug 2025 | 1 articles | Viewed by 605 | Submission Open

Keywords: animal; gut; microbiota; gut hormone; nutrients

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in Regenerative Medicine and Therapeutics

edited by Diana Torge

submission deadline 30 Aug 2025 | 1 articles | Viewed by 520 | Submission Open

Keywords: regenerative medicine; morphology; regenerative dentistry; biomaterials; scaffolds; organoids; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer

edited by

Yutang Wang

submission deadline 30 Aug 2025 | Viewed by 508 | Submission Open

Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer

(This special issue belongs to the Section Molecular Neurobiology)

The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations

edited by

Ioannis-Dimosthenis Adamakis

and

Kosmas Haralampidis

submission deadline 30 Aug 2025 | 1 articles | Viewed by 473 | Submission Open

Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

The Latest Molecular Research on Renal Disease

edited by Niels Henrik Buus

submission deadline 30 Aug 2025 | 1 articles | Viewed by 453 | Submission Open

Keywords: renal disease; chronic kidney disease; renal regeneration; kidney injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physics and Chemistry of Molecular Materials for Optoelectronic Applications

edited by

Aggelos Avramopoulos

submission deadline 30 Aug 2025 | Viewed by 408 | Submission Open

Keywords: polarization of matter; non-linear optics and non-linear optical phenomena; optical phenomena; quantum chemistry; density functional theory; physics and chemistry of molecular materials; molecular-based optoelectronics

(This special issue belongs to the Section Materials Science)

Molecular Research on Plant Breeding

edited by

Hélia Cardoso

, Sandra Correia and

Isaura Castro

submission deadline 30 Aug 2025 | 1 articles | Viewed by 407 | Submission Open

Keywords: plant breeding; proteomics; metabolomics; epigenomics; gene editing

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Quorum Sensing in Plant Microbiome: Advances and Prospects

edited by

Clarisse Brígido

submission deadline 30 Aug 2025 | Viewed by 364 | Submission Open

Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Latest Advances in Computational Drug Discovery

edited by

Sunil Gaikwad

submission deadline 30 Aug 2025 | Viewed by 344 | Submission Open

Keywords: design; synthesis; molecular docking; methodological reviews; novel docking approaches; ADME; toxicity; AI-driven molecular docking; molecular dynamics; bioisosteric replacement in drug design; rational drug design and synthesis; computational tools and algorithms; lead optimization and structure-based drug design; virtual screening of drug candidates; QSAR modelling; DFT

(This special issue belongs to the Section Molecular Pharmacology)

Trees Genetics, Genomics, and Molecular Breeding

edited by

Hengfu Yin

submission deadline 30 Aug 2025 | 1 articles | Viewed by 331 | Submission Open

Keywords: trees genetics; genomics; molecular; regulatory mechanism; genetic improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion

edited by

Baojun Xu

submission deadline 30 Aug 2025 | Viewed by 236 | Submission Open

Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Inflammation in Pregnancy and Childbirth

edited by

Małgorzata Szczuko

and Maciej Ziętek

submission deadline 30 Aug 2025 | Viewed by 193 | Submission Open

Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins

(This special issue belongs to the Section Molecular Immunology)

Advanced Research on Nanosensors for Molecular Sensing Applications

edited by

Giorgio Rispoli

submission deadline 30 Aug 2025 | Viewed by 182 | Submission Open

Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor

(This special issue belongs to the Section Molecular Nanoscience)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 30 Aug 2025 | Viewed by 179 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia

edited by

Moo Kon Song

submission deadline 30 Aug 2025 | Viewed by 175 | Submission Open

Keywords: targeted therapy; acute myeloid leukemia; genetic mutations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application and Molecular Mechanisms of Microwaves for Materials Processing

edited by

Valentin Craciun

submission deadline 30 Aug 2025 | Viewed by 174 | Submission Open

Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering

(This special issue belongs to the Section Materials Science)

Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources

edited by

Elena Dreassi

and

Annalaura Brai

submission deadline 30 Aug 2025 | Viewed by 144 | Submission Open

Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 30 Aug 2025 | Viewed by 136 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy

edited by

M. Letizia Motti

submission deadline 30 Aug 2025 | 1 articles | Viewed by 131 | Submission Open

Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules

(This special issue belongs to the Section Molecular Oncology)

New Insights in Biomarkers of Autoimmune and Autoinflammatory Diseases: 2nd Edition

edited by

Mariapaola Marino

submission deadline 30 Aug 2025 | Viewed by 126 | Submission Open

Keywords: inflammaging; inflammasome; autoantibodies; free light chains; cytokines; receptor; signal transduction; innate immunity; adaptive immunity

(This special issue belongs to the Section Molecular Immunology)

Molecular Applications of Antioxidants and Anti-Inflammatory Activities of Natural Products

edited by

Vassilis Athanasiadis

submission deadline 30 Aug 2025 | Viewed by 126 | Submission Open

Keywords: antioxidants; anti-inflammatory agents; natural products; molecular mechanisms; oxidative stress; signaling pathways; inflammation; bioactive compounds; proteomics; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Type 2 Diabetes and Its Complications: 2nd Edition

edited by

Anca Pantea Stoian

submission deadline 30 Aug 2025 | Viewed by 125 | Submission Open

Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 1001-1050 on page 21 of 68.

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