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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Machine Learning Approaches in Drug Molecule Design

edited by

Bing Niu

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1899 | Submission Open

Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Surfactants: Design, Synthesis and Application

edited by

Urszula Bazylinska

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1874 | Submission Open

Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic–lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics

(This special issue belongs to the Section Materials Science)

Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations

edited by

Ichiro Hanamura

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1857 | Submission Open

Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor–host interaction

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Plant Virus Infection, Resistance and Control

edited by

Carl Spetz

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1851 | Submission Open

Keywords: plant virus; host–pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1832 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

Decoding Parkinson’s: Molecular Symphonies and Dysregulated Pathways

edited by Hortensia Alonso-Navarro

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1823 | Submission Open

Keywords: Parkinson’s disease; neuropharmacology; movement disorders

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances in Cancer and Cell Metabolism—3rd Edition

edited by

Maria Mesuraca

Maria Concetta Faniello

and

Barbara Quaresima

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1798 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Oncology)

Molecular Research in Pregnancy-Related Complications

edited by Kallirhoe Kalinderi

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1789 | Submission Open

Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Metabolism in Human Diseases

edited by Neelanjan Vishnu

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1722 | Submission Open

Keywords: mitochondrial function; pathophysiology; cellular processes; disease development

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Biochemistry and Biophysics Tools for Peptide and Protein Research

edited by

Wenqi Li

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1706 | Submission Open

Keywords: protein–protein interactions; peptide therapeutics development; biosensor and labeling technologies; high-throughput screening; mass spectrometry proteomics; protein dynamics and folding; single-molecule biophysics; analytical ultra-centrifugation; computational protein design; structural biology techniques

(This special issue belongs to the Section Biochemistry)

Molecular Research of Host-Pathogen Interactions

edited by

Alina Maria Holban

and

Carmen Curutiu

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1627 | Submission Open

Keywords: host–pathogen interactions; host immunity during infection; new targets for resistant pathogens; molecular communication during infection; model systems in host–pathogen studies

(This special issue belongs to the Section Molecular Microbiology)

Polymer Composites: Advances and Applications

edited by

Saeid Sahmani

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1596 | Submission Open

Keywords: polymer composites; polymer nanocomposites; biocompatible polymer composites; structure-property relationships; interfacial engineering; molecular design; computational modelling; mechanical performance; advanced applications

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Natural Bioactive Compounds

edited by

Dušanka Kitić

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1574 | Submission Open

Keywords: natural products pharmacology; plant secondary metabolites; molecular mechanisms; phyto-chemicals; signal transduction pathways; structure–activity relationships; natural product

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Decoding the Microbial Influence on Host Gene Expression

edited by

Damian Kołat

and

Mateusz Kciuk

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1573 | Submission Open

Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo

(This special issue belongs to the Section Molecular Microbiology)

Precision Medicine in Cancer: Biomarker and Bioinformatics Research

edited by

Youping Deng

and

Shaoqiu Chen

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1567 | Submission Open

Keywords: precision medicine; cancer biomarkers; bioinformatics; multi-omics; machine learning; tumor heterogeneity

(This special issue belongs to the Section Molecular Informatics)

Animal Reproductive Biology and Genetic Breeding

edited by Chang Wu and Fangzhou Hu

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1554 | Submission Open

Keywords: genetic breeding; genetic variation; phenotype analysis; reproductive barrier; hybridization; multomics analysis

(This special issue belongs to the Section Molecular Biology)

Advances in Plant Breeding and Biotechnology: From Lab to Field

edited by

Wenlong Bao

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1443 | Submission Open

Keywords: crop improvement; genetic transformation; omics approaches; plant metabolites; plant resistance; plant breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Post-Transcriptional Gene Regulation of mRNA and Protein Expression

edited by Greco Hernández

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1403 | Submission Open

Keywords: translational control; protein synthesis; mRNA biochemistry; signal transduction; mTOR pathway; post-transcriptional regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Characterization and Utilization of Plant Genetic Resources

edited by

Roel Rabara

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1384 | Submission Open

Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics

(This special issue belongs to the Section Molecular Plant Sciences)

Animal Models for Neurobiological Diseases

edited by

Hiroki Toyoda

and

Jana Tchekalarova

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1378 | Submission Open

Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions

(This special issue belongs to the Section Molecular Neurobiology)

Genetic Determinants of Drug Response: From Molecular Mechanisms to Precision Therapy

edited by

Pedro Ayuso

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1369 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; drug response; drug metabolism; precision medicine; biomarkers; adverse drug reactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1368 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Brain–Organ Axis and Related Neurodegeneration

edited by

Nan-Shan Chang

and

Hieu-Huy Nguyen-Tran

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1302 | Submission Open

Keywords: brain–organ axis; microbiota–gut–brain axis; neurodegenerative diseases; neuroinflammation; signaling pathways and alterations; innate immunity

(This special issue belongs to the Section Molecular Neurobiology)

The Characterization and Application of Enzymes in Bioprocesses, 2nd Edition

edited by

Loredana Marcolongo

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1245 | Submission Open

Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing

(This special issue belongs to the Section Biochemistry)

Mitochondrial Bioenergetics and Signaling in Diseases

edited by

Carlos Palmeira

and

Anabela P. Rolo

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1234 | Submission Open

Keywords: mitochondria; bioenergetics; oxidative phosphorylation; mitochondrial signaling; metabolism; reactive oxygen species (ROS); mitochondrial dynamics; mitophagy; calcium signaling; mitochondrial DNA; redox homeostasis; cell death; inflammation; neurodegeneration; cancer metabolism; cardiometabolic diseases; aging; therapeutic targeting

(This special issue belongs to the Section Biochemistry)

Interplay Between Cytoskeletal Dynamics and Cell Signaling in Cancer

edited by

Aleksandra Glogowska

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1221 | Submission Open

Keywords: cytoskeleton; cancer; organelle function; golgi apparatus; endoplasmic reticulum; mitochondria; post-translational modification; tumor invasion; metastasis; chemoresistance; therapeutic targets

(This special issue belongs to the Section Molecular Oncology)

Molecular Adsorption Mechanisms: Theoretical and Experimental Studies

edited by

Anna Deryło-Marczewska

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1165 | Submission Open

Keywords: adsorption processes; adsorption mechanisms; adsorption equilibria; adsorption kinetics; porous materials; structure—property relationships; theoretical and experimental analysis; environmental, analytical, biomedical and technological applications

(This special issue belongs to the Section Molecular Biophysics)

Tumor Viruses: Infection, Carcinogenesis, and Treatment

edited by

Sherif T.S. Hassan

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1164 | Submission Open

Keywords: tumor viruses; viral oncogenesis; EBV, HPV, KSHV, HBV, HCV, HTLV-1, and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies

(This special issue belongs to the Section Molecular Microbiology)

Advances in Glyco-Based Anticancer Agents

edited by Pedro Colinas

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1130 | Submission Open

Keywords: carbohydrates; cancer; Warburg effect; glycolysis; enzyme inhibitors; transporters inhibitors; docking simulations; tumor microenvironment

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Pathogen Interaction and Host Immunity

edited by

Karolina Kot

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1127 | Submission Open

Keywords: host–pathogen interactions; innate and adaptive immunity; pattern recognition receptors (PRRs); immune signaling pathways; cytokines and interferons; immune evasion mechanisms; molecular pathogenesis; infectious diseases

(This special issue belongs to the Section Molecular Immunology)

Molecular Characterization of Glioblastoma: Implications for Diagnosis and Personalized Treatment

edited by Madan Mohan Kwatra

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1126 | Submission Open

Keywords: glioblastoma; diagnosis; molecular characterization; personalized treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Host-Pathogen Interactions in Plants: Molecular Mechanisms and Sustainable Strategies

edited by Muhammad Rahil Afzal and Misbah Naz

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1083 | Submission Open

Keywords: plant immunity; plant–pathogen interactions; molecular mechanisms; effector biology; hormonal crosstalk; non-coding RNAs and epigenetics

(This special issue belongs to the Section Molecular Plant Sciences)

Nanoparticle–Protein Interactions: Therapeutic Approaches and Supramolecular Chemistry

edited by Rodrigo da Silva Ferreira

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1066 | Submission Open

Keywords: nanoparticle–protein interactions; nanomedicine; supramolecular chemistry; surface functionalization; protein corona; nanocarriers; biointerfaces; molecular recognition; therapeutic nanomaterials; computational nano–bio modelling

(This special issue belongs to the Section Molecular Nanoscience)

New Molecular Insights into Myeloma

edited by Kotaro Shirakawa

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1052 | Submission Open

Keywords: multiple myeloma; clonal evolution and genetic heterogeneity; epigenomic dysregulation; transcriptional reprogramming; mitochondrial dysfunction; bone marrow microenvironment; tumor microenvironment; immunotherapy resistance; drug resistance; single-cell and spatial analysis

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathogenesis, Immunobiology, and Treatment of Hematological Malignancies

edited by Tatsuro Jo

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1049 | Submission Open

Keywords: hematological malignancies; molecular pathogenesis; tumor microenvironment; immunogenomics; clonal evolution; biomarkers; immune monitoring; T-cell receptor repertoire; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications

edited by Marius Rǎdulescu

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1043 | Submission Open

Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure–property relationships; functionalized silica; sol–gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling

(This special issue belongs to the Section Molecular Nanoscience)

Cellular and Molecular Mechanisms of Neuroinflammation

edited by

Maria Anttonietta Panaro

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1017 | Submission Open

Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Polymeric Nanomaterials in Medicine

edited by Prabhanjan Giram

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1015 | Submission Open

Keywords: nanomaterials; nanocomposites; biomolecules; nano pharmaceuticals; nanoparticles; applications of nanomaterials; nanoformulation design; characterization; nanodrug delivery system; targeted and controlled release therapies

(This special issue belongs to the Section Molecular Nanoscience)

Chlorophylls and Carotenoids: Metabolism and Regulation in Plants

edited by

Shan Lu

submission deadline 28 Feb 2027 | 1 articles | Viewed by 999 | Submission Open

Keywords: chlorophyll; carotenoid; metabolism; regulation; evolution; coordination

(This special issue belongs to the Section Molecular Plant Sciences)

Cardiovascular and Metabolic Sequelae of Peripheral Artery Disease: From Mechanisms to Therapeutic Targets

edited by

Tzong-Shyuan Lee

submission deadline 28 Feb 2027 | 1 articles | Viewed by 994 | Submission Open

Keywords: peripheral artery disease (PAD); cardiometabolic complications; molecular mechanisms; endothelial dysfunction; interorgan crosstalk

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition

edited by

Elena Vianello

submission deadline 28 Feb 2027 | 1 articles | Viewed by 957 | Submission Open

Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Gangliosides

edited by

Sandro Sonnino

and

Massimo Aureli

submission deadline 28 Feb 2027 | 1 articles | Viewed by 956 | Submission Open

Keywords: gangliosides; sphingolipids; plasma membrane; lysosomes; glycohydrolases; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Extracellular Vesicles: Biomarkers and Therapeutic Carriers in Human Health and Disease

edited by

José Eduardo Vargas

submission deadline 28 Feb 2027 | 1 articles | Viewed by 955 | Submission Open

Keywords: extracellular vesicles; cellular senescence; autophagy; biomarkers; drug delivery; translational medicine; human disease; cell fate

(This special issue belongs to the Section Molecular Biology)

Non-Coding RNAs and Post-Transcriptional Modifications in Cancer

edited by

Christos K. Kontos

submission deadline 28 Feb 2027 | 1 articles | Viewed by 948 | Submission Open

Keywords: solid tumors; hematological malignancies; long non-coding RNAs; circular RNAs; short non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Microfluidic Organ-on-a-Chip: Bridging Drug Discovery to Precision Medicine

edited by Yongjian Ai and Mengqi He

submission deadline 28 Feb 2027 | 2 articles | Viewed by 881 | Submission Open

Keywords: absorption; distribution; metabolism; excretion; toxicity; host–pathogen; host-immune; pharmacokinetic; pharmacodynamic; absorption; metabolism; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Advances in Oral and Periodontal Health

edited by

Giuseppina Malcangi

, Roxana Ioana Bordea and Grazia Marinelli

submission deadline 28 Feb 2027 | 1 articles | Viewed by 863 | Submission Open

Keywords: dental disease; dental materials; orthodontic diseases; growth factor; regenerative tissue; peritonitis; regulatory T cells; systemic disease; systemic inflammation; scaling and root planning

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Atlas of Cardiac Development and Diseases

edited by

Hector Alejandro Cabrera-Fuentes

submission deadline 28 Feb 2027 | Viewed by 852 | Submission Open

Keywords: cardiac development; molecular atlas; cardiovascular disease; single cell and spatial omics; multi omics integration; gene regulatory networks; cardiac remodeling; heart failure; systems biology; artificial intelligence in cardiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Plant–Microbial Interaction

edited by

Diby Paul

submission deadline 28 Feb 2027 | 1 articles | Viewed by 819 | Submission Open

Keywords: plant microbe intractions; molecular mechanisms; microbiome dynamics; multi-omics approach; stress responses; metagenomics; rhizosphere signalling

(This special issue belongs to the Section Molecular Microbiology)

Recent Advances in Algal Stress Physiology

edited by

Zakaria Tazart

submission deadline 28 Feb 2027 | 1 articles | Viewed by 798 | Submission Open

Keywords: algae; microalgae; cyanobacteria; stress physiology; molecular mechanisms; signal transduction; gene regulation; redox homeostasis; omics technologies; environmental stress; metabolic adaptation; biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Hormone/Receptor System in Human Diseases

edited by Elena Zocchi,

Sonia Spinelli

and