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Genetic Architecture and Molecular Breeding of Economically Important Traits in Marine Fish

A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Biology".

Deadline for manuscript submissions: 25 December 2026 | Viewed by 350

Editors


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Guest Editor
Division of Aquaculture & Genetic Breeding, South China Sea Fisheries Research Institutes, Chinese Academy of Fishery Scieces, Guangzhou 510300, China
Interests: fish genetics and breeding; aquaculture genomics; molecular breeding; genome-wide association studies; genomic selection
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Guest Editor Assistant
State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China
Interests: fish; genetic breeding; gene function; genomics; gene editing

Special Issue Information

Dear Colleagues,

Marine fish aquaculture is an important component of global food production. Yet, genetic improvement of many economically important marine fish species remains limited by long generation intervals, complex traits, and insufficient knowledge of their genetic architecture. Recent advances in high-throughput sequencing, genome-wide association studies, QTL mapping, population genomics, transcriptomics, and genomic prediction have provided powerful tools for dissecting the molecular basis of growth, body shape, disease resistance, stress tolerance, reproductive performance, feed utilization, and product quality in marine fish.

This Special Issue will provide a platform for advancing the understanding of genotype–phenotype relationships and promoting precision breeding strategies in marine aquaculture species. It aims to collect original research and review articles focusing on genome-wide association studies, genetic architecture, candidate gene identification, marker-assisted selection, genomic selection, molecular breeding, and functional validation of genes related to important traits in marine fish. Studies integrating GWAS with transcriptomics, epigenomics, metabolomics, population genomic analysis, or experimental validation are particularly encouraged.

Dr. Kecheng Zhu
Guest Editor

Dr. Jinmin Pan
Guest Editor Assistant

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Keywords

  • genomic selection
  • genotype–phenotype association
  • complex trait architecture
  • molecular breeding
  • aquaculture genomics

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Published Papers (1 paper)

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Research

21 pages, 6386 KB  
Article
Comparative Evolution of SLC12 Transporters in Tilapias and Salinity-Responsive Expression in Nile Tilapia
by Jin-Min Pan, Liu-Yang Li, Meng-Fan Dong, Qian-Hui Chen and Jun-Hong Xia
Int. J. Mol. Sci. 2026, 27(18), 8124; https://doi.org/10.3390/ijms27188124 - 12 Sep 2026
Viewed by 155
Abstract
Tilapia species differ markedly in salinity tolerance, providing a useful system for investigating the molecular basis of osmotic adaptation. The solute carrier family 12 (SLC12) encodes cation–chloride cotransporters that play central roles in ion homeostasis and osmoregulation. Here, we compared the [...] Read more.
Tilapia species differ markedly in salinity tolerance, providing a useful system for investigating the molecular basis of osmotic adaptation. The solute carrier family 12 (SLC12) encodes cation–chloride cotransporters that play central roles in ion homeostasis and osmoregulation. Here, we compared the SLC12 gene family among Nile tilapia (Oreochromis niloticus), Mozambique tilapia (O. mossambicus), and blue tilapia (O. aureus) using comparative genomic, phylogenetic, protein-structural, and chromosomal analyses. Separately, we re-analyzed a published long-term salinity RNA-seq dataset from GIFT Nile tilapia maintained for 3.5 months at 0, 17, or 27 ppt, focusing on SLC12 expression in the gill, intestine, and skin. All three tilapia species contained 17 SLC12 loci with identical subfamily copy numbers and broadly conserved chromosomal distributions. In the Nile tilapia transcriptomic dataset, paralogous SLC12A2, SLC12A7, and SLC12A10 copies displayed distinct tissue- and salinity-dependent expression patterns. SLC12A8 also showed salinity-responsive expression in Nile tilapia, prompting further comparative sequence and structural analysis. The three SLC12A8 orthologs were broadly similar in sequence and predicted structure, although several species-specific residue differences were observed. These findings reveal overall conservation of the SLC12 family among tilapias, identify salinity-responsive expression differences among paralogous members in Nile tilapia and interspecific sequence variation in SLC12A8, and provide candidate features for further functional investigation. Full article
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