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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Studies on Obesity and Related Diseases submission deadline 28 Feb 2027 | 2 articles | Viewed by 3371 | Submission Open
Keywords: obesity; adipose tissue; immunometabolism; adipokines; metabolomics; gut microbiota; thermogenesis; NAFLD; inflammation; precision nutrition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Cardiovascular and Vascular Biology
edited by
submission deadline 28 Feb 2027 | 4 articles | Viewed by 3329 | Submission Open
Keywords: cardiovascular diseases; vascular biology; molecular mechanisms; biomarkers; endothelial dysfunction; translational medicine
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Acute Lung Injury
edited by
submission deadline 28 Feb 2027 | 4 articles | Viewed by 3268 | Submission Open
Keywords: acute lung injury; ARDS; primary graft dysfunction; immune cells; neutrophils; pulmonary edema; alveolar epithelium; lung endothelium
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into the Stability and Degradation of Perovskite Solar Cells
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 3035 | Submission Open
Keywords: perovskite; thin films; solar cells; PCE, stability; molecular structure evolution (perovskite); perovskite precursor molecular design
(This special issue belongs to the Section Materials Science)
Advances in Molecular Pathobiology, Diagnosis, and Treatment of Neurodegenerative Diseases submission deadline 28 Feb 2027 | 3 articles | Viewed by 2995 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’s disease; Parkinson’s disease; dementia with Lewy bodies; motor neuron diseases; molecular pathobiology; diagnosis; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Genetic Mechanism of Stress Resistance in Plants
edited by Mohammad Nurul Matin
submission deadline 28 Feb 2027 | 1 articles | Viewed by 2879 | Submission Open
Keywords: stress response and resistance; environmental adaptation; abiotic and biotic stress; gene regulation network; functional genomics; molecular signalling pathways; CRISPR/cas systems; epigenetic regulation; transcriptome profiling; metabolic reprogramming; stress-responsive genes
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Cellular Basis of Oral Immunology
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2876 | Submission Open
Keywords: oral immunology; oral mucosa; immune tolerance; oral microbiome; oral diseases; periodontium; innate immunity; adaptive immunity
(This special issue belongs to the Section Molecular Immunology)
Advances in Molecular Research in Animal Reproduction
edited by
submission deadline 28 Feb 2027 | 5 articles | Viewed by 2876 | Submission Open
Keywords: animal reproduction; molecular regulation; spermatogenesis; embryonic development; epigenetics; reproductive hormones; oogenesis; environmental factors
(This special issue belongs to the Section Molecular Biology)
The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition
edited by
submission deadline 28 Feb 2027 | 4 articles | Viewed by 2834 | Submission Open
Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Toxicity Induced by Engineered Nanomaterials submission deadline 28 Feb 2027 | 2 articles | Viewed by 2716 | Submission Open
Keywords: toxicity; occupational health; engineered nanomaterials; physical–chemical characteristics; toxicokinetic; toxicodynamic; in vivo; NAMs; NGRA (new-generation risk assessment)
(This special issue belongs to the Section Molecular Toxicology)
Natural Products from Plants: Association with Human Health and Therapeutic Benefits, 2nd Edition submission deadline 28 Feb 2027 | 3 articles | Viewed by 2660 | Submission Open
Keywords: botanical products; phytochemicals; bio/pharmacological compounds; cellular and molecular targets; molecular and physiological mechanism; human health; disease prevention and treatment; inflammatory diseases; age-related disorders; chronic and (auto)immune diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Biopolymer-Based Materials: Synthesis, Characterization and Applications for a Sustainable Future submission deadline 28 Feb 2027 | 3 articles | Viewed by 2542 | Submission Open
Keywords: biodegradable polymers; biopolymers; biopolymer-based composite materials; synthesis and characterization of biopolymer materials; applications of biopolymers and biopolymer-based composites
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Pathways Involved in Toxicant-Induced Stress submission deadline 28 Feb 2027 | 3 articles | Viewed by 2486 | Submission Open
Keywords: oxidative stress; cell death; biomarkers; toxicant exposure; environmental toxicology; cell signaling pathways
(This special issue belongs to the Section Molecular Toxicology)
Insulin Resistance Mechanisms: From Epigenetics to Receptor-Mediated Signaling Pathways submission deadline 28 Feb 2027 | Viewed by 2395 | Submission Open
Keywords: epigenetics; insulin receptor; insulin resistance; inflammation; metabolic syndrome; protein phosphorylation; cardiometabolic syndrome
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition
edited by Vija Lavinia
submission deadline 28 Feb 2027 | 3 articles | Viewed by 2327 | Submission Open
Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition
edited by Fei Guo
submission deadline 28 Feb 2027 | 3 articles | Viewed by 2324 | Submission Open
Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications
(This special issue belongs to the Section Molecular Informatics)
Rewriting Medicine: Stem Cells and Regeneration
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2149 | Submission Open
Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering
(This special issue belongs to the Section Molecular Biology)
The Latest Molecular Insights into Animal Nutrition
edited by
submission deadline 28 Feb 2027 | 3 articles | Viewed by 2124 | Submission Open
Keywords: reproduction; animal production; development; immunity; emissions; digestion efficiency; microbiome; metabolism; molecular signaling; nutritional strategies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Multi-Omics in Cancer: Second Edition
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2102 | Submission Open
Keywords: cancer; multi-omics; genomics; transcriptomics; proteomics; metabolomics; lipidomics; epigenomics; artificial intelligence; machine learning; systems biology; biomarkers; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Advances in Neurodegenerative Diseases Research and Therapy, Fourth Edition
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 2035 | Submission Open
Keywords: neurodegenerative diseases; therapy; molecular mechanisms; neuron; astrocytes; microglia; inflammation; brain; drug delivery
(This special issue belongs to the Section Molecular Neurobiology)
Effect of Molecular Structure on the Distribution, Pharmacokinetics, and Metabolic Transformation of Bioactive Compounds
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 2018 | Submission Open
Keywords: molecular structure; pharmacokinetics; metabolic transformation; bioavailability; structure–activity relationship (SAR); drug metabolism; bioactive compounds; molecular modeling; ADMET; medicinal chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Breeding for Important Economic Traits in Livestock submission deadline 28 Feb 2027 | 2 articles | Viewed by 2016 | Submission Open
Keywords: molecular breeding; livestock genetics; economic traits; genomic selection; adipogenesis; feed efficiency; disease resistance; non-coding RNAs; multi-omics; genetic improvement
(This special issue belongs to the Section Molecular Biology)
Contemporary Perspective of Cardio-Kidney Metabolic Syndrome: From Prevention to Management
edited by Alberto Palazzuoli, and
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1993 | Submission Open
Keywords: cardiovascular risk factors; metabolic syndrome; chronic kidney disease; heart failure; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1991 | Submission Open
Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Pathways Shaping Therapeutic Vulnerability in Leukaemia
edited by
submission deadline 28 Feb 2027 | Viewed by 1989 | Submission Open
Keywords: leukaemia; acute myeloid leukaemia (AML); B-cell acute lymphoblastic leukaemia (B-ALL); pro-survival signalling; apoptosis; BH3 mimetics; drug resistance; combination therapy; functional drug screening; leukaemia mouse models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanoparticle-Based Biosensors and Their Applications
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1954 | Submission Open
Keywords: biosensors; metal nanoparticles (MNPs); synthesis methods; molecular spectroscopy characteristics; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Chronic Airway Diseases: Molecular Basis and Advanced Therapeutics
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1921 | Submission Open
Keywords: chronic airway diseases; asthma; chronic obstructive pulmonary disease (COPD); cystic fibrosis; bronchiectasis; pulmonary fibrosis; airway remodeling; cytokines; inflammation; immune dysregulation; mucociliary clearance; microbiome; epithelial–mesenchymal transition (EMT); molecular mechanisms; biomarkers; proteases; protease inhibitors; precision medicine; targeted therapeutics; RNA-based and gene therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights in Neuro-Ophthalmology
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1899 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Machine Learning Approaches in Drug Molecule Design
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1889 | Submission Open
Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery
(This special issue belongs to the Section Molecular Informatics)
Surfactants: Design, Synthesis and Application
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1871 | Submission Open
Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic–lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms of Plant Virus Infection, Resistance and Control
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1846 | Submission Open
Keywords: plant virus; host–pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Insights into Multiple Myeloma: Immune Microenvironment, Disease Mechanisms, and Therapeutic Innovations
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1846 | Submission Open
Keywords: multiple myeloma; bone marrow microenvironment; disease biology; disease progression; treatment resistance; CAR-T cells; bispecific antibodies (BsAbs); antibody-drug conjugates (ADCs); tumor–host interaction
(This special issue belongs to the Section Molecular Oncology)
Decoding Parkinson’s: Molecular Symphonies and Dysregulated Pathways
edited by Hortensia Alonso-Navarro
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1795 | Submission Open
Keywords: Parkinson’s disease; neuropharmacology; movement disorders
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Pregnancy-Related Complications
edited by Kallirhoe Kalinderi
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1763 | Submission Open
Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Cancer and Cell Metabolism—3rd Edition submission deadline 28 Feb 2027 | 3 articles | Viewed by 1745 | Submission Open
Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates
(This special issue belongs to the Section Molecular Oncology)
Mitochondrial Metabolism in Human Diseases
edited by Neelanjan Vishnu
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1699 | Submission Open
Keywords: mitochondrial function; pathophysiology; cellular processes; disease development
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Biochemistry and Biophysics Tools for Peptide and Protein Research
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1672 | Submission Open
Keywords: protein–protein interactions; peptide therapeutics development; biosensor and labeling technologies; high-throughput screening; mass spectrometry proteomics; protein dynamics and folding; single-molecule biophysics; analytical ultra-centrifugation; computational protein design; structural biology techniques
(This special issue belongs to the Section Biochemistry)
Molecular Research of Host-Pathogen Interactions submission deadline 28 Feb 2027 | 2 articles | Viewed by 1586 | Submission Open
Keywords: host–pathogen interactions; host immunity during infection; new targets for resistant pathogens; molecular communication during infection; model systems in host–pathogen studies
(This special issue belongs to the Section Molecular Microbiology)
Polymer Composites: Advances and Applications
edited by
submission deadline 28 Feb 2027 | 1 articles | Viewed by 1581 | Submission Open
Keywords: polymer composites; polymer nanocomposites; biocompatible polymer composites; structure-property relationships; interfacial engineering; molecular design; computational modelling; mechanical performance; advanced applications
(This special issue belongs to the Section Materials Science)
Decoding the Microbial Influence on Host Gene Expression submission deadline 28 Feb 2027 | 1 articles | Viewed by 1564 | Submission Open
Keywords: microbiota; host; gene expression; in silico; bioinformatics; in vitro; in vivo
(This special issue belongs to the Section Molecular Microbiology)
Animal Reproductive Biology and Genetic Breeding
edited by Chang Wu and Fangzhou Hu
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1522 | Submission Open
Keywords: genetic breeding; genetic variation; phenotype analysis; reproductive barrier; hybridization; multomics analysis
(This special issue belongs to the Section Molecular Biology)
Research Progress of Forensic Genetics submission deadline 28 Feb 2027 | 4 articles | Viewed by 1474 | Submission Open
Keywords: forensic genetics; genomics; phenotyping; DNA sequencing; pedigree; bioinformatics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Plant Breeding and Biotechnology: From Lab to Field
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1413 | Submission Open
Keywords: crop improvement; genetic transformation; omics approaches; plant metabolites; plant resistance; plant breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Natural Bioactive Compounds
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1403 | Submission Open
Keywords: natural products pharmacology; plant secondary metabolites; molecular mechanisms; phyto-chemicals; signal transduction pathways; structure–activity relationships; natural product
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Characterization and Utilization of Plant Genetic Resources
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1358 | Submission Open
Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics
(This special issue belongs to the Section Molecular Plant Sciences)
Animal Models for Neurobiological Diseases submission deadline 28 Feb 2027 | 2 articles | Viewed by 1352 | Submission Open
Keywords: animal models; mice; zebrafish; Alzheimer's disease; Parkinson's disease; multiple sclerosis; neuropsychiatric conditions
(This special issue belongs to the Section Molecular Neurobiology)
Genetic Determinants of Drug Response: From Molecular Mechanisms to Precision Therapy
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1346 | Submission Open
Keywords: pharmacogenetics; pharmacogenomics; drug response; drug metabolism; precision medicine; biomarkers; adverse drug reactions
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment
edited by
submission deadline 28 Feb 2027 | 2 articles | Viewed by 1340 | Submission Open
Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’s disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Characterization and Application of Enzymes in Bioprocesses, 2nd Edition submission deadline 28 Feb 2027 | 1 articles | Viewed by 1229 | Submission Open
Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing
(This special issue belongs to the Section Biochemistry)
Interplay Between Cytoskeletal Dynamics and Cell Signaling in Cancer submission deadline 28 Feb 2027 | 1 articles | Viewed by 1212 | Submission Open
Keywords: cytoskeleton; cancer; organelle function; golgi apparatus; endoplasmic reticulum; mitochondria; post-translational modification; tumor invasion; metastasis; chemoresistance; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
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