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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomaterials: From Design, Synthesis and Characterization to Application—2nd Edition
edited by and
submission deadline 28 Feb 2026 | Viewed by 142 | Submission Open
Keywords: biomaterials; synthesis; characterization; therapeutics; diagnosis
(This special issue belongs to the Section Materials Science)
Molecular Mechanism in Cardiac Remodeling
edited by Xianming Lin and
submission deadline 28 Feb 2026 | Viewed by 140 | Submission Open
Keywords: cardiomyopathy; cardiac arrhythmias; ion channel; calcium transient
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Using Model Organisms to Study Complex Human Diseases—2nd Edition submission deadline 28 Feb 2026 | Viewed by 130 | Submission Open
Keywords: model organism; Escherichia coli; yeast; Caenorhabditis elegans; Drosophila melanogaster; zebrafish; Arabidopsis thaliana; Xenopus laevis; rat and mouse model; human disease; inherited disease; cancer; rare disease; genetics
(This special issue belongs to the Section Molecular Biology)
Neurofibromatosis Type 1 and NF2-Related Schwannomatosis: Advances from Basic Research to Current Therapies
edited by and
submission deadline 28 Feb 2026 | Viewed by 128 | Submission Open
Keywords: neurofibromatosis type 1 (NF1); neurofibromin; RAS/MAPK pathway; malignant peripheral nerve sheath tumor (MPNST); NF2-related schwannomatosis (NF2 syndrome); Merlin (Schwannomin); vestibular schwannoma; meningioma; ependymoma
(This special issue belongs to the Section Molecular Neurobiology)
The Role of Trace Elements in Nutrition and Health, 2nd Edition
edited by Jie Feng
submission deadline 28 Feb 2026 | Viewed by 127 | Submission Open
Keywords: trace elements; nutrition; health; function; disease; metabolism; homeostasis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Flowers: Molecular and Genetic Regulation of Growth and Development
edited by Yaqin Wang
submission deadline 28 Feb 2026 | Viewed by 126 | Submission Open
Keywords: flower; growth and development; molecular regulation; genetic breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Applications of Photodynamic Therapy in Cancer submission deadline 28 Feb 2026 | Viewed by 120 | Submission Open
Keywords: tumor microenvironment; CAF; hypoxia; immune evasion; combined therapies; new cellular or molecular targets
(This special issue belongs to the Section Molecular Oncology)
Alcohol Use Disorder: From Molecular Mechanisms to Therapeutics submission deadline 28 Feb 2026 | Viewed by 116 | Submission Open
Keywords: alcohol; addiction; FASD; alcohol-related damage
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Strategies for the Discovery, Optimization, and Efficient Use of Green Pesticides
edited by
submission deadline 28 Feb 2026 | Viewed by 115 | Submission Open
Keywords: natural-product-based pesticides; total synthesis; structural optimization; bioactivity evaluation; structure– activity relationship
(This special issue belongs to the Section Molecular Pharmacology)
Bridging Molecules and Reactions: Next-Generation Approaches for Advancing Electrocatalytic Efficiency submission deadline 28 Feb 2026 | 1 articles | Viewed by 115 | Submission Open
Keywords: electrochemical nanomaterials; energy storage and conversion; electrocatalysis and reaction mechanisms; photoelectrochemical water splitting; electrochemical energy storage devices; nanocomposites and functionalized materials; molecular-level electrocatalysis; electrocatalyst and photocatalysts; in-situ spectroscopy and atomistic modeling; hybrid molecular– nanostructured systems; sustainable and natural resource– derived materials; DFT related to reaction kinetics; AOP
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Functional Foods: Molecular Insights into Nutrition and Health
edited by Patroklos Vareltzis
submission deadline 28 Feb 2026 | Viewed by 113 | Submission Open
Keywords: functional foods; bioactive compounds; disease prevention; nutritional health; food innovation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Dermatological Perspectives on Connective Tissue Diseases
edited by Yoshihide Asano
submission deadline 28 Feb 2026 | Viewed by 112 | Submission Open
Keywords: connective tissue diseases; systemic sclerosis; systemic lupus erythematosus; dermatomyo-sitis; rheumatoid arthritis; Sjö gren’ s syndrome; skin immunology; fibrosis; cytokines; targeted therapy
(This special issue belongs to the Section Molecular Biology)
Advances in Osteogenesis: 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 109 | Submission Open
Keywords: osteogenesis; osteoblast; bone formation; disease; bone
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations
edited by
submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open
Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor– host interaction
(This special issue belongs to the Section Molecular Oncology)
Oral and Dental Infectious Diseases: Molecular Pathology, Diagnosis and Therapy (2nd Edition) submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open
Keywords: oral; dental; periodontitis; tooth decay; periodontal diseases; gingivitis; oral microorganism; oral infections; dental infections; dental caries; microbial pathogenicity; porphyromonas gingivalis; antimicrobials; oral biofilm
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Vascular Sclerosis
edited by Michishige Terasaki
submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open
Keywords: atherosclerosis; genes; dyslipidemia; diabetes; macrophages; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurodegenerative Diseases: Molecular Mechanisms, Drug Targets and Therapeutic Strategies
edited by
submission deadline 28 Feb 2026 | Viewed by 104 | Submission Open
Keywords: beta amyloid peptide; tau protein; alpha-synuclein protein; huntingtin protein; autophagy; neuromodulators; neurotrophins; natural compounds; neuroinflammation; vascular dysfunction; neuronal death; drug development; therapeutic biomarkers; blood– brain barrier; small-molecule therapeutics
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies on Wnt Signaling
edited by Katalin Mészáros
submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open
Keywords: Wnt signaling pathway; inhibitor; cancer; treatment; drugs
(This special issue belongs to the Section Molecular Biology)
From Molecules to Cognition: Biomarkers and Neuropsychological Tools in Neurological Disorders
edited by
submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open
Keywords: biomarkers; neuropsychological assessment; neurological disorders; neuroimaging; cognitive function; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Molecular, Cellular Mechanisms and Pathophysiology of Glioblastoma
edited by Agnieszka Rusak
submission deadline 28 Feb 2026 | Viewed by 103 | Submission Open
Keywords: glioblastoma; targeted terapy; molecular patchway; drug carriers; biomaterials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune Responses, Viral Infection and Neurodegenerative Diseases
edited by and Barbara Hanson
submission deadline 28 Feb 2026 | Viewed by 102 | Submission Open
Keywords: immune response; innate immunity; viral neuropathogenesis; viral biomarker; AD; PD; neurodegenerative diseases
(This special issue belongs to the Section Molecular Immunology)
Structural Studies of Phosphorus Compounds Today
edited by
submission deadline 28 Feb 2026 | Viewed by 102 | Submission Open
Keywords: 31P NMR; NMR; organophosphorus compounds; transition-metal complexes with organophosphorus ligands; relativistic effects; solvent effects; quantum chemistry methods for NMR; chemical structure studies; chemistry of organophosphorus compounds
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Hepatocardiac Interactions and the Utility of Hepatic Biomarkers in Cardiovascular Disease submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open
Keywords: hepatocardiac interactions; hepatic biomarkers; cardiovascular disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neutrophil Extracellular Traps (NETs) in Human Disease: From Molecular Mechanisms to Therapeutic Translation
edited by and Julia Elrod
submission deadline 28 Feb 2026 | Viewed by 101 | Submission Open
Keywords: neutrophil extracellular traps (NETs); molecular mechanisms; human disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sigma-1 Receptor: Signaling, Functions and Therapeutic Potential
edited by Gabriela Cristina Brailoiu and Eugen Brailoiu
submission deadline 28 Feb 2026 | Viewed by 99 | Submission Open
Keywords: Sigma-1R; intracellular receptor; molecular mechanisms; calcium signaling; neurological diseases; neurodegenerative diseases; pain; cancer; addiction
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Plant Abiotic Stress Tolerance: 3rd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open
Keywords: acclimation; drought; salinity; pesticides; high–low temperature; high–low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Cancer Nanomedicine: Imaging, Targeting and Therapeutic Applications submission deadline 28 Feb 2026 | Viewed by 97 | Submission Open
Keywords: cancer nanomedicine; multimodal imaging; nanoparticle drug delivery; tumor targeting; theranostic nanoparticles; combination therapies
(This special issue belongs to the Section Molecular Nanoscience)
Liver Pathophysiology and Its Role in Systemic Diseases
edited by Vassilios Sevastianos
submission deadline 28 Feb 2026 | Viewed by 97 | Submission Open
Keywords: liver disease; endocrine functions; liver-targeted drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Transcriptional Regulation in Plant Development: 3rd Edition submission deadline 28 Feb 2026 | Viewed by 97 | Submission Open
Keywords: environmental stresses; plant development; vegetative development; plant physiology and biochemistry; transcriptional regulation; plant– environment interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products—the Underestimated Source of New Solutions for the Innovative Antimicrobial Therapies
edited by , Jarosław Widelski and
submission deadline 28 Feb 2026 | Viewed by 96 | Submission Open
Keywords: plant; medicines; natural product; antimicrobial activity; drug resistance; chemical analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring Melatonin and Related Indolic Agents
edited by
submission deadline 28 Feb 2026 | Viewed by 96 | Submission Open
Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan
(This special issue belongs to the Section Molecular Pharmacology)
Microbiota and Gut–Brain–Eye Neuromodulators in Neurodegenerative Disorders: Biomolecular Targets and Therapeutic Challenges submission deadline 28 Feb 2026 | Viewed by 95 | Submission Open
Keywords: gut microbiota; brain; eye diseases; neuroinflammation; neurodegeneration; chronic inflammation; chronic pain; probiotics; gastrointestinal disorders; metabolic diseases; machine learning; artificial intelligence
(This special issue belongs to the Section Molecular Neurobiology)
Current Research on Neuroprotective Phytochemicals and Their Multi-Target Mechanisms submission deadline 28 Feb 2026 | Viewed by 95 | Submission Open
Keywords: Alzheimer’ s disease; neuroprotective phytochemicals; green extraction; technologies; blood– brain barrier permeability; bioavailability; multi-target mechanisms; omics approaches; nanodelivery systems; brain health; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
Roles and Mechanisms of Non-Coding RNAs in Cancer
edited by Stefano Sechi and Daniela Scarabino
submission deadline 28 Feb 2026 | Viewed by 94 | Submission Open
Keywords: cancer; non-coding RNA (ncRNA); translational medicine; oncological therapy; biomarker; piRNA; lncRNA; circRNA
(This special issue belongs to the Section Molecular Genetics and Genomics)
Application of Spectroscopic Methods in Molecular Biology Research
edited by
submission deadline 28 Feb 2026 | Viewed by 92 | Submission Open
Keywords: spectroscopy; molecular characterization; biomaterials; computational chemistry; structure– property relationships; biomolecular interactions; biomedical applications
(This special issue belongs to the Section Molecular Biology)
Bioactive Phytochemicals in Plant Extracts: A Comprehensive Analysis of Their Diverse Chemical Structures and Therapeutic and Functional Effects
edited by
submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open
Keywords: extraction; phytochemicals; bioactive compounds; second metabolites; nutraceuticals; polyphenols; flavonoids; biological effects; therapeutic effects
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Functionalization of Biopolymers and Bio-Oligomers for Precision Therapeutics
edited by
submission deadline 28 Feb 2026 | 1 articles | Viewed by 91 | Submission Open
Keywords: precision therapeutics; biopolymers; drug delivery; biopharmaceuticals; pharmacology
(This special issue belongs to the Section Materials Science)
Roles and Mechanisms of Non-Coding RNAs in Human Health and Disease: 2nd Edition submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; polymorphisms; cancer; degenerative diseases; therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Inorganic Chemistry: From Molecules to Materials
edited by
submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open
Keywords: inorganic chemistry; molecular design and reactivity; metal– organic frameworks (MOFs); spin crossover compounds; functional materials; structure– property relationships
(This special issue belongs to the Section Materials Science)
Design, Synthesis, Application and Mechanism of Functional Polymers
edited by Jingyuan Liu
submission deadline 28 Feb 2026 | Viewed by 91 | Submission Open
Keywords: functional polymers; polymer synthesis; structure– property relationship; molecular mode of actions; interfacial interaction; molecular design; smart materials; functional coatings; biomedical applications; energy storage
(This special issue belongs to the Section Materials Science)
Therapeutic Strategies for Surgical Tissue Damage, Repair and Regeneration
edited by Alex K. Wong
submission deadline 28 Feb 2026 | Viewed by 89 | Submission Open
Keywords: surgical injury; tissue regeneration; vasculogenesis; wound healing in compromised settings; molecular therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Electromagnetic Field Interactions with Biomolecules submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open
Keywords: nonionizing electromagnetic fields; biomolecules; proteins; oxidative stress; Fe metabolism; amyloid-β peptide
(This special issue belongs to the Section Materials Science)
Molecular Immunity to Parasitic Infections
edited by Jamie A. Whitelaw and Stuart Woods
submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open
Keywords: parasitology; immunology; vaccines; cell therapy; gene editing; parasitic diseases; immune responses; inflammation; molecular mechanisms; immune evasion; host cell invasion and manipulation
(This special issue belongs to the Section Molecular Immunology)
Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition
edited by
submission deadline 28 Feb 2026 | Viewed by 88 | Submission Open
Keywords: endometriosis; reproductive system; endometrial cell; novel treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research into the Synthesis and Activities of Anticancer Compounds submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open
Keywords: cancer; synthesis; cell biology; molecular biology; chemistry; preclinical development
(This special issue belongs to the Section Molecular Biology)
Metabolic Signaling and Inflammation in Cardiac Pathophysiology submission deadline 28 Feb 2026 | Viewed by 87 | Submission Open
Keywords: cardiac metabolism; inflammation; metabolic signaling; heart disease; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Antioxidant and Antidiabetic Potential of Natural Products in the Management of Diabetes and Its Complications submission deadline 28 Feb 2026 | Viewed by 86 | Submission Open
Keywords: diabetes; natural products; obesity; medicinal plants; oxidative stress; antioxidants
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Perspective on Skeletal Muscle Regeneration
edited by Xuhui Liu
submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open
Keywords: skeletal muscle regeneration; satellite cells; stem cell niche; fibro/adipogenic progenitors; aging; muscle stem cells; cell– cell interactions; fibrosis and fatty infiltration; translational therapeutics
(This special issue belongs to the Section Molecular Biology)
Molecular Research and Utilization of Environmental Microbial Resources
edited by
submission deadline 28 Feb 2026 | Viewed by 85 | Submission Open
Keywords: environmental microbiology; molecular microbial resources; microbial metabolites; microbial diversity; microbial ecology; bioremediation; agricultural microbiology; omics technologies; biofilm formation; microbiome applications
(This special issue belongs to the Section Molecular Microbiology)
Mechanisms and Applications of Heterosis in Plants
edited by
submission deadline 28 Feb 2026 | Viewed by 84 | Submission Open
Keywords: heterosis; mechanism; prediction; application; breeding; plant
(This special issue belongs to the Section Molecular Plant Sciences)
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