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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Characterization of Immune and Inflammatory Tumor Microenvironment on Canine, Feline and Human Species

edited by

Luís Monteiro

submission deadline 31 Jan 2026 | Viewed by 95 | Submission Open

Keywords: inflammation; tumor microenvironment; cancer biomarkers; comparative pathology; cancer epidemiology; cancer risk factors; molecular diagnostics; proteomics; treatment response; targeted therapy; immunotherapy; translation cancer research

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathways and Pathogenesis in Orthopedic Diseases

edited by

Angelos Kaspiris

and

Elias Vasiliadis

submission deadline 31 Jan 2026 | Viewed by 95 | Submission Open

Keywords: intracellular interactions during fracture healing; molecular signaling of degenerative orthopedic diseases; growth factor expression in musculoskeletal disorders and deformities; pathophysiology of primary bone tumors and metastasis; clinical and molecular basis of orthopedic infections; biomarkers; molecular-driven treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Tumor Microenvironment of Pleural Mesothelioma and Opportunities for Novel Treatments

edited by

Marcella Barbarino

submission deadline 31 Jan 2026 | Viewed by 95 | Submission Open

Keywords: mesothelioma; tumor-associated stromal cells; immunotherapy; tumor microenvironment; cancer-associated fibroblast; mesenchymal stem cells; endothelial cells; cancer-associated adipocytes

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms in Postharvest Biology

edited by

Kangdi Hu

submission deadline 31 Jan 2026 | Viewed by 94 | Submission Open

Keywords: postharvest biology; fruit ripening; senescence; stress tolerance; disease resistance; molecular biology; gene regulatory networks; genomics; synthetic biology; nanotechnology; controlled atmosphere; biostimulants

(This special issue belongs to the Section Molecular Plant Sciences)

Pulmonary Hypertension: From Molecular Pathophysiology to New Therapeutic Approaches

edited by Claudia Mickael

submission deadline 31 Jan 2026 | Viewed by 94 | Submission Open

Keywords: pulmonary hypertension; molecular pathophysiology; vascular remodelling; targeted therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Aquatic Animal Reproduction, Breeding Strategies and Genetic Improvement

edited by

Jixing Zou

submission deadline 31 Jan 2026 | Viewed by 92 | Submission Open

Keywords: reproductive biology; aquaculture genetics; fish breeding; genomic selection; marker-assisted selection; genome editing; hybridization; genetic improvement; molecular breeding; sustainable animal production

(This special issue belongs to the Section Molecular Biology)

Effects of Natural Products on Neurological Diseases

edited by

Maytal Shabat-Simon

submission deadline 31 Jan 2026 | Viewed by 92 | Submission Open

Keywords: natural products; neurodegenerative diseases; oxidative stress; neuroinflammation; amyloid β ; TAU pathology; PI3K/AKT; BDNF-TrkB-CREB; phytochemicals; neuroprotection; cannabinoids; psilocybin/psilocyn; mitochondrial dysfunction; blood– brain barrier; high-throughput screening; animal models; structure– activity relationship; pharmacokinetics; bioavailability

(This special issue belongs to the Section Molecular Neurobiology)

Symbiosis and Molecular Mechanisms in Water Treatment

edited by

Binghan Xie

submission deadline 31 Jan 2026 | Viewed by 92 | Submission Open

Keywords: microbiomics; water treatment; bioenergy recovery; emerging contaminant degradation; antibiotic resistance genes (ARGs); microalgae biotechnology

(This special issue belongs to the Section Molecular Microbiology)

New Horizons in Structure and AI-Based Drug Design

edited by

Huiyong Sun

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Striated Muscle Physiology

edited by Xuesong Feng

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: striated muscle; physiology; myopathies; mitochondria; mechanotransduction; epigenetics regulation; muscle aging; muscle regeneration

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Research on Immune Cells and Cytokines (3rd Edition)

edited by

Athanasia Mouzaki

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Regulation of Glycoproteins in Cancer Biology

edited by

Josiah Ochieng

submission deadline 31 Jan 2026 | Viewed by 88 | Submission Open

Keywords: glycoprotein; metastasis; glycosylation; tumor progression

(This special issue belongs to the Section Molecular Biology)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open

Keywords: placental barrier; maternal– fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Obesity and Obesity-Associated Co-Morbidities: From Mechanisms to Mechanism-Based Therapies

edited by

Dario C. Ramirez

submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open

Keywords: obesity; adipose tissue inflammation; microbiota; oxidative stress; gene expression regulation; metabolism; obesity-associated co-morbidities; non-communicable disease; cancer; mechanism-based therapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Intracellular Host-Bacteria Dynamics: Unraveling the Molecular Basis

edited by

Apichai Tuanyok

submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open

Keywords: intracellular bacteria; granuloma; immune invasion; Mycobacterium tuberculosis; Burkholderia pseudomallei; Francisella; Brucella; Listeria; Coxiella

(This special issue belongs to the Section Molecular Microbiology)

Fibrous Proteins: Latest Developments in Molecular Study

edited by Priscila Casado

submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open

Keywords: fibrous proteins; molecular studies; translational applications; inflammatory markers; biomolecular expression; immunological pathways; personalized treatments; diagnostics; clinical practice; etiopathogenies

(This special issue belongs to the Section Molecular Biology)

Molecular Insights in Food Science: From Nutritional Value to Safety Evaluation

edited by

Mariachiara Bianco

submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open

Keywords: nutraceutical; food safety; analytical methods; novel foods; food analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanisms of Action of Environmental Neurotoxicants During Critical Periods of Brain Development

edited by

Yael Abreu-Villaça

submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open

Keywords: environmental neurotoxicants; developmental neurotoxicity; critical windows; animal models; early exposure; long-term programming

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pharmacognosy: Bioactive Natural Products and Mechanistic Insights

edited by Luísa Mota Da Silva

submission deadline 31 Jan 2026 | Viewed by 82 | Submission Open

Keywords: pharmacognosy; natural products; bioactive compounds; phytochemistry; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations

edited by

Paula Sandrin-Garcia

submission deadline 31 Jan 2026 | Viewed by 82 | Submission Open

Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy

(This special issue belongs to the Section Molecular Immunology)

Therapeutic Advances in Vaccines

edited by Dorota Kopciuch

submission deadline 31 Jan 2026 | Viewed by 80 | Submission Open

Keywords: therapeutic vaccines; mRNA vaccines; DNA-based vaccines; viral vector vaccines; protein-based vaccines; peptide vaccines; personalized cancer vaccines; antigen persistence; immune activation mechanisms

(This special issue belongs to the Section Molecular Immunology)

Unraveling Affective Disorders: From Pathogenesis to Drug Therapy

edited by Lawrence Shih-Hsin Wu

submission deadline 31 Jan 2026 | Viewed by 79 | Submission Open

Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene– environment interactions; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research in Renal Endocrinology

edited by Natalija Filipović

submission deadline 31 Jan 2026 | Viewed by 79 | Submission Open

Keywords: renin– angiotensin system; natriuretic peptides; calcitriol; erythropoietin; prostaglandins; endothelins; adrenomedullin

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Molecular Insights into Antimicrobial Peptides

edited by

Gloria Bua

submission deadline 31 Jan 2026 | Viewed by 77 | Submission Open

Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure– activity relationship

(This special issue belongs to the Section Molecular Microbiology)

Progression of Innate Immunity in Tuberculosis Infections

edited by

Octavio Miguel Rivero-Lezcano

submission deadline 31 Jan 2026 | Viewed by 77 | Submission Open

Keywords: macrophage; neutrophil; innate lymphoid cells; NK cells; mucosal associated invariant T (MAIT) cells; phagocytosis; trained innate immunity; collectins; autophagy; mucociliary clearance; NETosis

(This special issue belongs to the Section Molecular Immunology)

Recent Progress in 3D Cellular Models of the Tumor Microenvironment

edited by

Kalpana Mandal

submission deadline 31 Jan 2026 | Viewed by 72 | Submission Open

Keywords: 3D tumor models; immunotherapy; organ-on-a-chip; cell mechanics and mechanotransduction; drug delievery; tumor heterogenity; organoids/spheroids; biomaterials; hydrogels/scaffolds

(This special issue belongs to the Section Molecular Oncology)

New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition

edited by Fei Guo

submission deadline 31 Jan 2026 | Viewed by 72 | Submission Open

Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications

(This special issue belongs to the Section Molecular Informatics)

Small Molecules and Antibodies for Targeted Cancer Therapies

edited by Chitra Subramanian

submission deadline 31 Jan 2026 | Viewed by 69 | Submission Open

Keywords: targeted therapy; small molecules; antibodies; drug resistance; metastasis; cancer treatment; mechanism of resistance

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Cellular Mechanisms Underlying Kidney Disease

edited by

Dong-Jun Park

submission deadline 31 Jan 2026 | Viewed by 68 | Submission Open

Keywords: acute kidney injury; molecular mechanisms; therapeutic agents; experimental model; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Macrophage Dysfunction and Cytokine Storm in Pulmonary Disorders

edited by

Elżbieta Rutkowska

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: macrophage dysfunction; cytokine storm; lung diseases

(This special issue belongs to the Section Molecular Immunology)

Applications of Molecular Imaging in Nanomedicine

edited by

Manuela Malatesta

submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open

Keywords: nanoparticles; biodistribution; magnetic resonance imaging; positron emission tomography; computed tomography; ultrasound imaging; optical imaging; light microscopy; electron microscopy

(This special issue belongs to the Section Molecular Nanoscience)

Focus on Chemoradiation Resistance: The Challenge of Cancer Therapy

edited by

Karl Reinhard Aigner

and Hendrikx Marc José Henri

submission deadline 31 Jan 2026 | Viewed by 45 | Submission Open

Keywords: genetic; epigenetic; and metabolic determinants of chemoradiation resistance; tumor microenvironmental influences and immune system interactions; DNA damage response pathways and novel radiosensitizers/chemosensitizers; predictive and prognostic biomarkers for treatment response; emerging therapeutic combinations and personalized medicine strategies; concentration-dependent therapy and chemotherapy optimization; intra-arterial infusion and isolated perfusion chemotherapy; quality of life

(This special issue belongs to the Section Molecular Oncology)

Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy

edited by Hui Xu and

Ying Huang

submission deadline 1 Feb 2026 | 1 articles | Viewed by 830 | Submission Open

Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Female and Male Fertility: From Diseases to Current Trends and Research Developments

edited by Fabio Barra

submission deadline 4 Feb 2026 | Viewed by 82 | Submission Open

Keywords: female infertility; male infertility; reproductive health; reproductive outcomes; assisted reproductive technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Mechanisms for the Prevention and Treatment of Stroke

edited by

Cesare Patrone

submission deadline 10 Feb 2026 | 1 articles | Viewed by 944 | Submission Open

Keywords: stroke; pathophysiology; mechanisms; comorbidities; treatments

(This special issue belongs to the Section Molecular Neurobiology)

Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition)

edited by

Carmela Ricciardelli

submission deadline 10 Feb 2026 | Viewed by 106 | Submission Open

Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models

(This special issue belongs to the Section Molecular Oncology)

Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives

edited by Antonella Bonetti

submission deadline 10 Feb 2026 | Viewed by 100 | Submission Open

Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets

edited by

Konstantinos Arvanitakis

submission deadline 18 Feb 2026 | Viewed by 1692 | Submission Open

Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetic and Molecular Markers in Prostate Cancer

edited by Thaidy Moreno-Rodriguez

submission deadline 19 Feb 2026 | Viewed by 94 | Submission Open

Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology

(This special issue belongs to the Section Molecular Oncology)

The Role of Dysbiosis in Chronic Diseases

edited by

Ana Isabel Beltrán-Velasco

submission deadline 20 Feb 2026 | 5 articles | Viewed by 27620 | Submission Open

Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair

edited by Victoria Moreno-Manzano

submission deadline 20 Feb 2026 | 10 articles | Viewed by 24543 | Submission Open

Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Probiotics in Health and Disease

edited by

Jasna Novak

submission deadline 20 Feb 2026 | 3 articles | Viewed by 24543 | Submission Open

Keywords: probiotic; microbiota; quality; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites

edited by

Jen-Tsung Chen

submission deadline 20 Feb 2026 | 12 articles | Viewed by 23495 | Submission Open

Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines

(This special issue belongs to the Section Molecular Plant Sciences)

Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression

edited by Sonam Mittal

submission deadline 20 Feb 2026 | 7 articles | Viewed by 22845 | Submission Open

Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Advanced Research in Prediction of Protein Structure and Function, 2nd Edition

edited by

Shuai Cheng Li

submission deadline 20 Feb 2026 | 5 articles | Viewed by 22188 | Submission Open

Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment

(This special issue belongs to the Section Molecular Informatics)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases

edited by

Niels Schaft

submission deadline 20 Feb 2026 | 6 articles | Viewed by 20565 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Steroid Biosynthesis and Metabolism

edited by Amanda C. Swart

submission deadline 20 Feb 2026 | 6 articles | Viewed by 19437 | Submission Open

Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advancements in Cancer Biomarkers

edited by

Christos Mikropoulos

submission deadline 20 Feb 2026 | 10 articles | Viewed by 16214 | Submission Open

Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Alzheimer’s Disease

edited by Sudip Dhakal

submission deadline 20 Feb 2026 | 10 articles | Viewed by 15723 | Submission Open

Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Postharvest Biology and Molecular Research of Fruits

edited by

Xiangbin Xu

submission deadline 20 Feb 2026 | 6 articles | Viewed by 15167 | Submission Open

Keywords: postharvest biology; fruit; storage technologies; molecular mechanisms; senescence; chilling injury; browning; nutrition; disease; toxin

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 1551-1600 on page 32 of 69.

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