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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 25 Dec 2026 | Viewed by 375 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

Advances in the Design, Synthesis, and Characterization of Metal Complexes with Multifaceted Biological Activities

edited by

Luca Conti

submission deadline 25 Dec 2026 | Viewed by 373 | Submission Open

Keywords: metal complexes; molecular design; biological activity; structure–activity relationships; therapeutic applications

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Design and Application of Biocatalysts: Emerging Advances in Enzyme Technology

edited by

Salvadora Ortega-Requena

submission deadline 25 Dec 2026 | Viewed by 373 | Submission Open

Keywords: biocatalysis; enzyme engineering; green chemistry; directed evolution; computational design; industrial enzymes; nano-biocatalysts

(This special issue belongs to the Section Biochemistry)

New Advances in Omega-3 Polyunsaturated Fatty Acids: From Molecular Signaling to Therapeutic Applications

edited by

Feng-Yao Tang

submission deadline 25 Dec 2026 | Viewed by 361 | Submission Open

Keywords: N-3 polyunsaturated fatty acids; bioactive signaling molecules; stem cell; cancer; gut microbiota; precision nutrition

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of DNA Strand Exchange

edited by

Masayuki Takahashi

submission deadline 25 Dec 2026 | Viewed by 357 | Submission Open

Keywords: DNA strand exchange; homologous recombination: RecA-family recombinases; drug resistance: drug development against recombinases; evolution

(This special issue belongs to the Section Molecular Biophysics)

Regulatory Mechanism and Network of Abiotic Stress-Response in Plants: 3rd Edition

edited by

Yong-Hwan Moon

submission deadline 25 Dec 2026 | Viewed by 357 | Submission Open

Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Discoveries in Pharmacogenetics: From Bench to Bedside

edited by

Kumaraswamy Naidu Chitrala

submission deadline 25 Dec 2026 | Viewed by 355 | Submission Open

Keywords: pharmacogenetics; clincial practice; artficial intelligence; bioinformatics; personalized medicine; drug response; genetic variations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms and Therapeutics of Hepatocellular Carcinoma

edited by

Eleni-Myrto Trifylli

submission deadline 25 Dec 2026 | Viewed by 355 | Submission Open

Keywords: microRNAs (miRNAs); hepatocellular carcinoma (HCC); hepatic cancer; extracellular vesicles; noncoding RNAs; circular RNAs (circRNAs); gene regulation; epigenetics; drug resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 25 Dec 2026 | Viewed by 345 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Polymer Composites: Macromolecular Structure and Application

edited by

Donatella Duraccio

submission deadline 25 Dec 2026 | Viewed by 338 | Submission Open

Keywords: polymer composites; macromolecular structure; reinforcement strategies; structure–property relationships; sustainable materials

(This special issue belongs to the Section Macromolecules)

Biocatalysis: Mechanisms of Proteolytic Enzymes, 3rd Edition

edited by

Peter Goettig

submission deadline 25 Dec 2026 | Viewed by 335 | Submission Open

Keywords: aspartic proteases; cryptic ligand binding sites; cysteine proteases; metalloproteases; non-canonical amino acids; prodrugs; protease ligases; SARS-CoV-2 proteases; serine proteases; threonine proteases

(This special issue belongs to the Section Molecular Biophysics)

Bioactive Peptides: From Discovery and Characterization to Production, Therapeutic Applications, and Mechanistic Elucidation

edited by

José Thalles Lacerda

Taliana Bezerra

and

Luiz Juliano

submission deadline 25 Dec 2026 | Viewed by 333 | Submission Open

Keywords: bioactive peptides; mass spectrometry; machine learning; molecular dynamics simulation; synthetic biology; enzymology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights in Renal and Epithelial Physiology

edited by Pedro A. Jose

submission deadline 25 Dec 2026 | Viewed by 326 | Submission Open

Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance

(This special issue belongs to the Section Molecular Biology)

Molecular Determinants of Therapeutic Response and Resistance in Urological Cancers

edited by

Mehdi Kardoust Parizi

submission deadline 25 Dec 2026 | Viewed by 324 | Submission Open

Keywords: urological cancers; therapeutic resistance; treatment response; molecular determinants; precision oncology; biomarkers; tumor heterogeneity; genomics; epigenetics; tumor microenvironment; immune evasion; targeted therapy; immunotherapy; DNA damage repair; translational research

(This special issue belongs to the Section Molecular Oncology)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 25 Dec 2026 | Viewed by 322 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Recent Research on Metabolomics and Cancer Pathogenesis

edited by

Danuta Dudzik

submission deadline 25 Dec 2026 | Viewed by 315 | Submission Open

Keywords: cancer metabolomics; metabolic reprogramming; biomarkers; tumor microenvironment; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Amyloids: From Structure to Tailored Function

edited by

Laurent Marichal

submission deadline 25 Dec 2026 | Viewed by 311 | Submission Open

Keywords: amyloid; aggregation; self-assembly; seeding; protein structure

(This special issue belongs to the Section Macromolecules)

Immune Mechanisms of Autoimmune Rheumatic Diseases

edited by Immacolata Pietraforte

submission deadline 25 Dec 2026 | Viewed by 306 | Submission Open

Keywords: autoimmune diseases; autoinflammatory diseases; inflammation and immune-mediated diseases; T and B cells; APCs; Treg. Th17/Th23; chemokines

(This special issue belongs to the Section Molecular Immunology)

The Roles of Glycosylation in Diseases

edited by

Koichi Furukawa

submission deadline 25 Dec 2026 | Viewed by 301 | Submission Open

Keywords: glycoproteins; glycolipids; signaling; cell–cell interaction; cell membrane

(This special issue belongs to the Section Molecular Oncology)

Engineering Cell-Derived Nanostructures for Therapeutic Delivery

edited by

Tania Limongi

submission deadline 25 Dec 2026 | Viewed by 292 | Submission Open

Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Photocatalytic Degradation and Biomass Valorization for Green Chemistry Applications

edited by

David Contreras

submission deadline 25 Dec 2026 | Viewed by 271 | Submission Open

Keywords: photocatalysis; advanced oxidation processes; reactive oxygen species; in operando spectroscopy; biomass valorization; lignin depolymerization; green chemistry; emerging contaminants; structure–activity relationships; water reuse and treatment

(This special issue belongs to the Section Biochemistry)

Emerging Insights into Endothelial Biology and Metabolism

edited by

Hemant Giri

submission deadline 25 Dec 2026 | Viewed by 259 | Submission Open

Keywords: endothelial dysfunction; endothelial activation; vascular biology; endothelial migration; angiogenesis; vascular permeability; shear stress; microvascular and macrovascular remodeling; leukocyte trafficking; mitochondrial function

(This special issue belongs to the Section Molecular Biology)

Advances in Research on Cotton Breeding and Genetics

edited by

Yanpeng Zhao

submission deadline 25 Dec 2026 | Viewed by 257 | Submission Open

Keywords: cotton genomics; molecular breeding; gene regulation; abiotic stress tolerance; fiber quality improvement; disease resistance; genetic engineering; marker-assisted selection; transcriptomics; genome editing

(This special issue belongs to the Section Molecular Plant Sciences)

Drought Stress Tolerance in Crops: Physiological, Molecular, and Sustainable Management Approaches

edited by

Jamal Nasar

submission deadline 25 Dec 2026 | Viewed by 202 | Submission Open

Keywords: drought stress; crop resilience; water use efficiency; drought tolerance mechanism; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

New Developments in Fluorescent Biosensors

edited by

Chin-Feng Wan

submission deadline 25 Dec 2026 | Viewed by 187 | Submission Open

Keywords: carbon-based luminescent materials; green fluorescent sensors; C-dots; environmental sensing; biomedical applications; green synthesis strategies; fluorescence quenching; heavy metal detection

(This special issue belongs to the Section Molecular Biophysics)

Genetic Architecture and Molecular Breeding of Economically Important Traits in Marine Fish

edited by

Kecheng Zhu

and

Jinmin Pan

submission deadline 25 Dec 2026 | Viewed by 132 | Submission Open

Keywords: genomic selection; genotype–phenotype association; complex trait architecture; molecular breeding; aquaculture genomics

(This special issue belongs to the Section Molecular Biology)

Molecular Epidemiology, Surveillance, and Control of Infectious Diseases: From Pathogen Genomics to Public Health Action

edited by

Alexandra Porras-Ramirez

submission deadline 25 Dec 2026 | Viewed by 126 | Submission Open

Keywords: molecular epidemiology; infectious diseases; genomic surveillance; antimicrobial resistance; tuberculosis; dengue; viral hepatitis; vaccination; emerging pathogens; public health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Cancer Biomarkers, 2nd Edition

edited by

Christos Mikropoulos

submission deadline 25 Dec 2026 | Viewed by 124 | Submission Open

Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; microRNA; tumor microenvironment; gene methylation; proteomics

(This special issue belongs to the Section Molecular Oncology)

New Advances in Muscle Physiology and Biophysics

edited by

Massimo Reconditi

submission deadline 25 Dec 2026 | Viewed by 119 | Submission Open

Keywords: muscle; actin; myosin; titin; sarcomere; muscle energetics; muscle aging; exercise; excitation–contraction coupling

(This special issue belongs to the Section Molecular Biophysics)

Epigenetic Mechanisms at the Crossroads of Aging and Neuroinflammation

edited by Vicki Maltby

submission deadline 25 Dec 2026 | Viewed by 103 | Submission Open

Keywords: epigenetic; aging; neuroinflammation; microglial activation; astrocyte reprogramming; chromatin remodeling; DNA methylation; histone modifications; non-coding RNAs; neurodegeneration

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Alzheimer’s Disease: 2nd Edition

edited by

Sudip Dhakal

submission deadline 25 Dec 2026 | Viewed by 91 | Submission Open

Keywords: Alzheimer’s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Genetic Basis and Molecular Mechanism of Neurodevelopmental Disorders

edited by Antonio Falace

submission deadline 25 Dec 2026 | Viewed by 82 | Submission Open

Keywords: neurodevelopmental disorders (NDDs); genetic variants; neuronal development; synaptic function; ion channels; intracellular trafficking; endo-lysosomal pathway; disease mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Biomarkers for Targeted Therapies: 2nd Edition

edited by Vija Lavinia

submission deadline 25 Dec 2026 | Viewed by 50 | Submission Open

Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Inflammatory Microenvironments in Chronic Diseases: Immune Regulation, Tissue Adaptation, and Molecular Remodeling

edited by

Bat Erdene Jugder

submission deadline 28 Dec 2026 | Viewed by 379 | Submission Open

Keywords: inflammatory microenvironment; chronic inflammation; immune dysregulation; tissue adaptation; molecular remodeling; stromal remodeling; fibrosis; single-cell transcriptomics; spatial profiling; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Seaweed Bioactive Compounds in Agriculture and Biotechnology

edited by

Samira Etahiri

and

Omar Assobhei

submission deadline 28 Dec 2026 | Viewed by 169 | Submission Open

Keywords: seaweed bioactive compounds; marine algae; sustainable agriculture; biostimulants; biopesticides; plant growth promotion; crop stress tolerance; antimicrobial activity; natural products; biomaterials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanisms of Exercise Training on Vascular Disease

edited by Maxime Pellegrin

submission deadline 28 Dec 2026 | Viewed by 89 | Submission Open

Keywords: vascular disease; vascular health; exercise training; training modalities; molecular and cellular mechanisms; sex-dependent responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Tolerance to Stress

edited by

Xingguo Li

submission deadline 30 Dec 2026 | 6 articles | Viewed by 7712 | Submission Open

Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 30 Dec 2026 | 2 articles | Viewed by 5464 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

Mitochondrial Function and Therapies

edited by

Iain P. Hargreaves

submission deadline 30 Dec 2026 | 3 articles | Viewed by 3924 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; antioxidants; biogenesis; transcription factors

(This special issue belongs to the Section Biochemistry)

Advances in T Cell-Based Cancer Immunotherapy

edited by

Ying Luo

submission deadline 30 Dec 2026 | 2 articles | Viewed by 3508 | Submission Open

Keywords: T cell immunotherapy; CAR-T cell; immune checkpoint blockade; T cell exhaustion; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Research Progress on Disease Models Based on Induced Pluripotent Stem Cells

edited by

Delger Bayarsaikhan

submission deadline 30 Dec 2026 | 2 articles | Viewed by 1300 | Submission Open

Keywords: induced pluripotent stem cells; iPSC-derived cells; disease modeling; precision and regenerative medicine; genome editing; CRISP/Cas; organoid; cell sheet; personalized therapeutics; drug discovery

(This special issue belongs to the Section Molecular Biology)

Stem Cell Innovations and Reproductive Biotechnologies

edited by

Marcin Samiec

submission deadline 30 Dec 2026 | Viewed by 917 | Submission Open

Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine

(This special issue belongs to the Section Molecular Biology)

Advanced Research in Antioxidant Activity: Second Edition

edited by

Fotios Tekos

and Demetrios Kouretas

submission deadline 30 Dec 2026 | 1 articles | Viewed by 592 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Advances in Malnutrition and Infectious Diseases: Molecular Perspectives and Host-Pathogen Interactions

edited by

Sajid Ur Rahman

submission deadline 30 Dec 2026 | Viewed by 427 | Submission Open

Keywords: malnutrition; host-pathogen interactions; immunometabolism; micronutrient deficiency; innate and adaptive immunity; microbiome dysbiosis; infection-induced inflammation

(This special issue belongs to the Section Molecular Microbiology)

Hybrid Materials: Antimicrobial Performance and Molecular Mechanisms

edited by

Albena Bachvarova-Nedelcheva

and Kalina Ivanova

submission deadline 30 Dec 2026 | Viewed by 321 | Submission Open

Keywords: hybrid materials; molecular mechanisms; antimicrobial activity; nanomaterials; chemistry of ma-terials

(This special issue belongs to the Section Materials Science)

Molecular Interactions for Advanced Food Safety Biosensing

edited by

Long Wu

and Yang Zhou

submission deadline 30 Dec 2026 | Viewed by 300 | Submission Open

Keywords: food safety; molecular interaction; biosensors; signal transduction; precise recognition

(This special issue belongs to the Section Biochemistry)

Molecular Synthesis, Properties, and Biomedical Applications of Bioceramics

edited by

Amine Bendahhou

and

Mohamed Azzouzi

submission deadline 30 Dec 2026 | Viewed by 244 | Submission Open

Keywords: bioceramics; ceramic materials; dielectric materials; photocatalysis; perovskite ceramics; materials chemistry; solid-state materials; functional materials; environmental materials; energy materials

(This special issue belongs to the Section Materials Science)

Molecular Animal Nutrition

edited by