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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Proteases and Their Inhibitors
edited by
submission deadline 20 Mar 2026 | Viewed by 390 | Submission Open
Keywords: protease; serine proteases; thiol proteases; acid proteases; metalloproteases; protease inhibitor; SERPINs
(This special issue belongs to the Section Biochemistry)
Roles of Neutrophils in Autoimmune Diseases and Cancers
edited by
submission deadline 20 Mar 2026 | Viewed by 388 | Submission Open
Keywords: neutrophils; neutrophil extracellular traps (NETs); autoimmunity; autoimmune disease(s); cancer; oncology
(This special issue belongs to the Section Molecular Immunology)
Dietary Polyphenols for Improving Gut Health
edited by Andreia Gomes
submission deadline 20 Mar 2026 | Viewed by 387 | Submission Open
Keywords: microbiota diversity; gut health; polyphenols; polyphenol bioavailability; immune function; inflammation; therapeutic potential of polyphenols; host health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Advances in DNA Nanotechnology
edited by Zhaoqi Yang
submission deadline 20 Mar 2026 | Viewed by 385 | Submission Open
Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Pharmacology of Protein Kinase Inhibitor
edited by
submission deadline 20 Mar 2026 | Viewed by 380 | Submission Open
Keywords: protein kinase inhibitor; molecular pharmacology; signaling pathway; preclinical/clinical evaluation; computational modeling; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Discovery of Proteins Leading to New Asthma Treatments submission deadline 20 Mar 2026 | Viewed by 379 | Submission Open
Keywords: asthma; allergens; proteomic analysis; bioinformatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein-Based Composite Materials: 2nd Edition
edited by
submission deadline 20 Mar 2026 | Viewed by 362 | Submission Open
Keywords: protein biopolymer; composite film; fiber; foam; gel; particle; sensor; and device; biomacromolecules and functional materials; polymer composite design and characterization; protein physical and chemical properties
(This special issue belongs to the Section Materials Science)
Molecular Biology of Chagas Disease, Leishmaniasis, and West Nile Virus Vectors in the Old and New World submission deadline 20 Mar 2026 | Viewed by 359 | Submission Open
Keywords: triatominae; Trypanosoma cruzi; Leishmania; Culex; Lutzomya; phlebotomus; epidemiology; neglected; populations; vectors
(This special issue belongs to the Section Molecular Microbiology)
Advanced Molecular Research in Polymers and Organic Semiconductors
edited by Ovidio Amado Almanza
submission deadline 20 Mar 2026 | Viewed by 349 | Submission Open
Keywords: polymer; organic semiconductors; molecular design; molecular interactions; thermal properties; optical properties; biointerfaces; sustainable materials
(This special issue belongs to the Section Materials Science)
Squamous Cell Carcinoma: From Molecular Mechanisms to Therapeutics
edited by
submission deadline 20 Mar 2026 | Viewed by 337 | Submission Open
Keywords: squamous cell carcinoma; immunotherapy; melanoma; non-melanoma
(This special issue belongs to the Section Molecular Oncology)
Pediatric Gastrointestinal and Biliary Diseases: From Molecular Basis to Therapy
edited by
submission deadline 20 Mar 2026 | Viewed by 334 | Submission Open
Keywords: pediatrics; gastroenterology; biliary; therapy; genetics; biology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Chronic Obstructive Pulmonary Diseases
edited by
submission deadline 20 Mar 2026 | Viewed by 323 | Submission Open
Keywords: COPD; epigenetics; mitochondrial dysfunction; autophagy; proteomics; single-cell sequencing; metabolomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pain Chronicity and Relief: From Molecular Basis to Rehabilitation
edited by
submission deadline 20 Mar 2026 | Viewed by 313 | Submission Open
Keywords: exercise-induced hypoalgesia; barrier factor; chronic pain; neuropathic pain; spinal cord dorsal horn; mesocorticolimbic system; myokine; descending pain modulatory system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Agrifood Waste Valorization: From By-Products to Sustainable Resources submission deadline 20 Mar 2026 | Viewed by 305 | Submission Open
Keywords: antioxidants; by-products; antimicrobials; nutraceuticals; food industry; circular economy
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications
edited by
submission deadline 20 Mar 2026 | Viewed by 292 | Submission Open
Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy– entropy compensation; boundary surface; Langmuir isotherm; theoretical models
(This special issue belongs to the Section Biochemistry)
Cellular Plasticity in Health and Diseases
edited by
submission deadline 20 Mar 2026 | Viewed by 286 | Submission Open
Keywords: stem cells; cytokines; extracellular matrix; cell differentiation; cell locomotion; cell growth; tissue repair; chronic inflammation; dysplasia; hyperplasia; premalignant lesions; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Peptides: Microbial Fermentation-Driven Synthesis and Multifunctional Applications in Health and Industry
edited by
submission deadline 20 Mar 2026 | Viewed by 280 | Submission Open
Keywords: bioactive peptides; foods; probiotics; fermentation; pharmaceutical; herbs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Host Immunity and Viral Evolution: Dissecting the Molecular Variations of Viral Genomes
edited by Maria Victoria Preciado
submission deadline 20 Mar 2026 | Viewed by 277 | Submission Open
Keywords: virus evolution; immune response; host– virus interaction; vaccine design; antiviral design; virus emergence and reemergence; bioinformatics; immunoinformatics
(This special issue belongs to the Section Molecular Immunology)
Autophagy: Novel Insights from Molecular and Chemical Biology submission deadline 20 Mar 2026 | Viewed by 277 | Submission Open
Keywords: Alzheimer’ s disease; amyloid precursor protein; amyloid-β protein; protein aggregation; intracellular clearance pathways; autophagy– lysosomal pathway; ubiquitin-proteasome system; small molecule drugs; autophagy modulators; drug development
(This special issue belongs to the Section Molecular Biophysics)
Microgravity, Cell Shape and Gene Expression: State of the Art, Challenges and Prospects
edited by Masahiro Terada
submission deadline 20 Mar 2026 | Viewed by 273 | Submission Open
Keywords: microgravity; space radiation; closed environment; space flight; parabolic flight; clinostat; human; rodent; microorganism; countermeasure; artificial gravity
(This special issue belongs to the Section Molecular Biology)
From Plant Genomics Investigations to Plant Biotechnology Exploitation
edited by
submission deadline 20 Mar 2026 | Viewed by 273 | Submission Open
Keywords: sequencing; plant genomes; biotechnological applications; translational genomics; new discoveries
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia
edited by Fabrizio Barbetti
submission deadline 20 Mar 2026 | Viewed by 265 | Submission Open
Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Enzymes Involved in Amino Acid Metabolism: Molecular Structure and Function
edited by and Mirco Dindo
submission deadline 20 Mar 2026 | Viewed by 251 | Submission Open
Keywords: amino acids; enzyme; human disease; protein engineering; protein dynamics
(This special issue belongs to the Section Molecular Biology)
The Immune Regulation of Osteoclasts
edited by
submission deadline 20 Mar 2026 | Viewed by 248 | Submission Open
Keywords: hematopoietic stem cells; osteoclasts; osteoblasts; osteocytes; stromal cells; T cells; B cells; macrophages; dendritic cells; interleukins; cytokines
(This special issue belongs to the Section Molecular Immunology)
Structure-Based Design of Drugs and Other Bioactive Molecules
edited by
submission deadline 20 Mar 2026 | Viewed by 247 | Submission Open
Keywords: three-dimensional structure; molecular descriptor; molecular similarity; database searching; drug repositioning; target fishing; novel algorithm; data prediction
(This special issue belongs to the Section Molecular Informatics)
Marine Fungi: From Molecular Biology to Biotechnology Application
edited by
submission deadline 20 Mar 2026 | Viewed by 244 | Submission Open
Keywords: marine fungi; marine yeasts; marine filamentous fungi; biosynthesis; metabolic engineering; regulatory mechanism; functional biomolecules; exopolysaccharides; glycolipids; organic acids; biofuel; enzymes; cell factories; gene editing tools; fermentation optimization
(This special issue belongs to the Section Molecular Microbiology)
Obesity: Different Perspectives Based on Molecular Physiology and Pathology
edited by Hector I. Rocha-Gonzalez
submission deadline 20 Mar 2026 | Viewed by 243 | Submission Open
Keywords: obesity; rational management; perspectives; new ideas; pharmacology; lifestyle modification; molecular advances
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis
edited by
submission deadline 20 Mar 2026 | Viewed by 241 | Submission Open
Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions
(This special issue belongs to the Section Molecular Immunology)
Foundational Studies Using Model Systems for Molecular Insights into Metabolism, Aging, and Disease
edited by
submission deadline 20 Mar 2026 | Viewed by 236 | Submission Open
Keywords: Saccharomyces cerevisiae  and yeasts; Caenorhabditis elegans  and nematodes; Arabidopsis thaliana  and plants; Drosophila melanogaster; Mus musculus; established and emerging model systems  
(This special issue belongs to the Section Molecular Biology)
Biotransformation and Engineering of Fungals and Microalgae submission deadline 20 Mar 2026 | Viewed by 234 | Submission Open
Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy
(This special issue belongs to the Section Molecular Microbiology)
Research on Plant Genomics and Breeding: 3rd Edition submission deadline 20 Mar 2026 | Viewed by 229 | Submission Open
Keywords: gene cloning and function; genetic engineering; molecular genetics; genome editing; regulatory mechanisms; germplasm enhancement; molecular breeding and marker-assisted selection
(This special issue belongs to the Section Molecular Plant Sciences)
Emerging Insights into Lymphoid Organ Development, Regulation and Therapeutic Potential
edited by Hélia Neves
submission deadline 20 Mar 2026 | Viewed by 227 | Submission Open
Keywords: thymus; immune; signaling; molecular; pathways; epigenetics; organoids; bioengineering; regeneration; clinical application
(This special issue belongs to the Section Molecular Biology)
Advances in the Role of Retinoic Acid-Regulated Genes in Cancer Biology
edited by Fuming Tsai
submission deadline 20 Mar 2026 | Viewed by 214 | Submission Open
Keywords: retinoic acid; retinoic acid receptors; retinoic x receptors; tumorigenesis; metastasis; tumor microenvironment; molecular pathways
(This special issue belongs to the Section Molecular Genetics and Genomics)
Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms
edited by
submission deadline 20 Mar 2026 | Viewed by 212 | Submission Open
Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Statin Induced Neurotoxicity submission deadline 20 Mar 2026 | Viewed by 199 | Submission Open
Keywords: mitochondrial dysfunction; oxidative stress; coenzyme Q10; simvastatin; neurotoxicity; blood brain barrier
(This special issue belongs to the Section Molecular Neurobiology)
Regulation of Gene Expression in Cell Differentiation
edited by
submission deadline 20 Mar 2026 | Viewed by 196 | Submission Open
Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling
(This special issue belongs to the Section Molecular Genetics and Genomics)
Multifunctional Nano-Coatings for Biomedical Applications
edited by and Jana Valnohova
submission deadline 20 Mar 2026 | Viewed by 194 | Submission Open
Keywords: nanocoatings; nanomedicine; drug delivery; surface functionalization; diagnostics; therapeutics; prevention; stimuli-responsive materials; biomedical nanotechnology; targeted delivery systems; biocompatible coatings
(This special issue belongs to the Section Molecular Nanoscience)
Advancing Forensic Genetics Through Massive Parallel Sequencing
edited by Daniel Kling
submission deadline 20 Mar 2026 | Viewed by 190 | Submission Open
Keywords: forensic genetics; molecular biology; genetics and aging; biochemistry; population genetics; fo-rensic statistics
(This special issue belongs to the Section Molecular Genetics and Genomics)
From Diet to Health: Which Molecules or Chemicals Are at Work?
edited by Sara Baldelli
submission deadline 20 Mar 2026 | Viewed by 190 | Submission Open
Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Flexible Sensors for Biomedical Application
edited by
submission deadline 20 Mar 2026 | Viewed by 185 | Submission Open
Keywords: biomedical applications; molecular diagnostics; molecular recognition mechanisms; biosensors; electrochemical sensing; nanomaterials for sensing; implantable sensors; soft bioelectronics
(This special issue belongs to the Section Biochemistry)
Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment
edited by
submission deadline 20 Mar 2026 | Viewed by 185 | Submission Open
Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion
(This special issue belongs to the Section Molecular Oncology)
The Interaction Between Tumor Microenvironment and Cancer Stem Cell
edited by
submission deadline 20 Mar 2026 | Viewed by 178 | Submission Open
Keywords: tumor microenvironment; cancer stem cells; innate and adaptive immunity; mesenchymal stromal cells
(This special issue belongs to the Section Molecular Oncology)
Molecular, Genetic, and Omics Approaches to Disorders in Bone–Inflammation Crosstalk submission deadline 20 Mar 2026 | Viewed by 176 | Submission Open
Keywords: bone physiology; inflammatory; epigenetic regulation; molecular signaling pathways; cellular interactions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Future of Biomaterials in Dentistry: Innovations in Drug Delivery and Regenerative Medicine
edited by
submission deadline 20 Mar 2026 | Viewed by 175 | Submission Open
Keywords: dentistry; regenerative medicine; drug delivery; tissue engineering; biomaterials; tooth; periodontal
(This special issue belongs to the Section Materials Science)
Design, Synthesis and Application of Cellulose Materials
edited by and
submission deadline 20 Mar 2026 | Viewed by 174 | Submission Open
Keywords: cellulose; polymer materials; biomass
(This special issue belongs to the Section Materials Science)
Light-On Molecular Probes for Biomedical Analysis
edited by Aleksey A. Vasilev
submission deadline 20 Mar 2026 | Viewed by 172 | Submission Open
Keywords: fluorogenic dyes; nucleic acid binders; nucleic acid labels; molecular probes; fluorogenic polymers and nanomaterials
(This special issue belongs to the Section Materials Science)
Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications
edited by and Cristina Porta
submission deadline 20 Mar 2026 | Viewed by 172 | Submission Open
Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Polymer Dynamics
edited by
submission deadline 20 Mar 2026 | Viewed by 171 | Submission Open
Keywords: polymer dynamics; glass transition; segmental relaxation; bulk relaxation; structure– property relationship; functional polymers; spectroscopy; instrumental characterization; simulations and modeling; polymer diffusion
(This special issue belongs to the Section Materials Science)
Health Impacts of Environmental Pollution on the Urogenital and Reproductive Systems submission deadline 20 Mar 2026 | Viewed by 170 | Submission Open
Keywords: pollution; endocrine toxicity; endocrine disruptors; human biomonitoring; infertility; cancer; inflammation; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Retinal Neurodegeneration and Neuroprotection
edited by
submission deadline 20 Mar 2026 | Viewed by 165 | Submission Open
Keywords: retinal neurodegeneration; neuroprotection; therapeutic targets; retinal ischemia; excitotoxicity; oxidative stress; mitochondrial dysfunction; neuroinflammation; vascular dysfunction
(This special issue belongs to the Section Molecular Neurobiology)
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